LOCUS       NM_001104580            2571 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus vomeronasal 2, receptor 116 (Vmn2r116), mRNA.
ACCESSION   NM_001104580 XM_884066
VERSION     NM_001104580.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2571)
  AUTHORS   Osakada,T., Ishii,K.K., Mori,H., Eguchi,R., Ferrero,D.M.,
            Yoshihara,Y., Liberles,S.D., Miyamichi,K. and Touhara,K.
  TITLE     Sexual rejection via a vomeronasal receptor-triggered limbic
            circuit
  JOURNAL   Nat Commun 9 (1), 4463 (2018)
   PUBMED   30367054
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2571)
  AUTHORS   Hattori,T., Osakada,T., Masaoka,T., Ooyama,R., Horio,N., Mogi,K.,
            Nagasawa,M., Haga-Yamanaka,S., Touhara,K. and Kikusui,T.
  TITLE     Exocrine Gland-Secreting Peptide 1 Is a Key Chemosensory Signal
            Responsible for the Bruce Effect in Mice
  JOURNAL   Curr Biol 27 (20), 3197-3201 (2017)
   PUBMED   29033330
REFERENCE   3  (bases 1 to 2571)
  AUTHORS   Yoshinaga,S., Sato,T., Hirakane,M., Esaki,K., Hamaguchi,T.,
            Haga-Yamanaka,S., Tsunoda,M., Kimoto,H., Shimada,I., Touhara,K. and
            Terasawa,H.
  TITLE     Structure of the mouse sex peptide pheromone ESP1 reveals a
            molecular basis for specific binding to the class C
            G-protein-coupled vomeronasal receptor
  JOURNAL   J Biol Chem 288 (22), 16064-16072 (2013)
   PUBMED   23576433
  REMARK    GeneRIF: charge-charge interactions determine the specificity of
            ESP1 binding to V2Rp5 in the large extracellular region
            characteristic of class C GPCRs.
REFERENCE   4  (bases 1 to 2571)
  AUTHORS   Haga,S., Hattori,T., Sato,T., Sato,K., Matsuda,S., Kobayakawa,R.,
            Sakano,H., Yoshihara,Y., Kikusui,T. and Touhara,K.
  TITLE     The male mouse pheromone ESP1 enhances female sexual receptive
            behaviour through a specific vomeronasal receptor
  JOURNAL   Nature 466 (7302), 118-122 (2010)
   PUBMED   20596023
  REMARK    GeneRIF: ESP1 is recognized by a specific vomeronasal receptor,
            V2Rp5, and the ligand-receptor interaction results in sex-specific
            signal transmission to the amygdaloid and hypothalamic nuclei via
            the accessory olfactory bulb
REFERENCE   5  (bases 1 to 2571)
  AUTHORS   Young,J.M. and Trask,B.J.
  TITLE     V2R gene families degenerated in primates, dog and cow, but
            expanded in opossum
  JOURNAL   Trends Genet 23 (5), 212-215 (2007)
   PUBMED   17382427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CT485617.6.
            
            On Sep 14, 2007 this sequence version replaced XM_884066.3.
