LOCUS       NM_009504               4354 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus vitamin D (1,25-dihydroxyvitamin D3) receptor (Vdr),
            mRNA.
ACCESSION   NM_009504
VERSION     NM_009504.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4354)
  AUTHORS   Chen,Y., Liang,J., Chen,S., Lin,N., Xu,S., Miao,J., Zhang,J.,
            Chen,C., Yuan,X., Xie,Z., Zhu,E., Cai,M., Wei,X., Hou,S. and
            Tang,H.
  TITLE     Discovery of vitexin as a novel VDR agonist that mitigates the
            transition from chronic intestinal inflammation to colorectal
            cancer
  JOURNAL   Mol Cancer 23 (1), 196 (2024)
   PUBMED   39272040
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4354)
  AUTHORS   Doms,S., Verlinden,L., Janssens,I., Vanhevel,J., Eerlings,R.,
            Houtman,R., Kato,S., Mathieu,C., Decallonne,B., Carmeliet,G. and
            Verstuyf,A.
  TITLE     Coactivator-independent vitamin D receptor signaling causes severe
            rickets in mice, that is not prevented by a diet high in calcium,
            phosphate, and lactose
  JOURNAL   Bone Res 12 (1), 44 (2024)
   PUBMED   39164247
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4354)
  AUTHORS   Cong,J., Liu,P., Han,Z., Ying,W., Li,C., Yang,Y., Wang,S., Yang,J.,
            Cao,F., Shen,J., Zeng,Y., Bai,Y., Zhou,C., Ye,L., Zhou,R., Guo,C.,
            Cang,C., Kasper,D.L., Song,X., Dai,L., Sun,L., Pan,W. and Zhu,S.
  TITLE     Bile acids modified by the intestinal microbiota promote colorectal
            cancer growth by suppressing CD8+ T cell effector functions
  JOURNAL   Immunity 57 (4), 876-889 (2024)
   PUBMED   38479384
REFERENCE   4  (bases 1 to 4354)
  AUTHORS   Wang,H., Yu,X., Liu,D., Qiao,Y., Huo,J., Pan,S., Zhou,L., Wang,R.,
            Feng,Q. and Liu,Z.
  TITLE     VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis
            by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy
  JOURNAL   Adv Sci (Weinh) 11 (10), e2305563 (2024)
   PUBMED   38145959
  REMARK    GeneRIF: VDR Activation Attenuates Renal Tubular Epithelial Cell
            Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic
            Nephropathy.
REFERENCE   5  (bases 1 to 4354)
  AUTHORS   Wen,T., Xie,J., Ma,L., Hao,Z., Zhang,W., Wu,T. and Li,L.
  TITLE     Vitamin D Receptor Activation Reduces Hepatic Inflammation via
            Enhancing Macrophage Autophagy in Cholestatic Mice
  JOURNAL   Am J Pathol 194 (3), 369-383 (2024)
   PUBMED   38104651
  REMARK    GeneRIF: Vitamin D Receptor Activation Reduces Hepatic Inflammation
            via Enhancing Macrophage Autophagy in Cholestatic Mice.
REFERENCE   6  (bases 1 to 4354)
  AUTHORS   Johnson,J.A., Grande,J.P., Roche,P.C., Sweeney,W.E. Jr., Avner,E.D.
            and Kumar,R.
  TITLE     1 alpha, 25-dihydroxyvitamin D3 receptor ontogenesis in fetal renal
            development
  JOURNAL   Am J Physiol 269 (3 Pt 2), F419-F428 (1995)
   PUBMED   7573491
REFERENCE   7  (bases 1 to 4354)
  AUTHORS   Kamei,Y., Kawada,T., Fukuwatari,T., Ono,T., Kato,S. and Sugimoto,E.
  TITLE     Cloning and sequencing of the gene encoding the mouse vitamin D
            receptor
  JOURNAL   Gene 152 (2), 281-282 (1995)
   PUBMED   7835717
REFERENCE   8  (bases 1 to 4354)
  AUTHORS   Shamley,D.R., Buffenstein,R., Veale,G. and Pettifor,J.M.
  TITLE     Maternal vitamin D status has no effect on the ontogeny of
            calcium-binding proteins in the duodenum, kidney and cerebellum of
            fetal mice
  JOURNAL   J Endocrinol 139 (3), 473-478 (1993)
   PUBMED   8133214
REFERENCE   9  (bases 1 to 4354)
  AUTHORS   Noda,M., Vogel,R.L., Craig,A.M., Prahl,J., DeLuca,H.F. and
            Denhardt,D.T.
  TITLE     Identification of a DNA sequence responsible for binding of the
            1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3
            enhancement of mouse secreted phosphoprotein 1 (SPP-1 or
            osteopontin) gene expression
  JOURNAL   Proc Natl Acad Sci U S A 87 (24), 9995-9999 (1990)
   PUBMED   2175918
REFERENCE   10 (bases 1 to 4354)
  AUTHORS   Huang,Y.C., Lee,S., Stolz,R., Gabrielides,C., Pansini-Porta,A.,
            Bruns,M.E., Bruns,D.E., Miffin,T.E., Pike,J.W. and Christakos,S.
