LOCUS       NM_001185164            1197 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus vascular endothelial growth factor B (Vegfb),
            transcript variant 2, mRNA.
ACCESSION   NM_001185164
VERSION     NM_001185164.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1197)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 1197)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   3  (bases 1 to 1197)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1197)
  AUTHORS   Lee,C., Chen,R., Sun,G., Liu,X., Lin,X., He,C., Xing,L., Liu,L.,
            Jensen,L.D., Kumar,A., Langer,H.F., Ren,X., Zhang,J., Huang,L.,
            Yin,X., Kim,J., Zhu,J., Huang,G., Li,J., Lu,W., Chen,W., Liu,J.,
            Hu,J., Sun,Q., Lu,W., Fang,L., Wang,S., Kuang,H., Zhang,Y.,
            Tian,G., Mi,J., Kang,B.A., Narazaki,M., Prodeus,A., Schoonjans,L.,
            Ornitz,D.M., Gariepy,J., Eelen,G., Dewerchin,M., Yang,Y., Ou,J.S.,
            Mora,A., Yao,J., Zhao,C., Liu,Y., Carmeliet,P., Cao,Y. and Li,X.
  TITLE     VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1
            pathway
  JOURNAL   Signal Transduct Target Ther 8 (1), 305 (2023)
   PUBMED   37591843
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1197)
  AUTHORS   Chen,Y., Li,X., Zhang,J., Zhang,M., Adlat,S., Lu,X., Li,D., Jin,H.,
            Wang,C., Mar Oo,Z., Hayel,F., Chen,Q., Han,X., Chen,R., Feng,X.,
            Zhang,L. and Zheng,Y.
  TITLE     Regulation of adipose tissue development and energy metabolism by
            VEGFB isoforms
  JOURNAL   J Endocrinol 258 (1), e220329 (2023)
   PUBMED   37074365
  REMARK    GeneRIF: Regulation of adipose tissue development and energy
            metabolism by VEGFB isoforms.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1197)
  AUTHORS   Silins,G., Grimmond,S., Egerton,M. and Hayward,N.
  TITLE     Analysis of the promoter region of the human VEGF-related factor
            gene
  JOURNAL   Biochem Biophys Res Commun 230 (2), 413-418 (1997)
   PUBMED   9016794
REFERENCE   7  (bases 1 to 1197)
  AUTHORS   Olofsson,B., Pajusola,K., von Euler,G., Chilov,D., Alitalo,K. and
            Eriksson,U.
  TITLE     Genomic organization of the mouse and human genes for vascular
            endothelial growth factor B (VEGF-B) and characterization of a
            second splice isoform
  JOURNAL   J Biol Chem 271 (32), 19310-19317 (1996)
   PUBMED   8702615
REFERENCE   8  (bases 1 to 1197)
  AUTHORS   Townson,S., Lagercrantz,J., Grimmond,S., Silins,G.,
            Nordenskjold,M., Weber,G. and Hayward,N.
  TITLE     Characterization of the murine VEGF-related factor gene
  JOURNAL   Biochem Biophys Res Commun 220 (3), 922-928 (1996)
   PUBMED   8607868
REFERENCE   9  (bases 1 to 1197)
  AUTHORS   Olofsson,B., Pajusola,K., Kaipainen,A., von Euler,G., Joukov,V.,
            Saksela,O., Orpana,A., Pettersson,R.F., Alitalo,K. and Eriksson,U.
  TITLE     Vascular endothelial growth factor B, a novel growth factor for
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 93 (6), 2576-2581 (1996)
   PUBMED   8637916
REFERENCE   10 (bases 1 to 1197)
  AUTHORS   Lagercrantz,J., Larsson,C., Grimmond,S., Fredriksson,M., Weber,G.
            and Piehl,F.
