LOCUS       NM_178600                764 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus vitamin K epoxide reductase complex, subunit 1
            (Vkorc1), mRNA.
ACCESSION   NM_178600
VERSION     NM_178600.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 764)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 764)
  AUTHORS   Lacombe,J., Guo,K., Bonneau,J., Faubert,D., Gioanni,F., Vivoli,A.,
            Muir,S.M., Hezzaz,S., Poitout,V. and Ferron,M.
  TITLE     Vitamin K-dependent carboxylation regulates Ca2+ flux and
            adaptation to metabolic stress in beta cells
  JOURNAL   Cell Rep 42 (5), 112500 (2023)
   PUBMED   37171959
REFERENCE   3  (bases 1 to 764)
  AUTHORS   Krijger,I.M., Strating,M., van Gent-Pelzer,M., van der Lee,T.A.J.,
            Burt,S.A., Schroeten,F.H., de Vries,R., de Cock,M., Maas,M. and
            Meerburg,B.G.
  TITLE     Large-scale identification of rodenticide resistance in Rattus
            norvegicus and Mus musculus in the Netherlands based on Vkorc1
            codon 139 mutations
  JOURNAL   Pest Manag Sci 79 (3), 989-995 (2023)
   PUBMED   36309944
  REMARK    GeneRIF: Large-scale identification of rodenticide resistance in
            Rattus norvegicus and Mus musculus in the Netherlands based on
            Vkorc1 codon 139 mutations.
REFERENCE   4  (bases 1 to 764)
  AUTHORS   Bermejo-Nogales,A., Rodriguez Martin,J.A., Coll,J. and Navas,J.M.
  TITLE     VKORC1 single nucleotide polymorphisms in rodents in Spain
  JOURNAL   Chemosphere 308 (Pt 1), 136021 (2022)
   PUBMED   35970209
  REMARK    GeneRIF: VKORC1 single nucleotide polymorphisms in rodents in
            Spain.
REFERENCE   5  (bases 1 to 764)
  AUTHORS   Ruiz-Lopez,M.J., Barahona,L., Martinez-de la Puente,J., Pepio,M.,
            Valsecchi,A., Peracho,V., Figuerola,J. and Montalvo,T.
  TITLE     Widespread resistance to anticoagulant rodenticides in Mus musculus
            domesticus in the city of Barcelona
  JOURNAL   Sci Total Environ 845, 157192 (2022)
   PUBMED   35810904
  REMARK    GeneRIF: Widespread resistance to anticoagulant rodenticides in Mus
            musculus domesticus in the city of Barcelona.
REFERENCE   6  (bases 1 to 764)
  AUTHORS   Pelz,H.J., Rost,S., Hunerberg,M., Fregin,A., Heiberg,A.C.,
            Baert,K., MacNicoll,A.D., Prescott,C.V., Walker,A.S., Oldenburg,J.
            and Muller,C.R.
  TITLE     The genetic basis of resistance to anticoagulants in rodents
  JOURNAL   Genetics 170 (4), 1839-1847 (2005)
   PUBMED   15879509
  REMARK    GeneRIF: The genetic basis for resistance to anticoagulants lies in
            mutations in Vkorc1.
REFERENCE   7  (bases 1 to 764)
  AUTHORS   Rost,S., Fregin,A., Ivaskevicius,V., Conzelmann,E., Hortnagel,K.,
            Pelz,H.J., Lappegard,K., Seifried,E., Scharrer,I., Tuddenham,E.G.,
            Muller,C.R., Strom,T.M. and Oldenburg,J.
  TITLE     Mutations in VKORC1 cause warfarin resistance and multiple
            coagulation factor deficiency type 2
  JOURNAL   Nature 427 (6974), 537-541 (2004)
   PUBMED   14765194
  REMARK    GeneRIF: molecular cloning [VKORC1]
REFERENCE   8  (bases 1 to 764)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 764)
  AUTHORS   Liu,Y.Y., Tachiki,K.H. and Brent,G.A.
  TITLE     A targeted thyroid hormone receptor alpha gene dominant-negative
            mutation (P398H) selectively impairs gene expression in
            differentiated embryonic stem cells
  JOURNAL   Endocrinology 143 (7), 2664-2672 (2002)
   PUBMED   12072400
REFERENCE   10 (bases 1 to 764)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK003237.1 and CD774913.1.
