LOCUS       NM_145820               6450 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus ventricular zone expressed PH domain-containing 1
            (Veph1), mRNA.
ACCESSION   NM_145820
VERSION     NM_145820.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6450)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   2  (bases 1 to 6450)
  AUTHORS   He,L., Jones,J., He,W., Bjork,B.C., Wen,J. and Dai,Q.
  TITLE     PRDM16 regulates a temporal transcriptional program to promote
            progression of cortical neural progenitors
  JOURNAL   Development 148 (6) (2021)
   PUBMED   33597191
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6450)
  AUTHORS   Shi,X., Ma,W., Pan,Y., Li,Y., Wang,H., Pan,S., Tian,Y., Xu,C. and
            Li,L.
  TITLE     MiR-126-5p promotes contractile switching of aortic smooth muscle
            cells by targeting VEPH1 and alleviates Ang II-induced abdominal
            aortic aneurysm in mice
  JOURNAL   Lab Invest 100 (12), 1564-1574 (2020)
   PUBMED   32612287
  REMARK    GeneRIF: MiR-126-5p promotes contractile switching of aortic smooth
            muscle cells by targeting VEPH1 and alleviates Ang II-induced
            abdominal aortic aneurysm in mice.
REFERENCE   4  (bases 1 to 6450)
  AUTHORS   Dasgupta,K., Chung,J.U., Asam,K. and Jeong,J.
  TITLE     Molecular patterning of the embryonic cranial mesenchyme revealed
            by genome-wide transcriptional profiling
  JOURNAL   Dev Biol 455 (2), 434-448 (2019)
   PUBMED   31351040
REFERENCE   5  (bases 1 to 6450)
  AUTHORS   Shathasivam,P., Kollara,A., Ringuette,M.J., Virtanen,C., Wrana,J.L.
            and Brown,T.J.
  TITLE     Human ortholog of Drosophila Melted impedes SMAD2 release from
            TGF-beta receptor I to inhibit TGF-beta signaling
  JOURNAL   Proc Natl Acad Sci U S A 112 (23), E3000-E3009 (2015)
   PUBMED   26039994
REFERENCE   6  (bases 1 to 6450)
  AUTHORS   Muto,E., Tabata,Y., Taneda,T., Aoki,Y., Muto,A., Arai,K. and
            Watanabe,S.
  TITLE     Identification and characterization of Veph, a novel gene encoding
            a PH domain-containing protein expressed in the developing central
            nervous system of vertebrates
  JOURNAL   Biochimie 86 (8), 523-531 (2004)
   PUBMED   15388229
  REMARK    GeneRIF: Veph was strongly expressed in the ventricular zone of the
            embryonic brain, and its expression level gradually decreased in
            later stages.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC075649.1, AC121312.7 and AC098705.2.
            
            On Feb 1, 2013 this sequence version replaced NM_145820.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075649.1, AB085187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream ORF predicted to
                                                inhibit translation from
                                                upstream AUG
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1425              BC075649.1         1-1425
            1426-1426           AC121312.7         47868-47868         c
            1427-2709           BC075649.1         1427-2709
            2710-2711           AC098705.2         120879-120880       c
            2712-6450           BC075649.1         2710-6448
FEATURES             Location/Qualifiers
     source          1..6450
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 30.25 cM"
     gene            1..6450
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /note="ventricular zone expressed PH domain-containing 1"
                     /db_xref="GeneID:72789"
                     /db_xref="MGI:MGI:1920039"
     exon            1..235
