LOCUS       NM_027121               4935 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus vitamin K epoxide reductase complex, subunit 1-like 1
            (Vkorc1l1), transcript variant 1, mRNA.
ACCESSION   NM_027121 XM_149673
VERSION     NM_027121.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4935)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4935)
  AUTHORS   Yang,X., Wang,Z., Zandkarimi,F., Liu,Y., Duan,S., Li,Z., Kon,N.,
            Zhang,Z., Jiang,X., Stockwell,B.R. and Gu,W.
  TITLE     Regulation of VKORC1L1 is critical for p53-mediated tumor
            suppression through vitamin K metabolism
  JOURNAL   Cell Metab 35 (8), 1474-1490 (2023)
   PUBMED   37467745
  REMARK    GeneRIF: Regulation of VKORC1L1 is critical for p53-mediated tumor
            suppression through vitamin K metabolism.
REFERENCE   3  (bases 1 to 4935)
  AUTHORS   Lacombe,J., Guo,K., Bonneau,J., Faubert,D., Gioanni,F., Vivoli,A.,
            Muir,S.M., Hezzaz,S., Poitout,V. and Ferron,M.
  TITLE     Vitamin K-dependent carboxylation regulates Ca2+ flux and
            adaptation to metabolic stress in beta cells
  JOURNAL   Cell Rep 42 (5), 112500 (2023)
   PUBMED   37171959
REFERENCE   4  (bases 1 to 4935)
  AUTHORS   Ding,Y., Cui,J., Wang,Q., Shen,S., Xu,T., Tang,H., Han,M. and Wu,X.
  TITLE     The Vitamin K Epoxide Reductase Vkorc1l1 Promotes Preadipocyte
            Differentiation in Mice
  JOURNAL   Obesity (Silver Spring) 26 (8), 1303-1311 (2018)
   PUBMED   29963761
  REMARK    GeneRIF: Vkorc1l1 promotes adipogenesis and possibly obesity.
            Downregulation of Vkorc1l1 increases intracellular vitamin K2 level
            and impedes preadipocyte differentiation.
REFERENCE   5  (bases 1 to 4935)
  AUTHORS   Lacombe,J., Rishavy,M.A., Berkner,K.L. and Ferron,M.
  TITLE     VKOR paralog VKORC1L1 supports vitamin K-dependent protein
            carboxylation in vivo
  JOURNAL   JCI Insight 3 (1), 96501 (2018)
   PUBMED   29321368
  REMARK    GeneRIF: VKORC1L1 supports vitamin K-dependent (VKD) protein
            protein carboxylation in vivo.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4935)
  AUTHORS   Caspers,M., Czogalla,K.J., Liphardt,K., Muller,J., Westhofen,P.,
            Watzka,M. and Oldenburg,J.
  TITLE     Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in
            mouse: VKORC1 is highly expressed in exocrine tissues while
            VKORC1L1 is highly expressed in brain
  JOURNAL   Thromb Res 135 (5), 977-983 (2015)
   PUBMED   25747820
  REMARK    GeneRIF: quantified mRNA levels for VKORC1, VKORC1L1, GGCX, and
            NQO1 and measured VKOR enzymatic activities in 29 different tissues
REFERENCE   7  (bases 1 to 4935)
  AUTHORS   Hammed,A., Matagrin,B., Spohn,G., Prouillac,C., Benoit,E. and
            Lattard,V.
  TITLE     VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase
            activity in some extrahepatic tissues during anticoagulation
            therapy
  JOURNAL   J Biol Chem 288 (40), 28733-28742 (2013)
   PUBMED   23928358
  REMARK    GeneRIF: The involvement of VKORC1L1 in VKOR activity partly
            explains the low susceptibility of some extrahepatic tissues to
            vitamin K antagonists.
REFERENCE   8  (bases 1 to 4935)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   9  (bases 1 to 4935)
  AUTHORS   Rost,S., Fregin,A., Ivaskevicius,V., Conzelmann,E., Hortnagel,K.,
            Pelz,H.J., Lappegard,K., Seifried,E., Scharrer,I., Tuddenham,E.G.,
            Muller,C.R., Strom,T.M. and Oldenburg,J.
