LOCUS       NM_177184              13678 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus vacuolar protein sorting 13C (Vps13c), mRNA.
ACCESSION   NM_177184 XM_356166 XM_620758
VERSION     NM_177184.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 13678)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 13678)
  AUTHORS   Hancock-Cerutti,W., Wu,Z., Xu,P., Yadavalli,N., Leonzino,M.,
            Tharkeshwar,A.K., Ferguson,S.M., Shadel,G.S. and De Camilli,P.
  TITLE     ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant
            mtDNA-dependent STING signaling
  JOURNAL   J Cell Biol 221 (7) (2022)
   PUBMED   35657605
REFERENCE   3  (bases 1 to 13678)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   4  (bases 1 to 13678)
  AUTHORS   Ramseyer,V.D., Kimler,V.A. and Granneman,J.G.
  TITLE     Vacuolar protein sorting 13C is a novel lipid droplet protein that
            inhibits lipolysis in brown adipocytes
  JOURNAL   Mol Metab 7, 57-70 (2018)
   PUBMED   29175050
  REMARK    GeneRIF: Loss of VPS13C elevates lipolysis and promotes oxidative
            gene expression in brown adipocytes.
REFERENCE   5  (bases 1 to 13678)
  AUTHORS   Quesnel-Vallieres,M., Dargaei,Z., Irimia,M.,
            Gonatopoulos-Pournatzis,T., Ip,J.Y., Wu,M., Sterne-Weiler,T.,
            Nakagawa,S., Woodin,M.A., Blencowe,B.J. and Cordes,S.P.
  TITLE     Misregulation of an Activity-Dependent Splicing Network as a Common
            Mechanism Underlying Autism Spectrum Disorders
  JOURNAL   Mol Cell 64 (6), 1023-1034 (2016)
   PUBMED   27984743
REFERENCE   6  (bases 1 to 13678)
  AUTHORS   Mehta,Z.B., Fine,N., Pullen,T.J., Cane,M.C., Hu,M., Chabosseau,P.,
            Meur,G., Velayos-Baeza,A., Monaco,A.P., Marselli,L., Marchetti,P.
            and Rutter,G.A.
  TITLE     Changes in the expression of the type 2 diabetes-associated gene
            VPS13C in the beta-cell are associated with glucose intolerance in
            humans and mice
  JOURNAL   Am J Physiol Endocrinol Metab 311 (2), E488-E507 (2016)
   PUBMED   27329800
  REMARK    GeneRIF: The present data thus provide evidence for a limited role
            for changes in VPS13C expression in conferring altered type 2
            diabetes risk at this locus, particularly in females, and suggest
            that C2CD4A, but not C2CD4B, may also be involved.
REFERENCE   7  (bases 1 to 13678)
  AUTHORS   Quesnel-Vallieres,M., Irimia,M., Cordes,S.P. and Blencowe,B.J.
  TITLE     Essential roles for the splicing regulator nSR100/SRRM4 during
            nervous system development
  JOURNAL   Genes Dev 29 (7), 746-759 (2015)
   PUBMED   25838543
REFERENCE   8  (bases 1 to 13678)
  AUTHORS   Mizuno,E., Nakamura,M., Agemura,A., Kusumoto,A., Ichiba,M.,
            Kurano,Y., Muroya,S. and Sano,A.
  TITLE     Brain-specific transcript variants of 5' and 3' ends of mouse
            VPS13A and VPS13C
  JOURNAL   Biochem Biophys Res Commun 353 (4), 902-907 (2007)
   PUBMED   17196930
  REMARK    GeneRIF: VPS13C cDNA sequences and brain-specific variants of
            VPS13C were identified.
REFERENCE   9  (bases 1 to 13678)
  AUTHORS   Kurano,Y., Nakamura,M., Ichiba,M., Matsuda,M., Mizuno,E., Kato,M.,
            Agemura,A., Izumo,S. and Sano,A.
