LOCUS       NM_178027               6890 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus VPS26 retromer complex component B (Vps26b), mRNA.
ACCESSION   NM_178027
VERSION     NM_178027.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6890)
  AUTHORS   Simoes,S., Guo,J., Buitrago,L., Qureshi,Y.H., Feng,X., Kothiya,M.,
            Cortes,E., Patel,V., Kannan,S., Kim,Y.H., Chang,K.T.,
            Hussaini,S.A., Moreno,H., Di Paolo,G., Andersen,O.M. and Small,S.A.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Alzheimer's vulnerable brain region relies on a distinct retromer
            core dedicated to endosomal recycling
  JOURNAL   Cell Rep 37 (13), 110182 (2021)
   PUBMED   34965419
REFERENCE   2  (bases 1 to 6890)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6890)
  AUTHORS   Bugarcic,A., Zhe,Y., Kerr,M.C., Griffin,J., Collins,B.M. and
            Teasdale,R.D.
  TITLE     Vps26A and Vps26B subunits define distinct retromer complexes
  JOURNAL   Traffic 12 (12), 1759-1773 (2011)
   PUBMED   21920005
REFERENCE   4  (bases 1 to 6890)
  AUTHORS   Kim,E., Lee,Y., Lee,H.J., Kim,J.S., Song,B.S., Huh,J.W., Lee,S.R.,
            Kim,S.U., Kim,S.H., Hong,Y., Shim,I. and Chang,K.T.
  TITLE     Implication of mouse Vps26b-Vps29-Vps35 retromer complex in
            sortilin trafficking
  JOURNAL   Biochem Biophys Res Commun 403 (2), 167-171 (2010)
   PUBMED   21040701
  REMARK    GeneRIF: These results suggest that mouse Vps26b-Vps29-Vps35
            retromer complex is implicated in the transport of sortilin from
            endosomes to the trans-Golgi network.
REFERENCE   5  (bases 1 to 6890)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   6  (bases 1 to 6890)
  AUTHORS   Kim,E., Lee,J.W., Baek,D.C., Lee,S.R., Kim,M.S., Kim,S.H.,
            Imakawa,K. and Chang,K.T.
  TITLE     Identification of novel retromer complexes in the mouse testis
  JOURNAL   Biochem Biophys Res Commun 375 (1), 16-21 (2008)
   PUBMED   18656452
REFERENCE   7  (bases 1 to 6890)
  AUTHORS   Collins,B.M., Norwood,S.J., Kerr,M.C., Mahony,D., Seaman,M.N.,
            Teasdale,R.D. and Owen,D.J.
  TITLE     Structure of Vps26B and mapping of its interaction with the
            retromer protein complex
  JOURNAL   Traffic 9 (3), 366-379 (2008)
   PUBMED   18088321
  REMARK    GeneRIF: both Vps26A and Vps26B are incorporated into retromer
            complexes through binding of Vps35 to a highly conserved surface
            patch within the C-terminal subdomain
REFERENCE   8  (bases 1 to 6890)
  AUTHORS   Kerr,M.C., Bennetts,J.S., Simpson,F., Thomas,E.C., Flegg,C.,
            Gleeson,P.A., Wicking,C. and Teasdale,R.D.
  TITLE     A novel mammalian retromer component, Vps26B
  JOURNAL   Traffic 6 (11), 991-1001 (2005)
   PUBMED   16190980
  REMARK    GeneRIF: Vps26B was found in the cytoplasm with low levels at the
            plasma membrane, while Vps26A was predominantly associated with
            endosomal membranes
REFERENCE   9  (bases 1 to 6890)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031589.1, AK150929.1, AK163860.1, AK040818.1 and AI661668.1.
