LOCUS       NM_001039385            2553 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus VGF nerve growth factor inducible (Vgf), mRNA.
ACCESSION   NM_001039385 XM_894262 XM_901410 XM_917924 XM_925353
VERSION     NM_001039385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   Woo,M.S., Bal,L.C., Winschel,I., Manca,E., Walkenhorst,M.,
            Sevgili,B., Sonner,J.K., Di Liberto,G., Mayer,C.,
            Binkle-Ladisch,L., Rothammer,N., Unger,L., Raich,L., Hadjilaou,A.,
            Noli,B., Manai,A.L., Vieira,V., Meurs,N., Wagner,I., Pless,O.,
            Cocco,C., Stephens,S.B., Glatzel,M., Merkler,D. and Friese,M.A.
  TITLE     The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration
            via promoting neuronal glycolysis
  JOURNAL   J Clin Invest 134 (16), e177692 (2024)
   PUBMED   39145444
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2553)
  AUTHORS   Zhang,W., Miura,A., Abu Saleh,M.M., Shimizu,K., Mita,Y., Tanida,R.,
            Hirako,S., Shioda,S., Gmyr,V., Kerr-Conte,J., Pattou,F., Jin,C.,
            Kanai,Y., Sasaki,K., Minamino,N., Sakoda,H. and Nakazato,M.
  TITLE     The NERP-4-SNAT2 axis regulates pancreatic beta-cell maintenance
            and function
  JOURNAL   Nat Commun 14 (1), 8158 (2023)
   PUBMED   38071217
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2553)
  AUTHORS   Sahu,B.S., Razzoli,M., McGonigle,S., Pallais,J.P., Nguyen,M.E.,
            Sadahiro,M., Jiang,C., Lin,W.J., Kelley,K.A., Rodriguez,P.,
            Mansk,R., Cero,C., Caviola,G., Palanza,P., Rao,L., Beetch,M.,
            Alejandro,E., Sham,Y.Y., Frontini,A., Salton,S.R. and
            Bartolomucci,A.
  TITLE     Targeted and selective knockout of the TLQP-21 neuropeptide unmasks
            its unique role in energy homeostasis
  JOURNAL   Mol Metab 76, 101781 (2023)
   PUBMED   37482186
  REMARK    GeneRIF: Targeted and selective knockout of the TLQP-21
            neuropeptide unmasks its unique role in energy homeostasis.
REFERENCE   5  (bases 1 to 2553)
  AUTHORS   Gillis,H.L., Kalinina,A., Xue,Y., Yan,K., Turcotte-Cardin,V.,
            Todd,M.A.M., Young,K.G., Lagace,D. and Picketts,D.J.
  TITLE     VGF is required for recovery after focal stroke
  JOURNAL   Exp Neurol 362, 114326 (2023)
   PUBMED   36682400
REFERENCE   6  (bases 1 to 2553)
  AUTHORS   Watson,E., Hahm,S., Mizuno,T.M., Windsor,J., Montgomery,C.,
            Scherer,P.E., Mobbs,C.V. and Salton,S.R.
  TITLE     VGF ablation blocks the development of hyperinsulinemia and
            hyperglycemia in several mouse models of obesity
  JOURNAL   Endocrinology 146 (12), 5151-5163 (2005)
   PUBMED   16141392
  REMARK    GeneRIF: Modulation of VGF levels and/or VGF signaling may
            consequently represent an alternative means to regulate circulating
            glucose levels and insulin sensitivity.
REFERENCE   7  (bases 1 to 2553)
  AUTHORS   Rance,K.A., Fustin,J.M., Dalgleish,G., Hambly,C., Bunger,L. and
            Speakman,J.R.
  TITLE     A paternally imprinted QTL for mature body mass on mouse chromosome
            8
  JOURNAL   Mamm Genome 16 (8), 567-577 (2005)
   PUBMED   16180138
REFERENCE   8  (bases 1 to 2553)
  AUTHORS   Valenzuela,D.M., Murphy,A.J., Frendewey,D., Gale,N.W.,
            Economides,A.N., Auerbach,W., Poueymirou,W.T., Adams,N.C.,
            Rojas,J., Yasenchak,J., Chernomorsky,R., Boucher,M., Elsasser,A.L.,
            Esau,L., Zheng,J., Griffiths,J.A., Wang,X., Su,H., Xue,Y.,
            Dominguez,M.G., Noguera,I., Torres,R., Macdonald,L.E.,
            Stewart,A.F., DeChiara,T.M. and Yancopoulos,G.D.
