LOCUS       NM_001402868            4986 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus vascular endothelial zinc finger 1 (Vezf1), transcript
            variant 2, mRNA.
ACCESSION   NM_001402868 XM_036156627
VERSION     NM_001402868.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4986)
  AUTHORS   Paavola J, Alakoski T, Ulvila J, Kilpio T, Siren J, Perttunen S,
            Narumanchi S, Wang H, Lin R, Porvari K, Junttila J, Huikuri H,
            Immonen K, Lakkisto P, Magga J, Tikkanen I and Kerkela R.
  TITLE     Vezf1 regulates cardiac structure and contractile function
  JOURNAL   EBioMedicine 51, 102608 (2020)
   PUBMED   31911272
  REMARK    GeneRIF: Vezf1 regulates cardiac structure and contractile
            function.
REFERENCE   2  (bases 1 to 4986)
  AUTHORS   Gerald D, Adini I, Shechter S, Perruzzi C, Varnau J, Hopkins B,
            Kazerounian S, Kurschat P, Blachon S, Khedkar S, Bagchi M, Sherris
            D, Prendergast GC, Klagsbrun M, Stuhlmann H, Rigby AC, Nagy JA and
            Benjamin LE.
  TITLE     RhoB controls coordination of adult angiogenesis and
            lymphangiogenesis following injury by regulating VEZF1-mediated
            transcription
  JOURNAL   Nat Commun 4, 2824 (2013)
   PUBMED   24280686
  REMARK    GeneRIF: Nuclear RhoB-GTP controls expression of distinct gene sets
            in each endothelial lineage by regulating VEZF1-mediated
            transcription.
REFERENCE   3  (bases 1 to 4986)
  AUTHORS   Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu
            HS, Brennan J, Armstrong J, Little MH, McMahon AP and
            Southard-Smith EM.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4986)
  AUTHORS   Gowher H, Brick K, Camerini-Otero RD and Felsenfeld G.
  TITLE     Vezf1 protein binding sites genome-wide are associated with pausing
            of elongating RNA polymerase II
  JOURNAL   Proc Natl Acad Sci U S A 109 (7), 2370-2375 (2012)
   PUBMED   22308494
  REMARK    GeneRIF: find examples of genes in which Vezf1 binding sites are
            located near cassette exons, and in which loss of Vezf1 leads to a
            change in the relative abundance of alternatively spliced messages
REFERENCE   5  (bases 1 to 4986)
  AUTHORS   Koike S, Keino-Masu K and Masu M.
  TITLE     Deficiency of autotaxin/lysophospholipase D results in head cavity
            formation in mouse embryos through the LPA receptor-Rho-ROCK
            pathway
  JOURNAL   Biochem Biophys Res Commun 400 (1), 66-71 (2010)
   PUBMED   20692235
REFERENCE   6  (bases 1 to 4986)
  AUTHORS   Soncin F, Mattot V, Lionneton F, Spruyt N, Lepretre F, Begue A and
            Stehelin D.
  TITLE     VE-statin, an endothelial repressor of smooth muscle cell migration
  JOURNAL   EMBO J 22 (21), 5700-5711 (2003)
   PUBMED   14592969
REFERENCE   7  (bases 1 to 4986)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4986)
  AUTHORS   Damert A, Miquerol L, Gertsenstein M, Risau W and Nagy A.
  TITLE     Insufficient VEGFA activity in yolk sac endoderm compromises
            haematopoietic and endothelial differentiation
  JOURNAL   Development 129 (8), 1881-1892 (2002)
   PUBMED   11934854
REFERENCE   9  (bases 1 to 4986)
  AUTHORS   Xiong JW, Leahy A, Lee HH and Stuhlmann H.
  TITLE     Vezf1: A Zn finger transcription factor restricted to endothelial
            cells and their precursors
  JOURNAL   Dev Biol 206 (2), 123-141 (1999)
   PUBMED   9986727
REFERENCE   10 (bases 1 to 4986)
  AUTHORS   Belaoussoff M, Farrington SM and Baron MH.
  TITLE     Hematopoietic induction and respecification of A-P identity by
            visceral endoderm signaling in the mouse embryo
  JOURNAL   Development 125 (24), 5009-5018 (1998)
   PUBMED   9811585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL593853.12.
