LOCUS       NM_009506               1881 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus vascular endothelial growth factor C (Vegfc), mRNA.
ACCESSION   NM_009506
VERSION     NM_009506.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1881)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 1881)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   3  (bases 1 to 1881)
  AUTHORS   Chen,J., Zhang,X., DeLaughter,D.M., Trembley,M.A., Saifee,S.,
            Xiao,F., Chen,J., Zhou,P., Seidman,C.E., Seidman,J.G. and Pu,W.T.
  TITLE     Molecular and Spatial Signatures of Mouse Embryonic Endothelial
            Cells at Single-Cell Resolution
  JOURNAL   Circ Res 134 (5), 529-546 (2024)
   PUBMED   38348657
REFERENCE   4  (bases 1 to 1881)
  AUTHORS   Longtine,C., Eliason,C.M., Mishkind,D., Lee,C., Chiappone,M.,
            Goller,F., Love,J., Kingsley,E.P., Clarke,J.A. and Tabin,C.J.
  TITLE     Homology and the evolution of vocal folds in the novel avian voice
            box
  JOURNAL   Curr Biol 34 (3), 461-472 (2024)
   PUBMED   38183987
REFERENCE   5  (bases 1 to 1881)
  AUTHORS   Cui,T., Feng,C., Jiang,H., Jin,Y. and Feng,J.
  TITLE     Inhibition of PFKFB3 Expression Stimulates Macrophage-Mediated
            Lymphangiogenesis Post-Acute Myocardial Infarction
  JOURNAL   Front Biosci (Landmark Ed) 28 (11), 277 (2023)
   PUBMED   38062830
REFERENCE   6  (bases 1 to 1881)
  AUTHORS   Lagercrantz,J., Farnebo,F., Larsson,C., Tvrdik,T., Weber,G. and
            Piehl,F.
  TITLE     A comparative study of the expression patterns for vegf, vegf-b/vrf
            and vegf-c in the developing and adult mouse
  JOURNAL   Biochim Biophys Acta 1398 (2), 157-163 (1998)
   PUBMED   9689915
REFERENCE   7  (bases 1 to 1881)
  AUTHORS   Chilov,D., Kukk,E., Taira,S., Jeltsch,M., Kaukonen,J., Palotie,A.,
            Joukov,V. and Alitalo,K.
  TITLE     Genomic organization of human and mouse genes for vascular
            endothelial growth factor C
  JOURNAL   J Biol Chem 272 (40), 25176-25183 (1997)
   PUBMED   9312130
REFERENCE   8  (bases 1 to 1881)
  AUTHORS   Tamura,T., McMicken,H.W., Smith,C.V. and Hansen,T.N.
  TITLE     Gene structure for mouse glutathione reductase, including a
            putative mitochondrial targeting signal
  JOURNAL   Biochem Biophys Res Commun 237 (2), 419-422 (1997)
   PUBMED   9268726
REFERENCE   9  (bases 1 to 1881)
  AUTHORS   Fitz,L.J., Morris,J.C., Towler,P., Long,A., Burgess,P., Greco,R.,
            Wang,J., Gassaway,R., Nickbarg,E., Kovacic,S., Ciarletta,A.,
            Giannotti,J., Finnerty,H., Zollner,R., Beier,D.R., Leak,L.V.,
            Turner,K.J. and Wood,C.R.
  TITLE     Characterization of murine Flt4 ligand/VEGF-C
  JOURNAL   Oncogene 15 (5), 613-618 (1997)
   PUBMED   9247316
REFERENCE   10 (bases 1 to 1881)
  AUTHORS   Kukk,E., Lymboussaki,A., Taira,S., Kaipainen,A., Jeltsch,M.,
            Joukov,V. and Alitalo,K.
  TITLE     VEGF-C receptor binding and pattern of expression with VEGFR-3
            suggests a role in lymphatic vascular development
  JOURNAL   Development 122 (12), 3829-3837 (1996)
   PUBMED   9012504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120547.8 and AC163012.4.