            
            On Dec 13, 2008 this sequence version replaced NM_178027.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031589.1, BC049180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AK031589.1         4-84
            82-3605             AK150929.1         3-3526
            3606-4816           AK163860.1         1309-2519
            4817-6485           AK040818.1         1207-2875
            6486-6890           AI661668.1         1-405               c
FEATURES             Location/Qualifiers
     source          1..6890
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 12.07 cM"
     gene            1..6890
                     /gene="Vps26b"
                     /gene_synonym="1810012I05Rik; 2310075A12Rik"
                     /note="VPS26 retromer complex component B"
                     /db_xref="GeneID:69091"
                     /db_xref="MGI:MGI:1917656"
     exon            1..696
                     /gene="Vps26b"
                     /gene_synonym="1810012I05Rik; 2310075A12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             474..1484
                     /gene="Vps26b"
                     /gene_synonym="1810012I05Rik; 2310075A12Rik"
                     /note="vesicle protein sorting 26B; vacuolar protein
                     sorting 26 homolog B"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 26B"
                     /protein_id="NP_821170.1"
                     /db_xref="CCDS:CCDS22938.1"
                     /db_xref="GeneID:69091"
                     /db_xref="MGI:MGI:1917656"
                     /translation="MSFFGFGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGE
                     TVSGKVSLSLKNPNKRLEHQGIKIEFIGQIELYYDRGNHHEFVSLVKDLARPGEITQS
                     QAFDFEFTHVEKPYESYTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNS
                     SIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMEIDIIKRETTGTG
                     PNVYHENDTIAKYEIMDGAPVRGESIPIRLFLAGYELTPTMRDINKKFSVRYYLNLVL
                     IDEEERRYFKQQEVVLWRKGDIVRKSMSHQAAIASQRFEGTTSLGEVRTPGQLSDNNS
                     RQ"
     exon            697..853
                     /gene="Vps26b"
                     /gene_synonym="1810012I05Rik; 2310075A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1018
                     /gene="Vps26b"
                     /gene_synonym="1810012I05Rik; 2310075A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1194
                     /gene="Vps26b"
                     /gene_synonym="1810012I05Rik; 2310075A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1337
                     /gene="Vps26b"
                     /gene_synonym="1810012I05Rik; 2310075A12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..6873
                     /gene="Vps26b"
                     /gene_synonym="1810012I05Rik; 2310075A12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3558..3563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps26b"
                     /gene_synonym="1810012I05Rik; 2310075A12Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3606
