LOCUS       NP_084205                598 aa            linear   ROD 30-APR-2024
DEFINITION  vacuolar protein sorting-associated protein 33A isoform 1 [Mus
            musculus].
ACCESSION   NP_084205
VERSION     NP_084205.3
DBSOURCE    REFSEQ: accession NM_029929.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 598)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 598)
  AUTHORS   Yuan,Y., Liu,T., Huang,X., Chen,Y., Zhang,W., Li,T., Yang,L.,
            Chen,Q., Wang,Y., Wei,A. and Li,W.
  TITLE     A zinc transporter, transmembrane protein 163, is critical for the
            biogenesis of platelet dense granules
  JOURNAL   Blood 137 (13), 1804-1817 (2021)
   PUBMED   33513603
REFERENCE   3  (residues 1 to 598)
  AUTHORS   Hubert,V., Peschel,A., Langer,B., Groger,M., Rees,A. and Kain,R.
  TITLE     LAMP-2 is required for incorporating syntaxin-17 into
            autophagosomes and for their fusion with lysosomes
  JOURNAL   Biol Open 5 (10), 1516-1529 (2016)
   PUBMED   27628032
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 598)
  AUTHORS   Hao,Z., Wei,L., Feng,Y., Chen,X., Du,W., Ma,J., Zhou,Z., Chen,L.
            and Li,W.
  TITLE     Impaired maturation of large dense-core vesicles in muted-deficient
            adrenal chromaffin cells
  JOURNAL   J Cell Sci 128 (7), 1365-1374 (2015)
   PUBMED   25673877
REFERENCE   5  (residues 1 to 598)
  AUTHORS   Zhen,Y. and Li,W.
  TITLE     Impairment of autophagosome-lysosome fusion in the buff mutant mice
            with the VPS33A(D251E) mutation
  JOURNAL   Autophagy 11 (9), 1608-1622 (2015)
   PUBMED   26259518
  REMARK    GeneRIF: VPS33A(D251E) mutation plays dual roles by increasing the
            HOPS complex assembly and its association with the autophagic SNARE
            complex, which selectively affects the autophagosome-lysosome
            fusion.
REFERENCE   6  (residues 1 to 598)
  AUTHORS   Novak,E.K., Hui,S.W. and Swank,R.T.
  TITLE     Platelet storage pool deficiency in mouse pigment mutations
            associated with seven distinct genetic loci
  JOURNAL   Blood 63 (3), 536-544 (1984)
   PUBMED   6696991
REFERENCE   7  (residues 1 to 598)
  AUTHORS   Peters,J., Povey,S., Jeremiah,S. and De Giorgi,L.
  TITLE     Linkage relationships of peptidase-7, Pep-7, in the mouse
  JOURNAL   Biochem Genet 21 (7-8), 801-807 (1983)
   PUBMED   6626149
REFERENCE   8  (residues 1 to 598)
  AUTHORS   Hakansson,E.M. and Lundin,L.G.
  TITLE     Effect of a coat color locus on kidney lysosomal glycosidases in
            the house mouse
  JOURNAL   Biochem Genet 15 (1-2), 75-85 (1977)
   PUBMED   849254
REFERENCE   9  (residues 1 to 598)
  AUTHORS   Womack,J.E., Hawes,N.L., Soares,E.R. and Roderick,T.H.
  TITLE     Mitochondrial malate dehydrogenase (Mor-1) in the mouse: linkage to
            chromosome 5 markers
  JOURNAL   Biochem Genet 13 (9-10), 519-525 (1975)
   PUBMED   1203052
REFERENCE   10 (residues 1 to 598)
  AUTHORS   Swank,R.T., Paigen,K. and Ganschow,R.E.
  TITLE     Genetic control of glucuronidase induction in mice
  JOURNAL   J Mol Biol 81 (2), 225-243 (1973)
   PUBMED   4777306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB852750.1, AK041982.1, AK140553.1 and BU703144.1.
            
            On Jul 23, 2009 this sequence version replaced NP_084205.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046417.1, SRR1660815.194875.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..598
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.03 cM"
     Protein         1..598
                     /product="vacuolar protein sorting-associated protein 33A
                     isoform 1"
                     /note="vacuolar protein sorting-associated protein 33A;
                     vacuolar sorting protein 33a; buff; vacuolar protein
                     sorting 33A"
                     /calculated_mol_wt=67424
     Region          34..591
                     /region_name="Sec1"
                     /note="Sec1 family; pfam00995"
                     /db_xref="CDD:460020"
     CDS             1..598
                     /gene="Vps33a"
                     /gene_synonym="3830421M04Rik; bf"
                     /coded_by="NM_029929.3:35..1831"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19666.1"
                     /db_xref="GeneID:77573"
                     /db_xref="MGI:MGI:1924823"
ORIGIN      
        1 maahlsygrv nlnvlreavr relrefldkc agskaivwde yltgpfglia qysllkehev
       61 ekmftlkgsr lpaadvknii flvrprlelm diiaenvlse drrgptrdfh ilfvprrsll
      121 ceqrlkdlgv lgsfihreey sldlipfdgd llsmesegaf kecylegdqt slyhaakglm
      181 tlqalygtip qifgkgecar qvanmmvrmk reftgsqnsv fpvfdnllll drnvdlltpl
      241 asqltyegli deiygiqnsy vklppekfap kkqgggsggk dlpteakklq lnsaeelyae
      301 irdknfnavg svlskkakii saafeerhna ktvgeikqfv sqlphmqaar gslanhtsia
      361 elikdvttse dffdkltveq efmsgidtdk vnsyiedcia qkhplikvlr lvclqsvcns
      421 glkqkvldyy rreilqtygy ehiltlnnle kagllkaqtg grnnyptirk tlrlwmddvn
      481 eqnptdisyv ysgyaplsvr laqllsrpgw rsieevlril pgphfeerqp lptglqkkrq
      541 pgenrvtlvf flggvtfaei aalrflsqle dggteyviat tklmngnswi ealmekpf
//