  TITLE     In vivo distribution and localization of chorein
  JOURNAL   Biochem Biophys Res Commun 353 (2), 431-435 (2007)
   PUBMED   17188237
  REMARK    GeneRIF: Our findings provide basic information on chorein in vivo
            and may contribute to taking the first step toward understanding
            molecular pathogenesis of ChAc.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156799.2 and AB281675.1.
            
            On Jun 21, 2018 this sequence version replaced NM_177184.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB281675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC156799.2         160662-160706       c
            46-11568            AB281675.1         1-11523
            11569-13678         AC156799.2         3313-5422           c
FEATURES             Location/Qualifiers
     source          1..13678
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 36.77 cM"
     gene            1..13678
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /note="vacuolar protein sorting 13C"
                     /db_xref="GeneID:320528"
                     /db_xref="MGI:MGI:2444207"
     exon            1..176
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            177..220
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            221..263
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            264..359
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            360..461
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            462..524
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            525..590
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            591..700
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            701..760
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            761..820
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            821..901
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            902..959
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1087
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1194
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1366
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1429
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1556
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1651
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1794
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1987
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2102
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2239
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2363
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2481
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2611
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2690
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2830
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2984
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3064
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3124
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3284
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3401
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..3505
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3673
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..3978
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4126
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            4127..4235
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            4236..4369
