LOCUS       NM_178070               2595 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus vacuolar protein sorting 33B (Vps33b), mRNA.
ACCESSION   NM_178070
VERSION     NM_178070.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2595)
  AUTHORS   Xiang H, Tao Y, Jiang Z, Huang X, Wang H, Cao W, Li J, Ding R, Shen
            M, Feng R, Li L, Guan C, Liu J, Ni J, Chen L, Wang Z, Ye Y, Zhong
            Q, Liu J, Zou Q and Wu X.
  TITLE     Vps33B controls Treg cell suppressive function through inhibiting
            lysosomal nutrient sensing complex-mediated mTORC1 activation
  JOURNAL   Cell Rep 39 (11), 110943 (2022)
   PUBMED   35705052
  REMARK    GeneRIF: Vps33B controls Treg cell suppressive function through
            inhibiting lysosomal nutrient sensing complex-mediated mTORC1
            activation.
REFERENCE   2  (bases 1 to 2595)
  AUTHORS   Ma J, Han M, Yang D, Zheng T, Hu R, Wang B, Ye Y, Liu J and Huang
            G.
  TITLE     Vps33B in Dendritic Cells Regulates House Dust Mite-Induced
            Allergic Lung Inflammation
  JOURNAL   J Immunol 207 (11), 2649-2659 (2021)
   PUBMED   34732466
  REMARK    GeneRIF: Vps33B in Dendritic Cells Regulates House Dust
            Mite-Induced Allergic Lung Inflammation.
REFERENCE   3  (bases 1 to 2595)
  AUTHORS   Fu K, Wang C, Gao Y, Fan S, Zhang H, Sun J, Jiang Y, Liu C, Guan L,
            Liu J, Huang M and Bi H.
  TITLE     Metabolomics and Lipidomics Reveal the Effect of Hepatic Vps33b
            Deficiency on Bile Acids and Lipids Metabolism
  JOURNAL   Front Pharmacol 10, 276 (2019)
   PUBMED   30967781
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2595)
  AUTHORS   Wang C, Cheng Y, Zhang X, Li N, Zhang L, Wang S, Tong X, Xu Y, Chen
            GQ, Cheng S, Fan X and Liu J.
  TITLE     Vacuolar Protein Sorting 33B Is a Tumor Suppressor in
            Hepatocarcinogenesis
  JOURNAL   Hepatology 68 (6), 2239-2253 (2018)
   PUBMED   29729199
  REMARK    GeneRIF: Down-regulation of Vps33b expression is a critical step
            for inflammation-driven hepatocellular carcinoma, and Vps33b serves
            as an important tumor suppressor in hepatocarcinogenesis.
REFERENCE   5  (bases 1 to 2595)
  AUTHORS   Perez-Garcia V, Fineberg E, Wilson R, Murray A, Mazzeo CI, Tudor C,
            Sienerth A, White JK, Tuck E, Ryder EJ, Gleeson D, Siragher E,
            Wardle-Jones H, Staudt N, Wali N, Collins J, Geyer S,
            Busch-Nentwich EM, Galli A, Smith JC, Robertson E, Adams DJ,
            Weninger WJ, Mohun T and Hemberger M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   6  (bases 1 to 2595)
  AUTHORS   Xiang B, Zhang G, Ye S, Zhang R, Huang C, Liu J, Tao M, Ruan C,
            Smyth SS, Whiteheart SW and Li Z.
  TITLE     Characterization of a Novel Integrin Binding Protein, VPS33B, Which
            Is Important for Platelet Activation and In Vivo Thrombosis and
            Hemostasis
  JOURNAL   Circulation 132 (24), 2334-2344 (2015)
   PUBMED   26399659
REFERENCE   7  (bases 1 to 2595)
  AUTHORS   Bem D, Smith H, Banushi B, Burden JJ, White IJ, Hanley J, Jeremiah
            N, Rieux-Laucat F, Bettels R, Ariceta G, Mumford AD, Thomas SG,
            Watson SP and Gissen P.
  TITLE     VPS33B regulates protein sorting into and maturation of
            alpha-granule progenitor organelles in mouse megakaryocytes
  JOURNAL   Blood 126 (2), 133-143 (2015)
   PUBMED   25947942
  REMARK    GeneRIF: Abnormal protein trafficking and impairment in
            multivesicular bodies maturation in Megakaryocytes underlie the
            alpha-granule deficiency in Vps33b(fl/fl)-ER(T2) mouse and ARC
            patients.
