LOCUS       NM_016982                772 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus V-set pre-B cell surrogate light chain 1A (Vpreb1a),
            mRNA.
ACCESSION   NM_016982
VERSION     NM_016982.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 772)
  AUTHORS   Aranburu,A., Engstrom,E., Gerasimcik,N., Alsen,S., Camponeschi,A.,
            Yrlid,U., Grimsholm,O. and Martensson,I.L.
  TITLE     Clonal relationships of memory B cell subsets in autoimmune mice
  JOURNAL   Front Immunol 14, 1129234 (2023)
   PUBMED   36936947
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 772)
  AUTHORS   Yang,Y., Kong,S., Zhang,Y., Melo-Cardenas,J., Gao,B., Zhang,Y.,
            Zhang,D.D., Zhang,B., Song,J., Thorp,E., Zhang,K., Zhang,J. and
            Fang,D.
  TITLE     The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1
            controls a critical checkpoint in B cell development in mice
  JOURNAL   J Biol Chem 293 (33), 12934-12944 (2018)
   PUBMED   29907570
REFERENCE   3  (bases 1 to 772)
  AUTHORS   Ren,W., Grimsholm,O., Bernardi,A.I., Hook,N., Stern,A.,
            Cavallini,N. and Martensson,I.L.
  TITLE     Surrogate light chain is required for central and peripheral B-cell
            tolerance and inhibits anti-DNA antibody production by marginal
            zone B cells
  JOURNAL   Eur J Immunol 45 (4), 1228-1237 (2015)
   PUBMED   25546233
REFERENCE   4  (bases 1 to 772)
  AUTHORS   Kil,L.P., Corneth,O.B., de Bruijn,M.J., Asmawidjaja,P.S.,
            Krause,A., Lubberts,E., van Loo,P.F. and Hendriks,R.W.
  TITLE     Surrogate light chain expression beyond the pre-B cell stage
            promotes tolerance in a dose-dependent fashion
  JOURNAL   J Autoimmun 57, 30-41 (2015)
   PUBMED   25523463
  REMARK    GeneRIF: Data show no autoantibody production was detectable in
            surrogate light chain (SLC) components VpreB/CD179a and
            lambda5/CD179b transgenic mice.
REFERENCE   5  (bases 1 to 772)
  AUTHORS   Knoll,M., Yanagisawa,Y., Simmons,S., Engels,N., Wienands,J.,
            Melchers,F. and Ohnishi,K.
  TITLE     The non-Ig parts of the VpreB and lambda5 proteins of the surrogate
            light chain play opposite roles in the surface representation of
            the precursor B cell receptor
  JOURNAL   J Immunol 188 (12), 6010-6017 (2012)
   PUBMED   22566564
  REMARK    GeneRIF: VpreB probes the fitness of newly generated VH domains of
            IgH chains for later pairing with IgL chains, and its non-Ig part
            fixes the preBCRs on the surface.
REFERENCE   6  (bases 1 to 772)
  AUTHORS   Miller,R.D., Hogg,J., Ozaki,J.H., Gell,D., Jackson,S.P. and
            Riblet,R.
  TITLE     Gene for the catalytic subunit of mouse DNA-dependent protein
            kinase maps to the scid locus
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10792-10795 (1995)
   PUBMED   7479885
REFERENCE   7  (bases 1 to 772)
  AUTHORS   Okabe,T., Watanabe,T. and Kudo,A.
  TITLE     A pre-B- and B cell-specific DNA-binding protein, EBB-1, which
            binds to the promoter of the VpreB1 gene
  JOURNAL   Eur J Immunol 22 (1), 37-43 (1992)
   PUBMED   1730258
REFERENCE   8  (bases 1 to 772)
  AUTHORS   Okabe,T., Bauer,S.R. and Kudo,A.
  TITLE     Pre-B lymphocyte-specific transcriptional control of the mouse
            VpreB gene
  JOURNAL   Eur J Immunol 22 (1), 31-36 (1992)
   PUBMED   1730257
REFERENCE   9  (bases 1 to 772)
  AUTHORS   D'Hoostelaere,L.A., Bauer,S.R. and Melchers,F.
