LOCUS       NM_027889               3536 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus VPS11, CORVET/HOPS core subunit (Vps11), transcript
            variant 1, mRNA.
ACCESSION   NM_027889 XM_134794
VERSION     NM_027889.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3536)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3536)
  AUTHORS   Skoff,R.P., Bessert,D., Banerjee,S., Luo,X. and Thummel,R.
  TITLE     Characterization of the Expression of Vacuolar Protein Sorting 11
            (Vps11) in Mammalian Oligodendrocytes
  JOURNAL   ASN Neuro 13, 17590914211009851 (2021)
   PUBMED   33874780
  REMARK    GeneRIF: Characterization of the Expression of Vacuolar Protein
            Sorting 11 (Vps11) in Mammalian Oligodendrocytes.
REFERENCE   3  (bases 1 to 3536)
  AUTHORS   Ferder,I.C., Fung,L., Ohguchi,Y., Zhang,X., Lassen,K.G., Capen,D.,
            Brown,D., Xavier,R.J. and Wang,N.
  TITLE     Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1
            expression during spermatogenesis in mice
  JOURNAL   PLoS Genet 15 (5), e1008084 (2019)
   PUBMED   31059511
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3536)
  AUTHORS   Perini,E.D., Schaefer,R., Stoter,M., Kalaidzidis,Y. and Zerial,M.
  TITLE     Mammalian CORVET is required for fusion and conversion of distinct
            early endosome subpopulations
  JOURNAL   Traffic 15 (12), 1366-1389 (2014)
   PUBMED   25266290
REFERENCE   5  (bases 1 to 3536)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   6  (bases 1 to 3536)
  AUTHORS   Zhu,G.D., Salazar,G., Zlatic,S.A., Fiza,B., Doucette,M.M.,
            Heilman,C.J., Levey,A.I., Faundez,V. and L'hernault,S.W.
  TITLE     SPE-39 family proteins interact with the HOPS complex and function
            in lysosomal delivery
  JOURNAL   Mol Biol Cell 20 (4), 1223-1240 (2009)
   PUBMED   19109425
REFERENCE   7  (bases 1 to 3536)
  AUTHORS   Kim,B.Y., Sahara,Y., Yamamoto,A., Kominami,E., Kohsaka,S. and
            Akazawa,C.
  TITLE     The interaction of mammalian Class C Vps with nSec-1/Munc18-a and
            syntaxin 1A regulates pre-synaptic release
  JOURNAL   Biochem Biophys Res Commun 350 (3), 691-697 (2006)
   PUBMED   17027648
REFERENCE   8  (bases 1 to 3536)
  AUTHORS   Mulligan,M.K., Ponomarev,I., Hitzemann,R.J., Belknap,J.K.,
            Tabakoff,B., Harris,R.A., Crabbe,J.C., Blednov,Y.A., Grahame,N.J.,
            Phillips,T.J., Finn,D.A., Hoffman,P.L., Iyer,V.R., Koob,G.F. and
            Bergeson,S.E.
  TITLE     Toward understanding the genetics of alcohol drinking through
            transcriptome meta-analysis
  JOURNAL   Proc Natl Acad Sci U S A 103 (16), 6368-6373 (2006)
   PUBMED   16618939
REFERENCE   9  (bases 1 to 3536)
  AUTHORS   Richardson,S.C., Winistorfer,S.C., Poupon,V., Luzio,J.P. and
            Piper,R.C.
  TITLE     Mammalian late vacuole protein sorting orthologues participate in
            early endosomal fusion and interact with the cytoskeleton
  JOURNAL   Mol Biol Cell 15 (3), 1197-1210 (2004)
   PUBMED   14668490
REFERENCE   10 (bases 1 to 3536)
  AUTHORS   Kameya,S., Hawes,N.L., Chang,B., Heckenlively,J.R., Naggert,J.K.
            and Nishina,P.M.
  TITLE     Mfrp, a gene encoding a frizzled related protein, is mutated in the
            mouse retinal degeneration 6
  JOURNAL   Hum Mol Genet 11 (16), 1879-1886 (2002)
   PUBMED   12140190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC029004.1, AK004695.1 and AC122428.4.