            
            On Mar 23, 2022 this sequence version replaced XM_036156627.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.3268477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               AL593853.12        36166-36723
            559-1253            AL593853.12        40000-40694
            1254-1317           AL593853.12        41605-41668
            1318-1501           AL593853.12        43134-43317
            1502-1654           AL593853.12        45346-45498
            1655-4986           AL593853.12        48341-51672
FEATURES             Location/Qualifiers
     source          1..4986
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 52.4 cM"
     gene            1..4986
                     /gene="Vezf1"
                     /gene_synonym="db1"
                     /note="vascular endothelial zinc finger 1"
                     /db_xref="GeneID:22344"
                     /db_xref="MGI:MGI:1313291"
     exon            1..558
                     /gene="Vezf1"
                     /gene_synonym="db1"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..2082
                     /gene="Vezf1"
                     /gene_synonym="db1"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="vascular endothelial zinc finger 1 isoform 2"
                     /protein_id="NP_001389797.1"
                     /db_xref="GeneID:22344"
                     /db_xref="MGI:MGI:1313291"
                     /translation="MQNLQKIILSASGPIPVELIRGIGEFKITHCVIWLVLLRHVSNA
                     HEASHHQQQAAQNSLLPLLSSAVEPPDQKPLLPIPITQKPQAAPETLKDAIGIKKEKP
                     KTSFVCTYCSKAFRDSYHLRRHQSCHTGIKLVSRAKKTPTTVVPLISTIAGDSSRTSL
                     VSTIAGILSTVTTSSSGTNPSSSASTTSMPVPQSVKKPSKPVKKNHACEMCGKAFRDV
                     YHLNRHKLSHSDEKPFECPICNQRFKRKDRMTYHVRSHEGGITKPYTCSVCGKGFSRP
                     DHLSCHVKHVHSTERPFKCQTCTAAFATKDRLRTHMVRHEGKVSCNICGKLLSAAYIT
                     SHLKTHGQSQSINCNTCKQGISKTCMSEETSNQKQQQQQQQQQQQQQQQHVTSWPGKQ
                     VETLRLWEEAVKARKKEAANLCQTSTAATTPVTLTTPFNITSSVSSGTMSNPVTVAAA
                     MSMRSPVNVSSAVNITSPMNIGHPVTITSPLAMTSPLTLTTPVNLPTPVTAPVNIAHP
                     VTITSPMNLPTPMTLAAPLNIAMRPVESMPFLPQALPTSPPW"
     exon            559..1253
                     /gene="Vezf1"
                     /gene_synonym="db1"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1317
                     /gene="Vezf1"
                     /gene_synonym="db1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1501
                     /gene="Vezf1"
                     /gene_synonym="db1"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1654
                     /gene="Vezf1"
                     /gene_synonym="db1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..4986
                     /gene="Vezf1"
                     /gene_synonym="db1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctcgctc cgcgacccgc tcgaacgttc gctccggccc agtgggcgac gggaagcgga
       61 gagggagcgc aaagtccgct tacaaagccc ctagatgagt cactcatagg gagtatgggg