  TITLE     Mutations in VKORC1 cause warfarin resistance and multiple
            coagulation factor deficiency type 2
  JOURNAL   Nature 427 (6974), 537-541 (2004)
   PUBMED   14765194
  REMARK    GeneRIF: molecular cloning
REFERENCE   10 (bases 1 to 4935)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085133.1, CN701203.1, CK639505.1, AK078942.1, CF533903.1,
            AK033702.1, CN457470.1 and BE954096.1.
            
            On Nov 2, 2013 this sequence version replaced NM_027121.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.122071.1,
                                           SRR1660817.33191.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               BC085133.1         1-257
            258-806             CN701203.1         98-646
            807-1112            BC085133.1         697-1002
            1113-1671           CK639505.1         78-636
            1672-2941           BC085133.1         1561-2830
            2942-2972           AK078942.1         2775-2805
            2973-3502           CF533903.1         78-607
            3503-3692           AK033702.1         405-594
            3693-4123           CN457470.1         83-513
            4124-4915           AK033702.1         1026-1817
            4916-4935           BE954096.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..4935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 68.26 cM"
     gene            1..4935
                     /gene="Vkorc1l1"
                     /gene_synonym="2310024K08Rik"
                     /note="vitamin K epoxide reductase complex, subunit 1-like
                     1"
                     /db_xref="GeneID:69568"
                     /db_xref="MGI:MGI:1916818"
     exon            1..257
                     /gene="Vkorc1l1"
                     /gene_synonym="2310024K08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..594
                     /gene="Vkorc1l1"
                     /gene_synonym="2310024K08Rik"
                     /EC_number="1.17.4.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vitamin K epoxide reductase complex subunit 1-like protein
                     1; VKORC1-like protein 1"
                     /codon_start=1
                     /product="vitamin K epoxide reductase complex subunit
                     1-like protein 1 isoform 1"
                     /protein_id="NP_081397.1"
                     /db_xref="CCDS:CCDS19703.1"
                     /db_xref="GeneID:69568"
                     /db_xref="MGI:MGI:1916818"
                     /translation="MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDP
                     EHRALCDLGPWVKCSAALASRWGRGFGLLGSIFGKDGVLNQPNSVFGLIFYILQLLLG
                     MTASAVAALVLMTSSIVSVVGSLYLAYILYFVLKEFCIICVTTYVLNFLLLIINYKRL
                     VYLNEAWKRQLQPKED"
     exon            258..367
                     /gene="Vkorc1l1"
                     /gene_synonym="2310024K08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            368..4919
                     /gene="Vkorc1l1"
                     /gene_synonym="2310024K08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2952..2957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vkorc1l1"
                     /gene_synonym="2310024K08Rik"
                     /note="hexamer: AATATA"
     polyA_site      2973