                     /gene="Vps26b"
                     /gene_synonym="1810012I05Rik; 2310075A12Rik"
                     /note="major polyA site"
     regulatory      6850..6855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps26b"
                     /gene_synonym="1810012I05Rik; 2310075A12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6873
                     /gene="Vps26b"
                     /gene_synonym="1810012I05Rik; 2310075A12Rik"
ORIGIN      
        1 gtgcgcgtgg catcatcttc gcatccgggc cggagttctc ctgccccttc ccccgcccgg
       61 cgccgccgta gcacttcggt gcgttacgcc gcgggagtcc aggcagttct gtgtgtgcgg
      121 ctgggcgctg gaccccaccc ggtgggcgac gagacgcgcg tgcttggcgc ctttcctccc
      181 agggccctag tcgctgcacc gccaggatct gcgttggtac tgtgtctggc ctctcggtgc
      241 atcgctgctc tgggcgccgc aacccgcagc cgacctcctt cctccgccct gcctcacccc
      301 aggggcgcag gccatcggcg atcgcccacc gcccagctca gagcgagcgg ggctgcggtg
      361 cagcgtccag cgcgttcccg cagccggccc tccggcctgc cttccccgaa ggcagctcgc
      421 gcctgggagg gagggagcag tctgtgccga caccggcgcg gccaggcggg gagatgagct
      481 tcttcggctt cgggcagagc gtggaggtgg aaatcttgct gaatgatgcg gagagtagga
      541 agcgagcgga gcacaagact gaggacggga agaaggagaa atatttcctc ttctacgacg
      601 gggaaaccgt ctcggggaaa gtgagcctat cactgaagaa ccccaacaag cgactagagc
      661 accagggcat caagatcgag ttcattgggc agatcgaact ctactatgac cgtgggaacc
      721 accatgagtt tgtgtctttg gtgaaggacc tggctcggcc aggagagatc acccaatcgc
      781 aggccttcga ctttgagttc acccatgtgg aaaagccgta tgaatcctac acaggacaga
      841 atgtgaagct ccgctatttc cttcgagcca ccatcagccg ccgcctcaat gatgttgtta
      901 aagagatgga cattgtagtt cacacactta gcacataccc cgagctgaac tcatccatca
      961 agatggaagt tggcattgag gattgcctgc acattgaatt tgagtacaac aaatccaaat
     1021 accacttgaa agatgtcatt gtagggaaga tatacttcct gctggtgaga atcaagatca
     1081 agcacatgga gatagacatc atcaaacgag agacaacagg cacgggtccc aacgtgtacc
     1141 acgagaacga cacaatagcg aagtatgaga tcatggacgg ggcaccagtc cgaggtgagt
     1201 ccatccccat caggctcttc ctggcagggt atgagctcac acccaccatg cgtgacataa
     1261 ataagaagtt ctctgtgcgc tattacctca acttggtgct gatagatgag gaggaacggc
     1321 gctacttcaa gcagcaggaa gtggtgttgt ggcggaaggg tgacatcgta cggaagagca
     1381 tgtcccacca ggcagccatt gcctcacagc gcttcgaggg cacaacctcc ctgggtgagg
     1441 tgcggacccc tggccaactg tctgacaaca acagcaggca gtaggcccct ggggccaaga
     1501 agttgctggg cttccaccac agaaccccca tctgccgaat accagccact gcgggagggg
     1561 gaggatggtg tgaggttcaa ctggctgtta cttgcaacct tggaaacaaa tcatgttttt
     1621 tacttaaatt tttttctctg aagaacctaa ggggcttggg ttgggcagca gtctccccgg
     1681 gatgctgcag cctaggtagg gataaggaga ggaaacattc tggaagctaa tctcttcctt
     1741 gggaatgagc tctgtgtcaa ggctgtctca agccttaaag cagagttgag agcacacatc
     1801 cttggctcca ggttctctgg gcttcctgat acagaagctg agtgtgtccc tggcatttac
     1861 ctgccaccag ggctctgggt agtcgtgtct tatactccct gtgactgttc tgagatagtg
     1921 acagaagggc ctgtctcatc taacttggaa gaacactcaa gaacaggaag ctacctctcg
     1981 gggtgtccgg gacgtggtgc tctcgagttt ctacagtcac ctctggcctc tcactactgg