REFERENCE   8  (bases 1 to 2595)
  AUTHORS   Cullinane AR, Straatman-Iwanowska A, Zaucker A, Wakabayashi Y,
            Bruce CK, Luo G, Rahman F, Gurakan F, Utine E, Ozkan TB, Denecke J,
            Vukovic J, Di Rocco M, Mandel H, Cangul H, Matthews RP, Thomas SG,
            Rappoport JZ, Arias IM, Wolburg H, Knisely AS, Kelly DA, Muller F,
            Maher ER and Gissen P.
  TITLE     Mutations in VIPAR cause an arthrogryposis, renal dysfunction and
            cholestasis syndrome phenotype with defects in epithelial
            polarization
  JOURNAL   Nat Genet 42 (4), 303-312 (2010)
   PUBMED   20190753
  REMARK    Erratum:[Nat Genet. 2011 Mar;43(3):277]
REFERENCE   9  (bases 1 to 2595)
  AUTHORS   Gissen P, Johnson CA, Gentle D, Hurst LD, Doherty AJ, O'Kane CJ,
            Kelly DA and Maher ER.
  TITLE     Comparative evolutionary analysis of VPS33 homologues: genetic and
            functional insights
  JOURNAL   Hum Mol Genet 14 (10), 1261-1270 (2005)
   PUBMED   15790593
REFERENCE   10 (bases 1 to 2595)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032076.1, CD560991.1, AU257277.1 and BC028783.1.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_178070.5.
            
            On Oct 31, 2007 this sequence version replaced NM_178070.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032076.1, BC034170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK032076.1         3-17
            16-615              CD560991.1         7-606
            616-2292            AK032076.1         618-2294
            2293-2372           AU257277.1         72-151
            2373-2595           BC028783.1         1174-1396
FEATURES             Location/Qualifiers
     source          1..2595
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..2595
                     /gene="Vps33b"
                     /note="vacuolar protein sorting 33B"
                     /db_xref="GeneID:233405"
                     /db_xref="MGI:MGI:2446237"
     exon            1..425
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..2183
                     /gene="Vps33b"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 33B"
                     /protein_id="NP_835171.2"
                     /db_xref="CCDS:CCDS39997.1"
                     /db_xref="GeneID:233405"
                     /db_xref="MGI:MGI:2446237"
                     /translation="MAFPHRLDAPELPDFSMLKRLARDQLIYLLEQLPGKKDLFIEAD
                     LMSPLDRIANVSILKQHEVDKLYKVENKPALSANEQLCFLVRPRIKNMRYIASLVNAD
                     KLAGRIRKYKVILSPQKFYACEMVLEEEGVYGDVSCDEWAFSLLPLDVDLLSMELPEF
                     FRDYFLEGDQRWINTVAQALHLLSTLYGPFPNCYGIGRCAKMSYDLWRKLEEEEDSET
                     KGRKPEIGHIFLLDRDVDFVTALCSQVVYEGLVDDTFRIKCGSVDFGPEVTSSDKSLK
                     VLLNAEDKVFSEIRNEHFSNVFGFLSQKARNLQAQYDRRRGMDIKQMKNFVSQELKGL
                     KQEHRLLSLHIGACESIMKKKTKQDFQELIKTEHALLEGFNIRESTSYIEEHIDRQVS
                     PIESLRLMCLLSITENGLIPKDYRSLKTQYLQSYGPEHLLTFSNLRRAGLLTEQAPGD
                     TLTAVESKVSKLVTDKAAGKITDAFSSLAKRSNFRAISKKLNLIPRVDGEYDLKVPRD
                     MAYVFSGAYVPLSCRIIEQVLDRRSWQGLDEVVRLLNCSEFAFTDTAKEDKASSESLR
                     LILVVFLGGCTFSEISALRFLGREKGYRFIFLTTAVTNSARLMEAMSEVKS"
     exon            426..506
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            507..568
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            569..618
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            619..686
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            687..732
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            733..827
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            828..932
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1029
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1107
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1181
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1268