      121 gtcttcgctt cttctttttt tccttttgcc agaaacttca aagctaatgt tagcggatac
      181 ttcagccata cccttctcct accactttaa tgcgggaccc ctgattggaa ctttttcccc
      241 cctctgcttc ctttctgttt gcaaatgcat tgatgagcag tagagataag cacatgcaga
      301 aacttcagaa ctgaaggtta gggagctagt cgtttttaaa atgtgtcctt cccgcctccc
      361 tctttggagt tttcctaaat acttcgtgaa attccaaacg cgtagcttgg gcgcttgaga
      421 cctttggaaa tgcagaatct tcaaaagatt atactctccg catctggtcc catcccggtg
      481 gagttaatac ggggaattgg agaattcaaa attacccatt gtgtaatctg gcttgtccta
      541 ttaagacatg tttcaaatgc ccacgaagca tcccatcacc aacagcaggc agcgcagaac
      601 agcttgctgc ccctcctgag ttctgctgtg gagccccctg atcagaaacc gttgcttcca
      661 ataccaatta ctcagaaacc tcaggctgca ccagaaacat taaaggatgc cattgggatt
      721 aaaaaagaaa aacccaaaac ttcgtttgtg tgcacttact gcagtaaagc attcagggac
      781 agctatcacc tgaggcgcca tcagtcctgc cacacaggga tcaagttggt gtctcgggca
      841 aagaaaaccc ccaccacggt ggttcccctt atctccacca ttgctgggga cagcagccga
      901 acttcgttgg tttcaactat tgcaggcatc ttgtcaacag tcactacatc ttcctcgggc
      961 accaacccca gcagcagcgc tagtaccaca tcaatgcctg tgccccagtc tgtcaagaaa
     1021 cccagtaagc ctgtcaagaa gaaccacgcc tgtgagatgt gtgggaaggc cttccgggat
     1081 gtgtaccacc tcaatcggca caagctctcc cattcggacg aaaagccctt tgagtgtcct
     1141 atttgtaatc agcgcttcaa gaggaaggac cggatgactt accatgtgag gtctcatgaa
     1201 ggaggcatca ccaaacccta tacttgcagt gtttgtggga aaggcttctc aaggcctgac
     1261 cacctaagct gtcatgtaaa acatgtgcat tcaacagaaa gacccttcaa atgccaaacg
     1321 tgcactgctg cctttgccac caaagacaga ctacggacac acatggtgcg ccacgaaggc
     1381 aaggtatcat gtaacatctg tgggaagctc ttgagtgcag catatatcac cagccactta
     1441 aagacacatg ggcagagcca aagtatcaac tgtaacacgt gcaaacaagg catcagcaaa
     1501 acgtgcatga gtgaggagac cagcaatcag aagcagcagc agcagcagca gcaacagcag
     1561 cagcagcaac aacaacaaca tgtgacaagc tggccaggga agcaggtaga gacactgaga
     1621 ctgtgggaag aagctgtcaa agcaagaaag aaagaagctg ccaacctgtg ccaaacctcc
     1681 acggctgcta cgacaccagt gactctcact actccattca atataacgtc ctctgtgtcg
     1741 tctgggacta tgtcaaaccc agtcacagtg gcagctgcaa tgagcatgag aagtccagta
     1801 aatgtctcaa gtgcagttaa tataaccagc ccaatgaaca tagggcatcc cgtaaccata
     1861 accagcccct tagccatgac ctcaccttta acactcacca ccccagtcaa cctccccacc
     1921 cctgtgaccg ccccagtgaa tatagcacac cctgtcacca tcacatctcc aatgaacctg
     1981 cccactccta tgacattagc tgcccctctc aatatagcaa tgaggcctgt agaaagtatg
     2041 cctttcttgc cccaagcttt gcctacgtca ccgccttggt aaacagtatt ataaagtcaa
     2101 aattgggtta aagtaaatat ttaccagcaa cttaacctta gttgattaaa gcaaaaagca
     2161 gactatgaaa ttgggaggtt ttattatgtt agttaataag agtgtagtag ctccaatttt
     2221 gctggggttg ttcaaagtag ggtatatgtg taacttatca ctggaccact ttagtttact
     2281 cagaaacccc tttagctgac accattgctt aaacaggata gtagctggca agacgaaatg
     2341 ccagaattaa aaccaatcat aaaacccatt tcaaaataaa aaagcattat ttgtttttat
     2401 tattattttt aatacaacag aatcatttta ttgtaaacac tagcagagtt cttccctctg
     2461 tacaaggtgg acggttttaa cctggagctc aagcccacag actgagagct agtgtagcat
     2521 tgtctgtggt tttgctcgta tgagtgaaca gaggcattgt cataataaaa tgcatttcag