     2041 gaccagaccc ttctcttctt catcttctct agcttgtcaa gaactataca ggagcagaag
     2101 cttaaggaag ggtctgtgtc tgactcctct tacttgtgag aaacaggcac agagaagccc
     2161 tgattcggtg tcacacatgg atggcaaggg gctgaactag gtctcctgag ggggaaaaag
     2221 aaacatcagg caaggcaacc gtctgccttc accacatgac tcctcttggc aacccagtgt
     2281 ctgggttgtt gtagggaatt actttaagtt atccaacaag ccctaagcag agggtctgtt
     2341 tcctttagcc tagatcctag aagaggctgg gctccacttg cctcctaaag cagtttgtcc
     2401 tactccttgt cttctgcttg atttctggaa ctgggctttg tttcaagcat gtataagttt
     2461 tgtccttact cccacccaaa ccctttcatc ccaccatcta caaattaggg gaggaaggac
     2521 ctctgcacag ggctctgcta ctgtgactag agtaattctg cttgccaaat gacatctatc
     2581 ttcaccaatt cactgactca agtttaggac cactattttg ttttgttttg aatttaaaaa
     2641 caaaatagga caactgtggt ggatgttgtt atactagaga agaggtagtt cttcctcctg
     2701 ctctatgctt ggcctgcaag tagaaaaggg gttgactgtc tttctacctt gtctggaaat
     2761 gactagaatt accatctcct gttggctgtc ctcccctgtc tgagaaagat caagcagacc
     2821 tgatgttcaa caagtagtgt tcgctggtct gtgttccttg taatttggaa agtaaaggat
     2881 ttgttcctgt gtcatctttc agttcatgta gaaaatggga ctcttgcaat ctctggcttt
     2941 gacagggcgg gccgttggat gaaagactct tggaatgact gggggtagca gagctaagga
     3001 aagtaaagtt ttctccatgc acaaccccag gtttaggtgt gacatacaat ccccatggga
     3061 acaggttcac ccatccagct gtccttggct atcaaggctg ggccctagca tatgagggag
     3121 ttgggttctg ggctcttgcc cttttcagga tatgagacta gactctgccg tgcctccttt
     3181 taatatctca ttaaaaagca tttgtcaatt tctctgcctc ccagccgaca acacaaaatt
     3241 attttccaac ttttgctaat atcataagcc tttcttctgg gagaactaga aggtagaata
     3301 tgctgtttct ctcaggagct gtgcacaagc caagtatgtt ttctctgcct gtcccccgtt
     3361 ctcctttctc tgccaactgt gaaagtatgg gaaggttccc atccccatcc tttaaggttc
     3421 ccaaacctgg agtgcatagg tactaaacca agcagtgcaa cttgtaatta agaagctgca
     3481 gtgtttacat gtttcttaat gtgttgtctt ttcaatggct gtattttaaa agaacatttg
     3541 ttttaatgat gtctctaatt aaaggaagcc ctatggcttt ggaggcattg tgcccgtgat
     3601 ccaccagatt ctgtggtctt tccttcttaa cactgtctca tctctgacac agtatgcagc
     3661 atgcctttaa cactgccttc ttttccagtg gatggtaaac agtaatgagc actgtactaa
     3721 ccacccatta taggcaaaca tggcccagtt ctggccacac tgtctggcaa tgtgcctgaa
     3781 accccgtttt ccaccgtggt gggacaaaga agactaaaag tagcatggaa agatcaagac
     3841 atagatttac tgagtgttca aagaacaaga gactcagtcc tacattttgc tgtttactgc
     3901 gtaactacag aggtaggggc aggtgaaagt agaggtgcct acatcttcta gctgaccaaa
     3961 ggaaccaggc tgggatatga cacctccagt ggaggatcct tctacacaca acacaggttt
     4021 agaagaaaac acttccaacc ttgtcattaa atcttttatt aggaaaatta acaaaccatc
     4081 cgtgcacacg accccaggtg gatacagcaa gctttctcct tctgtcttat aaaatcttgg
     4141 cttgttcact ccatcagtag agccttctga ttaacttggt tctgtttcct ccaggctcaa
     4201 aataaaatca aactcttcta caaaaaagag gggttgaggg tgagactgag gtgtttatcg
     4261 tgtcccgcat agggaagttg aagggcagct cctgcagggg gcagctgtct attaagaagc
     4321 tggaacagct ggtactgggt atataacagt ggacagtgta gcacatagcc ttgcttgtgg
     4381 gtggctcagg tgagggcacc aactctccca tgttaggtct caccttgagt cagaggctga
