LOCUS       NM_011703               4929 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus vasoactive intestinal peptide receptor 1 (Vipr1),
            mRNA.
ACCESSION   NM_011703
VERSION     NM_011703.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4929)
  AUTHORS   Calo,G., Hauk,V., Vota,D., Van,C., Condro,M., Gallino,L.,
            Ramhorst,R., Waschek,J. and Perez Leiros,C.
  TITLE     VPAC1 and VPAC2 receptor deficiencies negatively influence
            pregnancy outcome through distinct and overlapping modulations of
            immune, trophoblast and vascular functions
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (2), 166593 (2023)
   PUBMED   36328148
  REMARK    GeneRIF: VPAC1 and VPAC2 receptor deficiencies negatively influence
            pregnancy outcome through distinct and overlapping modulations of
            immune, trophoblast and vascular functions.
REFERENCE   2  (bases 1 to 4929)
  AUTHORS   Davenport,C.M., Teubner,B.J.W., Han,S.B., Patton,M.H., Eom,T.Y.,
            Garic,D., Lansdell,B.J., Shirinifard,A., Chang,T.C., Klein,J.,
            Pruett-Miller,S.M., Blundon,J.A. and Zakharenko,S.S.
  TITLE     Innate frequency-discrimination hyperacuity in Williams-Beuren
            syndrome mice
  JOURNAL   Cell 185 (21), 3877-3895 (2022)
   PUBMED   36152627
REFERENCE   3  (bases 1 to 4929)
  AUTHORS   Lei,C., Sun,R., Xu,G., Tan,Y., Feng,W., McClain,C.J. and Deng,Z.
  TITLE     Enteric VIP-producing neurons maintain gut microbiota homeostasis
            through regulating epithelium fucosylation
  JOURNAL   Cell Host Microbe 30 (10), 1417-1434 (2022)
   PUBMED   36150396
REFERENCE   4  (bases 1 to 4929)
  AUTHORS   Casado-Bedmar,M., Heil,S.D.S., Myrelid,P., Soderholm,J.D. and
            Keita,A.V.
  TITLE     Upregulation of intestinal mucosal mast cells expressing VPAC1 in
            close proximity to vasoactive intestinal polypeptide in
            inflammatory bowel disease and murine colitis
  JOURNAL   Neurogastroenterol Motil 31 (3), e13503 (2019)
   PUBMED   30407703
  REMARK    GeneRIF: follicle-associated epithelium-adjacent villus epithelium
            in ileum of Crohn's disease possessed more mucosal mast cells and
            mucosal mast cells expressing VPAC1 but not VPAC2, compared to
            controls
REFERENCE   5  (bases 1 to 4929)
  AUTHORS   Kadmiel,M., Matson,B.C., Espenschied,S.T., Lenhart,P.M. and
            Caron,K.M.
  TITLE     Loss of receptor activity-modifying protein 2 in mice causes
            placental dysfunction and alters PTH1R regulation
  JOURNAL   PLoS One 12 (7), e0181597 (2017)
   PUBMED   28727763
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4929)
  AUTHORS   Balster,D.A., O'Dorisio,M.S., Albers,A.R., Park,S.K. and
            Qualman,S.J.
  TITLE     Suppression of tumorigenicity in neuroblastoma cells by
            upregulation of human vasoactive intestinal peptide receptor type 1
  JOURNAL   Regul Pept 109 (1-3), 155-165 (2002)
   PUBMED   12409228
  REMARK    GeneRIF: VIP modulation of neural crest differentiation is mediated
            via VPAC1 and high expression of VPAC1 induces differentiation in
            and decreases tumorigenicity of neuroblastoma cells.
REFERENCE   7  (bases 1 to 4929)
  AUTHORS   Karacay,B., O'Dorisio,M.S., Kasow,K., Hollenback,C. and Krahe,R.
  TITLE     Expression and fine mapping of murine vasoactive intestinal peptide
            receptor 1
  JOURNAL   J Mol Neurosci 17 (3), 311-324 (2001)
   PUBMED   11859927
  REMARK    GeneRIF: VPAC1 suggested as mediator of the neuroprotective effects
            of VIP
REFERENCE   8  (bases 1 to 4929)
  AUTHORS   Hashimoto,H., Nishino,A., Shintani,N., Hagihara,N., Copeland,N.G.,
            Jenkins,N.A., Yamamoto,K., Matsuda,T., Ishihara,T., Nagata,S. and
            Baba,A.
