LOCUS       NM_133672               3031 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus VPS26 retromer complex component A (Vps26a),
            transcript variant 1, mRNA.
ACCESSION   NM_133672
VERSION     NM_133672.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3031)
  AUTHORS   Chae,C.W., Choi,G.E., Jung,Y.H., Lim,J.R., Cho,J.H., Yoon,J.H. and
            Han,H.J.
  TITLE     High glucose-mediated VPS26a down-regulation dysregulates neuronal
            amyloid precursor protein processing and tau phosphorylation
  JOURNAL   Br J Pharmacol 179 (15), 3934-3950 (2022)
   PUBMED   35297035
  REMARK    GeneRIF: High glucose-mediated VPS26a down-regulation dysregulates
            neuronal amyloid precursor protein processing and tau
            phosphorylation.
REFERENCE   2  (bases 1 to 3031)
  AUTHORS   Simoes,S., Guo,J., Buitrago,L., Qureshi,Y.H., Feng,X., Kothiya,M.,
            Cortes,E., Patel,V., Kannan,S., Kim,Y.H., Chang,K.T.,
            Hussaini,S.A., Moreno,H., Di Paolo,G., Andersen,O.M. and Small,S.A.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Alzheimer's vulnerable brain region relies on a distinct retromer
            core dedicated to endosomal recycling
  JOURNAL   Cell Rep 37 (13), 110182 (2021)
   PUBMED   34965419
REFERENCE   3  (bases 1 to 3031)
  AUTHORS   Choi,S.A., Kim,Y.H., Park,Y.H., Yang,H.J., Jeong,P.S., Cha,J.J.,
            Yoon,S.B., Kim,J.S., Song,B.S., Lee,J.H., Sim,B.W., Huh,J.W.,
            Song,I.S., Lee,S.R., Kim,M.K., Kim,J.M., Bae,Y.S., Imakawa,K.,
            Kim,S.U. and Chang,K.T.
  TITLE     Novel crosstalk between Vps26a and Nox4 signaling during
            neurogenesis
  JOURNAL   Cell Death Differ 26 (9), 1582-1599 (2019)
   PUBMED   30464227
REFERENCE   4  (bases 1 to 3031)
  AUTHORS   Tang,F.L., Erion,J.R., Tian,Y., Liu,W., Yin,D.M., Ye,J., Tang,B.,
            Mei,L. and Xiong,W.C.
  TITLE     VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi
            Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy
            That Is Critical for alpha-Synuclein Degradation and Prevention of
            Pathogenesis of Parkinson's Disease
  JOURNAL   J Neurosci 35 (29), 10613-10628 (2015)
   PUBMED   26203154
REFERENCE   5  (bases 1 to 3031)
  AUTHORS   Zheng,H.J., Tsukahara,M., Liu,E., Ye,L., Xiong,H., Noguchi,S.,
            Suzuki,K. and Ji,Z.S.
  TITLE     The novel helicase helG (DHX30) is expressed during gastrulation in
            mice and has a structure similar to a human DExH box helicase
  JOURNAL   Stem Cells Dev 24 (3), 372-383 (2015)
   PUBMED   25219788
REFERENCE   6  (bases 1 to 3031)
  AUTHORS   Collins,B.M., Skinner,C.F., Watson,P.J., Seaman,M.N. and Owen,D.J.
  TITLE     Vps29 has a phosphoesterase fold that acts as a protein interaction
            scaffold for retromer assembly
  JOURNAL   Nat Struct Mol Biol 12 (7), 594-602 (2005)
   PUBMED   15965486
REFERENCE   7  (bases 1 to 3031)
  AUTHORS   Seaman,M.N.
  TITLE     Cargo-selective endosomal sorting for retrieval to the Golgi
            requires retromer
  JOURNAL   J Cell Biol 165 (1), 111-122 (2004)
   PUBMED   15078902
REFERENCE   8  (bases 1 to 3031)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3031)
  AUTHORS   Lee,J.J., Radice,G., Perkins,C.P. and Costantini,F.
  TITLE     Identification and characterization of a novel, evolutionarily
            conserved gene disrupted by the murine H beta 58 embryonic lethal
            transgene insertion
  JOURNAL   Development 115 (1), 277-288 (1992)
   PUBMED   1638986
REFERENCE   10 (bases 1 to 3031)
  AUTHORS   Radice,G., Lee,J.J. and Costantini,F.
  TITLE     H beta 58, an insertional mutation affecting early postimplantation
            development of the mouse embryo
  JOURNAL   Development 111 (3), 801-811 (1991)
   PUBMED   1879343
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB857335.1, AK167592.1, AK147989.1 and CO801094.2.