                     /gene="Vkorc1l1"
                     /gene_synonym="2310024K08Rik"
     regulatory      4895..4900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vkorc1l1"
                     /gene_synonym="2310024K08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4919
                     /gene="Vkorc1l1"
                     /gene_synonym="2310024K08Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgacgggcgg cggcgtctga ggtggaggcg gagggaggcg gcggcggcgg cggagggggg
       61 aagatggcgg cgcccgtcct gctgagagtg tcggtgccgc gttgggaacg ggtggcccgg
      121 tatgcagtgt gcgccgccgg gatcctgctc tccatctacg cctaccacgt ggagcgggag
      181 aaggagaggg acccggagca ccgggccctc tgcgacctgg ggccctgggt gaagtgctcc
      241 gccgccctgg cctccagatg gggtcgagga tttggtcttt tgggttccat ttttggaaaa
      301 gatggtgtat taaaccagcc aaacagtgtc tttggactta tattttatat actacagtta
      361 ttacttggca tgacagccag cgcagttgca gctctggtcc tcatgacctc ctccattgtg
      421 tctgtggtgg gctctttgta cctggcctac attctgtact ttgtgctgaa agagttttgc
      481 atcatctgcg tcaccacata tgtgctgaac ttcctcctcc tcatcatcaa ttacaaacga
      541 ctagtttatt tgaatgaggc ctggaagcga cagctgcagc ctaaggaaga ctgatggcca
      601 gcggatctcc acccaaccgt ctcaaacact tctttcatta agtttatttt gcaaggtgtt
      661 ttgttttttg ttttttgttt tttaattcac aacagacact ttccctcaga atcttaaact
      721 gattttttaa aatattgtaa attagaaggg gccctagcta tttcctgtgt cggtcttcat
      781 tttaaatctg gatacaaaaa aggatacacc gagccaatca aagacaagct ttaactttac
      841 cttgaagatg tttctgagat aataaaatgt agccctagcc cccagtcctc aactaaagtg
      901 agcagccatt gctagtaatt ctttaatgtg tataaattca atttcaggta taacaaatgt
      961 gatcatgaac atgaaaatat tttagaatag atactgtatt aaatattgcc atgtttacaa
     1021 tatgtaatat gtttttagcc gatggattta aacctgtaga ttcaattaga gtccatttgt
     1081 gtgatatttg taaataaagg tagaaacatt gggatccacc cctgcagaac ttactgtaca
     1141 gtttagttga agtgtagaaa ggaattgtca gctcatcgtg actgatacat agtgaagaaa
     1201 gtacaggcaa acagaacatc ttgggaaatg cgctgacagc cctggtgcag tgttgacagc
     1261 agaaacaggg tggttgattc ccttccatct cccactcaga gaggaagaaa cagtctgaac
     1321 acccagctca agtctgacta gtcagaactg gatggattgg aactctacag gatgtcacgt
     1381 gactagacct ttcatttcaa ggctctcagg acactgatgt gggaagtgga tgtagtcttt
     1441 ggagaaaaac cactatggcg tttctgggca atgcctctta aacagtagct gagctctcaa
     1501 cacatgtgtt cccttgattc cagtgccagt cagctcagca gtattatgac tgaagcaggc
     1561 acaagccaag tgctctgagg tcggtccata gtgtttcccc ttcttgtttc ttcttgcact
     1621 aaggatggtc agtaagtgtt tcagaatcac atactgaatt tgtaaacctt aggactatcg
     1681 ggagaaactg tttgctgact cagaagaaac acaaacgtag aaagacctgg aagagaaaca
     1741 tggaagcttt gtcccactcc agtagccaca cagaagcagt gagaagaaac ccagaggtga
     1801 tctaagtaca caccccagtg gcatggcgac tgtgtttctc tggttagcat cttacaggag
     1861 atgttaaaag tgccttctgt cttaaaatct caaaccaaat cattctgtgg gtagaactgg
     1921 ggcagaagta tccctccttc ccttccttac cacgaagcag agaacttgaa cttgcattct
     1981 accaggaagg tctgtgcggc cattttattc cttgggtgga gaagtggcag tgtttttttt
     2041 atgatttggt taatatgcta aaaaataggc aactagacag ggtactctga gacagcaatg
     2101 gttgagtggt ttacgacttt cagtcgaaac tgatgcacca taggatttct ggcctggggc
     2161 aggtataaaa tgggaattgt aatgttcctt taggaggctc taaccagttc cttaaaagac
     2221 cgcttaattc caatttcatc aaaggttgtg tttccccgtg aatgtgaaca tttctgtgac
