LOCUS       NM_009509               3117 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus villin 1 (Vil1), mRNA.
ACCESSION   NM_009509
VERSION     NM_009509.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Mulet,I., Grueso-Cortina,C., Cortes-Cano,M., Gerovska,D., Wu,G.,
            Iakab,S.A., Jimenez-Blasco,D., Curtabbi,A., Hernansanz-Agustin,P.,
            Ketchum,H., Manjarres-Raza,I., Wunderlich,F.T., Bolanos,J.P.,
            Dawlaty,M.M., Hopf,C., Enriquez,J.A., Arauzo-Bravo,M.J. and
            Tapia,N.
  TITLE     TET3 regulates terminal cell differentiation at the metabolic level
  JOURNAL   Nat Commun 15 (1), 9749 (2024)
   PUBMED   39557858
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3117)
  AUTHORS   Gong,K., Xue,C., Feng,Z., Pan,R., Wang,M., Chen,S., Chen,Y.,
            Guan,Y., Dai,L., Zhang,S., Jiang,L., Li,L., Wang,B., Yin,Z., Ma,L.,
            Iwakiri,Y., Tang,J., Liao,C., Chen,H. and Duan,Y.
  TITLE     Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on
            the endoplasmic reticulum to inhibit PCSK1 cleavage
  JOURNAL   Nat Commun 15 (1), 6845 (2024)
   PUBMED   39122737
  REMARK    Erratum:[Nat Commun. 2024 Sep 10;15(1):7902. doi:
            10.1038/s41467-024-52287-5.. PMID: 39256382]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3117)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3117)
  AUTHORS   Hayashi,M., Kaye,J.A., Douglas,E.R., Joshi,N.R., Gribble,F.M.,
            Reimann,F. and Liberles,S.D.
  TITLE     Enteroendocrine cell lineages that differentially control feeding
            and gut motility
  JOURNAL   Elife 12, e78512 (2023)
   PUBMED   36810133
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3117)
  AUTHORS   Douchi,D., Yamamura,A., Matsuo,J., Melissa Lim,Y.H.,
            Nuttonmanit,N., Shimura,M., Suda,K., Chen,S., Pang,S., Kohu,K.,
            Abe,T., Shioi,G., Kim,G., Shabbir,A., Srivastava,S., Unno,M.,
            Bok-Yan So,J., Teh,M., Yeoh,K.G., Chuang,L.S.H. and Ito,Y.
  TITLE     Induction of Gastric Cancer by Successive Oncogenic Activation in
            the Corpus
  JOURNAL   Gastroenterology 161 (6), 1907-1923 (2021)
   PUBMED   34391772
REFERENCE   6  (bases 1 to 3117)
  AUTHORS   Chin,H., Krall,M., Kim,H.L., Kozak,C.A. and Mock,B.
  TITLE     The gene for the alpha 1 subunit of the skeletal muscle
            dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse
            chromosome 1
  JOURNAL   Genomics 14 (4), 1089-1091 (1992)
   PUBMED   1335956
REFERENCE   7  (bases 1 to 3117)
  AUTHORS   Barton,C.H., Ajioka,J.W., Roach,T.I. and Blackwell,J.M.
  TITLE     Mapping Creb-1 to chromosome 1 in the mouse
  JOURNAL   Genomics 14 (3), 790-792 (1992)
   PUBMED   1358811
REFERENCE   8  (bases 1 to 3117)
  AUTHORS   Vidal,S.M., Epstein,D.J., Malo,D., Weith,A., Vekemans,M. and
            Gros,P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   9  (bases 1 to 3117)
  AUTHORS   Maunoury,R., Robine,S., Pringault,E., Leonard,N., Gaillard,J.A. and
            Louvard,D.
  TITLE     Developmental regulation of villin gene expression in the
            epithelial cell lineages of mouse digestive and urogenital tracts
  JOURNAL   Development 115 (3), 717-728 (1992)
   PUBMED   1425351
REFERENCE   10 (bases 1 to 3117)
  AUTHORS   Lafuse,W.P., Brown,D. and Zwilling,B.S.
  TITLE     Assignment of the microtubule-associated protein 2 gene to mouse
            chromosome 1
  JOURNAL   Mamm Genome 3 (1), 48-51 (1992)
   PUBMED   1581633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB871941.1, AK027908.1, AI663456.1 and BY426484.1.