            
            On Mar 30, 2004 this sequence version replaced NM_178600.1.
            
            Summary: Vitamin K is essential for blood clotting but must be
            enzymatically activated. This enzymatically activated form of
            vitamin K is a reduced form required for the carboxylation of
            glutamic acid residues in some blood-clotting proteins. The product
            of this gene encodes the enzyme that is responsible for reducing
            vitamin K 2,3-epoxide to the enzymatically activated form. Fatal
            bleeding can be caused by vitamin K deficiency and by the vitamin K
            antagonist warfarin, and it is the product of this gene that is
            sensitive to warfarin. In humans, mutations in this gene can be
            associated with deficiencies in vitamin-K-dependent clotting
            factors and, in humans and rats, with warfarin resistance.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV062359.1, BU558856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-744               AK003237.1         2-745
            745-764             CD774913.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.81 cM"
     gene            1..764
                     /gene="Vkorc1"
                     /gene_synonym="D7Wsu86e"
                     /note="vitamin K epoxide reductase complex, subunit 1"
                     /db_xref="GeneID:27973"
                     /db_xref="MGI:MGI:106442"
     exon            1..209
                     /gene="Vkorc1"
                     /gene_synonym="D7Wsu86e"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..522
                     /gene="Vkorc1"
                     /gene_synonym="D7Wsu86e"
                     /EC_number="1.17.4.4"
                     /note="vitamin K1 epoxide reductase (warfarin-sensitive);
                     phylloquinone epoxide reductase; vitamin K1 2,3-epoxide
                     reductase subunit 1; vitamin K 2,3-epoxide reductase
                     complex subunit 1; vitamin K epoxide reductase subunit I"
                     /codon_start=1
                     /product="vitamin K epoxide reductase complex subunit 1"
                     /protein_id="NP_848715.1"
                     /db_xref="CCDS:CCDS21883.1"
                     /db_xref="GeneID:27973"
                     /db_xref="MGI:MGI:106442"
                     /translation="MGTTWRSPGLVRLALCLAGLALSLYALHVKAARARDENYRALCD
                     VGTAISCSRVFSSRWGRGFGLVEHMLGADSVLNQSNSIFGCLFYTLQLLLGCLRGRWA
                     SILLVLSSLVSVAGSVYLAWILFFVLYDFCIVCITTYAINVGLMLLSFQKVPEHKTKK
                     H"
     exon            210..319
                     /gene="Vkorc1"
                     /gene_synonym="D7Wsu86e"
                     /inference="alignment:Splign:2.1.0"
     exon            320..748
                     /gene="Vkorc1"
                     /gene_synonym="D7Wsu86e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      725..730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vkorc1"
                     /gene_synonym="D7Wsu86e"
                     /note="hexamer: AATAAA"
     polyA_site      748
                     /gene="Vkorc1"
                     /gene_synonym="D7Wsu86e"
                     /note="major polyA site"
ORIGIN      
        1 gattcttccc tcctgtccct gggctgtact gtcgacatgg gcaccacctg gaggagccct
       61 ggactcgtgc ggcttgcact gtgcctcgct ggcttagccc tctcactgta cgcactgcac
      121 gtgaaggcgg cgcgcgcccg cgatgaaaat taccgcgcgc tctgcgatgt gggcacggcc
      181 atcagctgtt cccgcgtctt ctcctctcgg tggggccggg gctttgggct ggtggagcac
      241 atgctaggag cggacagcgt cctcaaccaa tccaacagca tatttggttg cctgttctac
      301 accttacagc tgttgttagg ttgcttgagg ggacgttggg cctctatcct actggtgctg
      361 agttccctgg tgtccgtcgc tggttccgtg tacctggcct ggatcctgtt ctttgtgtta
      421 tatgatttct gcattgtgtg cattaccacc tatgccatca atgtgggtct gatgttgctt
      481 agcttccaga aggtaccaga acacaagacc aaaaagcact gagttcccac ctcatgccag
      541 actaacctaa cttgctttgc cttggcacat gacccttgcc caagtgtgtg ggttcctaga
      601 aggccctacc cacatcattc aaacccccct ccataaccac acacagagaa atgaccaaac
      661 gtgcctctaa gttctgttcc catgggctgc attctgctgt tggttaaaga gaaggatttt
      721 gaacaataaa tttttctatg ttggtcaaaa aaaaaaaaaa aaaa
//
