LOCUS       NM_011696               1420 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus voltage-dependent anion channel 3 (Vdac3), transcript
            variant 2, mRNA.
ACCESSION   NM_011696
VERSION     NM_011696.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Mise,S., Matsumoto,A., Shimada,K., Hosaka,T., Takahashi,M.,
            Ichihara,K., Shimizu,H., Shiraishi,C., Saito,D., Suyama,M.,
            Yasuda,T., Ide,T., Izumi,Y., Bamba,T., Kimura-Someya,T.,
            Shirouzu,M., Miyata,H., Ikawa,M. and Nakayama,K.I.
  TITLE     Kastor and Polluks polypeptides encoded by a single gene locus
            cooperatively regulate VDAC and spermatogenesis
  JOURNAL   Nat Commun 13 (1), 1071 (2022)
   PUBMED   35228556
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Shimada,K., Park,S., Miyata,H., Yu,Z., Morohoshi,A., Oura,S.,
            Matzuk,M.M. and Ikawa,M.
  TITLE     ARMC12 regulates spatiotemporal mitochondrial dynamics during
            spermiogenesis and is required for male fertility
  JOURNAL   Proc Natl Acad Sci U S A 118 (6) (2021)
   PUBMED   33536340
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Zou,L., Linck,V., Zhai,Y.J., Galarza-Paez,L., Li,L., Yue,Q.,
            Al-Khalili,O., Bao,H.F., Ma,H.P., Thai,T.L., Jiao,J. and Eaton,D.C.
  TITLE     Knockout of mitochondrial voltage-dependent anion channel type 3
            increases reactive oxygen species (ROS) levels and alters renal
            sodium transport
  JOURNAL   J Biol Chem 293 (5), 1666-1675 (2018)
   PUBMED   29180450
  REMARK    GeneRIF: results suggest that knocking out mitochondrial VDAC3
            increases ROS, alters renal sodium transport, and leads to
            hypertension.
REFERENCE   5  (bases 1 to 1420)
  AUTHORS   Huang,H., Hu,X., Eno,C.O., Zhao,G., Li,C. and White,C.
  TITLE     An interaction between Bcl-xL and the voltage-dependent anion
            channel (VDAC) promotes mitochondrial Ca2+ uptake
  JOURNAL   J Biol Chem 288 (27), 19870-19881 (2013)
   PUBMED   23720737
  REMARK    GeneRIF: Bcl-xL interacts functionally with VDAC1 and -3 but not
            VDAC2.
REFERENCE   6  (bases 1 to 1420)
  AUTHORS   Sampson,M.J., Decker,W.K., Beaudet,A.L., Ruitenbeek,W.,
            Armstrong,D., Hicks,M.J. and Craigen,W.J.
  TITLE     Immotile sperm and infertility in mice lacking mitochondrial
            voltage-dependent anion channel type 3
  JOURNAL   J Biol Chem 276 (42), 39206-39212 (2001)
   PUBMED   11507092
REFERENCE   7  (bases 1 to 1420)
  AUTHORS   Wu,S., Sampson,M.J., Decker,W.K. and Craigen,W.J.
  TITLE     Each mammalian mitochondrial outer membrane porin protein is
            dispensable: effects on cellular respiration
  JOURNAL   Biochim Biophys Acta 1452 (1), 68-78 (1999)
   PUBMED   10525161
REFERENCE   8  (bases 1 to 1420)
  AUTHORS   Sampson,M.J., Ross,L., Decker,W.K. and Craigen,W.J.
  TITLE     A novel isoform of the mitochondrial outer membrane protein VDAC3
            via alternative splicing of a 3-base exon. Functional
            characteristics and subcellular localization
  JOURNAL   J Biol Chem 273 (46), 30482-30486 (1998)
   PUBMED   9804816
REFERENCE   9  (bases 1 to 1420)
  AUTHORS   Sampson,M.J., Lovell,R.S. and Craigen,W.J.
  TITLE     The murine voltage-dependent anion channel gene family. Conserved
            structure and function
  JOURNAL   J Biol Chem 272 (30), 18966-18973 (1997)
   PUBMED   9228078
REFERENCE   10 (bases 1 to 1420)
  AUTHORS   Sampson,M.J., Lovell,R.S., Davison,D.B. and Craigen,W.J.
  TITLE     A novel mouse mitochondrial voltage-dependent anion channel gene
            localizes to chromosome 8
  JOURNAL   Genomics 36 (1), 192-196 (1996)
   PUBMED   8812436
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY103517.1, AK150741.1 and AK002296.1.