            
            On Jun 19, 2008 this sequence version replaced NM_009509.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015267.1, AK027908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BB871941.1         2-5
            5-155               AK027908.1         2-152
            156-198             AI663456.1         148-190
            199-3072            AK027908.1         196-3069
            3073-3117           BY426484.1         318-362
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.54 cM"
     gene            1..3117
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /note="villin 1"
                     /db_xref="GeneID:22349"
                     /db_xref="MGI:MGI:98930"
     exon            1..53
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            54..139
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2548
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /codon_start=1
                     /product="villin-1"
                     /protein_id="NP_033535.2"
                     /db_xref="CCDS:CCDS15049.1"
                     /db_xref="GeneID:22349"
                     /db_xref="MGI:MGI:98930"
                     /translation="MTKLNAQVKGSLNITTPGIQIWRIEAMQMVPVPSSTFGSFFDGD
                     CYVVLAIHKTSSTLSYDIHYWIGQDSSQDEQGAAAIYTTQMDDYLKGRAVQHREVQGN
                     ESETFRSYFKQGLVIRKGGVASGMKHVETNSCDVQRLLHVKGKRNVLAGEVEMSWKSF
                     NRGDVFLLDLGKLIIQWNGPESNRMERLRGMALAKEIRDQERGGRTYVGVVDGEKEGD
                     SPQLMAIMNHVLGPRKELKAAISDSVVEPAAKAALKLYHVSDSEGKLVVREVATRPLT
                     QDLLKHEDCYILDQGGLKIFVWKGKNANAQERSGAMSQALNFIKAKQYPPSTQVEVQN
                     DGAESPIFQQLFQKWTVPNRTSGLGKTHTVGSVAKVEQVKFDALTMHVQPQVAAQQKM
                     VDDGSGEVQVWRIEDLELVPVESKWLGHFYGGDCYLLLYTYLIGEKQHYLLYIWQGSQ
                     ASQDEIAASAYQAVLLDQKYNDEPVQIRVTMGKEPPHLMSIFKGRMVVYQGGTSRKNN
                     LEPVPSTRLFQVRGTNADNTKAFEVTARATSLNSNDVFILKTPSCCYLWCGKGCSGDE
                     REMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQEENQVITPRLFEC
                     SNQTGRFLATEIFDFNQDDLEEEDVFLLDVWDQVFFWIGKHANEEEKKAAATTVQEYL
                     KTHPGNRDLETPIIVVKQGHEPPTFTGWFLAWDPFKWSNTKSYDDLKAELGNSGDWSQ
                     IADEVMSPKVDVFTANTSLSSGPLPTFPLEQLVNKSVEDLPEGVDPSRKEEHLSTEDF
                     TRALGMTPAAFSALPRWKQQNIKKEKGLF"
     exon            140..214
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            215..411
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            412..520
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            521..631
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            632..834
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            835..913
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1012
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1166
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1267
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1405
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1564
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1744
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1890
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2035
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2224
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2293
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2434
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..3117
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2660
                     /gene="Vil1"
                     /gene_synonym="Vil"
     regulatory      3050..3055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /note="hexamer: AATAAA"
     polyA_site      3075
                     /gene="Vil1"
                     /gene_synonym="Vil"
                     /note="major polyA site"
ORIGIN      
        1 gcttgccaca acttcctaag atctcccagg tggtggctgc ctcttccaga caggctcgtc