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     exon            236..520
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..2884
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /note="protein melted homolog"
                     /codon_start=1
                     /product="ventricular zone-expressed PH domain-containing
                     protein 1"
                     /protein_id="NP_665819.2"
                     /db_xref="CCDS:CCDS17391.1"
                     /db_xref="GeneID:72789"
                     /db_xref="MGI:MGI:1920039"
                     /translation="MHQLFRLVLGQKDLSKAGDLFSLDDAEIEDSLTEALEQIKVISS
                     SLDYQTNNNDQAVVEICITRITTAIRETESIEKHARALVGLWDSCLEHNLRPAGKDED
                     TPHAKIASDIMSCILQNYNRTPVMVLAVPIAVKFLHRGSKELCRNMSNYLSLAAITKA
                     DLLADHTEGIIKSILQGNAMLLRVLPAVYEKQPQPINRHLAELLALMSQLEQTEQYHL
                     LRLLHVAAKRKDVEVVQKCVPFLIRNLKDSTYNDIILNILIEIAGHEPLALNSFLPML
                     KEIAEQFPYLTGQMARIFGAVGHVDEERARSCLRYLVSQLANMEHPFHHILLLEIKSI
                     TDAFSSILGPHSRDIFRMSNSFTNIAKLLSRQLENSKADSSRRKTSTEVSIPEKLREL
                     NSMEPESEDHEKLQVKIQAFEDKINAESNTPGSGRRYSLDHISKEERKSIRFSRSRSL
                     ALNTVLTNGVSVEDNEVEEKAGMHASISLSQIDPLSHGIGKLPFKTDTHGSPLRNSSA
                     SHPSIIHTEPETMPETFKENIQEEILEAATSPIEYQDKLYLHLRENLSKVKAYALEIA
                     KKVPIPDQCTIEDTMRSCVAKLFFTCSLKGHYCLYSKSSFILVSQAPQPWIQVMFLSQ
                     QSLFPEPLSIQSGSVQFLKALWEKTQDTGAHSFEVAMTESTFPQQKDLEQLQLHLEEV
                     RFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTHY
                     FTLAGNQLLFQKGKSKDDPDDSPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDSKTYV
                     FKAKDEKNAEEWLQCINVALAQAKERESREVTTYL"
     exon            521..736
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     exon            737..911
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1078
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1288
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1509
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1719
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..2117
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2257
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2392
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2510
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2647
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..6431
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6412..6417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /note="hexamer: AATAAA"
     polyA_site      6431
                     /gene="Veph1"
                     /gene_synonym="2810471M23Rik; Veph"
                     /note="major polyA site"
ORIGIN      
        1 ctggaaaagg gaagaaagtt actcattcgc ctgataccac acggtgagtc cacaggaggg
       61 actcaggcgc agcgctgcat gacaagctca cagggacgtg ccagcagcca ccggcaggac
      121 aggcaggcgc tgcagggctg cctctgagcg tggtcctggg tcccagctga agtgttccaa
      181 gggatcaagc atttgccttc tgttgcctgc acctgccagt gtcccgtgct aggagagaca
      241 gccaaaggag accttagagc ctgcagaacc atggctcttc atggaatatg aagtgtacca
      301 gctgctacgt ggttttctat ctctaaccct gacaactgac catggccctg gattcacaga
      361 aatccaactg atccaacaca caatgcatca acttttcaga ttggttttgg gacaaaaaga
      421 tctttcaaaa gctggggacc tcttctcttt agatgatgct gagattgaag acagcctgac
      481 agaagctttg gagcagatta aagtaattag ctcatctttg gattaccaaa ctaataacaa
      541 tgaccaggcg gtggttgaaa tctgtatcac aaggattacc acagccatca gagagacaga
      601 atccattgaa aagcatgcca gagccctggt ggggctgtgg gattcctgct tggaacacaa