            
            On Nov 18, 2010 this sequence version replaced NM_011696.1.
            
            Transcript Variant: This variant (2) differs in the 5' coding
            region, compared to variant 1, and encodes an isoform (2) that is
            one amino acid shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002296.1, BC004743.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BY103517.1         10-68
            60-1402             AK150741.1         2-1344
            1403-1420           AK002296.1         1350-1367
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.42 cM"
     gene            1..1420
                     /gene="Vdac3"
                     /note="voltage-dependent anion channel 3"
                     /db_xref="GeneID:22335"
                     /db_xref="MGI:MGI:106922"
     exon            1..130
                     /gene="Vdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            131..199
                     /gene="Vdac3"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..984
                     /gene="Vdac3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     voltage-dependent anion-selective channel protein 3;
                     channel protein VDAC3; non-selective voltage-gated ion
                     channel VDAC3; mitochondrial outer membrane protein;
                     VDAC-3; mVDAC3; outer mitochondrial membrane protein porin
                     3"
                     /codon_start=1
                     /product="non-selective voltage-gated ion channel VDAC3
                     isoform 2"
                     /protein_id="NP_035826.1"
                     /db_xref="CCDS:CCDS22179.1"
                     /db_xref="GeneID:22335"
                     /db_xref="MGI:MGI:106922"
                     /translation="MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTS
                     GHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTI
                     FVPNTGKKSGKLKASYRRDCFSLGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTA
                     KSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNERIETSINLAWTAGSNNTR
                     FGIAAKYKLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFNAGGHKVG
                     LGFELEA"
     exon            200..249
                     /gene="Vdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            250..402
                     /gene="Vdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            403..455
                     /gene="Vdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            456..683
                     /gene="Vdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            684..834
                     /gene="Vdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            835..892
                     /gene="Vdac3"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1420
                     /gene="Vdac3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggacgacg ggcgcgcagg cgcacaggcg cggcggggga gcgaggtcgc gcaggcgcag
       61 acggcgttgg ttcgagaaga ccttcagcgt tgccttggtg gagcgggacg ggcccaccct
      121 cgggttgtag ctatgtgtaa cacaccaact tattgcgacc taggaaaggc tgccaaggat
      181 gtctttaaca aagggtatgg gtttggcatg gtcaagatag atctgaaaac caagtcttgt
      241 agtggagtgg aattttctac ttcaggtcat gcttatactg atacagggaa agcatcaggc
      301 aacctagaga ccaaatataa ggtctgcaac tatgggctca ccttcaccca aaagtggaat
      361 acagacaata ctcttgggac agaaatctct tgggagaata agttggctga agggttgaaa
      421 ctgactcttg ataccatatt tgtaccaaac acaggaaaga agagtgggaa attaaaggcc
      481 tcctatagac gggattgttt tagtctcggc agtaatgttg atatagattt ttctggaccg
      541 accatctatg gctgggctgt gttggccttt gaaggttggc ttgctggcta tcagatgagt
      601 tttgacacag ccaaatccaa actgtctcag aataatttcg ctcttggtta caaggctgca
      661 gacttccagc tgcatactca cgtgaatgat ggcactgagt ttggaggctc aatctaccag
      721 aaagttaacg agaggattga aacgtcaata aacctggcat ggacagctgg cagcaacaac
      781 actcgttttg gcatcgctgc taaatataag ctggattgta gaacttctct atctgccaaa
      841 gtaaacaatg ccagtttaat tggactgggt tatacgcaga ccctccgacc aggagtcaaa
      901 ctgaccctgt cagctttaat agatggaaag aacttcaatg caggaggcca caaggttgga
      961 ttgggatttg aactggaggc ttagtgtggt tttgagtaga gtatcacttg tccctggaaa
     1021 tgaagagaaa tgaacccact atgttttggc cttaaaattc tgtgaaattt caaaagtgtg
     1081 aactttttat tcttccaaag aattgtaatt cttcccacac tgaagtctag agattacaga
     1141 tctatccaat gggaggtcct ggaaggcatg cctggaaatt gtcatgtttg tgccacattt
     1201 cagttgagtt ctgcagagtt aatttaaata tgttcctcag caacaacgta gtgtcatgtt
     1261 aaaggagcga cctgcctccc cggtctgtac accgtgtcct gcatgtccca gtccactttt
     1321 ccatggcctt ttgttatatc agtctctgct ctagtgagag ctttggtttt gcatcagagt
     1381 aaaataaacc catcacattt ggaacacaat tgttcatctg
//