  TITLE     Expression of the VEGF-related factor gene in pre- and postnatal
            mouse
  JOURNAL   Biochem Biophys Res Commun 220 (1), 147-152 (1996)
   PUBMED   8602835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK148188.1, BC046303.1 and CF804631.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, compared to variant 1. This difference
            results in a frameshift and an isoform (Vegf-b167) with a shorter
            and distinct C-terminus, compared to isoform Vegf-b186.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046303.1, CB204266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AK148188.1         2-23
            23-1178             BC046303.1         1-1156
            1179-1197           CF804631.1         194-212
FEATURES             Location/Qualifiers
     source          1..1197
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.12 cM"
     gene            1..1197
                     /gene="Vegfb"
                     /gene_synonym="VEGF-B; Vrf"
                     /note="vascular endothelial growth factor B"
                     /db_xref="GeneID:22340"
                     /db_xref="MGI:MGI:106199"
     exon            1..300
                     /gene="Vegfb"
                     /gene_synonym="VEGF-B; Vrf"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..807
                     /gene="Vegfb"
                     /gene_synonym="VEGF-B; Vrf"
                     /note="isoform Vegf-b167 precursor is encoded by
                     transcript variant 2; VEGF-related factor"
                     /codon_start=1
                     /product="vascular endothelial growth factor B isoform
                     Vegf-b167 precursor"
                     /protein_id="NP_001172093.1"
                     /db_xref="CCDS:CCDS50373.1"
                     /db_xref="GeneID:22340"
                     /db_xref="MGI:MGI:106199"
                     /translation="MSPLLRRLLLVALLQLARTQAPVSQFDGPSHQKKVVPWIDVYAR
                     ATCQPREVVVPLSMELMGNVVKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQIL
                     MIQYPSSQLGEMSLEEHSQCECRPKKKESAVKPDSPRILCPPCTQRRQRPDPRTCRCR
                     CRRRRFLHCQGRGLELNPDTCRCRKPRK"
     exon            301..343
                     /gene="Vegfb"
                     /gene_synonym="VEGF-B; Vrf"
                     /inference="alignment:Splign:2.1.0"
     exon            344..540
                     /gene="Vegfb"
                     /gene_synonym="VEGF-B; Vrf"
                     /inference="alignment:Splign:2.1.0"
     exon            541..614
                     /gene="Vegfb"
                     /gene_synonym="VEGF-B; Vrf"
                     /inference="alignment:Splign:2.1.0"
     exon            615..650
                     /gene="Vegfb"
                     /gene_synonym="VEGF-B; Vrf"
                     /inference="alignment:Splign:2.1.0"
     exon            651..785
                     /gene="Vegfb"
                     /gene_synonym="VEGF-B; Vrf"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1181
                     /gene="Vegfb"
                     /gene_synonym="VEGF-B; Vrf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1159..1164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vegfb"
                     /gene_synonym="VEGF-B; Vrf"
                     /note="hexamer: GATAAA"
     polyA_site      1181
                     /gene="Vegfb"
                     /gene_synonym="VEGF-B; Vrf"
                     /note="major polyA site"
ORIGIN      
        1 gtcccggcca ccaccgccgc cactacaggc cgcctgcctg tcttgttcct caggccgtcg
       61 ctgcggcgct gcgttgcgct gcctgcgccc agggctcggg agggggccgc ggaggagccg
      121 ccccctgcgc cccgccccgg gtccccgggc ccgcgccatg gggctctggc tgccgccgcc
      181 ccccacgccg ccgggctagg gccatgcggg cgctcccggc gctcgccccc cgcgggcacc
      241 atgagccccc tgctccgtcg cctgctgctt gttgcactgc tgcagctggc tcgcacccag
      301 gcccctgtgt cccagtttga tggccccagc caccagaaga aagtggtgcc atggatagac
      361 gtttatgcac gtgccacatg ccagcccagg gaggtggtgg tgcctctgag catggaactc
      421 atgggcaatg tggtcaaaca actagtgccc agctgtgtga ctgtgcagcg ctgtggtggc
      481 tgctgccctg acgatggcct ggaatgtgtg cccactgggc aacaccaagt ccgaatgcag
      541 atcctcatga tccagtaccc gagcagtcag ctgggggaga tgtccctgga agaacacagc
      601 caatgtgaat gcagaccaaa aaaaaaggag agtgctgtga agccagacag ccccaggatc
      661 ctctgcccgc cttgcaccca gcgccgtcaa cgccctgacc cccggacctg ccgctgccgc
      721 tgcagacgcc gccgcttcct ccattgccaa gggcggggct tagagctcaa cccagacacc
      781 tgtaggtgcc ggaagccgcg aaagtgacaa gctgctttcc agactccacg ggcccggctg
      841 cttttatggc cctgcttcac agggagaaga gtggagcaca ggcgaacctc ctcagtctgg
      901 gaggtcactg ccccaggacc tggacctttt agagagctct ctcgccatct tttatctccc
      961 agagctgcca tctaacaatt gtcaaggaac ctcatgtctc acctcagggg ccagggtact
     1021 ctctcactta accaccctgg tcaagtgagc atcttctggc tggctgtctc ccctcactat
     1081 gaaaacccca aacttctacc aataacggga tttgggttct gttatgataa ctgtgacaca
     1141 cacacacact cacactctga taaaagagat ggaagacact aaaaaaaaaa aaaaaaa
//