            
            On Oct 26, 2017 this sequence version replaced NM_027889.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029004.1, AK004695.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BC029004.1         1-25
            26-3186             AK004695.1         1-3161
            3187-3536           AC122428.4         136677-137026
FEATURES             Location/Qualifiers
     source          1..3536
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..3536
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /note="VPS11, CORVET/HOPS core subunit"
                     /db_xref="GeneID:71732"
                     /db_xref="MGI:MGI:1918982"
     exon            1..226
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..2865
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vacuolar protein sorting-associated protein 11 homolog;
                     vacuolar protein sorting 11"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 11
                     homolog isoform 1"
                     /protein_id="NP_082165.1"
                     /db_xref="CCDS:CCDS40599.1"
                     /db_xref="GeneID:71732"
                     /db_xref="MGI:MGI:1918982"
                     /translation="MAAYLQWRRFVFFEKELVKEPLGNDGAAPGAAPVSGSAASKFLC
                     LPPGITVCDSGRGSLVFGDMEGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASV
                     GEDEEGINPLVKIWNLEKRDGGNPLCTRIFPAIPGTEPTVVSCLTVHENLNFMAIGFT
                     DGSVTLNKGDITRDRHSKTQILHKGNYPVTGLAFRQAGKTTHLFVVTTENVQSYIVSG
                     KDYPRVELDTHGCGLRCSALSDPSQDLQFIVAGDECVYLYQPDERGPCFAFEGHKLIV
                     HWFRGYLVIVSRDRKVSPKSEFTSRDSQNSDKQILNIYDLCNKFIAYSAGFEDIVDVL
                     AEWGSLYVLTRDGRVHALQEKDTQTKLEMLFKKNLFEMAINLAKSQHLDSDGLAQIFM
                     QYGDHLYSKGNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSLAN
                     ADHTTLLLNCYTKLKDSSKLEEFIKTKSESEVHFDVETAIKVLRQAGYYSHALYLAEN
                     HAHHEWYLKIQLEDIKNYQEALRYIGKLPFEQAESNMKRYGKTLMHHIPEQTTQLLKG
                     LCTDYRPSLEGRGDREALSCRASSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYD
                     TLLELRLQNWAHEKDPQAKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYL
                     YEQGKLFQQIMHYHMQHEQYRQVIAVCERHGEQEPSLWEQALSYFARKEEDCKEYVAA
                     VLRHIENKSLMPPLLVVQTLAHNSTATLSIIRDYLVQKLQKQSQQIAQDELRVRRYRE
                     ETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGHSFHQHCFESYSESDAD
                     CPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLKCSNDSFSVIADYFGRGVFNKLTLLT
                     DPPTARLTPSLEAGLQRDLLMHSRRGT"
     exon            227..375
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            376..511
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            512..675
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            676..923
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1125
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1277
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1464
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1611
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1800
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1962
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2102
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2305
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2477
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2700
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..3536
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3160..3165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3193
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /note="major polyA site"
     regulatory      3339..3344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3360
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
     polyA_site      3404
                     /gene="Vps11"
                     /gene_synonym="1200011A11Rik"
ORIGIN      
        1 cacgtgattt cgcttccgga ggcgggggcc ttcggcaaga tggcggccta cctgcagtgg
       61 cggcgtttcg ttttcttcga gaaggagctg gtgaaggagc cgctgggtaa tgatggggct
      121 gctcccggtg ccgcgcctgt gtcgggatcc gctgcttcca agttcctttg cctccctcct
