LOCUS       NM_007834               2419 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus VPS26 endosomal protein sorting factor C (Vps26c),
            mRNA.
ACCESSION   NM_007834
VERSION     NM_007834.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2419)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2419)
  AUTHORS   Vos,D.Y., Wijers,M., Smit,M., Huijkman,N., Kloosterhuis,N.J.,
            Wolters,J.C., Tissink,J.J., Pronk,A.C.M., Kooijman,S.,
            Rensen,P.C.N., Kuivenhoven,J.A. and van de Sluis,B.
  TITLE     Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte
            Lipoprotein Receptor Recycling to Control Postprandial
            Triglyceride-Rich Lipoproteins
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (1), e29-e45 (2023)
   PUBMED   36353989
REFERENCE   3  (bases 1 to 2419)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   4  (bases 1 to 2419)
  AUTHORS   Yaylaoglu,M.B., Titmus,A., Visel,A., Alvarez-Bolado,G., Thaller,C.
            and Eichele,G.
  TITLE     Comprehensive expression atlas of fibroblast growth factors and
            their receptors generated by a novel robotic in situ hybridization
            platform
  JOURNAL   Dev Dyn 234 (2), 371-386 (2005)
   PUBMED   16123981
REFERENCE   5  (bases 1 to 2419)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 2419)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   7  (bases 1 to 2419)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   8  (bases 1 to 2419)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
REFERENCE   9  (bases 1 to 2419)
  AUTHORS   Nakamura,A., Hattori,M. and Sakaki,Y.
  TITLE     Isolation of a novel human gene from the Down syndrome critical
            region of chromosome 21q22.2
  JOURNAL   J Biochem 122 (4), 872-877 (1997)
   PUBMED   9399594
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU709449.1, AK077628.1 and BY483431.1.
            
            On Jan 10, 2008 this sequence version replaced NM_007834.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB001990.1, AK077485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               BU709449.1         203-397
            196-2335            AK077628.1         2-2141
            2336-2419           BY483431.1         278-361
FEATURES             Location/Qualifiers
     source          1..2419
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 55.23 cM"
     gene            1..2419
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /note="VPS26 endosomal protein sorting factor C"
                     /db_xref="GeneID:13185"
                     /db_xref="MGI:MGI:1206040"
     exon            1..292
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1129
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /note="Down syndrome critical region gene A; Down syndrome
                     critical region protein A homolog; Down syndrome critical
                     region protein 3 homolog; Down syndrome critical region
                     gene 3; DSCR3 arrestin fold containing"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 26C"
                     /protein_id="NP_031860.1"
                     /db_xref="CCDS:CCDS28349.1"
                     /db_xref="GeneID:13185"
                     /db_xref="MGI:MGI:1206040"
                     /translation="MGTTLDIKIKRANKVYHAGEMLSGVVVISSKDSVQHQGVSLTME
                     GTVNLQLSAKSVGVFEAFYNSVKPIQIINSTIDVLKPGKIPSGKTEVPFEFPLLVKGS
                     KVLYETYHGVFVNIQYTLRCDMRRSLLAKDLTKTCEFIVHSAPQKGKLTPSPVDFTIT
                     PETLQNVKERASLPKFFIRGHLNSTNCAITQPLTGELVVEHSDAAIRSIELQLVRVET
                     CGCAEGYARDATEIQNIQIADGDICRNLSVPLYMVFPRLFTCPTLETTNFKVEFEVNV
                     VVLLHADHLITENFPLKLCRT"
     exon            293..436
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /inference="alignment:Splign:2.1.0"
     exon            437..586
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..667
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /inference="alignment:Splign:2.1.0"
     exon            668..742
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /inference="alignment:Splign:2.1.0"
