LOCUS       NM_010216               2030 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus vascular endothelial growth factor D (Vegfd),
            transcript variant 1, mRNA.
ACCESSION   NM_010216 XM_912805
VERSION     NM_010216.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2030)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   2  (bases 1 to 2030)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2030)
  AUTHORS   Keller,T.C.S. 4th, Lim,L., Shewale,S.V., McDaid,K.,
            Marti-Pamies,I., Tang,A.T., Wittig,C., Guerrero,A.A., Sterling,S.,
            Leu,N.A., Scherrer-Crosbie,M., Gimotty,P.A. and Kahn,M.L.
  TITLE     Genetic blockade of lymphangiogenesis does not impair cardiac
            function after myocardial infarction
  JOURNAL   J Clin Invest 131 (20) (2021)
   PUBMED   34403369
REFERENCE   4  (bases 1 to 2030)
  AUTHORS   Lohela,M., Bry,M., Tammela,T. and Alitalo,K.
  TITLE     VEGFs and receptors involved in angiogenesis versus
            lymphangiogenesis
  JOURNAL   Curr Opin Cell Biol 21 (2), 154-165 (2009)
   PUBMED   19230644
  REMARK    Review article
REFERENCE   5  (bases 1 to 2030)
  AUTHORS   Baldwin,M.E., Roufail,S., Halford,M.M., Alitalo,K., Stacker,S.A.
            and Achen,M.G.
  TITLE     Multiple forms of mouse vascular endothelial growth factor-D are
            generated by RNA splicing and proteolysis
  JOURNAL   J Biol Chem 276 (47), 44307-44314 (2001)
   PUBMED   11574540
REFERENCE   6  (bases 1 to 2030)
  AUTHORS   Farnebo,F., Piehl,F. and Lagercrantz,J.
  TITLE     Restricted expression pattern of vegf-d in the adult and fetal
            mouse: high expression in the embryonic lung
  JOURNAL   Biochem Biophys Res Commun 257 (3), 891-894 (1999)
   PUBMED   10208880
REFERENCE   7  (bases 1 to 2030)
  AUTHORS   Avantaggiato,V., Orlandini,M., Acampora,D., Oliviero,S. and
            Simeone,A.
  TITLE     Embryonic expression pattern of the murine figf gene, a growth
            factor belonging to platelet-derived growth factor/vascular
            endothelial growth factor family
  JOURNAL   Mech Dev 73 (2), 221-224 (1998)
   PUBMED   9622638
REFERENCE   8  (bases 1 to 2030)
  AUTHORS   Jenkins,N.A., Woollatt,E., Crawford,J., Gilbert,D.J., Baldwin,M.E.,
            Sutherland,G.R., Copeland,N.G. and Achen,M.G.
  TITLE     Mapping of the gene for vascular endothelial growth factor-D in
            mouse and man to the X chromosome
  JOURNAL   Chromosome Res 5 (7), 502-505 (1997)
   PUBMED   9421270
REFERENCE   9  (bases 1 to 2030)
  AUTHORS   Yamada,Y., Nezu,J., Shimane,M. and Hirata,Y.
  TITLE     Molecular cloning of a novel vascular endothelial growth factor,
            VEGF-D
  JOURNAL   Genomics 42 (3), 483-488 (1997)
   PUBMED   9205122
REFERENCE   10 (bases 1 to 2030)
  AUTHORS   Orlandini,M., Marconcini,L., Ferruzzi,R. and Oliviero,S.
  TITLE     Identification of a c-fos-induced gene that is related to the
            platelet-derived growth factor/vascular endothelial growth factor
            family
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11675-11680 (1996)
   PUBMED   8876195
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1997 Feb 18;94(4):1603]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732475.6.
            
            On Aug 12, 2022 this sequence version replaced NM_010216.2.
            
            Summary: This gene encodes a member of the vascular endothelial
            growth factor (VEGF) family that acts as a ligand for vascular
            endothelial growth factor receptor 3. Signalling through this
            protein is important for growth and development of endothelial and
            vascular tissue. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, May 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (VEGF-D358).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-526               AL732475.6         63668-64193
            527-752             AL732475.6         76078-76303
            753-943             AL732475.6         81876-82066
            944-1092            AL732475.6         84707-84855
            1093-1193           AL732475.6         86207-86307
            1194-1389           AL732475.6         90937-91132
            1390-2030           AL732475.6         92281-92921
FEATURES             Location/Qualifiers
     source          1..2030
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 76.35 cM"
     gene            1..2030
                     /gene="Vegfd"
                     /gene_synonym="Figf; VEGF-D"
                     /note="vascular endothelial growth factor D"
                     /db_xref="GeneID:14205"
                     /db_xref="MGI:MGI:108037"
     exon            1..526
                     /gene="Vegfd"
                     /gene_synonym="Figf; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     CDS             437..1513