  TITLE     Genomic organization and chromosomal location of the mouse
            vasoactive intestinal polypeptide 1 (VPAC1) receptor
  JOURNAL   Genomics 58 (1), 90-93 (1999)
   PUBMED   10331949
REFERENCE   9  (bases 1 to 4929)
  AUTHORS   Johnson,M.C., McCormack,R.J., Delgado,M., Martinez,C. and Ganea,D.
  TITLE     Murine T-lymphocytes express vasoactive intestinal peptide receptor
            1 (VIP-R1) mRNA
  JOURNAL   J Neuroimmunol 68 (1-2), 109-119 (1996)
   PUBMED   8784267
REFERENCE   10 (bases 1 to 4929)
  AUTHORS   Delgado,M., Martinez,C., Johnson,M.C., Gomariz,R.P. and Ganea,D.
  TITLE     Differential expression of vasoactive intestinal peptide receptors
            1 and 2 (VIP-R1 and VIP-R2) mRNA in murine lymphocytes
  JOURNAL   J Neuroimmunol 68 (1-2), 27-38 (1996)
   PUBMED   8784257
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052465.1, AC159810.2 and BP762347.1.
            
            On Mar 13, 2008 this sequence version replaced NM_011703.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052465.1, AF266282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2582              AK052465.1         2-2583
            2583-4894           AC159810.2         63493-65804         c
            4895-4929           BP762347.1         1-35                c
FEATURES             Location/Qualifiers
     source          1..4929
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.5 cM"
     gene            1..4929
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /note="vasoactive intestinal peptide receptor 1"
                     /db_xref="GeneID:22354"
                     /db_xref="MGI:MGI:109272"
     exon            1..211
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1513
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /note="vasoactive intestinal polypeptide receptor 1;
                     VIP-R-1; PACAP-R2; VPAC1 receptor; PACAP-R-2; PACAP type
                     II receptor; pituitary adenylate cyclase-activating
                     polypeptide type II receptor; VIP receptor subtype 1"
                     /codon_start=1
                     /product="vasoactive intestinal polypeptide receptor 1
                     precursor"
                     /protein_id="NP_035833.2"
                     /db_xref="CCDS:CCDS23633.1"
                     /db_xref="GeneID:22354"
                     /db_xref="MGI:MGI:109272"
                     /translation="MRPPSLPPARWLCVLAGALACALGPAGSRAASPHQECEYLQMIE
                     KQRQQCLEEAQLENETTGCSKMWDNLTCWPTTPWGQVVVLDCPLIFQLFSPIHGYNIS
                     RNCTEEGWSQLEPGPYHIACGLNDRASSMDEQQQTEFYDAVKTGYTIGYSLSLASLLV
                     AMAILSLFRKLHCTRNYIHMHLFMSFILRATAVFIKDMALFNNGETDHCSEASVSCKA
                     AVVFFQYCVMANFFWLLVEGLYLHTLLAVSFFSERKYFWGYILIGWGVPSVFIMIWTI
                     VRIHFEDFGCWDTIINSSLWWIIKGPILISILVNFILFICIIRILVQKLRPPDIGKND
                     SSPYSRLAKSTLLLIPLFGVHYVMFAFFPDNFKAQVKMVFELVVGSFQGFVVAILYCF
                     LNGEVQAELRRKWRRWHLQGVLGWSSKSQHPWGGSNGVSCSTQVSMLTRVSPSARRSS
                     SFQAEVSLV"
     exon            212..317
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..425
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..532
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..639
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..772
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..926
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..987