  TITLE     Effect of hormones and development on the expression of the rat
            1,25-dihydroxyvitamin D3 receptor gene. Comparison with calbindin
            gene expression
  JOURNAL   J Biol Chem 264 (29), 17454-17461 (1989)
   PUBMED   2551904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158787.14 and AK030339.1.
            
            On Dec 12, 2009 this sequence version replaced NM_009504.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030339.1, AK156789.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC158787.14        141034-141095       c
            63-1149             AK030339.1         64-1150
            1150-4354           AC158787.14        87226-90430         c
FEATURES             Location/Qualifiers
     source          1..4354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 53.85 cM"
     gene            1..4354
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /note="vitamin D (1,25-dihydroxyvitamin D3) receptor"
                     /db_xref="GeneID:22337"
                     /db_xref="MGI:MGI:103076"
     exon            1..62
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            63..138
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..286
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1409
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /note="1,25-dihydroxyvitamin D3 receptor; nuclear receptor
                     subfamily 1 group I member 1; vitamin D receptor"
                     /codon_start=1
                     /product="vitamin D3 receptor"
                     /protein_id="NP_033530.2"
                     /db_xref="CCDS:CCDS27784.1"
                     /db_xref="GeneID:22337"
                     /db_xref="MGI:MGI:103076"
                     /translation="MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGC
                     KGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQR
                     KREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPIRAD
                     VSTGSYSPRPTLSFSGDSSSNSDLYTPSLDMMEPASFSTMDLNEEGSDDPSVTLDLSP
                     LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTL
                     DDMSWDCGSQDYKYDITDVSRAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIV
                     SPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEH
                     SKQYRSLSFQPENSMKLTPLVLEVFGNEIS"
     exon            287..417
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..602
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..708
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..880
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1032
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1149
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..4354
                     /gene="Vdr"
                     /gene_synonym="Nr1i1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaagctgct gccgagccct aagcacggga agcgccgagc tgtgtgtcca ccgccagacc
       61 agagttcttt tggttggaca gatctgtgag tcttcccagg agagcaccct tgggctctgc
      121 tcgcccctgc tccttcaggg atggaggcaa tggcagccag cacctccctg cctgaccctg
      181 gtgactttga ccggaatgtg cctcggatct gtggagtgtg tggagaccga gccacgggct
      241 tccacttcaa cgctatgacc tgtgaaggct gcaagggttt cttcaggcgg agcatgaagc
      301 gcaaggccct gttcacctgc cccttcaatg gagattgccg catcaccaag gacaaccggc
      361 gacactgcca ggcctgccgg ctcaaacgct gcgtggacat tggcatgatg aaggagttca
      421 tcctcacaga tgaggaggtg cagcgtaagc gagagatgat catgaagagg aaggaggaag
      481 aggccttgaa ggacagtctg aggcccaagc tgtctgagga gcaacagcac attatcgcca
      541 tcctgctcga tgcccaccac aagacctacg accccaccta tgccgacttc cgggacttcc
      601 ggcctccaat tcgtgcagac gtaagtacag ggagctattc tccaaggccc acactcagct
      661 tctccggaga ctcctcctca aactctgatc tgtacacccc ctcactggac atgatggaac
      721 cggccagctt ttccacgatg gatctgaatg aagaaggctc cgatgacccc tctgtgaccc
      781 tggacctgtc tccgctctcc atgctgcccc acctggctga tcttgtcagt tacagcatcc
      841 aaaaggtcat cggctttgcc aagatgatcc ctggcttcag ggacctcacc tctgatgacc
      901 agattgtcct gcttaagtca agtgccattg aggtgatcat gttgcgctcc aaccagtctt
      961 ttaccttgga tgacatgtcc tgggactgtg gcagccaaga ctacaaatat gacatcactg