     2581 agaatatgca ttttaccttt gggaatatgt taatttcagg cagcattccc tatgggaaag
     2641 gtgataccag ctctgatatg caaagcatat gataatttat cattctaact tcaacatata
     2701 atagggattg tgacctgata tttggagatg taaatattgc tcagcatatt aatcctgatg
     2761 gaatatagca ttgtagttga ctttttaaaa aaaaaaaaca aaaacttaaa aaaaaacaac
     2821 aacaataaat tgtgttttga tgagaaaagg ctgcagctga ctgaggagaa gtcaggtgtg
     2881 cacgaagcag gctcctaacg ggtcagggga tcctgttcag gaggagtgag aacttcggaa
     2941 gagtttaaat ctattgcttt aaattggaag acattggagg cactgggatg tgatatgcct
     3001 ctctctctcc caatcaacgt ctgttgatgt tacaacaggc acagatgtgt tagatgctca
     3061 ctagagttta tgtcttatat taaattgtat acagttttta ttctaaccac taactaggta
     3121 gtatgcccct tcagaacaag cagagtgtat cttttccccc tccttctgtt taatcaagta
     3181 ttgtgcagat ttgttcaact ttgtaaatat ggacatcact tttttttttc ctttggaaaa
     3241 aaaaaaacaa caacaagccc ttgtatccgc tttctggagt ttccagggag gcagctgtct
     3301 gcatgctccg tggaagccct gcagtgagtg tgcacgctga gactgtgctt tttgtttctt
     3361 agcgggaagc tttatccctg tacatacagt agaaaccaga agctagggaa acagagactc
     3421 tatgccatca cgccacactt catgttttca aagcatcatg ttagagaaca gtttgttcaa
     3481 accaagaggt tgtaattgtt ttttacattg caatatgttt tgggtctttt tcatttttaa
     3541 tcatgcagtt aagagatatg ggaatgagtt ttagccctgc agaatgcatg caggactgtc
     3601 acagaagatg acttccgttt gtttataccc cactgtgtca gtacaaacat caaaatacca
     3661 tacgtctgag gcagacttcc tacatcaggg acaggtatct gtgtgtcatt atacaaaaca
     3721 gttctagggg gatgaactac atagtaaaaa aaaattaaaa taaatagtac ctagtgtaaa
     3781 ataattttat aaatgatctt ttgtacttta ggacattaaa ttgtacaact tttgtatata
     3841 aaaagcttag gaactttctg tttagcagga aggcaacaca ttcctacact tttaatgtat
     3901 atgtttgtta taatgtccat gtaaacatgc cctatgtttg tgccttttaa ttagtttgtc
     3961 tcaataaaca aaatgtagag aaaaatatgt agctatgact ttgttacaac agttcttctc
     4021 cacagtggaa aaatggtttg tttttaagtg tagaccatta tgtgtgagct ccagcaaggg
     4081 ctcatggggg aaggcctagg aatggcactg cggagacccg ggagggcagc ggtcacatgt
     4141 ggaggaaacc ttcatttcct ggcatgtgct ctgctcgtcg ggccttgtca tctctgttgt
     4201 gctggcagtc atggtcctta tggtcagata acccaggctt cctctacagt ggccaaggag
     4261 cagtcctcaa agtgggcagg tgtgggtcct tcccccaggc tacagcgtgg tcatgagatc
     4321 ctgaaagtat tagttcttac agaaagaaaa aaaaaaggat atatactaga aatggttgtt
     4381 ttatcaattc attgtaaaca ggagtgagac ttcattgtat gacttcagtt aaaatgctat
     4441 tttgtatgca tactttattc acttaagaag cttgtctgca ataataaagc cacgttgtgt
     4501 cttctttggg gagggagaga gttgaggcag gatgggtgag ggtagggcag agggggcaca
     4561 gataggccgt gtggtgaaat cctcccgtgg cccggacctg aaactgagtt gtgatgctga
     4621 tgctgagctg attcgcccgt gtgtcgaatg caccaacggc caccgttcta cagaaaggca
     4681 gagtatggtt tccctcctgg ttgtaacctg gtggagagct ttcccttatc agattggcag
     4741 ctaaacagtt gtattagata atcttcaaat ctgacatcca gcctgttatg cttgctctag
     4801 ggctcgctgc ttggcctgca tctcccttct cctgtgtatt catttccctc ctaaggtgtg
     4861 ctcctaaatg aaggtttcta tgtacgcgga tgatgattta cctgtcaata ccagcactgt
     4921 attactaaca tgcaaaatac tgcagattta ttttgacaaa ttaaagttaa ccagtcacaa
     4981 ctgtta
//