  TITLE     Restriction fragment analysis of V preB and lambda 5 within the
            genus Mus
  JOURNAL   Eur J Immunol 19 (1), 37-42 (1989)
   PUBMED   2563973
REFERENCE   10 (bases 1 to 772)
  AUTHORS   Kudo,A. and Melchers,F.
  TITLE     A second gene, VpreB in the lambda 5 locus of the mouse, which
            appears to be selectively expressed in pre-B lymphocytes
  JOURNAL   EMBO J 6 (8), 2267-2272 (1987)
   PUBMED   3117530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166832.2, AK010879.1 and BE852604.1.
            
            On Mar 30, 2010 this sequence version replaced NM_016982.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X05556.1, BY710289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC166832.2         36606-36612         c
            8-756               AK010879.1         2-750
            757-772             BE852604.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.46 cM"
     gene            1..772
                     /gene="Vpreb1a"
                     /gene_synonym="CD179a; Vpreb-1; Vpreb1"
                     /note="V-set pre-B cell surrogate light chain 1A"
                     /db_xref="GeneID:22362"
                     /db_xref="MGI:MGI:98936"
     exon            1..190
                     /gene="Vpreb1a"
                     /gene_synonym="CD179a; Vpreb-1; Vpreb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..573
                     /gene="Vpreb1a"
                     /gene_synonym="CD179a; Vpreb-1; Vpreb1"
                     /note="immunoglobulin iota chain; pre-B lymphocyte gene 1"
                     /codon_start=1
                     /product="immunoglobulin iota chain precursor"
                     /protein_id="NP_058678.1"
                     /db_xref="CCDS:CCDS27989.1"
                     /db_xref="GeneID:22362"
                     /db_xref="MGI:MGI:98936"
                     /translation="MAWTSVLLMLLAYLTGCGPQPMVHQPPLASSSLGATIRLSCTLS
                     NDHNIGIYSIYWYQQRPGHPPRFLLRYFSHSDKHQGPDIPPRFSGSKDTTRNLGYLSI
                     SELQPEDEAVYYCAVGLRSQEKKRMEREWEGEKSYTDLGS"
     exon            191..768
                     /gene="Vpreb1a"
                     /gene_synonym="CD179a; Vpreb-1; Vpreb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      748..753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vpreb1a"
                     /gene_synonym="CD179a; Vpreb-1; Vpreb1"
                     /note="hexamer: ATTAAA"
     polyA_site      768
                     /gene="Vpreb1a"
                     /gene_synonym="CD179a; Vpreb-1; Vpreb1"
                     /note="major polyA site"
ORIGIN      
        1 agagcccaga aagcctggga gggtggtgag caggaaccag gggtgcagtg accctctccc
       61 caaagcaggg aggagagtgc ttcccagctg gtcagggccc aggagcagtg gctgtagggg
      121 gcagggtgct gcaggtctgg agccatggcc tggacgtctg tcctgctcat gctgctggcc
      181 tatctcacag gttgtggccc tcagcccatg gtgcatcagc caccattagc atcttcttcc
      241 cttggagcca ccatccgcct ctcctgtacc ctgagcaacg accataacat tggcatttac
      301 agcatttact ggtaccagca gaggccgggc caccctccca ggttcctgct gagatacttc
      361 tcacactcag acaagcacca gggtcccgat atcccacctc gcttctccgg gtccaaagat
      421 acgaccagga acctggggta tctgagcatc tctgaactgc agcctgagga cgaggctgtg
      481 tattactgtg ccgtggggct ccggagccag gaaaagaaga ggatggagag ggagtgggaa
      541 ggagaaaagt cgtatacaga tttgggatct taggctctgg agacattcag accctgaact
      601 gaagacagag tttgctttgc tcggctagtc tggtatggga aggaggggta gaacgtgagg
      661 ttttgcagag cctagaagat ggaattatgc agcttttcct tgttctgcgg tgttgctatg
      721 agcccccatt ggaggctgga ttgtagaatt aaagctgttt ttactgaaaa aa
//
