LOCUS       NM_146168               2906 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus vesicular, overexpressed in cancer, prosurvival
            protein 1 (Vopp1), transcript variant 1, mRNA.
ACCESSION   NM_146168
VERSION     NM_146168.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2906)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2906)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2906)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2906)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC024822.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024822.1, AK031812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.82 cM"
     gene            1..2906
                     /gene="Vopp1"
                     /gene_synonym="Ecop"
                     /note="vesicular, overexpressed in cancer, prosurvival
                     protein 1"
                     /db_xref="GeneID:232023"
                     /db_xref="MGI:MGI:2141658"
     exon            1..199
                     /gene="Vopp1"
                     /gene_synonym="Ecop"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..664
                     /gene="Vopp1"
                     /gene_synonym="Ecop"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; EGFR-coamplified and overexpressed protein; WW
                     domain binding protein VOPP1"
                     /codon_start=1
                     /product="WW domain binding protein VOPP1 isoform a
                     precursor"
                     /protein_id="NP_666280.1"
                     /db_xref="CCDS:CCDS39497.1"
                     /db_xref="GeneID:232023"
                     /db_xref="MGI:MGI:2141658"
                     /translation="MGRRLGRVAALLLGLLVECTEAKKHCWYFEGLYPTYYICRSYED
                     CCGSRCCVRALSIQRLWYFWFLLMMGVLFCCGAGFFIRRRMYPPPLIEEPTFNVSYTR
                     QPPNPAPGAQQMGPPYYTDPGGPGMNPVGNTMAMAFQVQPNSPHGGTTYPPPPSYCNT
                     PPPPYEQVVKDK"
     exon            200..258
                     /gene="Vopp1"
                     /gene_synonym="Ecop"
                     /inference="alignment:Splign:2.1.0"
     exon            259..336
                     /gene="Vopp1"
                     /gene_synonym="Ecop"
                     /inference="alignment:Splign:2.1.0"
     exon            337..473
                     /gene="Vopp1"
                     /gene_synonym="Ecop"
                     /inference="alignment:Splign:2.1.0"
     exon            474..2886
                     /gene="Vopp1"
                     /gene_synonym="Ecop"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2867..2872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vopp1"
                     /gene_synonym="Ecop"
                     /note="hexamer: AATAAA"
     polyA_site      2886
                     /gene="Vopp1"
                     /gene_synonym="Ecop"
                     /note="major polyA site"
ORIGIN      
        1 ggcacgtcct cgagctccgc cggcttgccg cgcgtccttc tgccggcttc agctcgtatc
       61 cccggagtcc acccgcccgt cccggggtgc ggactggccc tgagctggcc gtacagcccg
      121 gcttcggacg gtcctcgctg gagccatggg ccgccggctc ggcagggtgg cggcgctgct
      181 gctcgggctg ctagtggagt gcactgaggc caaaaaacat tgctggtatt ttgaaggact
      241 ctatcccaca tactatatat gccgttccta tgaagactgc tgtggctcca ggtgctgtgt