            
            On Dec 20, 2006 this sequence version replaced NM_009506.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047844.1, BC096377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               AC120547.8         35171-35564         c
            395-596             AC163012.4         150407-150608
            597-787             AC163012.4         152742-152932
            788-939             AC163012.4         162474-162625
            940-1046            AC163012.4         174151-174257
            1047-1380           AC163012.4         174536-174869
            1381-1881           AC163012.4         179403-179903
FEATURES             Location/Qualifiers
     source          1..1881
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.2 cM"
     gene            1..1881
                     /gene="Vegfc"
                     /gene_synonym="VEGF-C"
                     /note="vascular endothelial growth factor C"
                     /db_xref="GeneID:22341"
                     /db_xref="MGI:MGI:109124"
     exon            1..394
                     /gene="Vegfc"
                     /gene_synonym="VEGF-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1495
                     /gene="Vegfc"
                     /gene_synonym="VEGF-C"
                     /note="VRP; flt4-L; flt4 ligand; vascular endothelial
                     growth factor-related protein"
                     /codon_start=1
                     /product="vascular endothelial growth factor C precursor"
                     /protein_id="NP_033532.1"
                     /db_xref="CCDS:CCDS22306.1"
                     /db_xref="GeneID:22341"
                     /db_xref="MGI:MGI:109124"
                     /translation="MHLLCFLSLACSLLAAALIPSPREAPATVAAFESGLGFSEAEPD
                     GGEVKAFEGKDLEEQLRSVSSVDELMSVLYPDYWKMYKCQLRKGGWQQPTLNTRTGDS
                     VKFAAAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGAATNTFFKPPCVSVYRCGG
                     CCNSEGLQCMNTSTGYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVH
                     SIIRRSLPATLPQCQAANKTCPTNYVWNNYMCRCLAQQDFIFYSNVEDDSTNGFHDVC
                     GPNKELDEDTCQCVCKGGLRPSSCGPHKELDRDSCQCVCKNKLFPNSCGANREFDENT
                     CQCVCKRTCPRNQPLNPGKCACECTENTQKCFLKGKKFHHQTCSCYRRPCANRLKHCD
                     PGLSFSEEVCRCVPSYWKRPHLN"
     exon            395..596
                     /gene="Vegfc"
                     /gene_synonym="VEGF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            597..787
                     /gene="Vegfc"
                     /gene_synonym="VEGF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            788..939
                     /gene="Vegfc"
                     /gene_synonym="VEGF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1046
                     /gene="Vegfc"
                     /gene_synonym="VEGF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1380
                     /gene="Vegfc"
                     /gene_synonym="VEGF-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1881
                     /gene="Vegfc"
                     /gene_synonym="VEGF-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1860..1865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vegfc"
                     /gene_synonym="VEGF-C"
                     /note="hexamer: AATGAA"
     polyA_site      1878
                     /gene="Vegfc"
                     /gene_synonym="VEGF-C"
                     /note="major polyA site"
ORIGIN      
        1 ccgccaccga gggcagttcg gatgtccggt ttcctgtgag gctcgtacct gacacccggg
       61 agcctctccc ccgtgagggc tgccagagcc gagggcaaaa gttgcgagcc gccgagtccc
      121 gggagacgct cgcccagggg ggtccccggg aggaaaccac gggacaggga ccaggagagg
      181 acctcagcct cacgccccag cctgcgccag ccaacggacc ggcctccctg ctcccggtcc
      241 atccaccatg cacttgctgt gcttcttgtc tctggcgtgt tccctgctcg ccgctgcgct
      301 gatccccagt ccgcgcgagg cgcccgccac cgtcgccgcc ttcgagtcgg gactgggctt
      361 ctcggaagcg gagcccgacg ggggcgaggt caaggctttt gaaggcaaag acctggagga
      421 gcagttgcgg tctgtgtcca gcgtagatga gctgatgtct gtcctgtacc cagactactg
      481 gaaaatgtac aagtgccagc tgcggaaagg cggctggcag cagcccaccc tcaataccag
      541 gacaggggac agtgtaaaat ttgctgctgc acattataac acagagatcc tgaaaagtat
      601 tgataatgag tggagaaaga ctcaatgcat gccacgtgag gtgtgtatag atgtggggaa
      661 ggagtttgga gcagccacaa acaccttctt taaacctcca tgtgtgtccg tctacagatg
      721 tgggggttgc tgcaacagcg aggggctgca gtgcatgaac accagcacag gttacctcag
      781 caagacgttg tttgaaatta cagtgcctct ctcacaaggc cccaaaccag tcacaatcag
      841 ttttgccaat cacacttcct gccggtgcat gtctaaactg gatgtttaca gacaagttca
      901 ttcaattatt agacgttctc tgccagcaac attaccacag tgtcaggcag ctaacaagac
      961 atgtccaaca aactatgtgt ggaataacta catgtgccga tgcctggctc agcaggattt
     1021 tatcttttat tcaaatgttg aagatgactc aaccaatgga ttccatgatg tctgtggacc
     1081 caacaaggag ctggatgaag acacctgtca gtgtgtctgc aagggggggc ttcggccatc
     1141 tagttgtgga ccccacaaag aactagatag agactcatgt cagtgtgtct gtaaaaacaa
     1201 acttttccct aattcatgtg gagccaacag ggaatttgat gagaatacat gtcagtgtgt
     1261 atgtaaaaga acgtgtccaa gaaatcagcc cctgaatcct gggaaatgtg cctgtgaatg
     1321 tacagaaaac acacagaagt gcttccttaa agggaagaag ttccaccatc aaacatgcag
     1381 ttgttacaga agaccgtgtg cgaatcgact gaagcattgt gatccaggac tgtcctttag
     1441 tgaagaagta tgccgctgtg tcccatcgta ttggaaaagg ccacatctga actaagatca
     1501 taccagtttt cagtccacca ttttactctc ttgaagaact gttgccacat tagcactgtc
     1561 tatgcacaga aagactctgt gggaccatgg taacagaggc ccaagtctgt gtttattgaa
     1621 ccatgtggat tactgcggga gaggactggc actcatgtgc aaaaaaacct cttcaaagac
     1681 tggttttctg ccagggacca gacagctgag gtttttctct tgtgatttaa aaaaagaatg
     1741 actatataat ttatttccac taaaaatatt gttcctgcat tcatttttat agcaataaca
     1801 attggtaaag ctcactgtga tcagtatttt tataacatgc aaaactatgt ttaaaataaa
     1861 atgaaaattg tattataagc t
//