            
            Sequence Note: This record was generated from sequence identified
            by Janet Young (Fred Hutchinson Cancer Research Center).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               CT485617.6         48447-48643
            198-486             CT485617.6         49556-49844
            487-1299            CT485617.6         50246-51058
            1300-1527           CT485617.6         52403-52630
            1528-1651           CT485617.6         61281-61404
            1652-2571           CT485617.6         64589-65508
FEATURES             Location/Qualifiers
     source          1..2571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 11.56 cM"
     gene            1..2571
                     /gene="Vmn2r116"
                     /gene_synonym="EG619697; V2Rp5"
                     /note="vomeronasal 2, receptor 116"
                     /db_xref="GeneID:619697"
                     /db_xref="MGI:MGI:3646674"
     CDS             1..2571
                     /gene="Vmn2r116"
                     /gene_synonym="EG619697; V2Rp5"
                     /note="vomeronasal receptor Vmn2r116; vomeronasal 2
                     receptor p5; vomeronasal type-2 receptor P5; vomeronasal
                     type-2 receptor 116"
                     /codon_start=1
                     /product="vomeronasal type-2 receptor 116 precursor"
                     /protein_id="NP_001098050.1"
                     /db_xref="CCDS:CCDS50009.1"
                     /db_xref="GeneID:619697"
                     /db_xref="MGI:MGI:3646674"
                     /translation="MFTLIFLFLFLNIPLLVADFISPRCFWKMKQNEYRDRHHGTGCI
                     FLILAIQQPVKKEYFSHILNIQTHTENHKYALALAFSIYEINRNPDLLPNMSLIFIFS
                     ADSCEWESELSLIRFGLQNSDNLPNYLCEELTKCILALTNMNWATTVTLHTILSNFLS
                     DQLLHITYGTFHPALSDHEKFPYLHQMASDHTSLALALVSFIIHFGWNWVGLVISDSD
                     QGIQFLSYLRREMEKYTLCFAFVNMIPLNINLYMSRAEVYYNQIMTSSTNVVIIYGDT
                     DSTLAVSFRMWESLGIQRLWITTSQWDVSPSMKDFTFGNKYGTFAFEQHHSEISGFKH
                     FVQTLNSVKCPDEYLVKLEWMHFNCEVSASKCKTLKNCSSNHSLKWLMVHTFDMAFIE
                     ESYYIYNAVYAFAHVLHQFTFQKFDNLPKDNGKEHNYSCKKLYSYLRKNHFINPVGDR
                     VSMNQRDKLQEEYDIVYIWNFPQGLGLRVKIGMFSPYFPNGQQVHLSEDMLKWARGST
                     QVPTSMCSADCGPGSRKFRMDGMAACCFHCKPCPENEISNETNVDNCVQCPEDQYANT
                     EQNHCIRKAVVFLSYEEPLGVALSLLSLCFSAFTTVVLGIFVKHHNTPIVKANNRTLT
                     YLLLISLIFCFLCPLLFIGHPNSATCILQQLTFGVVFTVSLSTVLAKTITVVLAFKII
                     ASQRMMKYFLISGAINYIIPICILIQVIVCAVWLRASPPSVDIDAHSEHGQIIIVCHK
                     GSVNAFYCVLGYLAILAFGSFTLAFLSRNLPGAFNEAKSITFSMLVFCSVWVTFIPVY
                     HSTKGKVMVAVEIFSTLASSAGMLGCIFVPKCYTILFRQDQNSLEMIRVKSSSNVHVS
                     "
     exon            1..197
                     /gene="Vmn2r116"
                     /gene_synonym="EG619697; V2Rp5"
                     /inference="alignment:Splign:2.1.0"
     exon            198..486
                     /gene="Vmn2r116"
                     /gene_synonym="EG619697; V2Rp5"
                     /inference="alignment:Splign:2.1.0"
     exon            487..1299
                     /gene="Vmn2r116"
                     /gene_synonym="EG619697; V2Rp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1527
                     /gene="Vmn2r116"
                     /gene_synonym="EG619697; V2Rp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1651
                     /gene="Vmn2r116"
