LOCUS       NM_011704               2416 bp    mRNA    linear   ROD 20-FEB-2024
DEFINITION  Mus musculus vanin 1 (Vnn1), mRNA.
ACCESSION   NM_011704
VERSION     NM_011704.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   Sun,C., Liang,J., Zheng,J., Mao,S., Chen,S., Aikemu,A. and Liu,C.
  TITLE     Brown adipose Vanin-1 is required for the maintenance of
            mitochondrial homeostasis and prevents diet-induced metabolic
            dysfunction
  JOURNAL   Mol Metab 80, 101884 (2024)
   PUBMED   38246587
  REMARK    GeneRIF: Brown adipose Vanin-1 is required for the maintenance of
            mitochondrial homeostasis and prevents diet-induced metabolic
            dysfunction.
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Qin,W., Kang,M., Li,C., Zheng,W. and Guo,Q.
  TITLE     VNN1 overexpression in pancreatic cancer cells inhibits
            paraneoplastic islet function by increasing oxidative stress and
            inducing beta-cell dedifferentiation
  JOURNAL   Oncol Rep 49 (6) (2023)
   PUBMED   37114564
  REMARK    GeneRIF: VNN1 overexpression in pancreatic cancer cells inhibits
            paraneoplastic islet function by increasing oxidative stress and
            inducing beta-cell dedifferentiation.
REFERENCE   3  (bases 1 to 2416)
  AUTHORS   Chen,J., Lu,H., Wang,X., Yang,J., Luo,J., Wang,L., Yi,X., He,Y. and
            Chen,K.
  TITLE     VNN1 contributes to the acute kidney injury-chronic kidney disease
            transition by promoting cellular senescence via affecting RB1
            expression
  JOURNAL   FASEB J 36 (9), e22472 (2022)
   PUBMED   35959877
REFERENCE   4  (bases 1 to 2416)
  AUTHORS   Lu,P., Zhang,C., Fu,L., Wei,Y., Huang,Y., Wang,X., Lv,C. and
            Chen,L.
  TITLE     Near-Infrared Fluorescent Probe for Imaging and Evaluating the Role
            of Vanin-1 in Chemotherapy
  JOURNAL   Anal Chem 93 (29), 10378-10387 (2021)
   PUBMED   34275284
  REMARK    GeneRIF: Near-Infrared Fluorescent Probe for Imaging and Evaluating
            the Role of Vanin-1 in Chemotherapy.
REFERENCE   5  (bases 1 to 2416)
  AUTHORS   Naquet,P., Kerr,E.W., Vickers,S.D. and Leonardi,R.
  TITLE     Regulation of coenzyme A levels by degradation: the 'Ins and Outs'
  JOURNAL   Prog Lipid Res 78, 101028 (2020)
   PUBMED   32234503
  REMARK    Review article
REFERENCE   6  (bases 1 to 2416)
  AUTHORS   Granjeaud,S., Naquet,P. and Galland,F.
  TITLE     An ESTs description of the new Vanin gene family conserved from fly
            to human
  JOURNAL   Immunogenetics 49 (11-12), 964-972 (1999)
   PUBMED   10501839
REFERENCE   7  (bases 1 to 2416)
  AUTHORS   Galland,F., Malergue,F., Bazin,H., Mattei,M.G., Aurrand-Lions,M.,
            Theillet,C. and Naquet,P.
  TITLE     Two human genes related to murine vanin-1 are located on the long
            arm of human chromosome 6
  JOURNAL   Genomics 53 (2), 203-213 (1998)
   PUBMED   9790769
REFERENCE   8  (bases 1 to 2416)
  AUTHORS   Aurrand-Lions,M., Galland,F., Bazin,H., Zakharyev,V.M., Imhof,B.A.
            and Naquet,P.
  TITLE     Vanin-1, a novel GPI-linked perivascular molecule involved in
            thymus homing
  JOURNAL   Immunity 5 (5), 391-405 (1996)
   PUBMED   8934567
REFERENCE   9  (bases 1 to 2416)
  AUTHORS   Lepesant,H., Pierres,M. and Naquet,P.