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            4370..4526
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            4527..4606
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            4607..4666
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            4667..4829
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            4830..4943
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            4944..5047
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            5048..5215
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            5216..5520
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            5521..5668
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            5669..5819
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            5820..5929
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            5930..6099
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            6100..6347
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            6348..6577
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            6578..6670
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            6671..7036
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            7037..7123
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            7124..7273
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            7274..7538
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            7539..7699
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            7700..7821
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            7822..8116
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            8117..8506
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            8507..8611
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            8612..8776
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            8777..8905
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            8906..9039
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            9040..9166
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            9167..9402
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            9403..9544
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            9545..9685
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            9686..9767
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            9768..9837
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            9838..9949
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            9950..10063
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            10064..10203
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            10204..10285
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            10286..10399
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            10400..10475
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            10476..10639
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            10640..10685
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            10686..10809
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            10810..10924
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            10925..11013
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            11014..11137
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            11138..11221
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     exon            11222..13678
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13655..13660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /note="hexamer: AATAAA"
     polyA_site      13676
                     /gene="Vps13c"
                     /gene_synonym="C230055H22Rik; chorein"
                     /note="major polyA site"
ORIGIN      
        1 agtctctgcg ccggccacag ccctcccctg cgcgctgcgt tccggctcct ccctctcccg
       61 cctcctggtc cccgccatgg tgctggagtc ggtggtcgct gacttgctga accgcttcct
      121 aggggactac gtggagaacc tgaacaagtc ccagctaaag ctggggatct ggggcggtaa
      181 tgtggctttg gataatctgc agataaaaga aaatgctctg agtgaattgg acgttccttt
      241 caaagtcaag gctggccaga ttgataaatt aactttgaag attccttgga aaaaccttta
      301 tggagaagca gtcgttgcca cgctagaagg attatacctg cttgtggtcc ctggagcaag
      361 tattaagtat gacgctgaga aagaagaaaa atccttgcag gatattaaac agaaagaact
      421 ttgccgaatt gaagaagccc ttcagaaagc agcagagaaa ggtgcacact caggggagtt
      481 catgtatggc ttggaaaact tgctttacaa ggacgtcaag cctggacgta agcgtaaaaa
      541 gcacaaaaaa cattttaaga aacgttttaa aggtcttgat cgctccaaag ataagcccaa
      601 agaagcaaaa aaggatacat ttctggaaaa attggcaact caagtaataa aaaatgttca
      661 agtgaaaatt acagacattc acattaaata tgaagatgat atcacggatc cagaaaggcc
      721 gctttcattt ggtgtcaccc tgagagaatt tagtctgttg acaactaatg aacactggac
      781 tccatgcatt ttaaatgaag cagaaaaaat tatatataag ctcgtgaagc tggacagtct
      841 cagcgcctat tggaacgttg gctgctgcat gtcttaccgt ggatcgaggg agcacatctt
      901 ggagcaactg aaacgtgaaa ttcttacaag tacaaacatc cccccagacc atcagtacat
      961 tttccagcca atatcagcct ctgcaaaact ctacatgaat cctggtgcag aatcagagct
     1021 caaaaccccc aaactcgatg ggaacgtaga ggtgcagaat attgccatcg agctgacgaa
     1081 gcctcagtat ttaagcatga ttgacttttt ggagtcactg gattatatgg ttagaaatgc
     1141 accatacagg aagtacaaac cttgcttgcc acttcacacc aactgtcggc aatggtggaa
     1201 atatgctatt gattctgttc ttgaagttca tataagaaga tatactcagc catggtcatg
     1261 gagtaacata aaaaaccata ggcagttact caagagttac aaaatggcct acaaaaccaa
     1321 gttaacacaa gccaaagtct cagaagagat acagaaacaa atacaggact tggagaagag
     1381 tctagatgtt tttaacataa ttttagtgag acaacaagca caagttgagg tcattcattc
     1441 tgggcagaag ttaaggaaaa agtctgcgga ggcaggagag aaacgtggct ggtttagtgg
     1501 gttttggggc aagaaggaat ctaagaagag agatgaggag tcttcagtcc ctgagaccat
     1561 cgatgacctt atgactccag aggagaagga caagctcttc actgccattg ggtacagtga
     1621 gaatgcctac aacttggctt tgcccaagca gtatgtggcc catatactga ctctgaagtt
     1681 ggtcagcacc tctattataa taagagaaaa caggaatgtt ccagaaatct tgagagtcca
     1741 gataattggc ttgggtaccc aagtctccca gcgaccagga gcacaagcat tgaagataga
     1801 agcaaaatta gaacactggt acgtcacagg tttgcgacaa caagacattg tgccatcact
     1861 ggtggcttcc attggtgaca ctacatcgtc cttgctcaaa attgagtttg aaaccaaccc
     1921 tgagaacagt cctgctgacc agactctgat tgttcagtca cagcccgtgg aggtcatcta
     1981 tgacgctaaa actatcaatg ctgttgttga attctttcag tcaaataagg ggttggatct
     2041 tgagcaaatt acatcagcta ccttgatgaa actggaagag attaaagaga ggacagctac
     2101 aggacttacg catatcattg agactcggaa agttctcgat ttaaggataa atctgaagcc
     2161 ttcttacctg ataattccac agacaggttt tcaccatgaa aagtcaaatc ttctcatttt
     2221 agattttggt acttttcagc tcaacagtaa agaccaaggc gcacagaaga ctgctaatgc
     2281 atcccttgaa gaaataatag acaaggcgta tgacaagttt gatgtggaga taaggagtgt
     2341 gcagttgctc tttgcaaaag cagaggaaaa ttggaaaaag tgtagattcc agcatccatc
     2401 gactatgcat atactgcagc caatggatat tcacgttgag ttggccaagg caatggtgga
     2461 gaaggatgtt agaatggcca aatttaaagt gtcaggagga ctgcctttga tgcatgtgag
