LOCUS       NM_011702               1544 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus vasoactive intestinal polypeptide (Vip), transcript
            variant 1, mRNA.
ACCESSION   NM_011702
VERSION     NM_011702.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1544)
  AUTHORS   Tamboli,S., Topolnik,D., Radhakrishnan,R., Veilleux-Lemieux,D. and
            Topolnik,L.
  TITLE     Protocol for synchronized wireless fiber photometry and video
            recordings in rodents during behavior
  JOURNAL   STAR Protoc 5 (4), 103407 (2024)
   PUBMED   39425933
REFERENCE   2  (bases 1 to 1544)
  AUTHORS   Sung,K., Jeong,M.J., Yoo,T., Jung,J.H., Kang,S., Yoo,J.Y.,
            Kim,H.J., Park,K., Pyo,J.H., Lee,H.Y., Koo,N., Choi,S.H. and
            Kim,J.H.
  TITLE     ErbB4 precludes the occurrence of PTSD-like fear responses by
            supporting the bimodal activity of the central amygdala
  JOURNAL   Exp Mol Med 56 (12), 2703-2713 (2024)
   PUBMED   39623093
REFERENCE   3  (bases 1 to 1544)
  AUTHORS   Jiang,Y.Q., Lee,D.K., Guo,W., Li,M. and Sun,Q.
  TITLE     Hypothalamic regulation of hippocampal CA1 interneurons by the
            supramammillary nucleus
  JOURNAL   Cell Rep 43 (11), 114898 (2024)
   PUBMED   39446584
REFERENCE   4  (bases 1 to 1544)
  AUTHORS   Shore,A.N., Li,K., Safari,M., Qunies,A.M., Spitznagel,B.D.,
            Weaver,C.D., Emmitte,K., Frankel,W. and Weston,M.C.
  TITLE     Heterozygous expression of a Kcnt1 gain-of-function variant has
            differential effects on somatostatin- and parvalbumin-expressing
            cortical GABAergic neurons
  JOURNAL   Elife 13, 92915 (2024)
   PUBMED   39392867
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1544)
  AUTHORS   Lin,Z.J., Gu,X., Gong,W.K., Wang,M., Wu,Y.J., Wang,Q., Wu,X.R.,
            Zhao,X.Y., Zhu,M.X., Wang,L.Y., Liu,Q., Yuan,T.F., Li,W.G. and
            Xu,T.L.
  TITLE     Stimulation of an entorhinal-hippocampal extinction circuit
            facilitates fear extinction in a post-traumatic stress disorder
            model
  JOURNAL   J Clin Invest 134 (22), e181095 (2024)
   PUBMED   39316444
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1544)
  AUTHORS   Mikkelsen,J.D. and Fahrenkrug,J.
  TITLE     Concentrations and distribution of vasoactive intestinal peptide
            (VIP), peptide histidine isoleucine (PHI) and peptide histidine
            valine (PHV) in the cerebral cortex and the suprachiasmatic nucleus
            of the mouse
  JOURNAL   Brain Res 656 (1), 95-107 (1994)
   PUBMED   7804850
REFERENCE   7  (bases 1 to 1544)
  AUTHORS   Sena,M., Bravo,D.T., Von Agoston,D. and Waschek,J.A.
  TITLE     High conservation of upstream regulatory sequences on the human and
            mouse vasoactive intestinal peptide (VIP) genes
  JOURNAL   DNA Seq 5 (1), 25-29 (1994)
   PUBMED   7894056
REFERENCE   8  (bases 1 to 1544)
  AUTHORS   Laemle,L.K. and Rusa,R.
  TITLE     VIP-like immunoreactivity in the suprachiasmatic nuclei of a mutant
            anophthalmic mouse
  JOURNAL   Brain Res 589 (1), 124-128 (1992)
   PUBMED   1422812
REFERENCE   9  (bases 1 to 1544)
  AUTHORS   Mathew,R.C., Cook,G.A., Blum,A.M., Metwali,A., Felman,R. and
            Weinstock,J.V.
  TITLE     Vasoactive intestinal peptide stimulates T lymphocytes to release
            IL-5 in murine schistosomiasis mansoni infection
  JOURNAL   J Immunol 148 (11), 3572-3577 (1992)
   PUBMED   1588046
REFERENCE   10 (bases 1 to 1544)
  AUTHORS   Lamperti,E.D., Rosen,K.M. and Villa-Komaroff,L.
  TITLE     Characterization of the gene and messages for vasoactive intestinal
            polypeptide (VIP) in rat and mouse
  JOURNAL   Brain Res Mol Brain Res 9 (3), 217-231 (1991)
   PUBMED   1851524
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK018599.1 and BE990430.1.
            
            On Sep 17, 2015 this sequence version replaced NM_011702.2.
            
            Summary: This gene encodes a neuropeptide of the glucagon/secretin
            superfamily with potent bronchodilator, immunomodulator and
            anti-inflammatory properties. The encoded protein is
            proteolytically processed to generate two structurally similar
            neuropeptides - vasoactive intestinal peptide (VIP) and peptide
            histidine isoleucine (PHI). In the digestive tract, VIP stimulates
            relaxation of enteric smooth muscle, secretion of water and
            electrolytes, release of insulin and glucagon, and inhibition of
            gastric acid secretion. In the cardiovascular system, VIP causes
            coronary vasodilation and stimulates contractility in the heart.
