LOCUS       NM_177683               3563 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus vestigial like family member 4 (Vgll4), transcript
            variant 1, mRNA.
ACCESSION   NM_177683
VERSION     NM_177683.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3563)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3563)
  AUTHORS   Tian,Q., Li,J., Wu,B., Wang,J., Xiao,Q., Tian,N., Yi,L., Luo,M.,
            Li,Z., Pang,Y., Shi,X. and Dong,Z.
  TITLE     Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to
            ameliorate neuronal dysfunction in a cellular model relevant to
            Alzheimer's disease
  JOURNAL   FASEB J 37 (12), e23290 (2023)
   PUBMED   37921465
  REMARK    GeneRIF: Hypoxia-sensing VGLL4 promotes LDHA-driven lactate
            production to ameliorate neuronal dysfunction in a cellular model
            relevant to Alzheimer's disease.
REFERENCE   3  (bases 1 to 3563)
  AUTHORS   Zhong,Y., Tan,X., Wang,X., Jiang,J., Song,K., Chen,H., Zhang,H.,
            Wang,Z., Zhang,L., Guo,C., Liang,H. and Yu,W.
  TITLE     Generation of Vgll4-DreER transgenic mouse for visualizing and
            manipulating VGLL4-expressing cells in vivo
  JOURNAL   J Biochem Mol Toxicol 37 (10), e23435 (2023)
   PUBMED   37352117
REFERENCE   4  (bases 1 to 3563)
  AUTHORS   Sheldon,C., Farley,A., Ma,Q., Pu,W.T. and Lin,Z.
  TITLE     Depletion of VGLL4 Causes Perinatal Lethality without Affecting
            Myocardial Development
  JOURNAL   Cells 11 (18), 2832 (2022)
   PUBMED   36139407
  REMARK    GeneRIF: Depletion of VGLL4 Causes Perinatal Lethality without
            Affecting Myocardial Development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3563)
  AUTHORS   Nezhad,F.Y., Riermeier,A., Schonfelder,M., Becker,L., de
            Angelis,M.H. and Wackerhage,H.
  TITLE     Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that
            Lats1 deletion increases the percentage of type I muscle fibers
  JOURNAL   Transgenic Res 31 (2), 227-237 (2022)
   PUBMED   34984591
REFERENCE   6  (bases 1 to 3563)
  AUTHORS   Xie,W., Hao,J., Zhang,K., Fang,X. and Liu,X.
  TITLE     Adenovirus armed with VGLL4 selectively kills hepatocellular
            carcinoma with G2/M phase arrest and apoptosis promotion
  JOURNAL   Biochem Biophys Res Commun 503 (4), 2758-2763 (2018)
   PUBMED   30119884
  REMARK    GeneRIF: Adenovirus armed with VGLL4 selectively kills
            hepatocellular carcinoma in a mouse model with G2/M phase arrest
            and apoptosis promotion.
REFERENCE   7  (bases 1 to 3563)
  AUTHORS   Lin,Z., Guo,H., Cao,Y., Zohrabian,S., Zhou,P., Ma,Q., VanDusen,N.,
            Guo,Y., Zhang,J., Stevens,S.M., Liang,F., Quan,Q., van Gorp,P.R.,
            Li,A., Dos Remedios,C., He,A., Bezzerides,V.J. and Pu,W.T.
  TITLE     Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal
            Cardiac Growth
  JOURNAL   Dev Cell 39 (4), 466-479 (2016)
   PUBMED   27720608
  REMARK    GeneRIF: VGLL4 inhibits cardiomyocyte proliferation by inhibiting
            TEAD1-YAP interaction and by targeting TEAD1 for degradation.
REFERENCE   8  (bases 1 to 3563)
  AUTHORS   Jiao,S., Wang,H., Shi,Z., Dong,A., Zhang,W., Song,X., He,F.,
            Wang,Y., Zhang,Z., Wang,W., Wang,X., Guo,T., Li,P., Zhao,Y., Ji,H.,
            Zhang,L. and Zhou,Z.
  TITLE     A peptide mimicking VGLL4 function acts as a YAP antagonist therapy
            against gastric cancer
  JOURNAL   Cancer Cell 25 (2), 166-180 (2014)
   PUBMED   24525233
REFERENCE   9  (bases 1 to 3563)
  AUTHORS   Mann,K.M., Ward,J.M., Yew,C.C., Kovochich,A., Dawson,D.W.,
            Black,M.A., Brett,B.T., Sheetz,T.E., Dupuy,A.J., Chang,D.K.,
            Biankin,A.V., Waddell,N., Kassahn,K.S., Grimmond,S.M., Rust,A.G.,
            Adams,D.J., Jenkins,N.A. and Copeland,N.G.
  CONSRTM   Australian Pancreatic Cancer Genome Initiative
  TITLE     Sleeping Beauty mutagenesis reveals cooperating mutations and
            pathways in pancreatic adenocarcinoma
  JOURNAL   Proc Natl Acad Sci U S A 109 (16), 5934-5941 (2012)
   PUBMED   22421440
REFERENCE   10 (bases 1 to 3563)
  AUTHORS   Chen,H.H., Mullett,S.J. and Stewart,A.F.
