LOCUS       NM_153786               1667 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus vestigial like family member 2 (Vgll2), transcript
            variant 1, mRNA.
ACCESSION   NM_153786
VERSION     NM_153786.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1667)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   2  (bases 1 to 1667)
  AUTHORS   Niki,Y., Kobayashi,Y. and Moriyama,K.
  TITLE     Expression pattern of transcriptional enhanced associate domain
            family member 1 (Tead1) in developing mouse molar tooth
  JOURNAL   Gene Expr Patterns 40, 119182 (2021)
   PUBMED   33984529
REFERENCE   3  (bases 1 to 1667)
  AUTHORS   Aslanpour,S., Rosin,J.M., Balakrishnan,A., Klenin,N., Blot,F.,
            Gradwohl,G., Schuurmans,C. and Kurrasch,D.M.
  TITLE     Ascl1 is required to specify a subset of ventromedial hypothalamic
            neurons
  JOURNAL   Development 147 (10) (2020)
   PUBMED   32253239
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1667)
  AUTHORS   Aslanpour,S., Han,S., Schuurmans,C. and Kurrasch,D.M.
  TITLE     Neurog2 Acts as a Classical Proneural Gene in the Ventromedial
            Hypothalamus and Is Required for the Early Phase of Neurogenesis
  JOURNAL   J Neurosci 40 (18), 3549-3563 (2020)
   PUBMED   32273485
REFERENCE   5  (bases 1 to 1667)
  AUTHORS   Kurrasch,D.M., Cheung,C.C., Lee,F.Y., Tran,P.V., Hata,K. and
            Ingraham,H.A.
  TITLE     The neonatal ventromedial hypothalamus transcriptome reveals novel
            markers with spatially distinct patterning
  JOURNAL   J Neurosci 27 (50), 13624-13634 (2007)
   PUBMED   18077674
REFERENCE   6  (bases 1 to 1667)
  AUTHORS   Kitagawa,M.
  TITLE     A Sveinsson's chorioretinal atrophy-associated missense mutation in
            mouse Tead1 affects its interaction with the co-factors YAP and TAZ
  JOURNAL   Biochem Biophys Res Commun 361 (4), 1022-1026 (2007)
   PUBMED   17689488
REFERENCE   7  (bases 1 to 1667)
  AUTHORS   Chen,H.H., Maeda,T., Mullett,S.J. and Stewart,A.F.
  TITLE     Transcription cofactor Vgl-2 is required for skeletal muscle
            differentiation
  JOURNAL   Genesis 39 (4), 273-279 (2004)
   PUBMED   15287000
  REMARK    GeneRIF: Vestigial like 2 homolog is required for muscle gene
            expression, in part by switching DNA binding of TEF-1 factors
            during muscle differentiation.
            GeneRIF: A transcription cofactor required for skeletal muscle
            differentiation that modifies DNA target selectivity of the
            Transcriptional Enhancer Factor-1 (TEF-1) transcription factors.
REFERENCE   8  (bases 1 to 1667)
  AUTHORS   Gunther,S., Mielcarek,M., Kruger,M. and Braun,T.
  TITLE     VITO-1 is an essential cofactor of TEF1-dependent muscle-specific
            gene regulation
  JOURNAL   Nucleic Acids Res 32 (2), 791-802 (2004)
   PUBMED   14762206
  REMARK    GeneRIF: VITO-1 is a crucial new cofactor of the muscle regulatory
            programme; VITO-1, a new scalloped interaction domain-containing
            protein, binds to TEF1 in vitro and strongly stimulates
            transcription of a reporter plasmid together with TEF-1
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1667)
  AUTHORS   Maeda,T., Chapman,D.L. and Stewart,A.F.
  TITLE     Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2
            transcription factors that promotes skeletal muscle differentiation
  JOURNAL   J Biol Chem 277 (50), 48889-48898 (2002)
   PUBMED   12376544
REFERENCE   10 (bases 1 to 1667)
  AUTHORS   Mielcarek,M., Gunther,S., Kruger,M. and Braun,T.
  TITLE     VITO-1, a novel vestigial related protein is predominantly
            expressed in the skeletal muscle lineage
  JOURNAL   Mech Dev 119 Suppl 1, S269-S274 (2002)
   PUBMED   14516696
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153950.8, AK048390.1 and
            AF542181.1.
            
            On Jul 17, 2014 this sequence version replaced NM_153786.1.
            
            Summary: This gene is a member of the Vestigial-like (Vgl) gene
            family and is upregulated during muscle differentiation. The
            product of this gene interacts with and modifies the DNA-binding
            properties of the transcription factor, TEF-1, and is important for
            muscle tissue development. Reduced expression of this gene leads to
            a reduction in the terminal differentiation of muscle cells.