     1021 atgtctccag agctgggcac accctggagc tgatcgaacc cctcataaag ttccaggtgg
     1081 ggctgaagaa gctgaacctc catgaggaag aacatgtgct gctcatggcc atctgcattg
     1141 tctccccaga ccgacctggg gtacaggatg ctaagctggt tgaagccatt caggaccgcc
     1201 tatccaacac actgcagacc tacatccgct gccgccaccc gcccccgggc agccaccagc
     1261 tctacgccaa gatgatccag aagctggctg acctgcgaag cctcaatgag gagcactcca
     1321 aacagtaccg ttccctctcc ttccagccgg agaacagcat gaagctcaca ccccttgtgc
     1381 tagaggtgtt cggcaatgag atctcctgac cagggtggcc tgcagtggtg cctgggtagg
     1441 gccgctcctc tggggccctg tgcccaggcc ctgggctggt tgcagcccag cagtgcctcc
     1501 tgcccctcct ggagttcagc tcctcctctg ccgtggcccg tgtctgtctg gctcatcctt
     1561 tctcctgccc agcctcacac ctgatctccc tttcctgtag actgcaggtt gctcctgtcc
     1621 cttgagatct cagttaggag acactgctgt ttatttgaca aagaaactca agtgtgggat
     1681 ggggggaaga gggtagaggg cagaggctga aggcagagag ctctgcctag ggaatgcctc
     1741 cgccataagg ggccactgct tgtgtcaagg gaggcaggca gaagagatga gtccattcct
     1801 cagggacagg tacctgtacc taccccgatt ccaaacctac ctgcctggtg agaactcctg
     1861 cccctgccta caaagggtac acaacctacc catcatccct agtgtgtccc gtctcctcct
     1921 gccacctgtc tgtattattc tgacccaggg gagtcagtca ctgtggggcc tccttcctct
     1981 gctggtatac tcatggactc attcactgcc aagatgacca aatactctac cacactaacc
     2041 aaggagccct ccctagccct gcagttccca cctttgaggt tttgttatgg taagtcccca
     2101 agtccagtac ctctggtaaa gtggacttct tcccccatcc ctagaaccag ggacctagaa
     2161 accaccattg gaaagtcccc agggaatgga atacagagcc caagcaatga ggagcaggca
     2221 aagccagcct cccagcagga caacaaatgg aggtccatct atctttgtca ccaagctgag
     2281 gtgtctgaag cctggagcta ctgggacccc tcctctcctc tatagctatt agatgtgtca
     2341 ggaccaagtt gaccccaact ttcagaacgt ccctagccct gtcttcatcc cttcccctgc
     2401 cagtgcctta ccacctaccc aggaaagcag gtccttgagc cacccaggcc ttacaatttg
     2461 atcaccaaga gtatcccaga agttatctca gcttctccat cacccccact tggagcaaca
     2521 gtgtcacatc tccaccccac ttaccaataa aagctaccct ttccacccag tggaatggga
     2581 tggcagaaaa ccaacagtgg cccagatgga cctccaagtc tgcttttcag gtgtaaagcc
     2641 agacatgagc tctcccacct cagggaaaag gtagaggggg caggttagaa cttgtggtac
     2701 agtgatattg gtccagttcc tcctgactct tcactctacc acccaaaagt caatgtagac
     2761 ctacgaaacg gtcaggtgat gggctaggga cgtatcttca aactccattt cttcctctgt
     2821 agtagcccag tccaggactt tggaaccctg gtctcattca ccccaaatat acttcttgct
     2881 gatcatgcgt tgtgggggtg tggggggacc catgcagagg aggttctctt cataaggggg
     2941 actcacagaa ggaccttcca gtgaatgttt gacctaggga atgcagccac actggaagca
     3001 ccaatagagg gctaaggtca gacggagcat ggccccacga gccccagatt ccctgaaaat
     3061 cctgagatca atcacattta acatcagaag aacccttagt gtccacctgg ccctatgttt
     3121 cccagaattc aagcggaaaa catctgagaa tggctttccc atattgcatt acggcatgca
     3181 gaaggcttta ttttaaagtc attccatcag aggtgttctc agaattagac cccacctgta
     3241 ctgtgttcta acactgaggg tggtggcacc tgattcagag cagtgtgtgt gtgtgtgaaa
     3301 atactgtata ttaatgatta ttgttactgc acacacacac acatacaaaa aaaaaaaaaa
     3361 aaccctagag aaagaccttt gattttagca gcagaacaca ttgatctggc ttactactca
     3421 acaggaggga aagtctgaaa gttgataagc tagttcgact cctttataat gagaacctga
     3481 catcagagga gagtgtgatt tacctgggct catataatta gaagcatctc caggcctgga
     3541 gaaaatttga acttatggtc ccgggctgct ttgtagtgag cctgtttcca ctgctctggt
     3601 agctgagcca ggctatgagg aaaccctgga tatcagcata aacctatgtc tgggactacg
     3661 atcccttttc cctgggtaat aaactcagcc acccatccta aggaggcaag cacttggcct
     3721 ctttgagtga gacttggctt taggactctc tgcatcagcc ttgtgtgcat caggcactgg
     3781 aaagcctctg tcttcccagc ccttgcctct ccaggaaact ccacaggcct ccagagaata
     3841 ccagtttctc agcccaaggg gtccatcact gagaagtgcc caaagggaag tcagggagct
     3901 gggaggaaaa gacagcagga ccaagtagga ttccgaagcc gaactgggag agaacagcat
     3961 catctatttt tattctgaat gtacaaaggc agggccttga aagagctcac acttccgagg
     4021 cggaaatggg taccaaaatg agagatcagc aagatttccc aagataggag aatcctcctg
     4081 ctgcctgcgt gggagaaagt aggggaggag tccaaaccag gccaccagag atggttgaga
     4141 taaatgacaa atctggtgga agtcagacat ggctctaaag agcttcctaa gagacttccc
     4201 gagagagaga caaaagtgtt tgtttgtttt gtttccagga gcttgtcaaa taaaccaatg
     4261 aaaaagcttt gccgatgata ataaaagatg ctcacacttt catagcgctt gctacgtgac
     4321 aagtaccgct gtaaataaat gcctcatgaa aacc
//