     exon            743..893
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1046
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..2405
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1645..1650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /note="hexamer: AATAAA"
     polyA_site      1662
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /note="major polyA site"
     regulatory      2319..2324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /note="hexamer: AATAAA"
     regulatory      2323..2328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /note="hexamer: AAGAAA"
     polyA_site      2341
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /note="major polyA site"
     polyA_site      2346
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
     regulatory      2381..2386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
                     /note="hexamer: AGTAAA"
     polyA_site      2401
                     /gene="Vps26c"
                     /gene_synonym="Dcra; Dscr3"
ORIGIN      
        1 gttccggaag tgtgtgtgtg tgtgttcgcg cgcgcgcgcg cgcgcgcgtg tgggtttcgt
       61 gcccctgtcc gcgctaagcc acgccctgtg cccgaaggag ggaggtgtgt gaggtgtggc
      121 gcgaaagccg gtcacgtgcc accactgcgg aaggcgccgg aggggcgggt tcgtaggggg
      181 cggggcaacc gggtcacgag tggccggaag ttgcggcctt tgcggataat ctgagatggg
      241 gaccactctg gacatcaaga ttaaaagagc gaataaagtg tatcacgccg gggaaatgct
      301 ctctggtgtg gtggtcatct ctagcaagga ctcagtccag caccagggag tctctttgac
      361 aatggaaggg actgtaaacc tccagctcag tgccaaaagt gtgggtgtgt tcgaagcctt
      421 ttacaactct gtgaagccga tccagattat caacagcacc atagacgtgc tgaagccagg
      481 aaagattccc agtggcaaga ctgaggtccc ctttgagttc ccactgcttg tgaaaggcag
      541 caaggtcctg tatgagactt accacggcgt gtttgtcaac attcagtaca cactgcgctg
      601 tgacatgcgg cggtccctgt tggccaagga cctgaccaag acctgtgaat tcatcgttca
      661 ctctgcccct cagaagggga agttgacccc aagtcctgtt gacttcacga tcactccgga
      721 aaccttgcag aacgtcaaag agagagcttc acttcccaaa ttcttcatta gaggacatct
      781 gaactccact aactgcgcta tcacgcagcc cctgacagga gagctggtgg tggaacactc
      841 ggatgctgct atccggagca tagagcttca gttggtccgg gtggagacct gtgggtgtgc
      901 agaaggctat gcacgagatg ccacagagat tcagaatatt caaatcgctg atggggacat
      961 ttgtagaaac ctttctgttc ccctgtacat ggtcttcccc agactgttca cctgtccaac
     1021 actggagacc accaacttca aagtggagtt tgaggtcaat gtggtggtcc tccttcatgc
     1081 tgaccacctc atcactgaga actttccgct gaagctctgt cggacatagt ccagctgcag
     1141 gaaggggaga gccagaatgg ccatgtggac attgacccag tcatctgctc acatggggac
     1201 gtcacacaga ccacctgctc acaggcatca catcagcagc atacatcttc atgtcttctc
     1261 atggcctcaa agcttgttcc ctgcaggtgc cttacctcag ccctcacgtc tggaatgcaa
     1321 caggatttct cctgtgtgtt gcaagatcac agaaagcgtt cccaatggct ccagatgtgc
     1381 ctgtttcttc ttaggttcat taagcagtgt gtctgcacat taagatgggc tgcctagtga
     1441 gatcatggag gcagaagaga gcccccaccc ctctatcttg cccagactcc tgacagcaaa
     1501 gagtcagcaa ccagcaagct ctctgattga gtctgtaatc ccctccaagg agtgacagtg
     1561 acttcatctg ggaatacgga gttttccctt cttgacatct tgatagtgtt tcactaaagc
     1621 ctctaaatgt tttagggcac tggaaataaa aaccaacaaa tagtcctggt tctcacagag
     1681 ggagaatggt gaacagtggc tgttgctgga gtgtttgtgt gtgtggtact ggcacacagt
     1741 taatgctgcc atattcccag aatgtattga gagacaaggt gcttgcataa ggggaagaat
     1801 gcacatggac tactggtaag tactaggttc tgagtgacag gacaccgtgc tgaggaaggg
     1861 caatggcctt ggcctgtccc tgaccccctg ggtcacatgg ctttagcctc acactgtaac
     1921 tcatactgta tggagggtat gttgcaatac tttgcttcct ttgaatctcg ctgttgttct
     1981 gttggtccag agttaatgag cgccctgtac accagctggc ctgccttcac aggttctggg
     2041 gggcaggccg aggcaaagca ggcccgactg gcagcctcct ggctgcactc ccactgttct
     2101 gaacagctga gggaactggg gcactgctgc tggggcctca ccagggaaac tgagaagact
     2161 tagctgagtc acctgacagt gagttcccag agaatgtact tttgctttgt catacttatc
     2221 cttgttatat ttaaacaatc tagtacccaa aaaatgtggg ccgtactttc tagtgagtct
     2281 aaggaaaagt catctttgat tacataattt ttttaatgaa taaagaaagc taaacaagtt
     2341 ttttaatggt ttggactgca tattgttata taacatcttt agtaaacttt cagaattgtg
     2401 atgaaaaaaa aaaaaaaaa
//