  TITLE     Deficient antigen presentation by thymic epithelial cells reveals
            differential induction of T cell clone effector functions by
            CD28-mediated costimulation
  JOURNAL   Cell Immunol 161 (2), 279-287 (1995)
   PUBMED   7697739
REFERENCE   10 (bases 1 to 2416)
  AUTHORS   Shibata,K., Gross,C.J. and Henderson,L.M.
  TITLE     Hydrolysis and absorption of pantothenate and its coenzymes in the
            rat small intestine
  JOURNAL   J Nutr 113 (10), 2107-2115 (1983)
   PUBMED   6619987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB838710.1 and AK145984.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_011704.4.
            
            On Jul 8, 2009 this sequence version replaced NM_011704.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145984.1, AK002773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                BB838710.1         1-95
            96-2416             AK145984.1         2-2322
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 11.33 cM"
     gene            1..2416
                     /gene="Vnn1"
                     /gene_synonym="V-1"
                     /note="vanin 1"
                     /db_xref="GeneID:22361"
                     /db_xref="MGI:MGI:108395"
     exon            1..404
                     /gene="Vnn1"
                     /gene_synonym="V-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1727
                     /gene="Vnn1"
                     /gene_synonym="V-1"
                     /EC_number="3.5.1.92"
                     /note="pantetheine hydrolase; vascular non-inflammatory
                     molecule 1; pantetheinase"
                     /codon_start=1
                     /product="pantetheinase precursor"
                     /protein_id="NP_035834.2"
                     /db_xref="CCDS:CCDS35868.1"
                     /db_xref="GeneID:22361"
                     /db_xref="MGI:MGI:108395"
                     /translation="MGMSWWLACAAAFSALCVLKASSLDTFLAAVYEHAVILPKDTLL
                     PVSHSEALALMNQNLDLLEGAIVSAAKQGAHIIVTPEDGIYGVRFTRDTIYPYLEEIP
                     DPQVNWIPCDNPKRFGSTPVQERLSCLAKNNSIYVVANMGDKKPCNTSDSHCPPDGRF
                     QYNTDVVFDSQGKLVARYHKQNIFMGEDQFNVPMEPEFVTFDTPFGKFGVFTCFDILF
                     HDPAVTLVTEFQVDTILFPTAWMDVLPHLAAIEFHSAWAMGMGVNFLAANLHNPSRRM
                     TGSGIYAPDSPRVFHYDRKTQEGKLLFAQLKSHPIHSPVNWTSYASSVESTPTKTQEF
                     QSIVFFDEFTFVELKGIKGNYTVCQNDLCCHLSYQMSEKRADEVYAFGAFDGLHTVEG
                     QYYLQICILLKCKTTNLRTCGSSVDTAFTRFEMFSLSGTFGTRYVFPEVLLSEVKLAP
                     GEFQVSSDGRLVSLKPTSGPVLTIGLFGRLYGKDWASNASSDFIAHSLIIMLIVTPII
                     HYLC"
     exon            405..535
                     /gene="Vnn1"
                     /gene_synonym="V-1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..728
                     /gene="Vnn1"
                     /gene_synonym="V-1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..1020
                     /gene="Vnn1"
                     /gene_synonym="V-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1379
                     /gene="Vnn1"
                     /gene_synonym="V-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1550
                     /gene="Vnn1"
