LOCUS       NM_001164567            2915 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus villin-like (Vill), transcript variant 1, mRNA.
ACCESSION   NM_001164567
VERSION     NM_001164567.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2915)
  AUTHORS   Man,J.C.K., Mohan,R.A., Boogaard,M.V.D., Hilvering,C.R.E.,
            Jenkins,C., Wakker,V., Bianchi,V., Laat,W., Barnett,P.,
            Boukens,B.J. and Christoffels,V.M.
  TITLE     An enhancer cluster controls gene activity and topology of the
            SCN5A-SCN10A locus in vivo
  JOURNAL   Nat Commun 10 (1), 4943 (2019)
   PUBMED   31666509
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2915)
  AUTHORS   Rieder,G., Tessier,A.J., Qiao,X.T., Madison,B., Gumucio,D.L. and
            Merchant,J.L.
  TITLE     Helicobacter-induced intestinal metaplasia in the stomach
            correlates with Elk-1 and serum response factor induction of villin
  JOURNAL   J Biol Chem 280 (6), 4906-4912 (2005)
   PUBMED   15576363
  REMARK    GeneRIF: H. pylori induction of villin in the stomach correlates
            with activation and cooperative binding of Elk-1 and the SRF to the
            proximal promoter of villin
REFERENCE   3  (bases 1 to 2915)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   4  (bases 1 to 2915)
  AUTHORS   Hackney,J.A., Charbord,P., Brunk,B.P., Stoeckert,C.J.,
            Lemischka,I.R. and Moore,K.A.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
REFERENCE   5  (bases 1 to 2915)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   6  (bases 1 to 2915)
  AUTHORS   Fu,X. and Kamps,M.P.
  TITLE     E2a-Pbx1 induces aberrant expression of tissue-specific and
            developmentally regulated genes when expressed in NIH 3T3
            fibroblasts
  JOURNAL   Mol Cell Biol 17 (3), 1503-1512 (1997)
   PUBMED   9032278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028229.1, CN670511.1, CF171710.1, BQ833192.1 and AK166823.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028229.1, AJ344341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AK028229.1         2-274
            274-541             CN670511.1         250-517
            542-1107            CF171710.1         99-664
            1108-1269           BQ833192.1         179-340
            1270-2633           AK028229.1         1271-2634
            2634-2915           AK166823.1         3621-3902
FEATURES             Location/Qualifiers
     source          1..2915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.32 cM"
     gene            1..2915
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /note="villin-like"
                     /db_xref="GeneID:22351"
                     /db_xref="MGI:MGI:1201781"
     exon            1..51
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            52..123
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..2637
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /note="isoform 1 is encoded by transcript variant 1;
                     villin-like protein; EF-6"
                     /codon_start=1
                     /product="villin-like protein isoform 1"
                     /protein_id="NP_001158039.1"
                     /db_xref="CCDS:CCDS52962.1"
                     /db_xref="GeneID:22351"
                     /db_xref="MGI:MGI:1201781"
                     /translation="MDINQDLPAIDSHRALQIWITENLKMLPLPERAHGNFFEECCYV
                     VLHVPQSPKATQGGFSDLHYWIGKDASAEAREAAVSFVQCLQEDLGDQTVLHRESQGH
                     ESDCFHSYFHPGVIYRKGGRDSALKFAETNMYNVQRLLHIRGRKHVSATEVALSWNSF
                     NKGDIFLLDLGKVMIQWNGPKASISEKARALTLTCNLRDRERGGRAQIAVVDAENEAT
                     NLLRIMEAVLGCRSGSLCPSVPSNSVSQLQKANVRLYHVCEKGTDLVVQELATRPLTQ
                     DLLQEDGCYLLDQGGFKIYMWQGRKSSPQEKKAALSRAVGFIQAKGYPNYTNVEVVND
                     GAESTAFQQLFWSWSKELDRKKHPEKSKLVQGNLEVGKLHTQPELAAQLRMVDDGSGK
                     VEVWYIQDLQRQPVHPKYYGQLCSGNCYLVLYTYQKLGCVQYLLYLWQGHQSTVEDTK
                     ALNCSAEELDLMHQGALAQGHVTMGSEPPHFLAIFQGRLVVFQGNAGNKGERPPVSDT
                     RLFHVQGTESHNTRTMEVPARASSLTSGDVFFLITSHVCYLWFGKGCHGDQREMARTV
                     VSVFPGNNKETVLEGQEPLYFWEALGGRAPYPSNKRLPEEVWSIQPRLFECSSHAGCL
                     VLTEVLFFGQEDLDKYDIMLLDTCQEIFLWLGEAAGEWKKEAVAWGLEYLRTHPAERS
                     LATPIFVVKQGHEPATFTGWFVTWDPYKWMNSQSYEEMVGNSLGPGSAISEMTAEVHN
                     FQLTPRLSDNKAGHPALQAFKGSQDSPENELGLDLRVDGANPSMNHTSSCSDSMVNGS
                     LPRERLMHQALEDLPPGVDPARKEFYLSDSDFQDIFGKSKEEFYSMAKWKQQQAKKKL
                     GFF"
     exon            124..198
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            199..404
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            405..513
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            514..624
