LOCUS       NM_016983                429 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus V-set pre-B cell surrogate light chain 1B (Vpreb1b),
            mRNA.
ACCESSION   NM_016983 XM_489629
VERSION     NM_016983.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 429)
  AUTHORS   Aranburu,A., Engstrom,E., Gerasimcik,N., Alsen,S., Camponeschi,A.,
            Yrlid,U., Grimsholm,O. and Martensson,I.L.
  TITLE     Clonal relationships of memory B cell subsets in autoimmune mice
  JOURNAL   Front Immunol 14, 1129234 (2023)
   PUBMED   36936947
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 429)
  AUTHORS   Ren,W., Grimsholm,O., Bernardi,A.I., Hook,N., Stern,A.,
            Cavallini,N. and Martensson,I.L.
  TITLE     Surrogate light chain is required for central and peripheral B-cell
            tolerance and inhibits anti-DNA antibody production by marginal
            zone B cells
  JOURNAL   Eur J Immunol 45 (4), 1228-1237 (2015)
   PUBMED   25546233
REFERENCE   3  (bases 1 to 429)
  AUTHORS   Kil,L.P., Corneth,O.B., de Bruijn,M.J., Asmawidjaja,P.S.,
            Krause,A., Lubberts,E., van Loo,P.F. and Hendriks,R.W.
  TITLE     Surrogate light chain expression beyond the pre-B cell stage
            promotes tolerance in a dose-dependent fashion
  JOURNAL   J Autoimmun 57, 30-41 (2015)
   PUBMED   25523463
  REMARK    GeneRIF: Data show no autoantibody production was detectable in
            surrogate light chain (SLC) components VpreB/CD179a and
            lambda5/CD179b transgenic mice.
REFERENCE   4  (bases 1 to 429)
  AUTHORS   Knoll,M., Yanagisawa,Y., Simmons,S., Engels,N., Wienands,J.,
            Melchers,F. and Ohnishi,K.
  TITLE     The non-Ig parts of the VpreB and lambda5 proteins of the surrogate
            light chain play opposite roles in the surface representation of
            the precursor B cell receptor
  JOURNAL   J Immunol 188 (12), 6010-6017 (2012)
   PUBMED   22566564
  REMARK    GeneRIF: VpreB probes the fitness of newly generated VH domains of
            IgH chains for later pairing with IgL chains, and its non-Ig part
            fixes the preBCRs on the surface.
REFERENCE   5  (bases 1 to 429)
  AUTHORS   Kurey,I., Kobets,T., Havelkova,H., Slapnickova,M., Quan,L.,
            Trtkova,K., Grekov,I., Svobodova,M., Stassen,A.P., Hutson,A.,
            Demant,P. and Lipoldova,M.
  TITLE     Distinct genetic control of parasite elimination, dissemination,
            and disease after Leishmania major infection
  JOURNAL   Immunogenetics 61 (9), 619-633 (2009)
   PUBMED   19705113
REFERENCE   6  (bases 1 to 429)
  AUTHORS   Puech,A., Saint-Jore,B., Merscher,S., Russell,R.G., Cherif,D.,
            Sirotkin,H., Xu,H., Factor,S., Kucherlapati,R. and Skoultchi,A.I.
  TITLE     Normal cardiovascular development in mice deficient for 16 genes in
            550 kb of the velocardiofacial/DiGeorge syndrome region
  JOURNAL   Proc Natl Acad Sci U S A 97 (18), 10090-10095 (2000)
   PUBMED   10963672
REFERENCE   7  (bases 1 to 429)
  AUTHORS   Lund,J., Chen,F., Hua,A., Roe,B., Budarf,M., Emanuel,B.S. and
            Reeves,R.H.
  TITLE     Comparative sequence analysis of 634 kb of the mouse chromosome 16
            region of conserved synteny with the human velocardiofacial
            syndrome region on chromosome 22q11.2
  JOURNAL   Genomics 63 (3), 374-383 (2000)
   PUBMED   10704284
REFERENCE   8  (bases 1 to 429)
  AUTHORS   Dul,J.L., Argon,Y., Winkler,T., ten Boekel,E., Melchers,F. and
            Martensson,I.L.
  TITLE     The murine VpreB1 and VpreB2 genes both encode a protein of the
            surrogate light chain and are co-expressed during B cell
            development
  JOURNAL   Eur J Immunol 26 (4), 906-913 (1996)
   PUBMED   8625987
REFERENCE   9  (bases 1 to 429)
  AUTHORS   D'Hoostelaere,L.A., Bauer,S.R. and Melchers,F.
  TITLE     Restriction fragment analysis of V preB and lambda 5 within the
            genus Mus
  JOURNAL   Eur J Immunol 19 (1), 37-42 (1989)
   PUBMED   2563973
REFERENCE   10 (bases 1 to 429)
  AUTHORS   Kudo,A. and Melchers,F.
  TITLE     A second gene, VpreB in the lambda 5 locus of the mouse, which
            appears to be selectively expressed in pre-B lymphocytes
  JOURNAL   EMBO J 6 (8), 2267-2272 (1987)
   PUBMED   3117530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X05563.1.
            
            On Sep 3, 2004 this sequence version replaced XM_489629.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="DBA/2 x C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.14 cM"
     gene            1..429
                     /gene="Vpreb1b"
                     /gene_synonym="CD179b; Vpreb-2; VpreB1; Vpreb2"
                     /note="V-set pre-B cell surrogate light chain 1B"
                     /db_xref="GeneID:22363"
                     /db_xref="MGI:MGI:98937"
     CDS             1..429
                     /gene="Vpreb1b"
                     /gene_synonym="CD179b; Vpreb-2; VpreB1; Vpreb2"
                     /note="immunoglobulin omega chain; Lambda 5; pre-B
                     lymphocyte gene 2"
                     /codon_start=1
                     /product="immunoglobulin omega chain precursor"
                     /protein_id="NP_058679.1"
                     /db_xref="CCDS:CCDS28015.1"
                     /db_xref="GeneID:22363"
                     /db_xref="MGI:MGI:98937"
                     /translation="MAWTSVLLMLLAHLTGCGPQPMVHQPPSASSSLGATIRLSCTLS
                     NDHNIGIYSIYWYQQRPGHPPRFLLRYFSHSDKHQGPDIPPRFSGSKDTARNLGYLSI
                     SELQPEDEAVYYCAVGLRSHEKKRMEREWEGEKSYTDLGS"
     exon            1..46
                     /gene="Vpreb1b"
                     /gene_synonym="CD179b; Vpreb-2; VpreB1; Vpreb2"
                     /inference="alignment:Splign:2.1.0"
     exon            47..429
                     /gene="Vpreb1b"
                     /gene_synonym="CD179b; Vpreb-2; VpreB1; Vpreb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcctgga cgtctgtcct gctcatgctg ctggcccacc tcacaggttg tggccctcag
       61 cccatggtgc atcagccacc atcagcatct tcttcccttg gagccaccat ccgcctctcc
      121 tgtaccctga gcaacgacca taacattggc atttacagca tttactggta ccagcagagg
      181 ccgggccacc ctcccaggtt cctgctgaga tacttctcac actcagacaa gcaccagggt
      241 cccgatatcc cacctcgctt ctccgggtcc aaagatacgg ccaggaacct ggggtatctg
      301 agcatctctg aactgcagcc tgaggacgag gctgtgtatt actgcgctgt ggggctccgg
      361 agccacgaaa agaagagaat ggagagagag tgggaaggag aaaagtcgta tacagatttg
      421 ggatcttag
//