  TITLE     High-throughput engineering of the mouse genome coupled with
            high-resolution expression analysis
  JOURNAL   Nat Biotechnol 21 (6), 652-659 (2003)
   PUBMED   12730667
REFERENCE   9  (bases 1 to 2553)
  AUTHORS   Hahm,S., Fekete,C., Mizuno,T.M., Windsor,J., Yan,H., Boozer,C.N.,
            Lee,C., Elmquist,J.K., Lechan,R.M., Mobbs,C.V. and Salton,S.R.
  TITLE     VGF is required for obesity induced by diet, gold thioglucose
            treatment, and agouti and is differentially regulated in
            pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons
            in response to fasting
  JOURNAL   J Neurosci 22 (16), 6929-6938 (2002)
   PUBMED   12177191
REFERENCE   10 (bases 1 to 2553)
  AUTHORS   Hahm,S., Mizuno,T.M., Wu,T.J., Wisor,J.P., Priest,C.A., Kozak,C.A.,
            Boozer,C.N., Peng,B., McEvoy,R.C., Good,P., Kelley,K.A.,
            Takahashi,J.S., Pintar,J.E., Roberts,J.L., Mobbs,C.V. and
            Salton,S.R.
  TITLE     Targeted deletion of the Vgf gene indicates that the encoded
            secretory peptide precursor plays a novel role in the regulation of
            energy balance
  JOURNAL   Neuron 23 (3), 537-548 (1999)
   PUBMED   10433265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX236774.1 and AC147986.3.
            
            On or before Feb 5, 2006 this sequence version replaced
            XM_917924.1, XM_925353.1, XM_894262.1, XM_901410.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX236774.1, BC138553.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-642               CX236774.1         1-642
            643-2553            AC147986.3         109307-111217       c
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.13 cM"
     gene            1..2553
                     /gene="Vgf"
                     /gene_synonym="Gm1052"
                     /note="VGF nerve growth factor inducible"
                     /db_xref="GeneID:381677"
                     /db_xref="MGI:MGI:1343180"
     exon            1..167
                     /gene="Vgf"
                     /gene_synonym="Gm1052"
                     /inference="alignment:Splign:2.1.0"
     exon            168..2553
                     /gene="Vgf"
                     /gene_synonym="Gm1052"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2041
                     /gene="Vgf"
                     /gene_synonym="Gm1052"
                     /note="neurosecretory protein VGF"
                     /codon_start=1
                     /product="neurosecretory protein VGF precursor"
                     /protein_id="NP_001034474.1"
                     /db_xref="CCDS:CCDS19760.1"
                     /db_xref="GeneID:381677"
                     /db_xref="MGI:MGI:1343180"
                     /translation="MKTFTLPASVLFCFLLLIQGLGAAPPGRPDVFPPPLSSEHNGQV
                     AEDAVSRPKDDGVPEVRAARNPEPQDQGELFQGVDPRALASVLLQALDRPASPPSVPG
                     GSQQGTPEEAAEALLTESVRSQTHSLPAPEIQAPAVAPPRPQTQDRDPEEDDRSEELE
                     ALASLLQELRDFSPSNAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQA
                     RVPERAPLPPPVPSQFQARMSESAPLPETHQFGEGVSSPKTHLGETLTPLSKAYQSLG
                     GPFPKVRRLEGSFLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDL
                     LLQYLLQGGARQRDLGGRELQETQQERENEREEEAEQERRGGGEDDVGEEDEEAAEAE
                     AEAEEAERARQNALLFAEEEDGEAGAEDKRSQEEAPGHRRKDAEGAEEGGEEDDDDEE
                     MDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVR
                     SPQPPPPAPARDELPDWNEVLPPWDREEDEVFPPGPYHPFPNYIRPRTLQPPASSRRR