     2281 tatcttactg tgtatgcatt gctgttgtct tctgaagtag ttagagaacg tctagaaagt
     2341 actgaatggt ctttgtggtc aaccaagtcc tcgttcgaga actgtacagt gagctcatct
     2401 catagccctg tgtccaggtc tcccaaggca gtggaatggc tactcgctaa gacttctgct
     2461 gcttacatat caaggctctg ctaaacatgt cccttgggcc ccatttccaa atgacctttt
     2521 ctgtcttcta tcactcagca gagtggagtt aaagcttgtc ttgacattgc agatgtctcc
     2581 aacccttact caagaaaatg tgagagggtt ccctccacca gacccctcaa ggcttccctt
     2641 tgctttccta agtcttggga gtaccaccat tactgattgt atgaattgct tgtttgtttg
     2701 tttgtttgtt acattcctgt gacctaatag gatgaatacc cctttctcac tgagcgttaa
     2761 caggtgctgt tggaaataac agcatttgcc gaacagtgtg ctcatgcttg cctgcagtcc
     2821 catcacttgg gatataaatg caggaggatc aggaattcaa ggtcatcctt gactacatag
     2881 caaaatagag accagcatta gctacaggag accctagctt tttaaaaaaa aatttttttt
     2941 ttttttgcta aaatatatgt tctctataag tgagcctgtt gtgttttatt tggtagtttt
     3001 gccctgaggg aatccagtct tcttctctac catctattaa accttataga acgggggaga
     3061 aaaacactgt gttataaaac tgctaatatt gttatgactg tttcagacag agtatttaaa
     3121 cactgaagaa gcagggtttg gctgggcctg gtgacacaca ccttgagtct cactcagtac
     3181 ttggggagca gaggcaggtg gatttctgag ttctaggcca ccctagccta gataaggagc
     3241 tccaggacaa ccagggttat atagtgaaac cctgactcaa aaagcctacc cacaaaataa
     3301 taacactgct agttgattta acaataaata cggaagggca gaccaggggg aaaatgattc
     3361 ctgcagtaat tctgggcttc atgctttcga agtgattcat aacagtggaa gcctcacttc
     3421 agattttcgg gaggaagaga aagtctggct aggtgtgctc cagagcctgt ggttggctta
     3481 tgggatttcc cttgatcctt tcccacagct agttttgtca gggagggtaa acttctggta
     3541 caactcaggt ttaactagtt gcactagcta tattccaaga attatttttt gcttcatctg
     3601 tatagcctct ccttcagctc ttttgttgtg gttgttgttt tgttttgttt ttaaagagac
     3661 agataatctt tctctgtagc ctaggctgtc ctagagctca gtacatagcc caggctggct
     3721 tcaaacttga cattcctcct gccttagcct cccaagtgct cagattcata tacagaagga
     3781 atgttgaaaa gcatttgagt tttttcaagt aaagagacaa gttctggggg ctggggagat
     3841 aggtggctta gcagttaaga acacttgtaa aggacccagg tttggcgcca accacccaca
     3901 tgtctgctta acctttagct gcaactccaa ttcctgggga tctgaccccc tctcatggct
     3961 cctgaaggcc ctgcatgcat atggtgtata gacatatatg caggcaaaac acccacatag
     4021 atatgaaagt atttcgtttg ctacaaaaga tccttgtacc tatgaggtag aggacaataa
     4081 aattaatatt gttgcttttt tgttttattt ataattatat tcaaaagact aaaaatgcag
     4141 ccaggcatgg tagtacatgc ctataaaccc agcacttggg aagtagaggc aggaagacca
     4201 gaagttcatt caggggcaat ctgggctatt ttgagaccat gtttctagaa aagcaaaaac
     4261 tcaaaacaca aaaactgctc agcagttact tgctaagctc tagttggtgc caccagttga
     4321 ttctggtgga tactggcagg tggtgggtga cctgacctta aaagtcagta aaatgtcagt
     4381 aaaatgtcag cagagtcccc cactgttctg tccaggaact tgtttggggc tgtgaacttc
     4441 cccgacttct tccagtgcgt atacatcagt gaagccaccc ctctccacct tttagcattt
     4501 taggcagtat gtgtatgaat cctattttgt gagaacaacc ttgtcataaa gaacagggta
     4561 ggaatccagg caatgtgatc aggccctccc ttcccccttt taaaccgatt ggcccaggag
     4621 aggtgaagtg ttatgaggct gtactaagat aatagcatag ataataggtg tctatgacct
     4681 gtgaagtgtg gtccatctaa aatactactc ctgcttcgaa agctcctgag taagccttca
     4741 tgtaagaagg agttcaccgg ggagattccc tctttaatat agatagaaat attctttatc
     4801 agagatttag gatagcattt tgctaactgg taaataaaaa cagatgtaca tatgtaagaa
     4861 tgtttatttg ttgcacataa cttttttggt ataaaataaa tgtagacatt acctgtggaa
     4921 aaaaaaaaaa aaaaa
//