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1359
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1434
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1499
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1554
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1601
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1734
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1808
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1910
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..1986
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2103
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2568
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctctgggta ggaggcgggg ttccccggca cgctgccgag tgtgcggatg tcgttgggaa
       61 tcctgctgac aggctgagtg gactcgggcg ggaccagtga ctataggtct ccaaggagag
      121 tcgcctgagc ctgtggccgt ccgtccggga ggtggtcggt cattcatccg tcgagtacgg
      181 cagaggagcg agggcccctt gggggtcctg ggatccagag cccaggcaag cggggtacca
      241 gcctgcagta acaccttggg ctgtcgccgg cctttgcaga acagggagaa ttctgctgct
      301 ctcacacggt ggctcaggtg accgctgcca tggcttttcc ccatcggctg gacgcccctg
      361 agcttcccga cttctctatg ctcaagaggc tggctcggga ccagctcatc tatctgctag
      421 aacagcttcc tggaaaaaag gatttgttca ttgaggcaga tctcatgagc cctttggatc
      481 gaattgctaa cgtctctatc ctgaagcaac atgaagtgga caagctgtac aaggtggaga
      541 acaaacctgc cctcagcgcc aatgaacaac tgtgcttctt ggtcagacct cgaatcaaga
      601 atatgcgcta cattgccagt cttgtcaatg ctgacaagct ggctggcaga attagaaaat
      661 acaaagtcat cctaagccct cagaagtttt atgcatgtga gatggtgctt gaggaagagg
      721 gagtctatgg agatgtgagc tgtgatgagt gggccttttc tctgctgcct cttgatgtcg
      781 atctgctgag catggaactg ccagaatttt tcagggatta cttcctggaa ggtgatcagc
      841 gttggatcaa cactgtggct caggccttac accttctcag tactctctat gggccctttc
      901 ctaactgcta tggcattggc agatgtgcaa agatgtcata tgacctgtgg aggaaactgg
      961 aggaggaaga agacagtgaa accaaaggtc ggaaaccaga gattggacac atctttctcc
     1021 tggacagaga tgtggacttt gtgacagcac tttgctccca agtggtttac gagggcttgg
     1081 tagatgacac cttccgaatc aagtgtggaa gtgttgactt tggcccagaa gtcacatcct
     1141 ctgacaagag cctgaaggtg ctactcaacg ctgaggacaa ggtgttcagt gagatccgca
     1201 atgagcactt ctccaatgtc tttggcttct tgagccagaa ggcccggaac ttgcaggccc
     1261 aatatgaccg ccggagaggc atggacataa agcagatgaa gaacttcgtg tcgcaagagc
     1321 tcaagggact gaagcaggag caccgccttc tgagtctcca tattggggct tgtgaatcaa
     1381 tcatgaagaa gaaaaccaag caggacttcc aggagctaat caagaccgag catgcgctgc
     1441 tggagggctt caacatccga gagagcacta gctacattga agagcacata gaccggcagg
     1501 tgtcgcccat agagagccta cgcctcatgt gccttttgtc catcactgag aatggtttga
     1561 tacccaagga ttatcggtcc ctgaaaacac agtatctgca gagctatggc cccgagcacc
     1621 tgctaacctt ctccaacctg cggagagccg ggcttctaac agagcaggct cctggggaca
     1681 ccctcacagc agtagagagt aaagtgagca agctggtgac ggacaaggct gcagggaaaa
     1741 tcactgacgc cttcagttct ctggccaaga ggagcaattt tcgtgccatc agcaaaaagc
     1801 tgaatttgat cccacgtgta gatggggagt atgacctgaa agtgccccga gacatggctt
     1861 atgtcttcag tggtgcctat gtgcctctga gctgccgaat cattgagcag gtgctggacc
     1921 ggcggagttg gcagggcctt gatgaagtgg tacggctgct aaactgcagt gagtttgcat
     1981 tcacagacac ggctaaggaa gacaaggctt ccagtgagtc actgcgcctc atcttggtgg
     2041 tgttcctggg gggctgcacg ttctcagaga tatcagccct gcgcttcctg ggtagagaga
     2101 aagggtacag atttattttt ctgacaactg ctgttacaaa cagtgctcgc ctcatggaag
     2161 ccatgagtga ggtgaaatcc tgatgttttc ctggccagtg ctgaagtatt tcctgattgt
     2221 ggatcccagt gagatgctgg tgtttggcat ctaccttcta cgattcctgt cacacacaca
     2281 cacacacaca cacacacaca cacacacaca cacatataca catacacaca cacacataca
     2341 cacacacaca cacacacaca cacacacaca ccccagctac acttaatact cagagctggg
     2401 aactttggaa ctaattttgg gggagagaat tcatgtccta tcctccagga tactcctctt
     2461 gcttataaat tgtatatagt tcatgctgct aagatatgag gggagaggta ttctttgcaa
     2521 atcctgtttg aatattattg taaataaagc ctctgttctc tctctctcaa aaaaaaaaaa
     2581 aaaaaaaaaa aaaaa
//