      661 cctgagacct gcagggaaag acgaagatac tccacatgca aaaatcgcct ctgatatcat
      721 gagttgcatc ttacagaatt acaaccggac ccctgtgatg gtcttagctg tccccatcgc
      781 agtgaaattc ctccacagag gcagcaagga gctgtgtagg aacatgtcca actacctgtc
      841 cctggctgcc atcaccaagg cggatctgct ggctgaccac actgaaggga taataaagag
      901 catactccaa ggaaatgcca tgctgttaag ggtgctacct gctgtatatg aaaagcagcc
      961 ccaaccaatc aacagacacc tggcagaact cctggccttg atgtctcaat tggagcagac
     1021 agaacagtac catctactaa ggcttctgca cgtagcagca aagagaaaag atgtggaggt
     1081 ggttcagaaa tgtgttcctt tcctgatcag aaatttgaag gattcaacct ataatgacat
     1141 catcctaaac attctcatag aaatagcagg ccatgagcca ctggccttga acagtttcct
     1201 cccgatgctg aaagagattg cagagcaatt cccctacctc actggacaga tggcaaggat
     1261 ctttggtgct gttggtcatg tggatgaaga gagagccagg agctgcctac gatacctggt
     1321 gagccagctg gctaatatgg agcatccatt ccaccatatt ctcctgctgg aaattaagag
     1381 tatcacagat gccttctcct ccatcctggg cccgcacagc agggacatct tccgaatgag
     1441 caacagcttc accaacattg ccaagctcct ttccagacaa ctggaaaaca gcaaggctga
     1501 cagtagcagg agaaaaacca gcactgaagt tagcattcct gagaaactga gagaactcaa
     1561 ttccatggag cctgaaagtg aagaccatga aaaactccaa gttaaaatcc aagcctttga
     1621 agacaaaata aatgctgaga gcaatacccc aggctctggc cggagataca gcttagacca
     1681 catctctaag gaagaacgaa aaagcattag atttagcagg tccagaagtt tggctttgaa
     1741 tactgtgctc acaaacggtg tgagtgtgga agataacgaa gtcgaagaaa aggcaggaat
     1801 gcacgccagc atctctcttt cgcaaataga cccactcagc cacgggattg gcaagttgcc
     1861 ctttaagaca gacactcatg gatcaccact gagaaattcc tcagcttcac acccaagtat
     1921 tatacatact gaaccagaga ctatgcccga aacttttaaa gaaaacatcc aagaagaaat
     1981 tctagaggca gccacaagtc ctattgaata ccaagataag ctctacttgc atttaaggga
     2041 aaacctcagc aaagtgaagg cttatgcctt ggaaatcgca aaaaaggtcc caatcccaga
     2101 ccagtgcacc attgaagata ctatgagaag ttgcgtggca aagctgttct ttacctgttc
     2161 tttaaagggc cattactgcc tatacagcaa gtccagcttc atccttgtca gccaagcacc
     2221 ccagccgtgg atccaggtca tgtttctctc ccaacagagc ctgtttcctg agcccctgtc
     2281 cattcagagt gggtctgtgc agttcctcaa agccctatgg gagaaaacgc aggacacggg
     2341 agcgcacagc tttgaagtcg ccatgacaga gtccaccttt ccacagcaga aggatctgga
     2401 gcagcttcag ctccatctgg aagaagtgcg gttcttcgac gtgtttggct tcagtgaaac
     2461 agcgggggca tggcagtgct tcatgtgcaa caaccctgaa aaggcaactg ttgtaaatca
     2521 agatggccag cctctcatcg aaggaaaact taaggagaaa caagtgaggt ggaagttcat
     2581 caagaggtgg aaaacgcatt attttacact ggccggaaac caacttctgt ttcaaaaggg
     2641 gaaatctaag gatgaccctg atgattcccc gatagaactc agcaaggtac agagcgtgaa
     2701 agctgtggct aagaaacgcc gggaccgctc tctgcctcgg gcgtttgaaa tcttcacaga
     2761 tagtaagacc tatgttttca aagccaagga tgagaagaac gcagaggaat ggctgcagtg
     2821 catcaacgtg gcgctggccc aggcaaagga gagggaaagc cgagaagtaa ccacatatct
     2881 gtagcgattc gcacacccgc tcttatggcc atgcaagata agcattgcca gtgtcaacaa
     2941 agaggaaccc accatggcgc tattgggttt cactaaatac cagggaaacc attatcccta
     3001 aggagagcct aaaatggcag ggttctcagt aaacctcacg ccctcgcaac tctggtatta
     3061 actccaagtt ttctgcctga agttcatgag aaagagaggc cacggagttc acagtggatc
     3121 gtgtgggcca gaaagggaac gctgcgaata aaagaacttc tgtagctatg tgatttatga
     3181 ctgtaagaaa acagtgagtg gggccagcag gaaggctcag caggtaaagg gcacttgctg
     3241 ccaagccaga ttgcctgagt tctagcccca taactgactt ggtggaagga gaactaactc
     3301 ttggcggttt tcctctgttt tctgcatgcc atggcacatc tatttcccca gtttaaaaaa
     3361 gaaaaagaaa ttaattaatt aattaattaa attttaaaac aacagaggcc tgaaagatcc
     3421 atcttgaagg aaaactgtca cattaaagac attttttaat atttttatta ggtattttcc
     3481 tcatttacat ttccaatgct atcccaaaag tcccccatac cctcccccca ctcccctacc