  TITLE     Vgl-4, a novel member of the vestigial-like family of transcription
            cofactors, regulates alpha1-adrenergic activation of gene
            expression in cardiac myocytes
  JOURNAL   J Biol Chem 279 (29), 30800-30806 (2004)
   PUBMED   15140898
  REMARK    GeneRIF: Vgl-4 modulates the activity of TEF-1 factors and
            counteracts alpha1-adrenergic activation of gene expression in
            cardiac myocytes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149276.2.
            
            On Aug 29, 2022 this sequence version replaced NM_177683.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.2063799.1,
                                           SRR17784643.1099539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               AC149276.2         87844-88348         c
            506-695             AC149276.2         57144-57333         c
            696-891             AC149276.2         30411-30606         c
            892-1015            AC149276.2         29283-29406         c
            1016-3563           AC149276.2         26416-28963         c
FEATURES             Location/Qualifiers
     source          1..3563
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.07 cM"
     gene            1..3563
                     /gene="Vgll4"
                     /gene_synonym="VGL-4"
                     /note="vestigial like family member 4"
                     /db_xref="GeneID:232334"
                     /db_xref="MGI:MGI:2652840"
     exon            1..505
                     /gene="Vgll4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..1287
                     /gene="Vgll4"
                     /gene_synonym="VGL-4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription cofactor vestigial-like protein 4; vestigial
                     like 4"
                     /codon_start=1
                     /product="transcription cofactor vestigial-like protein 4
                     isoform 1"
                     /protein_id="NP_808351.1"
                     /db_xref="CCDS:CCDS20436.1"
                     /db_xref="GeneID:232334"
                     /db_xref="MGI:MGI:2652840"
                     /translation="MLFMKMDLLNYQYLDKMNNNIGVLCYEGEASLRGEPRMQTLPVA
                     SALSSHRTGPPPISPSKRKFSMEPGDKDLDCENDHVSKMSRIFSPHLNKTVNGDCRRD
                     PRERSRSPIERAAAPAVSLHGGHLYASLPSLMEQPLALTKNSSDTGRSAVERQQNRPS
                     VITCASAGARNCNLSHCPIAHSGCSAPGSASYRRPPSATATCDPVVEEHFRRSLGKNY
                     KEPEPAPNSVSITGSVDDHFAKALGDTWLQIKAAKDSASSSPESASRRGQPASPTAHM
                     VSHSHSPSVVS"
     exon            506..695
                     /gene="Vgll4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            696..891
                     /gene="Vgll4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1015
                     /gene="Vgll4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..3563
                     /gene="Vgll4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3543..3548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vgll4"
                     /gene_synonym="VGL-4"
                     /note="hexamer: AATAAA"
     polyA_site      3563
                     /gene="Vgll4"
                     /gene_synonym="VGL-4"
                     /note="major polyA site"
ORIGIN      
        1 gagtcatacc aagcatagcc cgcatgtcag tgcagtcagc ttgcagcggg ctgtgaggga
       61 gagtgccttt gtcctgagaa atgtgctttg tgtttttctt ttttactgct ttctttttaa
      121 acccccaaga cgggctcgag aagtcttctg aaatgatttt ttaaagccga atagaagaca
      181 caatcagaca ccttccacaa gcccttgacg ggttttgttt gagtctgatt tttgtgtgtg
      241 tgtgtgtgtg tgtatgattt ttaaaaacct tttacatact ttgttttgat ctcctgaggc
      301 tgggcctctg tcttcctgaa gttttaggag agcctggagc tactcagcta agactgaatt
      361 ttgaaacttt ctctttgggg gtgaaagcaa agaactgttt ttctttgcta gccggacaga
      421 taaatgctgt ttatgaagat ggacctgttg aactaccaat acttggacaa gatgaacaac