     2521 gatttctgac cagaagataa aggatgcgct gtgtttgatt aacagtatac ctttgccaca
     2581 gaagtcatcc acaccgtctc cagagagaca ggtagcctca attcctgttc tttcaggagg
     2641 gacgaaagca cttcttggga cttcattgtt gctagatgga gtggaatcag agtctgacga
     2701 ggagttcttt gatgctgagg acggagactc gcaggctgct agaactgtca aagcctcaga
     2761 actgaaaaaa gctgctgaag ttccaaatga ggagctggtt agtctcctgc tcaagtttga
     2821 gattaaagag gtggttttgg aactcactaa acaacagaaa gaagaagaga caatcctagt
     2881 atttaatgtc actcagttag ggacagaagc aacaatgagg acatttgacc tgactgcggt
     2941 gtcctatttg aggaaaatca gcttggatta ccatgacatt aaaggatcca gaaagaagcc
     3001 aattcacttg attagctctt cagacagacc tggactagat cttttaaaag tggagtacat
     3061 taaggttgat aggaatgggc ctagttttca aactactttt gagaaaactg aacaaactgt
     3121 taaggtggcc ttttcatctt tgaatctgtt gctacaaacg caagctcttc tgtcttctct
     3181 taactacttg acaactgtca tcccatcaga cagtcagaac acgggtgtgg ccaaggaggt
     3241 gcaggccatg cctgagaaac aaaagaactc tcccctgcag aaagtgatgg tcccctccag
     3301 agatagtgac gtgattggct ttaggctgtt tgccaaactg aatgctttct gtgtcactgt
     3361 ctgtgatgag aagagcaata ttgctgaaat caagatacaa ggccttgatt cttctctttc
     3421 tcttcaatca aagaagcagt cactttttgc caggctggaa aacattattg tcacagatgt
     3481 tgatcccaaa acaattcata agaaagctgt atccatagtt gggaatgaag tttttcgctt
     3541 taacctggat ttgtatccgg atgctactga aggggattcc tacactgaca tgtccacagt
     3601 ggatggcgtg gtggcactgc acgtcggctg tattcagatt gtctaccttc ataaattcct
     3661 tatgtcgctg ctgagcttcc tgaacaattt ccaggtggcc aaggaggcgc tgagtgcagc
     3721 cactgcccag gctgcggaaa aggcggccac gagcgtgaag gatctcgccc agagaagctt
     3781 ccgtgtttct gtcgatattg atttgaaagc acccgtcatt gtcattccgc agtcctctct
     3841 ctccaccaat gctgttgtgg tggatcttgg gctaattaga gttcacaatc ggttcagtct
     3901 ggtgtctgga gaagacactg caaatcctcc agtgatcgac aaaatggagg tgcagctcac
     3961 gaaactgaaa ctctctagga cagcaatcca gccaggcacc tcccaccctg atattcagct
     4021 gttgcaccca attaacttgg agttttttgt aagtcggaat ctagctgcaa attggtacca
     4081 taaggtgcct gttgtagaaa ttaaagggcg tcttgactca atgaatgtta gtctaaatca
     4141 agaggatctt aatcttctgt ttagaatatt ggcagaaaat cttggcgagg ccactgaaga
     4201 cttggataaa gggaaaccta gaatacaaga gagaggtgaa acaaaagcct gccgagaagt
     4261 ctctacaccg caggatgtgc acaccacaca aggtgtgcca gcagccagag tggaggagac
     4321 cagacccgta gacatcatta atgtactgtt gaactttgaa attaaagagg ttgtggttac
     4381 tttgatgaaa aaagcagaaa ggaaaggaag cccctttcat gaactaaaga tcctgcatct
     4441 tgggatggaa gctaaagtaa aagcccacga catgactgct gcagcctacc tcaggaacat
     4501 tagcatgcgg tgtttccact tccctgattc taaaggggag cctctgcgca ttgtcaacac
     4561 ctctgatgtg tctgatggga tcctcctgaa actgctgttc atcaaggcag acagtgatgg
     4621 accagacttt aagaccattc atgataacac caaacagaag ctgaaggttt cgttttcatc
     4681 cttggacttg gtacttcatt tggaagcttt actttccctc atggattttt tgtcatctgc
     4741 tatcccatcc tctgactctt cttcctctga gaaggaacct gagctaaagc cacttgtggg
     4801 ggagtccaga agtcttgcca tcagagccgt gcccagctct tatgagggtg acgcgtttga
     4861 tttgaagatc acagctgaat taaatgcctt taacatcttc atttgtgatc agaagagtaa
     4921 catagcagaa attaaaatac atggaatgga tgcctcgatt tctgtgaagc caaagcagac
     4981 tgatgtattt gccagactta agaatatcat agttatgaat gttgattcac tgtccattca
     5041 caaaaaggct gtctctattt tgggagatga agtcttccgg ttccagatga gtctgtatcc
     5101 agatgccaca gaaggagaga attatggcga tatgtctaaa gtggatggca gacttagtct
     5161 caaagtgggc tgtattcaga ttgtctatgt tcataaattc tttatgtctc tcttgagctt
     5221 cctcaacaat ttccaagctg ccaaggaagc cttgagcaca gccacagtcc aggctgcaga