       61 caccatgact aaactgaatg cccaagtcaa aggctctctc aacatcacca ctcccgggat
      121 acagatatgg aggatcgagg ctatgcagat ggtacctgtt ccttccagca cctttggaag
      181 cttcttcgat ggtgactgct atgtagtcct ggctatccac aagaccagca gcactctctc
      241 ctatgatatc cactactgga ttggccagga ctcgtcccag gatgagcagg gggcagctgc
      301 catctacacc acacagatgg atgactacct gaagggccgg gctgtccagc accgcgaggt
      361 tcaaggcaac gagagcgaga ctttccggag ctacttcaag caaggccttg tgatccggaa
      421 agggggagtg gcttccggca tgaagcacgt agaaacaaac tcctgtgatg tccagcgact
      481 gttgcacgtc aagggcaaga ggaatgtgct ggctggagag gtggaaatgt cctggaagag
      541 tttcaacaga ggggatgtct tcctgctgga ccttgggaag cttattatcc agtggaatgg
      601 gccagagagt aaccgcatgg agagacttcg gggcatggcc ttggccaaag agatccgaga
      661 ccaggaacgg ggtggacgta cctacgtagg tgtggtggac ggggagaagg aaggggactc
      721 cccacagctg atggcaatta tgaaccacgt gctgggccca cgcaaagaac tgaaggctgc
      781 tatttctgac tcagtggtgg agccggccgc taaggctgca ctcaagctgt accatgtgtc
      841 tgactccgaa ggaaaactgg tggttagaga agttgctact cggccactca cacaagacct
      901 gctcaagcat gaggactgtt acatcctgga ccagggaggc ctgaagatct ttgtgtggaa
      961 gggaaaaaat gccaacgctc aggagaggag cggagccatg agccaggcct tgaacttcat
     1021 caaagccaag cagtacccac cgagcacgca ggttgaggtg cagaatgacg gggccgagtc
     1081 ccccatcttc caacaactct tccagaagtg gacagtgccc aaccggacct caggcctcgg
     1141 caaaacccac actgtgggct ctgtggctaa ggtggaacag gtgaagtttg atgctctgac
     1201 catgcatgta caacctcagg tggctgccca gcagaaaatg gtggatgacg ggagtgggga
     1261 agtgcaggtg tggcgcatcg aggacttgga gctggtgcct gtggagtcca agtggctggg
     1321 ccatttctac ggtggtgact gctacctgct gctctacacc tacctcatag gggaaaagca
     1381 acactacttg ttatatatct ggcagggcag ccaggccagc caggatgaaa ttgcagcctc
     1441 ggcgtatcaa gccgtcctgt tggaccagaa gtacaatgac gagccagtac agatccgggt
     1501 cacgatgggc aaggagccgc ctcacctcat gtctatcttc aagggccgca tggtggttta
     1561 tcagggaggc acctcccgaa agaacaactt ggagcctgtg ccctctacga ggctatttca
     1621 ggtccgaggg accaatgctg ataacaccaa ggcttttgag gtgacagccc gggccacgtc
     1681 cctcaactcc aatgatgtct tcatactcaa gactccgtcc tgctgctacc tgtggtgtgg
     1741 gaagggctgc agtggggatg agagggagat ggccaagatg gttgctgata ccatctctcg
     1801 gacggagaaa caagtggtag tagaggggca ggagccagcc aacttctgga tggctctggg
     1861 cgggaaggcg ccctacgcca acaccaagag gctgcaggag gaaaaccaag tcatcactcc
     1921 tcggctcttc gagtgctcca accagaccgg acgctttctg gccacagaga tctttgactt
     1981 caatcaggat gacctggagg aggaggatgt gttcctattg gatgtctggg accaggtctt
     2041 cttctggata gggaaacatg ccaatgagga agagaagaag gctgcagcta caactgtaca
     2101 agaatacctc aagacccacc ctggaaaccg agaccttgag acccctatca tcgtggtgaa
     2161 gcagggacac gagcccccca ccttcacagg ctggttcctg gcttgggatc ccttcaagtg
     2221 gagtaacacc aaatcctatg atgaccttaa ggcagagctg ggaaactctg gggactggag
     2281 ccagattgct gacgaggtta tgagcccgaa agtggacgtt ttcactgcca ataccagtct
     2341 gagttctggg cccctgccca ccttccccct ggagcagctg gtaaacaagt ctgtagagga
     2401 tctccctgag ggtgtggacc ccagcaggaa ggaggagcac ctgtccaccg aagacttcac
     2461 tagggccttg ggcatgactc cagctgcctt ctctgccctg cctcgatgga agcaacaaaa
     2521 catcaagaaa gaaaaaggac tgttttgaga attgaagctc tctggctgtc cagcagcccc
     2581 taccctgcct tcaagggctt tgtgccgcca ttactggttt tagtcctgtg gcagatgaaa
     2641 atgtccaatt gtacctgtga gccacagtgt gacaattcct tttgtttata atagtaattt
     2701 gcccattcct tcagacgcat gccacagacc catggaaatc ttgtagagtt ttcttttctt
     2761 agatggacag ctaagtactc caggagacat tagcgtctgg gggtttctct ggcaccgtca
     2821 ctcactcagg atcttatcct gatcttaccc tcctcacact caaaagggag ggctaaggcc
     2881 aaagctgggc ttacagctct aacccagagc ctttgcaaag ctccacagac tcctcaaatg
     2941 acaacaccag gaacatgggt ttgctacgtg aagtccaatc agaagccaat aggtgatttt
     3001 ctcttaaaac tggttatcca gtgtccccag gaacatgtcc ctttaaacaa ataaatcaaa
     3061 ctaatatgag gttaataaag gctttaatgt ctctcacaca ttaaaacaaa acaaaac
//