      301 gagggccctt tccatacaga ggctgtggta tttttggttc ctgctgatga tgggtgtgct
      361 gttctgctgt ggtgccggtt tcttcattcg ccggcgcatg tatccgccac cactcattga
      421 ggagcccaca ttcaatgtgt cctataccag gcagccacca aatcctgctc caggagcaca
      481 gcaaatggga ccgccatatt acaccgaccc tggaggaccc gggatgaatc ctgttggcaa
      541 taccatggct atggctttcc aggtccagcc caattcacct cacggaggca caacttaccc
      601 accccctcct tcctactgca acacgcctcc acccccctat gaacaggtgg tgaaggacaa
      661 gtagcaagat gctacatcaa aggcaaagag gatggacagg cccttttgtt taccttccca
      721 tcctcaccga tacttgctga tagggtggtc caagggaaaa cttggatatt ctcaaagcaa
      781 gcccagctct ctttcaagtc ttttgtggag gacatttgaa tccacactgt ctcctctgtt
      841 gcttctgttt ctgatgtagt ctgtgctctc tgagagagtg tggcaacagt ccctgagggt
      901 tgatattcct agggtgtcca gggtagatcc tcgggagaga ggctaagggg aaaggaaggc
      961 atagcctgtg tgttaggggg cagataaagt ggtcaggctg agataagact cacatgatgc
     1021 agtagttggc agtgaacttc gaagagacac tatccaccat cccagcccat tctcctaata
     1081 gaagctgtgg ggctgtgttg ttgatgctct ttggtctcca ctcacatttt gaaaataggc
     1141 tttcctctgc aggaatagga aagacccaag tacatatttg cttccactta aaaatgaggg
     1201 tcagaaccag gcctcagttg gacatctata gttaaataaa ggccattaga gaggggaaat
     1261 ctttaagtta ggggaaattc tctaaatgga gacattgcgt tttatgaatc atcgtctggc
     1321 ttttctttta gtgcatgtat tgaagtgagg gtgtcctttg agatcagatg gggagagtga
     1381 actctgcggg gggtggggtg tctctactca gagggctcca acaccctttt cttaggtagt
     1441 tctggtgatg ggttttatgg gcactataga gctgaggggc acattaggcc gggtagttac
     1501 attgaccctt ggagaggaag aggacagcca aagaaactca gcaaagcaag accagcattg
     1561 ctgagttaga gctagggttg tatgtgatcc caacagagat gtgctggcct cagaagaggg
     1621 gacgtttgtg gatagagccg tgaaaaccta cttagttgca cagatgacat aatcaaaagt
     1681 agagaaagaa gtgtagttag agatgccatt tcccaggtga gaatcagagc tcatccatag
     1741 atttacaagt agtggctgga gttaacagta tggagttctt ttcccttgcg tagttagtca
     1801 cgttgatgtg tatttaaacc caggttgaga ccttgtgtac taagagcaag gaagtatagc
     1861 taagatgtct agattattta tatgtagtat ggtggggagt ggggctgcaa ggaagggggc
     1921 tgacattgta aatgagaaaa tcagagccat ttgataaact gttacttgtt ggatcaggca
     1981 tccaaaagtg tctcttgagt ggacattgag tattctttac cacctacaag accaggaggc
     2041 atggtgtcat tctccattgg ggtatttata tgaggtagag gttcaggaat cgacagtagc
     2101 tgtgtgggct tagtttaagg actgaaagca tagggactgg tagacagttt cataggaaac
     2161 tgcggggaag gaatggatac ctttaaagac agtttgtgga tgcagatgct gccacccatc
     2221 attgagcacc cttgtgtctc tggcttcctg tcactggatc cagtacccct ccatgcttgg
     2281 gtccttgttt tacataagac aacaaagcac aatgtctgct gtttacaatc aagacgacta
     2341 catggtccaa acatttcttc tctcttctat cacttgtggc tttaacttcc atttcctccg
     2401 ttccttttta aaatcaagaa gcacagtcag agctgcccct gggattgcat cagggaacgg
     2461 ctgatcaagg cattcagtgt ccatgactaa atcttatctt tttgatagca aatcctttta
     2521 agaaactgaa caattgctaa ggctcagcaa ttttatactc caatgtctgt gtaaggtaaa
     2581 ttttgtttgc cattgagccc acattggaat tccttctgac gtcaacactg acaatgccta
     2641 tggaaattgc acttctgggt atatgtccca gcatccttgt tttcttatgt ttggtgagta
     2701 aggctcaccc cttccagcag ctctacttct gtgtgctgag gtcctgtaga gccggggctt
     2761 gggcacagac atgaggcaga cttgtgcatg ctctttcttg gcaacacttg gctcatattt
     2821 cttgttctct tttgatagag tcctgtttcc tatgtattta aaaaataata aaagtgaatt
     2881 tagtcaaaaa aaaaaaaaaa aaaaaa
//
