LOCUS       NM_009507               2758 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus von Hippel-Lindau tumor suppressor (Vhl), mRNA.
ACCESSION   NM_009507
VERSION     NM_009507.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2758)
  AUTHORS   Shen,H., Ojo,O.A., Ding,H., Mullen,L.J., Xing,C., Hossain,M.I.,
            Yassin,A., Shi,V.Y., Lewis,Z., Podgorska,E., Andrabi,S.A.,
            Antoniewicz,M.R., Bonner,J.A. and Shi,L.Z.
  TITLE     HIF1alpha-regulated glycolysis promotes activation-induced cell
            death and IFN-gamma induction in hypoxic T cells
  JOURNAL   Nat Commun 15 (1), 9394 (2024)
   PUBMED   39477954
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2758)
  AUTHORS   Fan,Z., Karakone,M., Nagarajan,S., Nagy,N., Mildenberger,W.,
            Petrova,E., Hinte,L.C., Bijnen,M., Hane,P., Nelius,E., Chen,J.,
            Ferapontova,I., von Meyenn,F., Trepiccione,F., Berber,M.,
            Ribas,D.P., Eichmann,A., Zennaro,M.C., Takeda,N., Fischer,J.W.,
            Spyroglou,A., Reincke,M., Beuschlein,F., Loffing,J., Greter,M. and
            Stockmann,C.
  TITLE     Macrophages preserve endothelial cell specialization in the adrenal
            gland to modulate aldosterone secretion and blood pressure
  JOURNAL   Cell Rep 43 (7), 114395 (2024)
   PUBMED   38941187
REFERENCE   3  (bases 1 to 2758)
  AUTHORS   Grammer,C., Komorowska,J.A. and Swann,J.B.
  TITLE     Vhl safeguards thymic epithelial cell identity and thymopoietic
            capacity by constraining Hif1a activity during development
  JOURNAL   iScience 27 (7), 110258 (2024)
   PUBMED   39040069
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2758)
  AUTHORS   Ting,K.K.Y., Yu,P., Dow,R., Ibrahim,H., Karim,S., Polenz,C.K.,
            Winer,D.A., Woo,M., Jongstra-Bilen,J. and Cybulsky,M.I.
  TITLE     Cholesterol accumulation impairs HIF-1alpha-dependent
            immunometabolic reprogramming of LPS-stimulated macrophages by
            upregulating the NRF2 pathway
  JOURNAL   Sci Rep 14 (1), 11162 (2024)
   PUBMED   38750095
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2758)
  AUTHORS   Wolf,M.M., Madden,M.Z., Arner,E.N., Bader,J.E., Ye,X., Vlach,L.,
            Tigue,M.L., Landis,M.D., Jonker,P.B., Hatem,Z., Steiner,K.K.,
            Gaines,D.K., Reinfeld,B.I., Hathaway,E.S., Xin,F., Tantawy,M.N.,
            Haake,S.M., Jonasch,E., Muir,A., Weiss,V.L., Beckermann,K.E.,
            Rathmell,W.K. and Rathmell,J.C.
  TITLE     VHL loss reprograms the immune landscape to promote an inflammatory
            myeloid microenvironment in renal tumorigenesis
  JOURNAL   J Clin Invest 134 (8), e173934 (2024)
   PUBMED   38618956
  REMARK    GeneRIF: VHL loss reprograms the immune landscape to promote an
            inflammatory myeloid microenvironment in renal tumorigenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2758)
  AUTHORS   Makalowski,W., Zhang,J. and Boguski,M.S.
  TITLE     Comparative analysis of 1196 orthologous mouse and human
            full-length mRNA and protein sequences
  JOURNAL   Genome Res 6 (9), 846-857 (1996)
   PUBMED   8889551
REFERENCE   7  (bases 1 to 2758)
  AUTHORS   Gnarra,J.R., Duan,D.R., Weng,Y., Humphrey,J.S., Chen,D.Y., Lee,S.,
            Pause,A., Dudley,C.F., Latif,F., Kuzmin,I., Schmidt,L., Duh,F.M.,
            Stackhouse,T., Chen,F., Kishida,T., Wei,M.H., Lerman,M.I., Zbar,B.,
            Klausner,R.D. and Linehan,W.M.