     5281 gagagctgcg tccagtgtga aggacctggc ccagaagagc ttccggcttc tgatggacat
     5341 cgatttgaaa gcacctgtca tcactattcc ccagtcttct gtgtcaccaa atgtcgttat
     5401 agcagatctg ggcttgatca gagttgagaa caagtttagc ttggtttctg tggagcagct
     5461 cgcgcttccc ccagtggccg acgagatgag catccagctc acccagctga agcttgccag
     5521 aactgtttta caagctgatt cacctcagca tgacgttgaa atcttaaaac ctgtgaacat
     5581 gcttttatgc atacagcgga atttgtcagc agcgtggtac acacagattc caggcatgga
     5641 gataaaaggc gaacttaaac ctatgcaggt tgctctcagt caagatgact tgacagtttt
     5701 aatgaaaatt ttgctggaaa accttgggga agcttcttca caaccaagcc ctacacagta
     5761 tgcacaggag gctgcacggg tgaagagaga tactcggagt gggcctgact atcttaaaga
     5821 acaagagctg gcggacccaa agccgcccgg ggaccagacc gtcactcttc agtttgattt
     5881 ccactttgac tctctttcca tcatccttta caacagtgat agcagccagg agcccaggct
     5941 ttcatttcac aatgacagtt tccgtttggg tgagctcaca ctacacctga tggcttctgc
     6001 tgggaagatg ttcaaggatg ggtctatgaa tgtcagcctt aaacttaaga cgtgcacgct
     6061 tgatgatctc cgagaaggaa tcgagagagc cacctccagg atgattgaca aaaagaatga
     6121 ccaggacaac aacagctcta tgattgatat aagttatagc caggataaaa atggaagcca
     6181 ggtcgatgct gtccttgaca agctgtacgt gtgtgccagt gtggagtttc tgatgaccgt
     6241 ggctgatttc ttcatcaaag ctatgcctca gagtccagaa aacatagcca aagaaataca
     6301 gattccatca agacagactg ccgcgggaag agtcaagatg gagaaagatg actctgtgag
     6361 gccaaatatg actctgaagg ccatgatcac agacccagaa gtggtgtttg ttgccagcct
     6421 gactaaggcc gatgctcccg ctctcacggc ctccttccag tgcaacctct ccctctcaac
     6481 gtccaaactg gagcagatga tggaagcttc tgtgagagac ctgaaagtgc tggcctgccc
     6541 tttcctcaga gaaaggagag gaaagagcat caccacggtg ttgcaacctt gctccttatt
     6601 tatggaaaag tgcacatggg cttccgggaa acaaaacatc aatattgtgg ttaaagagtt
     6661 tgtgattaag atctcaccta taatccttaa tactgtaatg acaatcatgg ctgctatgtc
     6721 tccaaagacc aaagaagatg aatggaaaga cactcctaag gagacagaca atctctgggc
     6781 tgtcaaatct attactgatt ataactcttg gtttctcggg gttgacatgg caacagaagt
     6841 aacagaaaat tttagagact ctgaacatcc atcgatagag gaaaattgtg tggttgctgt
     6901 ggagtcagtt caagtcacct tagagtgtgg cctagggcat cgcactgtgc ccctgttatt
     6961 ggcagagtcc aagttctctg gaaatattaa aaactggact tctctaatgg ccgctgctgc
     7021 tgacatgaca ctagaggttc actattacaa tgaaactcat gccgtctggg agccactgat
     7081 tgaaagagtg gaggggaaca agccgtggag cttaaagctt aatgtaaaga aaaacccgat
     7141 ccaggataaa agtttgatgc caggagatga ctttattcct gagccacaaa cagcagttca
     7201 tatttcttca ggagctacga tgaatatcac aatatccaaa agctgtctta atgttttcag
     7261 caatttagca aaaggtttct ccgagggagc ggcttctacg tttgactact ctctgaaaga
     7321 cagggctcct tttacagtca aaaatgcgct gggtgtcccc atgaaggtgc agcccaatcg
     7381 taacctcaag gtcatgggct cccctgagaa gagtgacatt tatgacgtgg gcgctggtca
     7441 gcacttggag ctggactacg ccagcctgga accttcgcgc caagggaagc tgtccatcct
     7501 gagccggcag gagagctcgc tcttcacact gacctttgta ccatatggtt atacagaagt
     7561 agctagtgtt cctgtcgcca ggcctggccg acgattgtat aatgtgcgga accccagtgc
     7621 cagccattcg gattccgtgt tggtgcagat tgacgcaaca gaaggcaata aggttgtcac
     7681 tcttcgctca cctctgcaga ttaaaaacca cttctcaata gcatttatca tctacaaatt
     7741 tgtcaagaat gttaagctgt tggagcgcat cggaatagcc agacctgagg aagagttcca
     7801 tgttcctctg gattcctata ggtgccagtt gtatgttcag ccggctggcg gcttggagca
     7861 gcagtacaca cactcctcca cctacatttc ctggaaggag gagcttcacc gcagcaggga
     7921 ggtcaggtgc atgctgcagt gtcctgcagt ggaagtcagc ttcctacccc tcatcgtgaa
     7981 cacggtcgct ctgcccgatg agctgagtta catcggtgcc cacggggaag actgggatcc
     8041 agcctacgtc attcatcttt accctcctct caccttgcgg aaccttctcc cgtattcgct
