LOCUS       NM_029478               2794 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus vacuole membrane protein 1 (Vmp1), transcript variant
            1, mRNA.
ACCESSION   NM_029478
VERSION     NM_029478.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2794)
  AUTHORS   Yao,Y., Gu,J., Li,M., Li,G., Ai,J. and Zhao,L.
  TITLE     WHSC1L1-mediated epigenetic downregulation of VMP1 participates in
            herpes simplex virus 1 infection-induced mitophagy impairment and
            neuroinflammation
  JOURNAL   Mol Immunol 163, 63-74 (2023)
   PUBMED   37748280
  REMARK    GeneRIF: WHSC1L1-mediated epigenetic downregulation of VMP1
            participates in herpes simplex virus 1 infection-induced mitophagy
            impairment and neuroinflammation.
REFERENCE   2  (bases 1 to 2794)
  AUTHORS   Liu,Y., Ma,Y., Xu,J., Zhang,G., Zhao,X., He,Z., Wang,L., Yin,N. and
            Peng,M.
  TITLE     VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains
            naive T cell survival
  JOURNAL   J Exp Med 220 (6) (2023)
   PUBMED   36971758
  REMARK    GeneRIF: VMP1 prevents Ca2+ overload in endoplasmic reticulum and
            maintains naive T cell survival.
REFERENCE   3  (bases 1 to 2794)
  AUTHORS   Ni,H.M., Ding,B. and Chen,A.
  TITLE     Loss of hepatic VMP1 trapped VLDL in the bilayer of endoplasmic
            reticulum membrane
  JOURNAL   Liver Res 7 (2), 161-163 (2023)
   PUBMED   38405163
REFERENCE   4  (bases 1 to 2794)
  AUTHORS   Jiang,X., Chen,A., Ding,W.X. and Ni,H.M.
  TITLE     VMP1 regulates hepatic lipoprotein secretion and NASH independent
            of autophagy
  JOURNAL   Autophagy 19 (1), 367-369 (2023)
   PUBMED   35617134
  REMARK    GeneRIF: VMP1 regulates hepatic lipoprotein secretion and NASH
            independent of autophagy.
REFERENCE   5  (bases 1 to 2794)
  AUTHORS   Jiang,X., Fulte,S., Deng,F., Chen,S., Xie,Y., Chao,X., He,X.C.,
            Zhang,Y., Li,T., Li,F., McCoin,C., Morris,E.M., Thyfault,J.,
            Liu,W., Li,L., Davidson,N.O., Ding,W.X. and Ni,H.M.
  TITLE     Lack of VMP1 impairs hepatic lipoprotein secretion and promotes
            non-alcoholic steatohepatitis
  JOURNAL   J Hepatol 77 (3), 619-631 (2022)
   PUBMED   35452693
  REMARK    GeneRIF: Lack of VMP1 impairs hepatic lipoprotein secretion and
            promotes non-alcoholic steatohepatitis.
REFERENCE   6  (bases 1 to 2794)
  AUTHORS   Grasso,D., Ropolo,A., Lo Re,A., Boggio,V., Molejon,M.I.,
            Iovanna,J.L., Gonzalez,C.D., Urrutia,R. and Vaccaro,M.I.
  TITLE     Zymophagy, a novel selective autophagy pathway mediated by
            VMP1-USP9x-p62, prevents pancreatic cell death
  JOURNAL   J Biol Chem 286 (10), 8308-8324 (2011)
   PUBMED   21173155
  REMARK    GeneRIF: Zymophagy, a novel selective autophagy pathway mediated by
            VMP1-USP9x-p62, prevents pancreatic cell death.
REFERENCE   7  (bases 1 to 2794)
  AUTHORS   Kozomara,A. and Griffiths-Jones,S.
  TITLE     miRBase: integrating microRNA annotation and deep-sequencing data
  JOURNAL   Nucleic Acids Res 39 (Database issue), D152-D157 (2011)
   PUBMED   21037258
REFERENCE   8  (bases 1 to 2794)
  AUTHORS   Hu,S.J., Ren,G., Liu,J.L., Zhao,Z.A., Yu,Y.S., Su,R.W., Ma,X.H.,
            Ni,H., Lei,W. and Yang,Z.M.