  TITLE     Molecular cloning of the von Hippel-Lindau tumor suppressor gene
            and its role in renal carcinoma
  JOURNAL   Biochim Biophys Acta 1242 (3), 201-210 (1996)
   PUBMED   8603073
  REMARK    Review article
REFERENCE   8  (bases 1 to 2758)
  AUTHORS   Kikuchi,Y., Kobayashi,E., Nishizawa,M., Hamazaki,S., Okada,S. and
            Hino,O.
  TITLE     Cloning of the rat homologue of the von Hippel-Lindau tumor
            suppressor gene and its non-somatic mutation in rat renal cell
            carcinomas
  JOURNAL   Jpn J Cancer Res 86 (10), 905-909 (1995)
   PUBMED   7493907
REFERENCE   9  (bases 1 to 2758)
  AUTHORS   Kessler,P.M., Vasavada,S.P., Rackley,R.R., Stackhouse,T., Duh,F.M.,
            Latif,F., Lerman,M.I., Zbar,B. and Williams,B.R.
  TITLE     Expression of the Von Hippel-Lindau tumor suppressor gene, VHL, in
            human fetal kidney and during mouse embryogenesis
  JOURNAL   Mol Med 1 (4), 457-466 (1995)
   PUBMED   8521303
REFERENCE   10 (bases 1 to 2758)
  AUTHORS   Gao,J., Naglich,J.G., Laidlaw,J., Whaley,J.M., Seizinger,B.R. and
            Kley,N.
  TITLE     Cloning and characterization of a mouse gene with homology to the
            human von Hippel-Lindau disease tumor suppressor gene: implications
            for the potential organization of the human von Hippel-Lindau
            disease gene
  JOURNAL   Cancer Res 55 (4), 743-747 (1995)
   PUBMED   7850784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153987.4.
            
            On May 30, 2018 this sequence version replaced NM_009507.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052417.1, AK171264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               AC153987.4         54549-54933
            386-508             AC153987.4         58647-58769
            509-2758            AC153987.4         59940-62189
FEATURES             Location/Qualifiers
     source          1..2758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.81 cM"
     gene            1..2758
                     /gene="Vhl"
                     /gene_synonym="pVHL; Vhlh"
                     /note="von Hippel-Lindau tumor suppressor"
                     /db_xref="GeneID:22346"
                     /db_xref="MGI:MGI:103223"
     exon            1..385
                     /gene="Vhl"
                     /gene_synonym="pVHL; Vhlh"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..693
                     /gene="Vhl"
                     /gene_synonym="pVHL; Vhlh"
                     /note="von Hippel-Lindau syndrome protein homolog"
                     /codon_start=1
                     /product="von Hippel-Lindau disease tumor suppressor"
                     /protein_id="NP_033533.1"
                     /db_xref="CCDS:CCDS20429.1"
                     /db_xref="GeneID:22346"
                     /db_xref="MGI:MGI:103223"
                     /translation="MPRKAASPEEAAGEPGPEEMEAGRPRPVLRSVNSREPSQVIFCN
                     RSPRVVLPLWLNFDGEPQPYPILPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELF
                     VPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDYPSV
                     RKDIQRLSQEHLESQHLEEEP"
     exon            386..508
                     /gene="Vhl"
                     /gene_synonym="pVHL; Vhlh"
                     /inference="alignment:Splign:2.1.0"
     exon            509..2758
                     /gene="Vhl"
                     /gene_synonym="pVHL; Vhlh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2734..2739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vhl"
                     /gene_synonym="pVHL; Vhlh"
                     /note="hexamer: AATAAA"