                     /gene_synonym="EG619697; V2Rp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..2571
                     /gene="Vmn2r116"
                     /gene_synonym="EG619697; V2Rp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttcacct tgattttcct cttcttgttc ctgaacattc cacttcttgt ggctgatttt
       61 atttctccca gatgcttttg gaaaatgaag cagaatgaat acagggatag acaccatggt
      121 acaggatgta tcttcctgat tcttgcaata caacagcctg tgaagaaaga gtattttagt
      181 catatattga atatacaaac tcacactgaa aaccacaagt atgctctggc tttggctttt
      241 tccatatatg aaatcaacag gaaccctgat cttttgccaa atatgtctct aatatttata
      301 ttctcagcag acagttgtga atgggaatct gaattgagtc tcattcgttt tggtttacaa
      361 aattctgata atctccctaa ttatttgtgt gaagaattaa ccaaatgtat actggccctt
      421 acaaacatga attgggcaac aactgtgaca cttcatacaa tcctaagtaa cttcttgtct
      481 gaccagctcc ttcatattac ttatggaact tttcatcctg ccctgagtga tcatgaaaaa
      541 tttccctatc tacatcagat ggcctctgat catacatctc tagcccttgc cctggtatcc
      601 ttcataattc attttggttg gaactgggta gggttggtca tctcagacag tgatcaaggt
      661 attcaatttc tctcctattt gagaagagag atggaaaaat atacactctg ctttgccttt
      721 gtcaacatga ttccattaaa cattaattta tacatgtcaa gagctgaagt gtattacaac
      781 caaatcatga catcatccac aaatgttgtc atcatttatg gtgatacaga cagtacctta
      841 gctgtgagct ttagaatgtg ggaatcccta ggtatacaga gactatggat caccacctca
      901 cagtgggatg tcagtcctag tatgaaagac tttacatttg gtaacaaata tgggactttt
      961 gcctttgaac aacaccatag tgagatttct gggtttaaac attttgtcca gacattgaac
     1021 tctgtcaaat gcccagatga atatctggta aagctggaat ggatgcactt taactgcgag
     1081 gtctcagcct ctaaatgtaa gacactgaag aactgctcat ccaatcactc attgaaatgg
     1141 ttaatggtac atacttttga catggccttt attgaagaga gttattacat atacaatgct
     1201 gtgtatgctt ttgcccatgt actccatcag tttacttttc aaaagtttga taatctgccc
     1261 aaggacaatg ggaaagaaca caattatagc tgcaagaagc tgtattccta tctaagaaag
     1321 aaccacttca ttaaccctgt tggggacaga gtgagtatga accaaagaga caaactgcag
     1381 gaagagtatg acattgtcta catttggaat ttcccacagg gccttggact tagagttaaa
     1441 atagggatgt ttagtccata ttttccaaat ggtcaacagg tacatttatc tgaagatatg
     1501 ctaaagtggg caagaggaag tacacaggta ccaacttcta tgtgcagtgc tgattgtggt
     1561 cctggatcta gaaaatttcg gatggatgga atggcagcat gctgttttca ttgcaaaccc
     1621 tgccctgaaa atgaaatttc taatgagaca aatgtggata attgtgtcca gtgtccagag
     1681 gaccaatatg ctaacacaga acagaatcac tgcattcgta aagctgttgt atttctcagc
     1741 tatgaagaac cactgggggt ggcactttcc ttactctcct tgtgcttctc tgcattcaca
     1801 actgtggttc ttgggatctt tgtgaagcac cacaatactc caattgttaa ggccaataac
     1861 agaactctca cctacctctt gcttatctca ctcatctttt gtttcctctg ccctttgctc
     1921 ttcattggcc atccaaactc agccacctgc attctacaac aactcacatt tggagttgta
     1981 tttactgttt ctctctccac tgtcttggct aaaacaatta ctgtagttct ggcattcaaa
     2041 atcatagcct cccaaagaat gatgaagtac tttctaattt caggggcaat taactacatc
     2101 attcccattt gtattctcat ccaagttatt gtatgtgcag tctggctgag agcttctcct
     2161 ccttctgttg atattgatgc acattctgag catggacaga tcatcattgt atgccacaag
     2221 ggttcagtca atgcatttta ctgtgttctg ggatacttgg ctatcctggc ctttgggagc
     2281 ttcactctgg ctttcctttc cagaaacctt cctggtgcct ttaatgaagc caaatccata
     2341 acattcagca tgctggtgtt ctgcagtgtc tgggttactt tcatccctgt ttaccatagc
     2401 accaaaggca aggtcatggt ggctgtggag atcttttcca ctttggcttc cagtgcaggg
     2461 atgctgggat gcatctttgt ccctaaatgt tacacaatat tgtttagaca agaccaaaat
     2521 tctcttgaaa tgatcagggt gaaatcatct tccaatgttc atgtttcata a
//