     3541 cacccactcc cactttttgg ccctggcatt cccctgtact ggggcatata cagtttgcat
     3601 gaccaatggg cctctctttc cagtgatggc cgactaggcc atcttttgat acatatgcag
     3661 ctagagacaa gagcttaaaa accattagga gccaggcagt ggtggcgcat gcctttaatc
     3721 ccagcacttg ggagacagag gcaggtagat ttctaaattc gaggccagcc tggtctacag
     3781 agtgagttcc agaacagcca gggctataca gagaaacact gtctcaaccc ccatccttca
     3841 aaaaaaaaaa aaattaggaa aagttgaact aaggtacatt caagaaaacc attaacttca
     3901 gtatattagt tagctttctg ttccgtggca aaataccctg atgaaaatag cgtacaggcg
     3961 aaaggattta ttttgtttat ggttccagag ggatggagtc cattgtgtca gggaatacat
     4021 ggcaccaggc agaaaaagca cagcagcaag aacaagatgc tggctgattc ttatttagac
     4081 cgaggaagca gtgaaggtgg gaagtagggt gtggtaataa accacaaggc ccacctccat
     4141 cgatgtactt cctctaccaa ggctccgccc ccccaggggc tccgtaactt cctgaagcag
     4201 tcctacaatg gggccacgca ttcaaatatg tgagcatatg gaggcattaa aattgttcaa
     4261 ttatttaaat taccacactt aaacatttat cttctcaaca cagaagatgg cagcacatgt
     4321 tacaatgact cttattccag ttacataatt aaatttaggc tcttattaga gtgtaaattg
     4381 gattttaatg tttagacacg tggttctatc tactgtctga ggcagtaaaa aagaataaga
     4441 atagaaagac accttttctt ctttgtaaat atatgcatca cctcccttaa aattgaagat
     4501 ttttttaatt aaaattctgt ggttttcttc tctgtgttaa gcgttgtagt gcccaaatta
     4561 taagcattta ttggtttttc ctattaccct tatataattt tgaattaagc tgccataggc
     4621 agtttaggtg acatccagtg acctgtgccc cgtaataatg ttctgcccct tgagtggtgg
     4681 agggtgggac ctgaagcgtg cttctaactt acataatatg gcaaaggtga cagaattgtc
     4741 tctcctacaa ttgtgttaca ttacaacgga aattttaaaa ttaacagatg aattaaggtc
     4801 tctcagatgt cttaagtaaa ctgatacatc ctgaatagcc aggttatcag ctaagttatt
     4861 tacgtcagcc tctcctagtg aacttgaata agctgccacg gaactatcgc tgcaaggcaa
     4921 ggagtgagcc tgtgccaaca tccacgtgac cctgaacaac agtgagcctc tcgggatcca
     4981 gcccaccatc accttgttcg gagctatgag gtcctctgct cagagggccg ggataagatg
     5041 gagtcctgcc cccacagaaa ctatgcagta acaatgtatc ctgctttaaa tgcaaaccat
     5101 gtggtgattt gttatgcact gattaattca tataaaaccc cgctggtaat atatcaaaga
     5161 taactttttt ctgtaaaatt tatttattat gtattttagc agagaagccc agaaaagttg
     5221 tcaccgcgct gacactacag ttaactcact ggcataggaa atgtaaaagg ggtcatactt
     5281 gagcaaagaa acttaattca attttaacat gtaaagtttg aggatattat gagccacaga
     5341 aattattaca cgctggaaat agagttcaag aggtcaaatt ttgggtccac tgcatatgta
     5401 ggtaattgtg aaagaaatgg aattggctga attacataag aaatggagaa ttgaaaatga
     5461 ccccttggga taacaatatt tagacaaagg caggttagat tagctgatca gtattcagag
     5521 atgatgtagc ccaggagaca tgatattaca aaagctaaat taagaaggat tttcaggatg
     5581 tcagcaattt gaagtcctga agatagaact tgactttcat aattaggaag caattgatgt
     5641 cactagtaag aacaatttca ttggaacaat gcagtaaaag ttaactttcg atgtgctgta
     5701 gtaatcgact gctggatttt aattttttaa aaggtggggt taaggtgaaa gagcagaata
     5761 gatgaatggt ttcttatttt gtttttaggt gacgtcacca taagaaagaa gacagtttaa
     5821 taaatataga caaggaaaga caaggtcaag tttgctaagt gtgatagaga ataattttca
     5881 agttctgtat ccaggggccg gagaaatgtt tcaatcatga gagagcttgc ctacacacat
     5941 cagcccctga tgtcaaatca gcaacacata catgaaaatc gcagcatggc tttgggggcc
     6001 tgtaactctc cctgcactgg gagttggagg caagtacatc ccaagagctc cttggccatc
     6061 agtccaactg aagtcatgaa cttctgacca agtgagaaac tccatatggt agtttggaca
     6121 agaagggccc ccataggctt acctatttga ccacttgatc tccagttggt ggaactattc
     6181 gggaaagatc cgaaggcgtg gtcttgttgg agaaggtgtg tcactggtgg gtgggctttg
     6241 agggttcaaa agcccatagc gtttcaagtt agccacccta ccacctgcct ctgccacatg
     6301 gttatgcctc atgatgcatg ctctcaacta cagctccagg accatgcctg cctactgcca
     6361 tgctctctgc catgatggaa atatatttat cctctgaaac tgtaaacctc caataaactc
     6421 tttcttctat aaaaaaaaaa aaaaaaaaaa
//