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1057
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1149
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1279
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1321
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..4902
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4874..4879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /note="hexamer: ATTAAA"
     polyA_site      4895
                     /gene="Vipr1"
                     /gene_synonym="VIP-R1; VPAC1"
                     /note="major polyA site"
ORIGIN      
        1 cccgccgccc tcccctagcc tggagctgtg cctcatagcg cccgggccgc tggcccgcgc
       61 cactctcccg cgctgcgtta gccacagacc ccgtaggcgc tctcggctgc ctgccgcggg
      121 ctcagggcgg accatgcgcc ctccgagcct accgcctgcc cgctggctct gcgtgctggc
      181 aggagccctc gcctgcgccc tcggacccgc gggcagccgg gcagccagcc cacaccagga
      241 gtgtgagtac ctgcagatga ttgagaaaca gcgtcagcag tgcctggagg aggcccagct
      301 ggagaatgaa accacaggct gcagcaagat gtgggacaac ctcacctgct ggccaacgac
      361 cccttggggc caggtggtag tcctggactg ccccctcatc tttcaactgt tttcccccat
      421 tcacggctat aacatcagcc gtaactgcac tgaagaaggc tggtcacaac tggaacctgg
      481 cccctaccac attgcctgcg gcctgaatga cagggcatct agtatggatg agcagcaaca
      541 gactgagttc tacgatgcag tgaagaccgg ctacaccatc ggctacagct tgtcccttgc
      601 cagcctcctg gttgccatgg ctatcttgag cctgttcagg aagctgcact gtactcgaaa
      661 ctacatccac atgcatctct tcatgtcctt catcctgagg gccaccgccg tcttcatcaa
      721 ggatatggcc ctcttcaaca acggggagac agaccactgc tctgaggcct cggtgagctg
      781 caaggcagca gtggttttct tccagtattg cgtcatggcc aacttcttct ggctgctggt
      841 cgagggcctc tacctacaca ccctgctggc cgtctccttc ttctctgagc ggaagtactt
      901 ctgggggtac atactcatcg gctggggagt gcccagtgtg ttcatcatga tatggacgat
      961 tgtcaggatc cattttgagg atttcgggtg ctgggacacc atcatcaact cctcactgtg
     1021 gtggatcata aagggcccca tcctcatctc catcttggtg aacttcatcc tgtttatctg
     1081 catcatccga atcctggttc agaagctacg gccacccgac attgggaaga atgatagcag
     1141 cccatactcg aggctggcca agtccacact tctgctcatc cctctgtttg gagttcacta
     1201 tgtcatgttt gccttcttcc ccgacaactt taaggcccag gtgaaaatgg tctttgaact
     1261 cgtcgtaggg tctttccagg gttttgtggt ggccatcctc tactgcttcc tcaatggcga
     1321 ggtgcaggca gagctgcgac ggaagtggcg gcgttggcat ctgcagggcg tcctgggctg
     1381 gagctccaaa tcacaacacc cgtggggagg cagcaacggc gtctcgtgca gcacacaggt
     1441 gtccatgctg acccgcgtca gcccgagcgc gcgccgctcc tccagcttcc aagcggaggt
     1501 ctccctggtc tgaccgccag aggccgccag gccccttcgc accctcccca cgccagcccc
     1561 tggagcagag gtctgcagcg acgccgctgg ctccagcctt ttgtagggac acaatccttt
     1621 gctgcagcca ggacccggtc catgctagct ggagagctgg gaggtctaac cctggaggat
     1681 gcaaggagga accagcatcg gactccacca cccaaggctg ctctgccagt catgcgcaca
     1741 acatctgcat tcacctcctg gaaagcaaac cgcctgccct caaagctttg gaactctgag
     1801 ggcaaaaggt tccgccccgt cggtgcctag aattccactg gggcgctcaa gtcgctttgg
     1861 gttaagcgtt gccattgaga ctcctctctg aggatgcagc cccctccctc cgtttatctg
     1921 ccagctcttc cgggtgggtg agttcttcta cctcaggcag atatggttgt gacctggagt
     1981 ttcagtttgg ggatcacagc tgtgttgcgg tcctccctca ggatggaatt gccccagtga
     2041 atcgtcagac ctgggagctc agggacctat ctctggggag gaggggtggg gagaaggcag
     2101 ccctgcccgt gctcaccaag tgactttgtc catcaagtag gaccagtcca ctagccttat
     2161 gtacaaccaa agcaatagcg agctgccgcc tctgggcgct tatctacaca ccaaccactg