            Alternate splicing results in multiple protein isoforms. [provided
            by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF542181.1, AJ578054.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC153950.8         61135-61163         c
            30-184              AK048390.1         2-156
            185-1667            AF542181.1         1-1483
FEATURES             Location/Qualifiers
     source          1..1667
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 26.16 cM"
     gene            1..1667
                     /gene="Vgll2"
                     /gene_synonym="C130057C21Rik; vgl-2; VITO-1; Vito1"
                     /note="vestigial like family member 2"
                     /db_xref="GeneID:215031"
                     /db_xref="MGI:MGI:2447460"
     exon            1..302
                     /gene="Vgll2"
                     /gene_synonym="C130057C21Rik; vgl-2; VITO-1; Vito1"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1190
                     /gene="Vgll2"
                     /gene_synonym="C130057C21Rik; vgl-2; VITO-1; Vito1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription cofactor vestigial-like protein 2; vestigial
                     like 2 homolog"
                     /codon_start=1
                     /product="transcription cofactor vestigial-like protein 2
                     isoform 1"
                     /protein_id="NP_722481.1"
                     /db_xref="CCDS:CCDS23837.1"
                     /db_xref="GeneID:215031"
                     /db_xref="MGI:MGI:2447460"
                     /translation="MSCLDVMYQVYGPPQPYFAAAYTPYHQKLAYYSKMQEAQECASP
                     GSSASGSSSFSNPTPASVKEEEGSPEKERPPEAEYINSRCVLFTYFQGDISSVVDEHF
                     SRALSHPSSYTPSCTSSKAHRSSGPWRAEGTFPMSQRSFPASFWNSAYQAPVPAPLGS
                     PLAAAHSELPFATDPYSPATLHGHLHQGAADWHHAHPHHAHPHHPYALGGALGAQASA
                     YPRPAVHEVYAPHFDPRYGPLLMPAATGRPGRLAPASAPAPGSPPCELAAKGEPAGSA
                     WAAPGGPFVSPTGDVAQSLGLSVDSGKRRRECSLPSAPPALYPTLG"
     exon            303..609
                     /gene="Vgll2"
                     /gene_synonym="C130057C21Rik; vgl-2; VITO-1; Vito1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..1650
                     /gene="Vgll2"
                     /gene_synonym="C130057C21Rik; vgl-2; VITO-1; Vito1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1628..1633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vgll2"
                     /gene_synonym="C130057C21Rik; vgl-2; VITO-1; Vito1"
                     /note="hexamer: AATAAA"
     polyA_site      1650
                     /gene="Vgll2"
                     /gene_synonym="C130057C21Rik; vgl-2; VITO-1; Vito1"
                     /note="major polyA site"
ORIGIN      
        1 aaatgcgctc tagcgggagc ccaggcgctt ctgcccggga gcaccgccgg gctggaaccg
       61 ccgagataga ggggagcgag tttgccgcag ccccagccca gcgctgcccc gcagcccatg
      121 actccggggc tcgggcgccg ccttcgcagc tgcagcatcc ttgagcttcg cgaaaacagc
      181 gttgatgaga aaccactcag ctgcctccgc ggcggggagc catgagctgt ctggatgtta
      241 tgtaccaggt ctacggtccc ccgcagcctt atttcgcagc cgcctacact ccctaccacc
      301 agaaactagc ctactactca aaaatgcagg aagctcaaga gtgcgccagc cctggcagca
      361 gtgccagcgg gagctcctca ttttccaacc caaccccagc cagtgtcaag gaagaggagg
      421 gcagcccaga gaaagagcgc ccgcccgaag ctgagtacat caactccaga tgtgtcctct
      481 tcacctactt ccagggggac atcagctctg tggtggacga acatttcagt agggccctta
      541 gccacccaag cagctacacc ccaagctgta ccagcagcaa agcacacaga agctctggac
      601 cctggagagc agaaggcacc ttcccgatga gccagcgcag cttccccgcc tccttctgga
      661 acagcgcgta ccaggcgcct gtgcccgcgc cactaggcag tcctctggcc gccgcacact
      721 cggagctgcc ctttgccacc gacccctact ctcccgccac tctgcacggc cacctgcacc
      781 agggcgcggc cgactggcac cacgcgcacc cgcaccacgc gcacccgcac catccctatg
      841 cgctgggcgg cgccctggga gcacaagcct ctgcctaccc gcggccagca gtgcacgagg
      901 tctacgcgcc ccacttcgac ccgcgctatg ggccgctgct catgcccgcg gccactggcc
      961 gccccggccg cctggcccct gcctcggcgc cggctcccgg cagccctccc tgcgagcttg
     1021 cggccaaggg cgagccggcg ggcagcgcat gggctgcgcc cgggggaccc ttcgtgagcc
     1081 ccacggggga tgtggcccag agcctgggtc tcagcgtgga ctcaggtaag cggaggaggg
     1141 aatgcagtct cccctctgcc cctccggcac tgtacccgac tctgggctaa gctctgggcg
     1201 cgcccacccc gacccccgac ccccacactt cccttgggag accacctccc tctacccccc
     1261 aggaccatgt ggctgagaga ttgcatgcca tcatttgttt ctacgggtag atgtctttag
     1321 gaagtagcac cctgccctcg gtctggctgg gtggtacaga ggactctttt tgttctttga
     1381 ataaagttca gccgaaaaga gaaagatggt agtctgagct ggtcaaaatt gtagccacta
     1441 aacacacgcg actactgagc ctttacggtg tgtggctagg atgaatggtg atgtggtcag
     1501 acataataca cactggattt ccaaaacaga aaaagaaaat aatgtaaaac ctcacctcct
     1561 taacatttta tactgaattt gcatgttcta ttatgtccag cggttgccta ttggttatat
     1621 tgggttaaat aaaatgcact attaaaatgc aaaaaaaaaa aaaaaaa
//
