LOCUS       NP_766126                780 aa            linear   ROD 28-APR-2025
DEFINITION  vezatin isoform 1 [Mus musculus].
ACCESSION   NP_766126
VERSION     NP_766126.2
DBSOURCE    REFSEQ: accession NM_172538.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 780)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 780)
  AUTHORS   Wang,Y., Yuan,J., Yu,X., Liu,X., Tan,C., Chen,Y. and Xu,T.
  TITLE     Vezatin regulates seizures by controlling AMPAR-mediated synaptic
            activity
  JOURNAL   Cell Death Dis 12 (10), 936 (2021)
   PUBMED   34642320
  REMARK    GeneRIF: Vezatin regulates seizures by controlling AMPAR-mediated
            synaptic activity.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 780)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 780)
  AUTHORS   Koppel,N., Friese,M.B., Cardasis,H.L., Neubert,T.A. and Burden,S.J.
  TITLE     Vezatin is required for the maturation of the neuromuscular synapse
  JOURNAL   Mol Biol Cell 30 (20), 2571-2583 (2019)
   PUBMED   31411944
REFERENCE   5  (residues 1 to 780)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   6  (residues 1 to 780)
  AUTHORS   Hyenne,V., Souilhol,C., Cohen-Tannoudji,M., Cereghini,S., Petit,C.,
            Langa,F., Maro,B. and Simmler,M.C.
  TITLE     Conditional knock-out reveals that zygotic vezatin-null mouse
            embryos die at implantation
  JOURNAL   Mech Dev 124 (6), 449-462 (2007)
   PUBMED   17452094
  REMARK    GeneRIF: These in vitro observations reinforce the idea that
            homozygous vezatin-null mutants die at the time of implantation
            because of a defect in intercellular adhesion.
REFERENCE   7  (residues 1 to 780)
  AUTHORS   Hyenne,V., Harf,J.C., Latz,M., Maro,B., Wolfrum,U. and Simmler,M.C.
  TITLE     Vezatin, a ubiquitous protein of adherens cell-cell junctions, is
            exclusively expressed in germ cells in mouse testis
  JOURNAL   Reproduction 133 (3), 563-574 (2007)
   PUBMED   17379651
REFERENCE   8  (residues 1 to 780)
  AUTHORS   Hyenne,V., Louvet-Vallee,S., El-Amraoui,A., Petit,C., Maro,B. and
            Simmler,M.C.
  TITLE     Vezatin, a protein associated to adherens junctions, is required
            for mouse blastocyst morphogenesis
  JOURNAL   Dev Biol 287 (1), 180-191 (2005)
   PUBMED   16199027
  REMARK    GeneRIF: Required for morphogenesis of the preimplantation mouse
            embryo.
REFERENCE   9  (residues 1 to 780)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   10 (residues 1 to 780)
  AUTHORS   Kussel-Andermann,P., El-Amraoui,A., Safieddine,S., Nouaille,S.,
            Perfettini,I., Lecuit,M., Cossart,P., Wolfrum,U. and Petit,C.
  TITLE     Vezatin, a novel transmembrane protein, bridges myosin VIIA to the
            cadherin-catenins complex
  JOURNAL   EMBO J 19 (22), 6020-6029 (2000)
   PUBMED   11080149
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK031848.1, BC056428.1,
            AK036017.1, AC122901.4, AK048068.1, AK031192.1, AK042209.1 and
            AW124866.1.
            
            On Jun 9, 2003 this sequence version replaced NP_766126.1.
            
            Summary: This gene encodes a transmembrane protein that is
            essential for the formation of adherens junctions. It is required
            for both the pre-implantation morphogenesis of a blastocyst and for
            the implantation process. The encoded protein is also a component
            of the ankle-link complex in cochlear hair cells, where it may
            effect resilience to sound trauma. It is also thought to be
            involved in dendritic spine morphogenesis. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Feb
            2015].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036017.1, BC056428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10"
     Protein         1..780
                     /product="vezatin isoform 1"
                     /calculated_mol_wt=87856
     Site            140..160
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3ZK22.2)"
     Region          150..438
                     /region_name="Vezatin"
                     /note="Mysoin-binding motif of peroxisomes; pfam12632"
                     /db_xref="CDD:463650"
     Site            162..182
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3ZK22.2)"
     Region          620..718
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3ZK22.2)"
     Region          757..780
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3ZK22.2)"
     CDS             1..780
                     /gene="Vezt"
                     /gene_synonym="A630071D13Rik"
                     /coded_by="NM_172538.5:95..2437"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS36038.1"
                     /db_xref="GeneID:215008"
                     /db_xref="MGI:MGI:2143698"
ORIGIN      
        1 mtpefdeevv fensplyqyl qdlghtdfei csssspkpek clttegpqpp ptrvlqrqgi
       61 llkltetiks wtfssqhskk ddllhkldtg frldslhtil qqevllqedv ellelldasi
      121 lsagqpqqes ghlptlcsla tpntwdvsll fafisllimf ptcwivsswl vwgiilflyl
      181 iirvlklwrt aklqmtlkky rvrledmaan sraftnlvrk slrliqetev isrgftlvsa
      241 acsfnkaaqh pgqhliglrk avyrtvranf qaarlatlym lknyplnses dnvtnyicvv
      301 pfkelglgls edqiseeear nltdgfslpa lkvlfqlwva qsseffrrla lllstansps
      361 gplltaallp hhilcdvtqg lphahsacld elkrsyeffr yfetqhqsvp qrlsktpqks
      421 relsnvhtav rslqlhlkal lneviilede leklvctket qellseaypi leqklkliep
      481 hvqasnscwe eaisqvdkll rrntdkkgkp gvacenphct aeplvrpalh iedrdpipee
      541 qeleayvddi diesefrkdd fyhlsqedre rqkreqeesr rvlqelksvl gfkaseaerq
      601 kwkqllfsdh avltslspvd pvesvsnsep pmnsdtekvn snateeetsk pcagdkedsr
      661 teyvcdspte gpskdtsadt glllpgaeet mchqheseak spqaaaagat apptprdtlq
      721 lsikqrlarl qlppeftfsa glaaevaars lsfttmqeqt fgdeeeeqlv eggeneveek
//