  TITLE     MicroRNA expression and regulation in mouse uterus during embryo
            implantation
  JOURNAL   J Biol Chem 283 (34), 23473-23484 (2008)
   PUBMED   18556655
REFERENCE   9  (bases 1 to 2794)
  AUTHORS   Ropolo,A., Grasso,D., Pardo,R., Sacchetti,M.L., Archange,C., Lo
            Re,A., Seux,M., Nowak,J., Gonzalez,C.D., Iovanna,J.L. and
            Vaccaro,M.I.
  TITLE     The pancreatitis-induced vacuole membrane protein 1 triggers
            autophagy in mammalian cells
  JOURNAL   J Biol Chem 282 (51), 37124-37133 (2007)
   PUBMED   17940279
REFERENCE   10 (bases 1 to 2794)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592222.11 and AL604063.4.
            
            On Mar 18, 2020 this sequence version replaced NM_029478.5.
            
            Transcript Variant: This variant (1), as well as variants 2 and 3,
            encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159468.1, AK043091.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AL592222.11        58541-58637         c
            98-199              AL592222.11        40578-40679         c
            200-335             AL592222.11        39455-39590         c
            336-426             AL592222.11        38284-38374         c
            427-537             AL592222.11        35924-36034         c
            538-705             AL592222.11        18299-18466         c
            706-837             AL592222.11        9976-10107          c
            838-918             AL604063.4         130902-130982       c
            919-1035            AL604063.4         126736-126852       c
            1036-1097           AL604063.4         121568-121629       c
            1098-1200           AL604063.4         106056-106158       c
            1201-2794           AL604063.4         103418-105011       c
FEATURES             Location/Qualifiers
     source          1..2794
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.82 cM"
     gene            1..2794
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /note="vacuole membrane protein 1"
                     /db_xref="GeneID:75909"
                     /db_xref="MGI:MGI:1923159"
     exon            1..97
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /inference="alignment:Splign:2.1.0"
     exon            98..199
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1344
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /note="isoform a is encoded by transcript variant 1;
                     transmembrane protein 49; NF-E2 induceble protein-2;
                     protein ni-2"
                     /codon_start=1
                     /product="vacuole membrane protein 1 isoform a"
                     /protein_id="NP_083754.2"
                     /db_xref="CCDS:CCDS25203.1"
                     /db_xref="GeneID:75909"
                     /db_xref="MGI:MGI:1923159"
                     /translation="MAENGKNCDQRRIAMSKDQHNGSLTDPSSVHEKKRRDREERQNI
                     VLWRQPLITLQYFSLETLVVLKEWTSKLWHRQSIVVSFLLLLAALVATYYVEGAHQQY
                     VQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEP
                     PYPDQIICPEEEGAEGAISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAE
                     PDDEEYQEFEEMLEHAEAAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGI
                     TCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIVTFSKHIVEQMVTFIGAVPGIGPSL
                     QKPFQEYLEAQRQKLHHRSEAGTPQGENWLSWMFEKLVVAMVCYFVLSIINSMAQNYA
                     KRIQQRLNSEEKTK"
     exon            200..335
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /inference="alignment:Splign:2.1.0"
     exon            336..426
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /inference="alignment:Splign:2.1.0"
     exon            427..537
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /inference="alignment:Splign:2.1.0"
     exon            538..705
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /inference="alignment:Splign:2.1.0"
     exon            706..837
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /inference="alignment:Splign:2.1.0"
     exon            838..918
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1035
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1097