     8101 aagatactta cttgagggaa ccgcagaaac ccacgagctg gcagaaggca gttctgctga
     8161 cgtccttcac tcacggatca gtggcgagat catagagctc gtcctggtga aatacctggg
     8221 caagaactgg aacggacact tccgcatctg tgacacactt cccgagttct tcctcgtgtg
     8281 cttttcctca gacactgcag aagtgatgac agttgacctg tcagttcacg tcaggcggat
     8341 tggctgccga atggagctgt ctgtctttag tccctattgg ctaatcaaca aaacttctcg
     8401 ggttctccag tatcgctctg aggagataca tgttaaacac ccagctgatt tcagggacat
     8461 cattttattc tctttcaaga agaagaacat ttttagtaaa aacaaggtac agctaaaaat
     8521 ttcaaccagt gcctggtcca atggtttctc actggacact gtgggcagtt acgggtgtgt
     8581 gaagtgcccg gccaccaata tggaatacct ggtcggggtt agcatcaaga tgagcagttt
     8641 taatctctca cgagtagtca ctctgactcc cttctgtact gttgcaaata agtcctcgtt
     8701 agacctagaa gttggagaga ttgcttcaga tggttccata cccaccaaca aatggcacta
     8761 tgttgcttcg tcagagtgta ttccattttg gcctgaaaat ttgtctggca aactttgtgt
     8821 gagagtggtg ggctacgaag gctcttccaa gccattcttt tacaaccgac aagacaacgg
     8881 cactttattg agcttagagg atctgaatgg aggcatcctg gtggacataa acactgctga
     8941 acactcaact gtcataacct tcagtgacta tcatgagggg tctgcgcctg ctctgataat
     9001 gaaccacaca cagtgggatg tcctcacgta taaacagagt gggtcacagg aggaactagt
     9061 attgctgcca ggagaaactc gactctttgc ctgggcagat cccactggca tcaggaaact
     9121 cacttggaac tatgcagcta actttgggga gcatgatctc ttaaaggatg agtgtggtca
     9181 gtttccgtac gatgcgaaca tccagataca ctgggtgtcc ttccttgatg ggcgccagag
     9241 ggttctgctt ttcacagatg atgttgcttt ggtttccaaa gcactccaag ctgaagaaat
     9301 ggaacaggcc gatcacgaag tagccttgtc gctccacagc ctcgggctct ctctggttaa
     9361 caatgaaaac aagcaggaag tctcatatgt cggaatcacc agctcaggtg ttgtttggga
     9421 gatgaagcca aaacagaaat ggaagccgtt tagtcagaag cagataatgt ccctggagca
     9481 ggcctattcg aagcgccttg catcacaaga ccgcggctgg gtcaagctgg acagtaattt
     9541 tgaggtcaat tttgacaaag tgccgatgga aatgcgcctc cctatccggt gccctattaa
     9601 acgggacttc ttatcaggga ttcaggttga gtttaagcag tctcctcacc agagaagcct
     9661 aagggcccgg ttgtattggc tccaggtcga taatcagtta ccaggcacaa tgttcccagt
     9721 tgtatttcac cctgtggctc ctcctaagtc cattgctttg gattcagagc ccaagccttt
     9781 catcgatgtg agtgtaatta cgaggttcaa tgagtacagt aaagtcttac agttcaagta
     9841 ttttatggtt ctcatccagg aaatggcctt aaaggttgat cagggcttcc ttggagctgt
     9901 tatttcactg tttactccca caactgatcc tgaggctgaa agaaaacgga caaagttaat
     9961 ccaacaagat attgatgctc tcaacacaga gttgatggag tcttcaatga ctgatatgtc
    10021 aatcctgagt ttctttgaac atttccacat ttcccctgtt aagttgcatc tgagtctgtc
    10081 tttgggatcc ggaggtgagg aatcagacaa agagaaacag gaaatgattg caattcattc
    10141 tgtgaacctg ctgttgaaga gcataggtgc cactctgacg gacgtggatg acctcatatt
    10201 caagcttgct tactatgaga ttcgctatca gttttacaag agagatcagc tcatgtggag
    10261 tgttgtcaga cactacagtg aacagttctt gaagcagatg tatgtgcttg tattgggctt
    10321 agacgtgctt ggaaacccat ttggactgat taggggcctg tccgaaggag ttgaagcact
    10381 gttctatgag cccttccagg gtgctgtcca aggtcctgaa gaatttgctg aaggattagt
    10441 gattggggtg agaagtctcg ttggacacac agtaggtggt gcagcgggag tcgtatctcg
    10501 aatcactggg tcagttggga aaggcctggc cgcaattaca atggacaaag agtatcagca
    10561 gaagagaaga gaggagatgg ggcgacagcc taaagatttt ggagacagtc ttgccagagg
    10621 agggaagggc ttcctgcgtg gagttgttgg tggggtgact ggaataataa caaagcccgt
    10681 ggaaggtgcc aagaaggagg gcgctgccgg cttctttaaa ggaattggaa aagggcttgt
    10741 gggtgccgtg gctcgtccaa ctggcgggat catagatatg gctagcagca ccttccaagg
    10801 cattcagagg gtagcagaat ccactgagga ggtgtccagc ctccgtccac ctcgtctgat