                     HFHHALPPARHHPDLEAQARRAQEEADAEERRLQEQEELENYIEHVLLHRP"
     regulatory      2529..2534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vgf"
                     /gene_synonym="Gm1052"
                     /note="hexamer: AATAAA"
     polyA_site      2553
                     /gene="Vgf"
                     /gene_synonym="Gm1052"
                     /note="major polyA site"
ORIGIN      
        1 gccggagcga gagcgctgtt gctgacccag ctgagcccag cttctaggac gccagccctc
       61 gaccatcgct catactccag ccacggaaca gagccaaggc ggaccggtcc cgactttccc
      121 cctgccccga ccctcctctc cacctcccgc cgtcgtgaca ccggctgtct ctggcagccc
      181 gttggtcatg aaaaccttca cgttgccggc atccgtcctc ttctgcttcc ttctactgat
      241 ccaggggttg ggagcagcgc cccccgggcg ccccgatgtt tttcctcctc ccctcagctc
      301 tgagcataat gggcaggtag ctgaggacgc agtgtcccgg ccaaaggatg acggcgtacc
      361 agaggtccga gctgctcgga atcccgagcc tcaggaccag ggagagctct tccagggcgt
      421 ggatccccgg gcgctggcct cggtactgtt gcaggcactg gaccgtccgg cctcgccccc
      481 gtcggtcccg ggaggttccc agcagggaac acccgaagaa gcagcagaag ctctgctgac
      541 cgagtccgtg cgcagtcaga cccatagcct cccggcacca gaaatccaag cgcccgctgt
      601 ggccccccct cgccctcaga ctcaggaccg cgatcccgag gaggacgacc gctcagaaga
      661 gctggaggcg ctagcatcct tgctccaaga acttcgagat ttcagtccga gcaatgctaa
      721 gcgccaacaa gagacggcgg cagcagagac tgaaacccgc acgcacacgc tgacccgagt
      781 caatctggag agccccgggc cagagcgcgt gtggcgcgct tcctggggag agttccaggc
      841 gcgcgttccg gagcgcgctc ctcttccgcc cccggtccct tcccaattcc aggctcgaat
      901 gtccgaaagc gctccccttc ccgaaactca tcagttcggg gaaggagtgt cctcccctaa
      961 aacacattta ggtgagactt tgacaccctt atccaaggcg tatcaaagtc taggtggccc
     1021 cttccctaag gtgcgccggc tcgagggctc attcctgggc ggctccgagg caggagagcg
     1081 cctgcttcag caaggattag ctcaggtaga ggcagggagg agacaggcgg aggccacccg
     1141 gcaggccgcg gcgcaagaag agcggctggc cgatctcgcc tccgacctgc tgctccagta
     1201 tctgttgcag ggcggagccc ggcagcgcga tctcgggggt cgcgagctgc aggagacgca
     1261 gcaagagcgg gagaacgaga gggaggagga ggcagagcag gagaggcgag gtggtgggga
     1321 ggacgatgtg ggggaagagg atgaggaggc ggcggaggcg gaggcggagg cagaggaggc
     1381 ggagagggcg cggcagaacg cactcctgtt cgccgaggag gaggacgggg aagccggagc
     1441 cgaggacaaa cgctcccagg aggaggcgcc aggccatcgg cggaaggatg ctgagggggc
     1501 agaggagggc ggggaggagg atgacgacga cgaggagatg gatccgcaga cgatcgatag
     1561 tctcattgaa ctgtccacca aactccacct gccagcagac gatgtggtca gcatcatcga
     1621 agaggtggag gagaaacgga agcggaagaa gaacgcccct cccgagccgg tgccgcctcc
     1681 cagggctgcc ccagccccga cccatgtccg ctctccgcag cccccacctc ccgccccagc
     1741 ccgggatgag ttgccggact ggaacgaagt gctcccaccc tgggatcggg aggaggatga
     1801 ggtgtttccc ccggggccct atcacccctt cccaaactac attcggccgc ggacactgca
     1861 gccgcccgca tcctcccgcc gccgtcactt ccatcacgcg ttgccacctg cgcgccacca
     1921 tccggatctg gaggcccagg ccaggcgcgc gcaggaggaa gcggacgcgg aggagcgccg
     1981 gctgcaggag caggaggagc tggagaatta cattgagcac gtgctgctgc accgcccgtg
     2041 acccgccccg gccccgcctc cgcgcgctcg ctcccagctg cgcgcgccac cacgcccccc
     2101 tccgtgtcgc tcctcctccc tctcagtgtt tgcatgcgcc ctggctccgc ccctcggctg
     2161 ccgcccggcc ccgccccaca aggccccgcc tcgggttctg tcggcaccgg acctgtcaga
     2221 cttccctggg gtctgcagtc tagaacacac aaaactcgca ggcaatcccg gggccagccc
     2281 aggcgggtgt gtggtttgtg cgagtcccct tatatcccca cttcctccag gggcctcgtc
     2341 cccatctagt ttctctagcg acttcccagt cccagacggg aaaggctgtt ctatttaatc
     2401 gtgtgaagtg tctgtctccc agccttgggg cccccggagc ctcccctctt ctccaaattg
     2461 ctgtgaactt acccacttct ccttctctgt tgtaaatacc cctcacggag gaaatagttt
     2521 tgctaagaaa taaaagtgac tattttatta gga
//
