LOCUS       NM_001142580            2552 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus VPS33B interacting protein, apical-basolateral
            polarity regulator, spe-39 homolog (Vipas39), transcript variant 1,
            mRNA.
ACCESSION   NM_001142580
VERSION     NM_001142580.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2552)
  AUTHORS   Rogerson,C. and Gissen,P.
  TITLE     VPS33B and VIPAR are essential for epidermal lamellar body
            biogenesis and function
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (5 Pt A), 1609-1621 (2018)
   PUBMED   29409756
  REMARK    GeneRIF: VPS33B and VIPAR are essential for epidermal lamellar body
            biogenesis and function
REFERENCE   2  (bases 1 to 2552)
  AUTHORS   Banushi,B., Forneris,F., Straatman-Iwanowska,A., Strange,A.,
            Lyne,A.M., Rogerson,C., Burden,J.J., Heywood,W.E., Hanley,J.,
            Doykov,I., Straatman,K.R., Smith,H., Bem,D., Kriston-Vizi,J.,
            Ariceta,G., Risteli,M., Wang,C., Ardill,R.E., Zaniew,M.,
            Latka-Grot,J., Waddington,S.N., Howe,S.J., Ferraro,F., Gjinovci,A.,
            Lawrence,S., Marsh,M., Girolami,M., Bozec,L., Mills,K. and
            Gissen,P.
  TITLE     Regulation of post-Golgi LH3 trafficking is essential for collagen
            homeostasis
  JOURNAL   Nat Commun 7, 12111 (2016)
   PUBMED   27435297
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2552)
  AUTHORS   Cullinane,A.R., Straatman-Iwanowska,A., Zaucker,A., Wakabayashi,Y.,
            Bruce,C.K., Luo,G., Rahman,F., Gurakan,F., Utine,E., Ozkan,T.B.,
            Denecke,J., Vukovic,J., Di Rocco,M., Mandel,H., Cangul,H.,
            Matthews,R.P., Thomas,S.G., Rappoport,J.Z., Arias,I.M., Wolburg,H.,
            Knisely,A.S., Kelly,D.A., Muller,F., Maher,E.R. and Gissen,P.
  TITLE     Mutations in VIPAR cause an arthrogryposis, renal dysfunction and
            cholestasis syndrome phenotype with defects in epithelial
            polarization
  JOURNAL   Nat Genet 42 (4), 303-312 (2010)
   PUBMED   20190753
  REMARK    Erratum:[Nat Genet. 2011 Mar;43(3):277]
REFERENCE   4  (bases 1 to 2552)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   5  (bases 1 to 2552)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 2552)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB610654.1, AK079055.1 and AK082261.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082261.1, AK049643.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BB610654.1         2-55
            55-2548             AK079055.1         2-2495
            2549-2552           AK082261.1         2477-2480
FEATURES             Location/Qualifiers
     source          1..2552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 41.44 cM"
     gene            1..2552
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /note="VPS33B interacting protein, apical-basolateral
                     polarity regulator, spe-39 homolog"
                     /db_xref="GeneID:104799"
                     /db_xref="MGI:MGI:2144805"
     exon            1..135
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1611
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /note="isoform a is encoded by transcript variant 1;
                     protein spe-39 homolog; VPS33B-interacting protein in
                     polarity and apical restriction; VPS33B-interacting
                     protein in apical-basolateral polarity regulator;
                     spermatogenesis-defective protein 39 homolog"
                     /codon_start=1
                     /product="spermatogenesis-defective protein 39 homolog
                     isoform a"
                     /protein_id="NP_001136052.1"
                     /db_xref="CCDS:CCDS49119.1"
                     /db_xref="GeneID:104799"
                     /db_xref="MGI:MGI:2144805"
                     /translation="MNRTKGDEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVNSLRD
                     IVDDDDDDDLERVSWTGEPVGSISWSIKETAGSSGSTPEGREQLKGRNSFYTQLPKPP
                     STYSLSSFFRGRTRPGSFQSLSDALSDTPAKSYAPELGRPKGEYRDYSNDWSLSDTVQ
                     RLRRGKVCSLERFRSLQDKLQLLEEAVSMHDGNVITAVLIFLKRTLSKEILFRELEVR
                     QVALRHLIHFLKEIGDQKLLLDLFRFLDRAEELALSHYREHLNIQDPEKRKEFLKTCI
                     GLPFSAEDAAHVQDHYTLLERQIIIEANDRHLESSGQTDIFRKHPRKASILNMPLVTT
                     LFYACFYHYTESEGTFSSPINLKKTFKIPDKQYVLTALAARAKLRAWNDVDALFTTKN
                     WLGYTKKRAPIGFHRVVEILHKNSAPVQILQEYVNLVEDVDTKLNLATKFKCHDVVID
                     TCRDLKDRQQLLAYRSKVDKGSAEEEKIDAILSSSQIRWKN"
     exon            136..228
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            229..331