            
            On Jan 9, 2008 this sequence version replaced NM_133672.2.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168213.1, AK147989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BB857335.1         16-75
            61-76               BB857335.1         77-92
            77-134              BB857335.1         94-151
            135-2340            AK167592.1         90-2295
            2341-2864           AK147989.1         2282-2805
            2865-3031           CO801094.2         284-450
FEATURES             Location/Qualifiers
     source          1..3031
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.41 cM"
     gene            1..3031
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /note="VPS26 retromer complex component A"
                     /db_xref="GeneID:30930"
                     /db_xref="MGI:MGI:1353654"
     exon            1..148
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            149..298
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            299..374
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            375..531
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            532..696
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            697..803
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            804..872
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1015
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..3031
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2585..2590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /note="hexamer: AATAAT"
     polyA_site      2602
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /note="major polyA site"
     regulatory      2620..2625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /note="hexamer: AATAAA"
     polyA_site      2642
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
     regulatory      3010..3015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
                     /note="hexamer: TATAAA"
     polyA_site      3031
                     /gene="Vps26a"
                     /gene_synonym="HB58; Vps26"
ORIGIN      
        1 ggggggggag ggagaagagg aaaaggagtg gtcacgtgcg gctgatggcc tacggtcacg
       61 tgacgggcgg cggggcgcag gcacccaggc tgggagttct tctgagggaa agccgagtgg
      121 agtgggcgac ccggcggcgg tgacaatgag ttttcttgga ggcttttttg gtcccatttg
      181 tgagattgat gttgccctta atgatgggga aaccaggaaa atggcagaaa tgaaaactga
      241 ggatggcaaa gtagaaaaac actatctctt ctatgatggc gagtctgtct caggaaaggt
      301 aaacctagcc tttaagcagc ctggaaagag gctagagcat caaggaatta gaattgaatt
      361 tgtaggtcaa attgagcttt tcaatgacaa gagtaatact catgaatttg taaacctagt
      421 gaaggaacta gccttgcctg gagaactgac tcagagcaga agctatgact ttgaatttat
      481 gcaagttgaa aagccatatg agtcatacat cggtgccaat gtccgcctga ggtattttct
      541 taaggtgaca attgtgagaa gattgacaga cttagtgaaa gagtacgatc ttattgttca
      601 tcagctagcc acctatcctg atgtcaacaa ctctattaaa atggaagtgg gcattgaaga
      661 ctgtctgcac atagagtttg aatataataa gtccaagtat catttaaagg atgtaattgt
      721 tggaaaaatt tacttcttat tagtaagaat aaaaatacaa cacatggaat tacagctgat
      781 caagaaagag atcacaggaa ttggacccag caccacaaca gagacagaaa caatcgctaa
      841 gtatgaaata atggatgggg cgccagtaaa aggagaatct attccgataa gattgttctt
      901 agcagggtat gacccaaccc ccacgatgag agatgtgaac aagaagtttt cagtaaggta
      961 ctttctaaac ctcgtgcttg ttgatgagga ggaccgaagg tacttcaagc agcaggagat
     1021 catcctgtgg agaaaagcac ccgagaaact gagaaaacag aggacgaact ttcaccagcg
     1081 gtttgaatct ccagactcgc aggcctctgc ggagcagcct gagatgtaag caggtgggca
     1141 gagcagcaag tgcaagaacc gggccaagag agcagctcag ctggctgacg acagtcgcag
     1201 cgtgcggaca tcccaactcc acgtctgcta gtcttcctta tcctagagtg ctgcgtttat
     1261 tttacagtat gattaaaggt tttgtgtata tacattttaa aaagtgcttc ttggaaacac
     1321 tggagaattc ctaagctgcc ttttttgttt tcttttttac tgcacactga taagcactca
     1381 gaagcataaa cattaaggat tttcatgtga gtagactggt atttgtaatt ttgctttctt
     1441 tatgcataat gttgaaaatc cttttctctg ttttcatgct aatgattacc tcttattctc
     1501 tatgtgcaaa aaattaaata tttttgttca agtaaaatga gaaaaacctg agcagccctt
     1561 atgtcctaca aagttttaag gcatggctcc tcagtatttt tgagaattgt gtttattttt
     1621 acatgtggat cagaaaccaa cctggtgtta catggtaggc acttctgggt ctaccattca
     1681 cagcctcctg aattttaatc tttgggatct ctgaggtata tgaaagattg tcaccccagg
     1741 gatgacatgg tttgtcatcg tggccctctt gccccttatt gaccacgttt gctatgactt
     1801 tctgtatcat catgtaggtt ctgcagtgtg gagttgacac attggcattt tagaacttgt
     1861 taaacctgta tcattttttt tccataaaga ctttgaaaca tgtatatatt ttttaattta
     1921 aggactactt tccatgtgta tgcaaatcgt cacctaggaa tgagagagct tgggagaacc
     1981 agccgaagtg tccatagccg gacaatttct tgttaactgg aatattggct agttcaaact
     2041 tgacttcacg tagtctattt aaaaaaaccc gaaccaaaca gaacaaaaaa cactaaattc
     2101 ataccattct ctgaaaagaa ggctgcagtc agctgagcac agacacacaa ctgaggcgta
     2161 tggggcagga ggaagcctgt gtgggggcca ctctcactca gggcttgttg gtttctgtac
     2221 cagtgttcct tgatacacct cagtacaggt ttgtcagtta actttacttt ctaggaagct
     2281 caacagccca acttatgttt ccttaaacct attttttact atgatggcac tttgataaaa
     2341 tggccagcaa ccagccctgg ccaaaggttc acataccacg tcctggagca gctattgtca
     2401 atgtgggttt ctaaggacgg ccatgttctc cttcatgtaa gtgcctgttc agagtctcaa
     2461 agtttcaaaa tgccaaatat tttcatggtc acttgcatgt ataatctagg aaatattcaa
     2521 ggagattttg aaaaacaatt gtatttaacc agcctcaagt tgtgcaacca tgatatataa
     2581 aataaataat ttgaaacaga aacttaagtt tgtagtttaa ataaaatgac tttattctca
     2641 aatcttgtca ttacagcatt gcccagtggt taggaagaca gtcacaacag tgaactttta
     2701 ttagtagtac tagcttcagg tttgttaagg ttttgttttg ctttgttttt ttaggtttta
     2761 tttattttat atgtattgct gttttggctg caagtatgtc tgtgcaggca tgtgggcagt
     2821 gcccaaggag ggcagaagag agcattagat ctcttggagc tgaaattaca ggtgtttgtg
     2881 agcggccatg ggggtgctgg gaacagaacc aaggtagcca gtgctgttga ccactgaacc
     2941 atctctgggt tctccagctt cagttttaag tagttatata atgcttttaa ttaatttgct
     3001 taaaactcat ataaaatgct tattcattcc a
//