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1200
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..2794
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1932..1937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /note="hexamer: TATAAA"
     polyA_site      1959
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /note="major polyA site"
     regulatory      2771..2776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
                     /note="hexamer: AATAAA"
     polyA_site      2794
                     /gene="Vmp1"
                     /gene_synonym="3110098I04Rik; 4930579A11Rik; mir-21a;
                     ni-2; Tango5; Tmem49"
ORIGIN      
        1 gagttccggt tggctggagc ccagcggcgg gtgtgagagt cggtgttgtg agccgcttcc
       61 aggatcctgc gatccggaga agccggggtc tgagcggctc ctccagagtt cctgatctat
      121 gaaatggcag agaatggaaa aaattgtgac cagagacgca tagcaatgag taaggatcag
      181 cacaatggaa gtctcacaga cccctcttca gttcatgaga agaagagaag ggatcgggaa
      241 gaaagacaga atattgtcct gtggagacag ccactcatta ccttgcagta tttctctctg
      301 gaaactcttg tagttttgaa ggaatggacc tcaaaattgt ggcatcgtca aagcattgtg
      361 gtgtcctttt tactgctgct tgctgcgctt gtagctacgt attatgtgga aggagcgcac
      421 caacagtatg tgcagcggat agagaagcag tttcttttgt atgcatactg gataggcctg
      481 gggattttgt cctctgttgg tcttggaaca ggactgcaca cctttctgct ttatctgggc
      541 ccacatatag cttcagttac attagctgct tatgaatgca attcggtgaa tttccctgag
      601 ccaccctatc ctgaccagat tatctgccca gaggaagaag gcgctgaggg agccatttct
      661 ttgtggagta tcatctcaaa agttagaatt gaagcctgca tgtggggcat tggaacagcc
      721 attggagagc tgcctccata tttcatggcc agggcagctc gcctctcagg tgctgaacca
      781 gatgatgaag agtatcagga atttgaagaa atgctggaac atgcagaggc tgcacaagac
      841 tttgcatcac gggctaaact ggcagttcaa aaactagtac agaaagttgg attttttgga
      901 attttggcct gtgcttctat tccaaacccc ctgtttgacc tggctggaat aacgtgtggg
      961 cacttccttg tacctttctg gaccttcttt ggtgcaaccc tgattgggaa agcaatcatt
     1021 aaaatgcata tccagaaaat atttgttata gtaactttca gcaagcacat cgtggagcag
     1081 atggtgactt tcattggtgc tgtccccggc ataggtccgt ctctgcagaa gccttttcaa
     1141 gagtacctgg aggcgcagcg gcagaagctt catcacagaa gtgaagcggg cacaccgcag
     1201 ggagaaaact ggttatcctg gatgtttgag aagctggtgg ttgcaatggt gtgttacttt
     1261 gtcctgtcta ttattaactc catggcacaa aactatgcca aacgaatcca gcagcgcttg
     1321 aactcagagg agaaaactaa ataagcagag agtttttatc tgcagaagtt aacatggtgg
     1381 agtcctgcct tacactggga gggctctaac caggaaggaa ggtccccgtt tccaacctgt
     1441 gttgattttt aaaacattct tcctgaaagc agtttagtcc atatgttaca ctgacatact
     1501 ttatttgtta aggtaaggtg tctacaccct cagttcaatc cacgtcgtat tctttagggt
     1561 ggatgtgatg ttctgctgca aacttaacaa aaactggcct tctgatacct tcacagggcc
     1621 acacagaacc ttctgaagta tgttaaatat gtcaggcttt ttaggcttgt cacaaatgat
     1681 tgtttttttc taagtcacca aatgtatata agttatatat attggatagc aatcttgcat
     1741 gtctatcatg gaacaattta atatgccttc ctttcccacc ctcaaaaagg ccattttatg
     1801 acgcattgca caccctctgg ggaaattgat ctttaaattt tgaaacagta taaggaaaat
     1861 ctggttggtg tctcacaaat gagtacgcca ttttttattc tgtatattta gaatgaagtc
     1921 gtgaaaaact ttataaagac atctttgatc attccgaaat tgtgtccgtt ttctttagtg
     1981 ctatggtttt ttgtttcttt ttcacttcta caaagcgagt ggcagccttg ccaattagac
     2041 ttaaaccaga attgcccagg cttttatgta ttgcctgaga gagctacctc caaggtgttt
     2101 tgttgttggg ctggagatct aagcgggact atgaggttca cctagagtgg gaatctctta
     2161 ctttataaaa acaagaagtg gtgatgtata aatcagagga cactagcaag aaaggctttt
     2221 tcatgttcat gttagtttta gctgtttgta ctccggcttt aacaggtgga agcttacttc
     2281 tctgtgtgat ttctgtgttt tatttcaatg tgattttcct ttgacatttt tttgattgac
     2341 cctgttcatt ttgttttgcc tggtaggaaa ataaacagct ttctttccta gaattggcat
     2401 taagccccag caaaccagag atgtttgctt tgctttaaac cctgcctgag cacctcgtgc
     2461 ttgccccctg tcgtggtcgt gacatcgcat ggctgtacca ccttgtcgga tagcttatca
     2521 gactgatgtt gactgttgaa tctcatggca acagcagtcg atgggctgtc tgacattttg
     2581 gtatctttca tctgaccatc catatcaaat gttttcattc aaacattacc cagcatcatg
     2641 gtttgcagtc aaaaattgtg gtccttatgt cttgtgagac ttggagccct tataccttgg
     2701 tacaacagca gcagtatcaa gagaaaactt cctaggaaat tggggtagtc gtcacagtca
     2761 taactaaata aataaaaatg aaaagtcacc ttgc
//