     polyA_site      2757
                     /gene="Vhl"
                     /gene_synonym="pVHL; Vhlh"
                     /note="major polyA site"
ORIGIN      
        1 agtttgaggg ctcccggcgg ccatttccgc cttcaagttg cccggagcgc gtctgggacc
       61 ggcagacctg tcccggagcg cgtagatccg cacgcacgca cgcgccgccc acgtccagct
      121 tgcgaatccg agggacccgt tccaataatg ccccggaagg cagccagtcc agaggaggcg
      181 gcgggggagc ccggtcctga ggagatggag gctgggcggc cgcggccggt gctgcgctcg
      241 gtgaactcgc gcgagccctc tcaggtcatc ttctgcaacc gcagcccgcg cgtcgtgctg
      301 cctttgtggc tcaacttcga cggcgagcct cagccctacc cgatcttacc accgggcacc
      361 ggccgccgca tccacagcta ccgaggtcat ctttggctct tcagggatgc ggggacccat
      421 gatggacttc tggttaacca aacggagctg tttgtgccat ccctcaatgt cgatggacag
      481 cctatttttg ccaacatcac attgccagtg tataccctga aagagcggtg ccttcaggtt
      541 gtgcggagcc tggtcaagcc tgagaactac aggagactgg acatcgtcag gtcactctat
      601 gaggatttgg aggactaccc aagtgtgcgg aaggacatac agcgactgag ccaagagcac
      661 cttgagagtc agcacctgga agaggagcct tgaaggagtc catggagatt aagtgttcct
      721 gagtttcagc cttgatggtc cgagattgat ctacacatag gacaggtcac tttctttcag
      781 ttttaaaatg gttcattctt ggagtaaaac tatccatcac gtaaaagaaa gttaactaac
      841 atccctgggc tttgtagtgt ttaagaataa acatgcaaag tgccactgcg tctgcccttt
      901 gtagagcact cacccgaggg aggaagacgt tttcagtttt gcttcctggt gaggctggaa
      961 gttgagtgta aggatgactg tgtaataagc tcagcagcag gagttgtact gtgtcctttc
     1021 atttgagcag agggctcttg cttgggaagg cagagaaggc ccttcccaaa cgctgggaca
     1081 gacctcctgt ggaggcccgc tgcctaaagc gtggagtctt cagtcatgaa tgttggacga
     1141 agaaaccatt ggatgcttgg tgggagagtt gggagggcct ggctctttgt ctgaggagag
     1201 ccttaagtgt tcatgtaagg aacagcttag cagcttctga tttcccacgt cccagcactt
     1261 tctctctgtt ttttatttta tttttgagac ttttgtatag cccaggccag cctcagtcac
     1321 tcagcagagg attcctgacc ctctgggatt atgtctcctg acattgggaa cacatgtgtg
     1381 cacacagcct gctctgctct tccttttccc atgttgagac gggctcctgc tgtagtcctg
     1441 cctggcctga gctggagtcg gtcctgcctc ctgaccgacc gtctggctgc tttctaagct
     1501 gggtagactt cccatactca ctgttacaga cagttacagc agagaagaac catccttgtg
     1561 taagtctggt tttgagagct cctgtctctg aggaagctgt tggcaggagc agggatttct
     1621 gttccttctt gtcagcccct agcattccac tttgttttgg caggcgctgg ttctgctttg
     1681 taggtggaag tgaagctcca ctcagccaca gactccagac agtgggtcac agagcagtct
     1741 ggaatgtgta gcagtcttat ggatggtcac agcttttctt acatattcat attctatcaa
     1801 acgttttgta aagtataatt ttttatttat ttttaatccc cttagagaaa aagtaaaagt
     1861 agagaagcct gggtattgtg tacacaacag aaaggacagt caaggaaagg gaagcagaaa
     1921 ggctcttatg tactctcagc ttcatgcaac ccctgtaact ggccgcatat gtagggcata
     1981 ttttaattgg ttaaagcagt ttgttgtggc tgaggtcata agatatatac agttttgtat
     2041 cctgattttt cactgaactt cattgttttt tgtttgcttg cttttccctt cttctttgtt
     2101 ttttgcttta ttgagatagg gtttctctgt agcccaggct gtcctagaac tccctttgta
     2161 gaccaaacat ctgattactg gcctcacatg gagagatctg tctctgcttt tccagcgctg
     2221 ggattgaagt aggcctaatc ttcatctaac ttcttagctt gtcttttcca tgttactaca
     2281 cacactgtgt aaataccagt gtgctaccct ccttctttga gggtgactgt tgggagtatt
     2341 tgtccaaatc ctgggctcct tgagtgcaga ctgatgctct aagatcagca aaatgactga
     2401 actacatcct aacacttccc agtgtcctct cagtgtctct tcttatctgc agcattgcag
     2461 gagtgaagtg gccacagacc agtgtggagg cctgtgtgtg ggaagtcagc aggtgccaag
     2521 ctattgaaac attggtttta tttttttaaa ccgatctctg tctctaaaag atgtgatgtt
     2581 tgtgttattc agctggaagt ttgaatactg ttctctgtgc tgtccaacaa gtgaagagtt
     2641 atgaaatgag ccacttgtcc tgggacatcc tgtaatgagt tcctcgggct tttctcctgt
     2701 gagttttctg aaaaaagctg acctttttag tacaataaac ggtgctaatt gaaggaag
//