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            625..824
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            825..903
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1002
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1138
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1239
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1377
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1536
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1716
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1862
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2007
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2193
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2265
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2523
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2915
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2696..2701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /note="hexamer: AATAAA"
     polyA_site      2716
                     /gene="Vill"
                     /gene_synonym="Villp"
                     /note="major polyA site"
ORIGIN      
        1 agtgttgccc acaggctgag tgaaggaagg tgcagaggca gttcccagaa gcccgggatg
       61 gacatcaacc aggacctccc agccatcgac agccacagag ccttgcaaat atggattact
      121 gagaacctaa agatgctgcc attgcctgaa agggctcatg ggaatttctt tgaagaatgc
      181 tgctatgtcg tccttcatgt ccctcagagt ccaaaagcta cccagggagg attcagtgac
      241 ctgcactact ggattggaaa ggatgccagc gcagaagccc gggaggctgc ggtctccttt
      301 gtgcaatgtc tgcaggagga cctaggagac cagactgtgc tgcaccgaga gtcacagggc
      361 cacgagtccg actgcttcca cagctatttc caccctggag tcatctacag gaagggaggc
      421 agagactctg ctctcaagtt tgcggagacc aacatgtaca atgtccagcg actgcttcac
      481 atcaggggaa ggaagcacgt gtctgccact gaggtggcct tgtcctggaa cagctttaac
      541 aagggggaca tcttcctgtt ggacctgggc aaggtgatga tccagtggaa tggacccaaa
      601 gccagcattt ctgagaaagc acgggctctg accctgactt gcaacctcag agacagggag
      661 cgaggtggcc gtgcccaaat tgctgtggta gatgcggaga atgaagccac caaccttctg
      721 cgcatcatgg aggctgtgct gggctgcaga tcaggcagcc tgtgtccctc tgtacccagc
      781 aacagtgtta gccagctaca aaaggccaat gtccgcctct accatgtctg tgagaagggg
      841 acagacctgg tggtccagga actggcgacc cgcccactga cccaggacct cctgcaagag
      901 gacggttgct atctcctgga ccagggtggc ttcaagatct acatgtggca gggacgaaag
      961 tccagccccc aggagaagaa ggctgccctc agcagggctg tgggcttcat ccaggccaag
     1021 ggttacccga actacaccaa tgtggaggtg gtgaacgacg gcgcggagtc cacagctttc
     1081 caacagctct tctggtcttg gtcgaaggag ctagatagga aaaaacaccc agagaagagt
     1141 aaactggtgc agggaaacct ggaggtaggc aagcttcaca cccagcctga gctcgcggcc
     1201 cagctcagaa tggtggacga cggctctggg aaggtggagg tgtggtacat ccaggactta
     1261 caaagacagc ctgtacatcc caagtactat ggccagttgt gctcaggaaa ctgctacctt
     1321 gtcctctaca cataccagaa actgggctgt gtccagtacc tcctgtacct atggcagggc
     1381 caccaaagca ctgtagaaga caccaaggcc ctgaactgca gtgctgaaga gttggacctc
     1441 atgcaccagg gtgcactggc gcaggggcat gtgaccatgg gcagtgagcc tccccacttc
     1501 ctagccatct tccaggggcg gctggtggtc ttccagggga atgcaggcaa caaaggggaa
     1561 agaccaccag tatccgacac caggcttttc cacgtgcaag ggaccgagag ccacaacacc
     1621 agaactatgg aggtgccggc ccgtgcctcc tccctcactt ctggtgacgt cttctttctg
     1681 atcacaagtc atgtttgcta tctctggttt gggaagggct gtcatgggga ccaacgtgag
     1741 atggcgcgga cggtggtcag tgtcttccca gggaataaca aggagacagt gctggagggt
     1801 caggagcctc tctacttctg ggaagccctc ggaggccggg ccccctatcc cagtaacaag
     1861 aggcttcccg aggaggtgtg gagcatccag ccccgactgt tcgagtgctc cagtcacgca
     1921 ggctgcctgg tcctcacgga agtgctgttc tttggccaag aggacttgga caagtatgac
     1981 atcatgttac tagacacctg tcaggagatc ttcctgtggc ttggggaagc tgcaggtgaa
     2041 tggaagaaag aagcagtggc ctggggcctt gagtacctga ggactcaccc agcagagagg
     2101 agcctggcca cacccatctt tgtggtcaag caaggccatg agccagccac ctttaccggg
     2161 tggtttgtca cctgggaccc ttacaagtgg atgaacagcc agtcctacga ggagatggtg
     2221 gggaacagcc tgggaccggg atctgcaatc tctgagatga cagcagaagt ccataacttc
     2281 cagctaactc cacggctgag tgataacaag gcaggtcacc cggcactgca ggccttcaag
     2341 ggttcccagg acagtccaga gaatgagctg gggctggacc tcagggtgga tggcgcaaac
     2401 cccagcatga accacaccag cagctgcagt gactcaatgg tcaatgggag cctgccccgg
     2461 gaaaggctga tgcaccaggc actggaggac ctgccaccgg gtgtggaccc agcccgtaag
     2521 gagttctatc tctcagactc tgatttccaa gacatcttcg ggaaatccaa ggaggagttc
     2581 tacagcatgg ccaagtggaa gcagcagcaa gcgaaaaaga agctgggctt cttctgatgt
     2641 ggggaaccct gtgccacata ccctgaaatt cctcctgggg taactcccac ttcctaataa
     2701 aagccagtgg ctggcatcgg gtgtggcacg tgtgcctgtg tgccttcgag ccccaccatc
     2761 tggtagagtc ccctcctcag tggcagggcc ctgtggcact ctgggacacc gtcttccgtg
     2821 gaaaggattc cttctgactg cttgcttccg gtcagaagag gtatgcatgt agatcttgag
     2881 ggactccctg gtgtctttgt aaagagacta gaagg
//