    10861 ccacgaagac ggtatcattc gtccatatga caggcaggaa tcggagggtt ccgacctatt
    10921 agagaatcac atcaagaagt tggagggcga ggcctaccag ttccactgtg ccgttcccgg
    10981 gaacaagagg gctgtcctta tgatcacaaa caggcgagca ctgtttataa aggaggttga
    11041 aatcctaggc catatgtctg tggactggca gtgtctgttt gaagattttg tatgtcctcc
    11101 tgaagtcagt gaaaatctgc tgaagatttc agttaaggag cagggtctgt tccataaaaa
    11161 agacagtgcc aatataggcc atcttcggaa aatttacctg aaggatccca tcacagccaa
    11221 gagggccttt gatgccattg agagcgccca gtcagcaagg cagcagcaga agctcatgag
    11281 gcagtcgtca gtgaaactcc tcaggcccca ggggccgtct tgaccatgga ttctacaagg
    11341 cttctgaggg ggaagcggcc gctgcagggc ctgctcaaga gaacatttcc agcgattcct
    11401 tggctctggg ttttggtgtt ttgttttgtt ttttgttttt gactcttaat tttgagtctt
    11461 gggaattctg catatattag gaatctactg ctacacgttt aggtcagacc tcaaagaaat
    11521 accacttcag cttggagaga cttattcatt aatattaaaa ttgtgaagca aagagtggtg
    11581 ggcttgtttt taattaatct ttactgaaga gaggagattt taaaatgagt agtattcttt
    11641 gaaaggtttt attcagacaa atagtggaca ctgacatttg tttaaaagta atttgtgcaa
    11701 taattgaact aagagaacac ttttggtaag ccagtcagtt gactgaagaa atgtatctaa
    11761 aggagaggca gtgcattttc tatgttcatt ttatgaaaat gttatttttc ttctaatagg
    11821 atgagtttta cacgagtgct ttttcttctc ctttctatct agtctcagac catgggcggt
    11881 ctggcagctt tggtgggcag ccctgcaccg ctgtctgtag cgaggcaccc accggctgtc
    11941 agagcatgag cacaacgacg gattcttgag aaatagaaac tgagaaattg cactatgagc
    12001 tcctcagcat tcaggaatat ataaaataca atattttttt atatttccag agatctattt
    12061 tagaatataa aagactacaa agggcgccat aaatgaacat ttaattctaa tgcatacctg
    12121 taaatgtctt ttaaatacct gttaggaaga atgaaaaatc cctacttact ttattgtata
    12181 ggttttcttc aaggtctgta cagagttggg aaacgggtgt tccctgtatg catcaagctg
    12241 ctgtccttcc tcgtctccct gaggcttgtt aggtcggggc tgcctgttgg caggttaggt
    12301 agaggggcac gggctgcctg ttactctgag ggattttatt tctttgggtg gacctttatt
    12361 tagccttttt cagggtgttg aacatggcat tgagttaaag cgcacagtca gcgatgagat
    12421 gaggaaggta tggatgctca tcttgctttg cctttgttga tgcaggtcct ccttccaccc
    12481 tcaatgccag tcacgctttc aagattgcac aggaagactt cttagcttcc cactgctgct
    12541 tcatgtttct ctaagggaga gtgcagaaat cagtatctga tttttagtag ttgttagatt
    12601 tttaattcaa ttccttcatt tcttatcctc accatgcccc ccatctccaa tctccagttc
    12661 cttcctccct ccctcccttc cttccttcct tccttccttc cttccttcct tccttccttc
    12721 cttcctctct ctttctctct ctctttctct ctctctatct ttttctcttc ccctccctcc
    12781 ctccctcccc tcctgtcctt ccttccttcc ttccttcctt ccttccttcc ttccttcctt
    12841 ccttccttcc ttcctctctc tttctctctt tctctctctc tctctctctc tttctctctt
    12901 tctctctctc tctctctctc tctctctctt tctccctccc tccctccctc cctctctccc
    12961 tccctctctc cctccctccc ttccttcctt ccttccttct ttccttcctt ccttcttccc
    13021 tccctccttc cctccctctc tgtctcttcc tttctttctt tccttccttc cttctctctt
    13081 tccttccttt cttccttccc tctttccatc cttttgatag gatctcacaa tgtagaacag
    13141 gctggcctta aactcacaga gatctgccta cctctgcctc ccaagtgctg ggataaaagg
    13201 catgcgccac tgtgcctagc ttaatactgt tattcctgtt aagaaaatca ttacatataa
    13261 aactgatagc tttaaaccta attgaacttt ctagagctag aaggcagtat gataagccta
    13321 ggaagtacac tagcaatcta tgtctttaaa actgacttaa tcaggaattt gaatatctga
    13381 ctacattttt catgttaatc ccagctgtca atggtattat aaatatttaa ggcattatat
    13441 tgcactgatg gtttattcca gaaacaaatg tacagaacat tagactaaga atagtcaagt
    13501 ctataaactc attgtctcag ttgatacctg tggcattttt atttgataca gtgttctggt
    13561 acaggagtaa cccactggtt gtatgtaatt aggtgtgtgg tcttttttac aaatgcattc
    13621 aggggcagtg acttgcttat aactttttga gagaaataaa acattgttac attgttta
//