     2221 ctgcaagggt cagaggcatg agcacacagg ccccttgatc ctgggccacc ctgatatcac
     2281 tggtagtgat actgagtcct gtgagagcag gtatcctttc ctgttgctaa agactacctt
     2341 ttttacatat tgtggtctgc tggattctct gggggtcgca ttaccataga tgctattgcc
     2401 accctcagtc tccagttcct gtggagagtg attatgtctg acataaaagc ctggggaggg
     2461 ggcaaggcat cttatgcctc cctccatctt tatagcgata atggcttcta atccaaactg
     2521 gtgtcagcgg gctcttctca gagctgcacc aggcttgtat gacaataaac attggctcta
     2581 gcaggcttgg ttcccctagc cactgtgggt ctcctgcttc ttctaagcag ctgtgtcacc
     2641 tctgctctag tgagagatga cccttctggc tttgggcagg agccccacac aagagccttt
     2701 gattcacatg taaatgtgaa gaggttgtga caggggtccg ttgtgaccct ccctccccta
     2761 aacccatctg ggaggagaca gattctgcct cagaccaaat caaaacagcc aacagagctg
     2821 tcacagccag caagggttcg acatcattcc tgaaaacaca gcaaacagga aatgcagcaa
     2881 ccaggtcgct gctgcctagg agccaaccaa gagggctcaa taatggagat tccccagcac
     2941 aagtgagaag aggccagtct ggctaatgga aaggagtaga cagagcagtg gggcaaagca
     3001 ggtgacattg gttggtcagt gagagacagc tagctcccaa gggtttgtgc aaacacactt
     3061 gtgtaaactt gtgggtgtca ggctggtgta aagaagccag catgggctag cagaggttca
     3121 aacctgcctg ccatacccca ttcaaaggct gctgcaccca gtaccaaccc cctgcctaaa
     3181 tgaatgggac caagatttcc ccagcagtgc tgtgttgtgg caccagcgta aggcgcaggg
     3241 ccctgggaga gcagcagtta ccagccaaga ggacaaagtg agtaaaactc aaagtgtgtt
     3301 caagagagga cgagcagagt taggaggtga gaggctaatt ggagggcatt tcggaataaa
     3361 gagagacttg ggaggcttgg gtgaggagct aagaaaactt gtgctggcat cctaggttag
     3421 tgacagccct gggacttcca ggacacccag gaccttttgg caggcgaact catctctatc
     3481 gccatctagt gggcacttca aagacttgac caactttggc caccttaggg cttcctattg
     3541 tcaagtaggt ctcaccctgg gagacaacca acaacgaaag catggctcca ttactgagct
     3601 cccaagagtg gtgtgtggac catacgtaag gcttgcccca cacctcgccc tcaggccaaa
     3661 ccactggccc cttgtgagtc ttgccttgac ccaaaaggac ctgatggaac ccagcccctg
     3721 gtggctcctt aaaactgaac cctacccaca atctccaagg acaaaggcta gttagctgaa
     3781 gcgggtatgg acagggatcc gtaaatctga gtccagagaa ggttcgttct gtgggaaagg
     3841 cttgttcaca ggcagtcctc ccactcagga cacagcctgt cggaagagac tggattaccg
     3901 gctagcagaa cagcactgag gtgtttgagg gctgggagtg gtcctagaat cccaagggaa
     3961 tgtgttgggt gtcagggaca cccaagtttg gggggcactt gccagtagag acaaagagaa
     4021 ggtctatcct tccgatgagg ctgagagatg gggagtggtt agttaacaca gagaaggacc
     4081 caggtctgga aagggtgcca ggccatccac aggaaagaga ggaggtgaga caatggcctg
     4141 gtttgggacc aggtgctgaa tgttgtgtct gcagggtatc tgagaagagc ccctctaagg
     4201 cggttagaaa ttacaaccta aagggacaga gggcaggaag accaaagcag tccctttgga
     4261 aggaacagtg agtgtccggg caagtcccca ggcaccccat ggggtgtgct gggcacagtc
     4321 tggagaggag actgactcag cccctccatc ctagctgcca cacagggtct gttttaatga
     4381 gcagtggcca gcttccctac ccccatgtgg gaacaagaac agctcttatc tctctggggg
     4441 aaggggaagg ggcgggacca cagctggcag tcattaaaca ccctgctcta ggcagggatg
     4501 gccaagatat taatagcttc gggagtctat ggccccaaag acttggcctc ccaggaaaag
     4561 gacagagcaa ccgcagcagg ccagagggat gcgtcaggag gccatcttgg caatgcccca
     4621 gcctccacac aaggcaaatg ggataaccag aaaatagaga aggaaaagtc attgtagagg
     4681 cagatgctga acccagcttt ccagaacccc tggtcgtgcc tcagatattc tatatcttgt
     4741 caaagatggg gtcatttggc tgtgccctac ctggaaacac aaaaagagtc gatccagtta
     4801 gcagtcctga ttccgtcttg acatattgtt tatcctgtat ttttgcatta attttgatat
     4861 tttaaaatac tgcattaaaa tattatttac cttgagtcct gaaaaaaaaa aaaaaaaaaa
     4921 aaaaaaaaa
//