     4441 acggaaagtc tctggcgggt gaagagagtc atgcttttta aggggccgcc agtagctttg
     4501 tgggcttggt gataggtttt aagctcctcc agagggatga agcgcttcat cattcgaaca
     4561 aactgtacat ccacctattc gacagcattt gaagggaaca gaaacacgtt cggccagacc
     4621 ctgcccaatt ttaagggatg ggtccactgt gttgcctagt gtgtccttaa attcctgttg
     4681 ctgaatcaat tttcaggcct cagcccaccg agtagctaag cgcatgtaca gccttgcttc
     4741 tgtgcacacc cagagttttt gctatttgca ggaggtgcct ggtattaggg ctgccaatat
     4801 tctgatatcc caattcagta aaacttcatc tagctgagag ctgggctgtg ctccctgacc
     4861 taacagtacc ccacattctt ttcccccttt tgtccactct gccctatgaa acaagaacag
     4921 ttcttaccat cgaccattta gggtcgtcct ctttgctgga tggatcgtaa tggggattac
     4981 ttttctcaaa ctgtgtgtgg tctgggtaag cctcctttac aatctgaaag caaaaaaccc
     5041 caatccagtc attttaaatc cctgcccaag tttttttttt ttttaataaa gatttattta
     5101 tttttatata tgagtgcatt gtagctgtct tcagacacac cagaagaagg catcagatcc
     5161 catcacagat ggttgtgagc caccatatgg ttgtgggaat tggactcggg acctctgaag
     5221 aacagcctgt gctcttaact gctgagccat ctcaccagcc tcctgcccaa attttaatat
     5281 gcatctaact caaatcccac ccccaccccc cattctaatc attttccctt gccatggaga
     5341 cagctggtac tctggaaata acaatctaag gaagcaaagc caggaaggag agctgaattt
     5401 tccaaggttt cacagccatg ttctaaaact caatgataag ttactgttgg aaacaggttt
     5461 ttattttctc ccaactccac acagttttat cctgaaattc ttagtgaaga ggagctactt
     5521 gatggaaacc tcagatagtg acaagtagta gtagggcctg aaatgaaggc cttcctattc
     5581 taatctctgt cacacaggtg atggtcaggg cacttttcct cactgactgt gacaggccga
     5641 gtgaggtcgt ttttgcctat ttaagctgta ggcctttcac aaatccctaa agggaagaat
     5701 ccaggctcag atgtgtgcgt ctaaccttca taagtccaac aatgccaggc tgtttgcagt
     5761 tgctatggta gaagaaggct tcatcctcca atttcatggc cctgaggaag ttccgagcct
     5821 gtgtcaaaga agaaacaagg gctacccact taacagctgg gaagaaagca agtctgtttt
     5881 tattcaatgt ttatttctgt tttgcagctt ctctccattc ataatgaaat ctgttccttt
     5941 gttcagagtc ctagccttgt tccaggacac tagccagaac caagctactt tgcagactgc
     6001 atgctgtcac agcgattatg atatttctga aaacattttc agatagagtt cagggaaaag
     6061 cagtactggc taaaaggccc tgctcctgca gactgcgatg gaggaggcag gcatgtacct
     6121 agtgtggtca gcttcagggt ccctgccctc atttccttac ctgatagttg cgaacaccat
     6181 cccagcaagc tgtctgcttg ggctgtgctt tgagatcctc gatgctgaac tagacaaaag
     6241 aaaatcaagc cattcattac taaaaggtca ctggccagtc ggtaagcttc tatggaaaca
     6301 aaaagttctc tccttaatcc tgaaaagtgc tacagctgta aaggagctag gtaggttact
     6361 ggaaactagt tccagggagt cactggtgtt gaacgtgtaa gtagccttgg gttttgcatt
     6421 gtgagctttg ctaattaatt tagttgaatg gataatcagg ataataaaag tctgctggtt
     6481 ccctgtattt cacttattaa aatatcataa ttctctaata tttctatttt tctcaagcta
     6541 gtactaaaat tggctaatct tcactacctg aatacatggc cacacttgtc agggagacgt
     6601 ctgggagcac ggcaaccagt aagaaaaatc taccaaccaa ggagggccag gtgtgggggt
     6661 gcacgcctgt aactccagcc ctcataaacc tgaatgcaag gaggaactta aattcaaggg
     6721 gcaacctggg ctacttcaaa agttaagagg ccagcttggg ctacatagtt agatcgtctt
     6781 aaaaacacgt aacagcaaaa tcaaactaag attgacactg gaaaactgaa ccaaatgcct
     6841 gattttataa ataaagtttt accttttaat gtaaaaaaaa aaaaaaaaaa
//