                     /gene="Vegfd"
                     /gene_synonym="Figf; VEGF-D"
                     /note="isoform VEGF-D358 preproprotein is encoded by
                     transcript variant 1; c-fos induced growth factor"
                     /codon_start=1
                     /product="vascular endothelial growth factor D isoform
                     VEGF-D358 preproprotein"
                     /protein_id="NP_034346.1"
                     /db_xref="CCDS:CCDS30521.1"
                     /db_xref="GeneID:14205"
                     /db_xref="MGI:MGI:108037"
                     /translation="MYGEWGMGNILMMFHVYLVQGFRSEHGPVKDFSFERSSRSMLER
                     SEQQIRAASSLEELLQIAHSEDWKLWRCRLKLKSLASMDSRSASHRSTRFAATFYDTE
                     TLKVIDEEWQRTQCSPRETCVEVASELGKTTNTFFKPPCVNVFRCGGCCNEEGVMCMN
                     TSTSYISKQLFEISVPLTSVPELVPVKIANHTGCKCLPTGPRHPYSIIRRSIQTPEED
                     ECPHSKKLCPIDMLWDNTKCKCVLQDETPLPGTEDHSYLQEPTLCGPHMTFDEDRCEC
                     VCKAPCPGDLIQHPENCSCFECKESLESCCQKHKIFHPDTCSCEDRCPFHTRTCASRK
                     PACGKHWRFPKETRAQGLYSQENP"
     exon            527..752
                     /gene="Vegfd"
                     /gene_synonym="Figf; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     exon            753..943
                     /gene="Vegfd"
                     /gene_synonym="Figf; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1092
                     /gene="Vegfd"
                     /gene_synonym="Figf; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1193
                     /gene="Vegfd"
                     /gene_synonym="Figf; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1389
                     /gene="Vegfd"
                     /gene_synonym="Figf; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..2030
                     /gene="Vegfd"
                     /gene_synonym="Figf; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2006..2011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vegfd"
                     /gene_synonym="Figf; VEGF-D"
                     /note="hexamer: AATAAA"
     polyA_site      2030
                     /gene="Vegfd"
                     /gene_synonym="Figf; VEGF-D"
                     /note="major polyA site"
ORIGIN      
        1 atagttgggt tttagcctgc tgtaactgca agtgtttgtg gtcataccac ctccttataa
       61 agcagctaga accttgagcg tagggtgggg tttttttttt tatcttcaac tttctggata
      121 agaaatgtct gtagagtgat ttctagtttc aagtggaaga tatgaccacc tcctgattat
      181 ttttgcagcg ggaaactttg aaatattttt cattgctttc tcccatacta agattgtgtg
      241 tgaggcagtg agggagtccc ttgacttact caagtcattt cattggattt taattacaac
      301 tgatcatgtg attgtttttt tccatgtaaa gtttggggct tcaaactttg cttctggaga
      361 atgccttttg caacactttt cagtagctgc ctggaaacaa ctgcttagtc atcggtagac
      421 atttaaaata ttcaaaatgt atggagaatg gggaatgggg aatatcctca tgatgttcca
      481 tgtgtacttg gtgcagggct tcaggagcga acatggacca gtgaaggatt tttcttttga
      541 gcgatcatcc cggtccatgt tggaacgatc tgaacaacag atccgagcag cttctagttt
      601 ggaggagttg ctgcaaatcg cgcactctga ggactggaag ctgtggcgat gccggttgaa
      661 gctcaaaagt cttgccagta tggactcacg ctcagcatcc catcgctcca ccagatttgc
      721 ggcaactttc tatgacactg aaacactaaa agttatagat gaagaatggc agaggaccca
      781 atgcagccct agagagacat gcgtagaagt cgccagtgag ctggggaaga caaccaacac
      841 attcttcaag cccccctgtg taaatgtctt ccggtgtgga ggctgctgca acgaagaggg
      901 tgtgatgtgt atgaacacaa gcacctccta catctccaaa cagctctttg agatatcagt
      961 gcctctgaca tcagtgcccg agttagtgcc tgttaaaatt gccaaccata cgggttgtaa
     1021 gtgcttgccc acgggccccc gccatcctta ctcaattatc agaagatcca ttcagacccc
     1081 agaagaagat gaatgtcctc attccaagaa actctgtcct attgacatgc tgtgggataa
     1141 caccaaatgt aaatgtgttt tgcaagacga gactccactg cctgggacag aagaccactc
     1201 ttacctccag gaacccactc tctgtggacc gcacatgacg tttgatgaag atcgctgtga
     1261 gtgcgtctgt aaagcaccat gtccgggaga tctcattcag cacccggaaa actgcagttg
     1321 ctttgagtgc aaagaaagtc tggagagctg ctgccaaaag cacaagattt ttcacccaga
     1381 cacctgcagc tgtgaggaca gatgtccttt tcacaccaga acatgtgcaa gtagaaagcc
     1441 agcctgtgga aagcactggc gctttccaaa ggagacaagg gcccagggac tctacagcca
     1501 ggagaaccct tgattcaact tcctttcaag tccccccatc tctgtcattt taaacagctc
     1561 actgctttgt caagttgctg tcactgttgc ccactacccc tgcccccccc cctccccgcc
     1621 tccaggtgtt agaaaagttg atttgaccta gtgtcatggt aaagccacat ttccatgcaa
     1681 tggcggctag gtgattcccc agttcactga caaatgactt gtagcttcag atgtctttgc
     1741 gccatcagca ctcagaaagg aaggggtctg aggagcccct tgttttgatg aataagaaaa
     1801 ggttgcctga aacagagtag taggtgccac tcgattggtt cctcgggctg gcaaagtcca
     1861 agggcaatgc tcatgagtta ttgtgcttct ttcttatgcg gaatttcatt tgtatgatca
     1921 gcactgatca attcccattc cacttgtact ttttaggttt actgaagcac tgcctgatgt
     1981 tttatatgta aatgtattta aaggaaataa acactgttat gcagcccaca
//