                     /gene_synonym="V-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..2416
                     /gene="Vnn1"
                     /gene_synonym="V-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcttgtct gcattcctga ccagagaact aaggacattt ctgaaactgt tgctttcagg
       61 gacaaagttt tcttaacttt gaaaaaaaat tttttgaagc taccaaggtc tgggaaccac
      121 gtgactcatg ccttgtttat aaaagtatcc tgcaaggttt tggtttcccg cagtctttgg
      181 acttcagcat gggcatgtct tggtggctgg cgtgtgctgc agcgttttct gccctctgtg
      241 tcttaaaagc cagttcgctg gatactttcc tcgcggctgt ttacgagcat gctgtgatcc
      301 tgcctaagga caccctgttg ccagtgtctc acagtgaggc tctggcatta atgaaccaga
      361 atctggacct tctggaagga gcgatcgtat ctgcagcgaa gcagggtgcg cacattattg
      421 tgactccaga agatggcata tacggtgtgc gtttcaccag ggatacgatc tacccatacc
      481 tggaggagat cccagaccct caagtaaact ggataccctg tgataaccct aaaagatttg
      541 gctctacccc ggtgcaggag agactcagct gcttggccaa gaacaactcc atctatgttg
      601 tggcgaacat gggagacaag aagccgtgta acaccagcga ctctcactgt ccacctgacg
      661 gcagattcca gtacaacact gatgtggtgt ttgattccca gggtaaactg gttgcgagat
      721 accataagca aaacattttc atgggagaag atcagttcaa tgtccccatg gagcctgagt
      781 ttgtgacttt cgacaccccc tttggaaagt ttggcgtctt cacctgtttc gatattctct
      841 tccatgatcc cgctgtcacc ctggtgacag aattccaggt ggacaccata ctgttcccaa
      901 ccgcctggat ggacgtcctt cctcatttgg cagccattga attccactca gcttgggcta
      961 tgggcatggg ggtcaatttc ctagcagcta atctacataa tccctcgagg agaatgacag
     1021 gaagtggtat ctatgcaccc gattctccaa gggtctttca ctacgacagg aagacccaag
     1081 aaggaaaact cctcttcgct cagctgaaat cccacccaat tcactccccg gtgaactgga
     1141 cttcctatgc tagcagtgta gaatcaaccc caaccaaaac ccaggaattt cagagtattg
     1201 tcttttttga tgagtttacc tttgtggagc tcaaagggat caaaggaaat tacactgttt
     1261 gccagaatga cctctgctgt cacctaagct accagatgtc tgagaagcga gcagatgagg
     1321 tttatgcctt tggagccttt gatgggctgc acaccgtgga agggcagtac tacctacaga
     1381 tctgcatcct gctaaaatgt aaaactacca atttacgcac ctgtggtagt tcagtggaca
     1441 cggcttttac caggtttgaa atgttctcgc tcagcggcac ttttggaacc cggtatgtct
     1501 tccctgaagt gttgctgagt gaggtcaagc tcgcacctgg ggagtttcag gtgtcaagtg
     1561 atgggcgcct ggttagcctg aagccaacct cgggacctgt gttaaccatc gggctctttg
     1621 ggaggttgta tgggaaggac tgggcatcca atgcttcctc agacttcata gcacactcgc
     1681 tgataataat gctgattgtg acgcctatta tacattactt gtgctgatgg aatttttaca
     1741 ttttttattt tatttagaaa atttaaaatt ggtggatgca gaaaaaataa ctgtttgtca
     1801 acagtggact cgggtgtaag caaataaagt gcctcttctt tagagaaaca tatgtacacc
     1861 agatacattt caggaaaatt aataaaactt tgagcattgg aacgagatgg agggccaagt
     1921 aaaggtcgca tgtgttttat tcagaagaaa taaaaattac agttaaaagg cacttcaaac
     1981 catcataaga tagatttaca agaggtgtaa atctattata catcttactc agttatgctt
     2041 agaatttcca atgtgtttgt tcatttgggc tattaagtat ttatctcaac atttccgttc
     2101 tctcatggac cagatcctgt agttttaatt cttcagttca agtcccagtt cccacaacct
     2161 cagaacgtga ctgccttggt gtctttggca atgaagacat aagaggcatc attagcatgg
     2221 actttaattc aatatgactg atctcctcag aagaaatcag gacaaagact tgcatcaagt
     2281 gaagcccttg tgaacacagg aaaagatggt catgtacaac aagaaagggg gcctcaggag
     2341 aacgcaaacc tgctaacgtg tcaaacttcc aggtctccag aatcatgagg caataaattt
     2401 ctgttttaaa tggtcc
//