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            332..472
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            473..511
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            512..576
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            577..633
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            634..726
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            727..760
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            761..863
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            864..891
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            892..965
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1041
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1176
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1218
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1308
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1395
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1485
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1590
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..2552
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2529..2534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /note="hexamer: AATAAA"
     polyA_site      2552
                     /gene="Vipas39"
                     /gene_synonym="6720456H09Rik; 9330175H22Rik; hSPE-39;
                     SPE-39; Spe39; Vipar"
                     /note="major polyA site"
ORIGIN      
        1 attcctttca ccttcttcag actcttctcc gctgtcccct tctgctcttc tctatgcctc
       61 acagcctgtt tagaaaggct ggtccagcgg ctgagcctgg cgctgtcctg agaaggagcg
      121 ctcggtgtgg aagagatgaa ccggacaaaa ggtgatgagg aggaatattg gaacagctcc
      181 aagttcaagg ctttcacttt tgatgatgaa gatgatgagc tctcacagtt aaaggaatcc
      241 aaacgcgcag tgaatagcct tcgagacatc gtggatgacg acgatgacga tgacctggag
      301 agagtcagct ggactggaga acctgtggga agtatctcat ggtccatcaa agagactgct
      361 gggagtagcg ggtcaacccc tgagggacgt gaacagctaa agggccgaaa cagcttctac
      421 acacagctac ccaaacctcc ttctacttac tccctcagca gcttcttcag aggtagaact
      481 agacctggga gtttccagtc cctttctgat gctctgtcag acacacctgc caaaagttat
      541 gctccagagc tggggaggcc taagggagaa tacagggatt acagcaatga ctggagcctc
      601 agtgatacag tgcaacgcct ccgccggggc aaggtctgtt cactagagcg cttccgctcc
      661 ctccaggata agctgcagct cctagaggag gcagtaagca tgcatgatgg gaacgtcatc
      721 actgcagttc tgatcttcct gaagaggacc ctgagcaaag agatcctttt tcgagagctg
      781 gaggtacgcc aggtcgcact gagacatctc attcattttc ttaaagaaat aggggaccaa
      841 aagctgcttt tagatctctt caggttccta gatagagcag aagaactggc gctatcccat
      901 tatcgagagc acttgaacat tcaggaccct gaaaaacgaa aagaatttct taagacttgc
      961 attggtttgc cattttcagc agaagacgct gcgcatgtac aagaccatta caccctgctg
     1021 gagcgccaga tcatcatcga ggcaaacgac cggcacctgg agtcttcagg gcagactgat
     1081 atcttccgga agcacccccg taaagcttcc attctcaaca tgccgttagt gacgacactc
     1141 ttctacgcct gcttctatca ctacacggag tctgagggaa ccttcagcag tcccatcaac
     1201 ctgaagaaaa cattcaagat cccagacaaa cagtatgtgc tgacagcctt ggctgcgcgt
     1261 gccaagctga gagcctggaa tgacgttgat gccctgttca ccacaaagaa ctggttgggt
     1321 tacaccaaga agagagcacc cattggcttc catcgagttg tggaaatttt gcacaagaac
     1381 agtgcccctg tccagatact gcaggaatat gtcaatctgg tggaagatgt ggacaccaag
     1441 ttgaacttag ctactaagtt caagtgccat gatgtcgtca ttgatacttg ccgagacctg
     1501 aaggatcgtc agcagttgct tgcatacagg agcaaagtag acaaaggatc cgccgaggaa
     1561 gagaagattg acgccattct cagcagctcg caaattcgat ggaagaacta agggtccttt
     1621 gctaccctga agcctcctcg cttcttactt ttctttctgc ctatgaaaac agagagctct
     1681 cttcttagga gagtcacagc attctacacg tgagcctgtc attcacaggc agtgcctgct
     1741 ggtttaggga cagaaaccag cctttgagca catgtatctt cagactgatc tgtccagggg
     1801 acattactta caggccagta gctaaaggct cggactctca agaaagatgc tctgcaccgg
     1861 tgcctgtgga aaggtggggg cccatcctgg gcaagatgcc tgtgctcaga gaaaagtgac
     1921 cactccagaa acacgtcggg actaagccac aagtgtctcg gggtggcagt gacattcctc
     1981 tgtcctttca gctgttctta cccagaacct ggtgttgggc ataggcattt cactctaaag
     2041 gagtcagaac agaactaaat tgactcttca ggggcctcgg aaagggatat cagtattgct
     2101 caggacctgc tggaaaccag acccaagttc tcaagacaca gggccactca tcaatgacag
     2161 acacttccta cacattgtgt accttcagcc agtatctacc tgctgtcacg gcactgtccc
     2221 tgtcaacttt gtgtagggac gtgtgaggga tatagggtcc ctctgacacc tgcacactgt
     2281 ccaggtggtg agccatctgc ttcagcacgt cttctgtttc tgtgtcagac acagtcttac
     2341 atggaattca gattcaccag tgctggagcg ctctttcagg caaaaatcat ttcaccagaa
     2401 gcagccacaa gtagcacctt gtttagatat ctccgtagag gccctgttag cctgctgggg
     2461 acttgagcag tgttccattc tgccctgtgc ctccctgaac aggatttccc tgacatgcct
     2521 acactcctaa taaaactgtt gcattccttg tg
//