      481 aatatcggcg ttctgtgcta tgaaggtgaa gcttccctca ggggagaacc caggatgcag
      541 accctcccgg tggcctctgc gctcagcagt caccgcacag gcccgcctcc catcagcccc
      601 agcaagagga aattcagcat ggagcccggg gacaaggact tggactgtga aaacgaccac
      661 gtctccaaga tgagccgcat cttcagcccc catttgaata agactgtcaa cggagactgc
      721 cgcagagatc cccgggagcg gagccgcagt cccattgaac gggctgcagc ccccgccgtg
      781 agcttgcatg gtggccacct gtacgcatct ctccccagcc tcatggagca gcctcttgcc
      841 ctgactaaga acagcagtga cacaggcagg tcagctgtgg agcggcagca gaaccggccc
      901 tctgtgatta cctgtgcatc cgcgggtgcc cgcaactgca acctctctca ctgtcccatc
      961 gcacacagtg gctgttctgc gcctgggtct gccagctacc ggagaccacc cagtgcaact
     1021 gccacctgtg accctgtggt ggaagagcac ttccgtcgga gcctgggcaa gaactacaag
     1081 gagccagagc cggcgcctaa ctcggtgtcc atcactggct cagtggatga ccactttgcc
     1141 aaagcactag gtgacacatg gcttcagatc aaagcagcca aggacagcgc atccagcagc
     1201 ccggagtcag cctcacgcag gggccagcca gccagcccca ctgcccacat ggtcagccat
     1261 agtcactccc cctctgtggt ctcctgaagg gggaaccacc cttcgaccac acaggaatct
     1321 gcatggtttg cctgagcttt gaacagtcag tgcttaaaaa aacagaaaga aaaaaaaaat
     1381 cctgggggga gggtgggtgg gtggtttatt cgcaaaacca tgttgtctgg acttctgttc
     1441 tgctctgttt tatacttgct tggtgttcat acaaggggcc tcagtgtggc aacagaacag
     1501 cacggagcat taagtccagc agagcatcct tgctccctgc cccggttacc aaagaaacct
     1561 ctgcaggtct gccacctggc agccgggacc ctgccgccct ttctcagtca caagccatga
     1621 cgacatgggg atccggacgc tttgtgctct tagcttctgt ggccgggtat gcacagcttg
     1681 gcttccacct gagcctggct cagtctgcat ttgcatgtgt ctgcctgaag acaactgtcc
     1741 tgatttgcac tacggagggc agagctgcct gctgggcagc tgtctgagat gccagtactg
     1801 agggcaaact gctagggaat acttctgacc atgtgtgctt gcattgttgc tgaacttaga
     1861 gggtctctag caggttctag gtctttctct aggcttgagg tgctcacagc tggactgcag
     1921 actccccctg accatgggca tttcccttct ctgagcactg cagtctgtga ggccggggac
     1981 aaggctggag gactccgtag tgcttctgac atggtgcatg tctcaaaaga aaaaaaaata
     2041 gctggtttct attgactaag cccagactgt agcactgcct ggcttcttgt ctggcctctt
     2101 gtcagcatta gcctgcgtca tcagtttcag ccctgataca ttcactgctg gtacagctgt
     2161 gcttctggga tgagtcaacg ctcactttac tccagagagg agcgcacagc cagtgggtgt
     2221 ggcaggctgg ggaagcccat tgctgctcat tttctgcatc ctgggctggg gacttggagt
     2281 tcatgtcttt aggctccttg atacacagac tgctcctttc caactcctgg ccaaacatcc
     2341 ggtgcctgac agcctgcagc gtggggctgc gtgcatgtcc tcctatgctg gggccaaggc
     2401 tgtacacatt cctctgacta tacagttatt cctgcactat taatagctac taactagaca
     2461 ttaggagcca gcaggacaga cacggctagg gatgcccgac agctgctgtt tctcccagcc
     2521 ttgagtgttt ctgtcccctg gcctggccca cctgagggca tcacctggct aggagctcct
     2581 cccccacaag gcattatgga ctcctgcaca gggaatcatg gggctgactt ttagtaggag
     2641 gaaacaggtt agctgtcgaa cttgggaaac ctgcacgggt gggaaggtgg ggactgatcc
     2701 tcgtggtcac agggtggcta ctggccttta caaacatgga cagccctcct cctgccccgc
     2761 acaaggttca cccactctcc tgggcttcca agcttggcat tcaggcccct atattttctg
     2821 taggaaaaaa agaattgttc agaacacttt ttttatatag gtaattttaa agaccatcat
     2881 tacgctgtgc gtaaagaatg tacagagaaa tttgtaggta ttttttgaag aacaattaat
     2941 ttgttaatga tatgtagcta tttaattttc cctttcctat cataatcatt catttttttg
     3001 ttgttgttgt ttgggggaaa aaagttgatc ttttttgtcg taggtgtgtc tgtaatcgtg
     3061 caggtacaca gttactccat gacaacactg cgtccgcatt aatagccact agtttgttat
     3121 tctacaggct actgaggttg tcacaggaaa acaaccgcac cgcggactgg ctctgtgggc
     3181 aacgggcctc agatacccgt cagtgagcgg gtcgtcgctg ttgggggagg gggggatggc
     3241 agtgcgggtg gctgggtccc tggtgcgctg acctatctgg aataggccgt gccctggagt
     3301 gggatacctc atttgtcagc tgaggagcct gccagcccgc ttgggcagga gcttgcgacc
     3361 tccccagaac caagccatct atgtgtgtgc tgacccctct gtgtttgtaa atctgtaata
     3421 taccattttc tgtggcctgt ttttttttcc tggaagaaga aaaaaaaaaa ggtttggcag
     3481 gccatctttt tttttttttt tttttttttt tttttgtact taaaagtagc cttaagaaca
     3541 ataataaagt gctcttaaac cga
//