      181 ggcatcactg tctgcgactc aggccgcggg agcctggtct ttggagatat ggaaggccag
      241 atctggttct tgccacgttc tctacagctt acagggttcc aggcctacaa actacgggtg
      301 acacacttat atcagctgaa gcagcacaat attctggcat cggttggtga ggatgaagag
      361 ggtattaacc ctctggtaaa gatctggaac ctggaaaaga gagacggtgg caatccactc
      421 tgcacccgga ttttccctgc catcccaggg acagagccaa ctgttgtgtc ttgtttgacg
      481 gtccatgaga atctcaactt tatggccatt gggttcacag atggcagtgt caccctgaac
      541 aagggagata ttacccggga ccggcacagc aagacgcaga ttttgcacaa gggcaactat
      601 cccgttactg ggctggcctt tcgccaagca ggaaagacca cccacttgtt tgtcgtgaca
      661 actgaaaatg ttcagtctta tatagtttct ggaaaggact accctcgtgt ggagttggac
      721 acccatggtt gtggcctgcg ctgttcagcc ctgagcgacc cttctcaaga cctgcagttc
      781 attgttgctg gggatgagtg tgtctacctt taccagcctg atgaacgtgg accctgcttt
      841 gcctttgagg gccataagct catcgtgcac tggtttagag gctaccttgt cattgtctcc
      901 cgtgaccgga aagtttctcc caagtccgag tttaccagca gggactcaca gaactccgac
      961 aagcagattc tcaacatcta tgacctgtgc aacaagttca tagcctacag cgctgggttt
     1021 gaggatatag tggatgtgct ggctgagtgg ggctccttgt acgtgctgac gcgggatggg
     1081 cgggtccacg cattgcagga gaaggacaca cagaccaaac tggagatgct gtttaagaag
     1141 aatctatttg agatggcaat taatctggct aagagtcaac atttggacag tgatgggttg
     1201 gctcaaatct tcatgcagta tggagaccat ctctacagca agggcaacca tgatggggct
     1261 gtgcagcagt atatccgaac cattggaaag ttggagccat cctatgtgat ccggaagttt
     1321 ctggatgccc agcgcatcca caacttgacc gcctacctgc aaaccctgca tcggcagtct
     1381 ctggctaatg ctgatcatac caccctgctt ctgaactgct ataccaagct caaggacagc
     1441 tcgaagctgg aggaattcat caagacaaag agtgagagtg aagtccactt tgatgtagag
     1501 acagccatca aggtcctccg gcaggctggc tactactccc atgccctcta tctggctgag
     1561 aatcatgcac atcatgagtg gtacttgaag atccagctag aggacattaa gaactatcag
     1621 gaagcccttc ggtatatcgg gaagctgcct ttcgagcaag cggagagtaa catgaaacgc
     1681 tatggcaaga ccctcatgca ccacataccg gagcagacaa cccagttgct gaaaggcctc
     1741 tgcactgact atcgacccag tctggaaggc cgaggcgatc gggaggctct gagctgccgg
     1801 gccagttctg aggagttcat ccccatcttt gccaacaacc cacgagagct gaaagccttc
     1861 ctagaacaca tgagtgaggt gcagccggac tcaccgcagg gcatctatga cacgctcctg
     1921 gagctgcggc tgcagaactg ggcccatgag aaagatcccc aggccaagga gaaacttcat
     1981 gcagaggcca tctccctgct gaagagtggc cgattctgtg acgtgtttga caaggcattg
     2041 gttctgtgcc agatgcacga cttccaggat ggggtccttt acctctatga gcaggggaag
     2101 ctgttccagc agatcatgca ttaccacatg cagcacgagc agtaccggca ggtgattgcc
     2161 gtgtgtgagc gccatggaga gcaggagccc tccctgtggg aacaggccct cagctacttc
     2221 gcccgcaagg aggaggactg caaggagtat gtggcggctg tgctcaggca cattgagaac
     2281 aagagcctca tgccgcctct tctagtggtg cagaccctgg cccacaactc cacagctacc
     2341 ctgtctatca tccgagatta cctggtccaa aaactgcaga aacagagcca gcagattgca
     2401 caggatgagc tccgggtgcg gcgatacaga gaggagacca ctcgcatccg ccaggaaatc
     2461 caggagctca aggcgagtcc aaagattttc cagaagacca agtgtagcat ctgtaacagt
     2521 gccttggagc tgccctcagt ccacttcctg tgtggccact ccttccacca acactgcttt
     2581 gagagttact cagaaagtga tgctgactgc cccacctgcc tccctgagaa ccgcaaggtg
     2641 atggatatga tccgggccca ggaacagaaa cgagatctcc acgatcagtt ccaacatcag
     2701 ctcaagtgct cgaatgacag cttctctgtg attgcggact actttggccg aggggttttc
     2761 aacaagttga ctctgctgac cgaccctcct acagccagac tgacccccag cctggaggct
     2821 ggactgcagc gggacctgct gatgcactcc aggaggggaa cttagttagg cagctcctgg
     2881 ggaagcctat atccctgggc ctctgaagca cagacgtagg cctgaggaag agatggtagc
     2941 agacatgacc acagttccgg agcctcagga ctcaagaagg gactctgctt ttcctgcctc
     3001 ctccttttgc cagcctgctg tccctcctgc tgaccagcag tatagattct tctacaccag
     3061 tgaggaaggc cacctcagca acctctctgg acaatagctg ctttattctc tactcaaggg
     3121 caccaggctg tgcttgggtc cttgctccca gagcctataa ataaaagtat aatagtatga
     3181 ggactgaaaa agactttatg gagactttcc aggtgtttct ttttttgttt ttgagacagg
     3241 atgtcattgt gtatcctcgg ccggcttata actcattatg tagaccaggc tggcctcaaa
     3301 ctcacaaaga ttctcctgct ctgtctcctg agtctgggat taaaggcatg tgtcatcaca
     3361 cttcgccctc aggtgacaaa tatctaagaa cgtcctgagt tctagttcct tgcctgtggt
     3421 cttcctgtct ggttggctcc ataacacttg agtagtgggt ggggcctgtg acctctggga
     3481 aggttaagaa gttcactgtg ttgatacata gggcaaatat actaagctgt acactc
//