            Mice lacking VIP exhibit airway hyperresponsiveness and airway
            inflammation. Male mice lacking VIP exhibit moderate pulmonary
            arterial hypertension resulting in increased mortality. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018599.1, BC089511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1527              AK018599.1         2-1528
            1528-1544           BE990430.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1544
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 1.97 cM"
     gene            1..1544
                     /gene="Vip"
                     /note="vasoactive intestinal polypeptide"
                     /db_xref="GeneID:22353"
                     /db_xref="MGI:MGI:98933"
     exon            1..153
                     /gene="Vip"
                     /inference="alignment:Splign:2.1.0"
     exon            154..270
                     /gene="Vip"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..679
                     /gene="Vip"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; VIP peptides; PHI, peptide histidine
                     isoleucine"
                     /codon_start=1
                     /product="VIP peptides isoform 1 preproprotein"
                     /protein_id="NP_035832.1"
                     /db_xref="CCDS:CCDS56682.1"
                     /db_xref="GeneID:22353"
                     /db_xref="MGI:MGI:98933"
                     /translation="MEARSKPQFLAFLILFSVLFSQSLAWPLFGPPSVVSRLDDRMPF
                     EGAGDPDQVSLKADSDILQNPLAENGTPYYDVSRNARHADGVFTSDYSRLLGQISAKK
                     YLESLIGKRISSSISEDPVPIKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEG
                     DSADFLEELEK"
     exon            271..396
                     /gene="Vip"
                     /inference="alignment:Splign:2.1.0"
     exon            397..501
                     /gene="Vip"
                     /inference="alignment:Splign:2.1.0"
     exon            502..633
                     /gene="Vip"
                     /inference="alignment:Splign:2.1.0"
     exon            634..714
                     /gene="Vip"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1530
                     /gene="Vip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1503..1508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vip"
                     /note="hexamer: AATAAA"
     polyA_site      1530
                     /gene="Vip"
                     /note="major polyA site"
ORIGIN      
        1 agcttggaca gcagagcact agccagctac agccaaccgt tccccaggaa ccgggaacag
       61 actggtggag ccttccctag agcagaactt cagcacccta gacagctgcc acgaagccgg
      121 aaaggcagcc ctgcctgaag gaaacagcca aggaggcacc gagatggaag ccagaagcaa
      181 gcctcagttc ctggcattcc tgatactctt cagtgtgctg ttctctcagt cgctggcctg
      241 gcctctcttt ggaccacctt ctgtagtgag taggctggat gacaggatgc cgtttgaagg
      301 agcaggtgac cctgaccaag tctctttaaa agcagactct gacatcttgc agaatccctt
      361 agcagaaaat ggcacaccct attatgatgt gtcaagaaat gccaggcatg ctgatggagt
      421 tttcaccagc gattacagca gacttctggg tcagatttct gccaaaaaat accttgagtc
      481 actcattggc aaacgaatca gcagcagcat ctcggaagat cctgtgccaa tcaaacgaca
      541 ctctgatgcc gtcttcacag ataactacac ccgcctcaga aagcaaatgg ctgtgaagaa
      601 atacctgaac tccatcctga atggaaagag gagcagtgag ggagattctg cagactttct
      661 tgaagagctg gagaaatgat gggaagaggc ctctgggcag agctgaaatc agagaattct
      721 cgaaggaaaa caaccacgtg attacattat gagttctaca tgtctaattc aagaaaaaaa
      781 cttccatagc aaaaccaaat aaaatgtgtt gtgaatattg tggtttcctt tatgtaataa
      841 ctgtgatgtt tacattgtaa atattatttg agcattctaa cattcatctg tagctcatga
      901 aatgcttata atttcatatg ctatatattc tttcaaagaa aagtatattt aatgataggt
      961 agatactaga ttaattgcaa ttatctgaag ctttctgcaa gggtagcaat cgaggaaaat
     1021 tgatgtgttt atttatagca tgtagttaac tattcaacag agcagaacag ataatcagtg
     1081 tgaacaagtc taaatgctaa gcagataggc tgctgtgtta cataaggcaa aatatctaag
     1141 gggaataaca aattatggat aaaagagata tgtggcaaaa ggattttcag aattgtattt
     1201 ctccagtgat aggtactcca tctctcacgg attcatctct cccattaggc tttgcaatcc
     1261 ccaaaggcta cttcagagat gcttcagcta ggaaaagccc atcgtccaat ctggggcttc
     1321 ccctttctgc gtgtgctatg gatgtgtaaa ctagaagcta aatggagtgc ttgatttcca
     1381 gtagtaaata cttctcccat agtcactcac aatgatattt tgtcttattg gcttcctttg
     1441 ctgaaagtac atttgtagac acaactattt ttccaatgtg attgtatgaa attaaagaca
     1501 ggaataaaga tctttggtta tcattgcaaa aaaaaaaaaa aaaa
//
