LOCUS       NM_001362693            2611 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus voltage-dependent anion channel 1 (Vdac1), transcript
            variant 1, mRNA.
ACCESSION   NM_001362693 XM_017314500
VERSION     NM_001362693.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2611)
  AUTHORS   Zhao,Z., Song,X., Wang,Y., Yu,L., Huang,G., Li,Y., Zong,R., Liu,T.,
            Ji,Q., Zheng,Y., Liu,B., Zhu,Q., Chen,L., Gao,C. and Liu,H.
  TITLE     E3 ubiquitin ligase TRIM31 alleviates dopaminergic
            neurodegeneration by promoting proteasomal degradation of VDAC1 in
            Parkinson's Disease model
  JOURNAL   Cell Death Differ 31 (11), 1410-1421 (2024)
   PUBMED   38918620
  REMARK    GeneRIF: E3 ubiquitin ligase TRIM31 alleviates dopaminergic
            neurodegeneration by promoting proteasomal degradation of VDAC1 in
            Parkinson's Disease model.
REFERENCE   2  (bases 1 to 2611)
  AUTHORS   Ha,H.T., Liu,S., Nguyen,X.T., Vo,L.K., Leong,N.C., Nguyen,D.T.,
            Balamurugan,S., Lim,P.Y., Wu,Y., Seong,E., Nguyen,T.Q., Oh,J.,
            Wenk,M.R., Cazenave-Gassiot,A., Yapici,Z., Ong,W.Y., Burmeister,M.
            and Nguyen,L.N.
  TITLE     Lack of SPNS1 results in accumulation of lysolipids and lysosomal
            storage disease in mouse models
  JOURNAL   JCI Insight 9 (8), e175462 (2024)
   PUBMED   38451736
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2611)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2611)
  AUTHORS   Xia,T., Yu,J., Chen,Y., Chang,X. and Meng,M.
  TITLE     Phosphoglycerate mutase 5 aggravates alcoholic liver disease
            through disrupting VDAC-1-dependent mitochondrial integrity
  JOURNAL   Int J Med Sci 21 (4), 755-764 (2024)
   PUBMED   38464835
  REMARK    GeneRIF: Phosphoglycerate mutase 5 aggravates alcoholic liver
            disease through disrupting VDAC-1-dependent mitochondrial
            integrity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2611)
  AUTHORS   Beutner,G., Burris,J.R., Collins,M.P., Kulkarni,C.A.,
            Nadtochiy,S.M., de Mesy Bentley,K.L., Cohen,E.D., Brookes,P.S. and
            Porter,G.A. Jr.
  TITLE     Coordinated metabolic responses to cyclophilin D deletion in the
            developing heart
  JOURNAL   iScience 27 (3), 109157 (2024)
   PUBMED   38414851
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2611)
  AUTHORS   Wu,S., Sampson,M.J., Decker,W.K. and Craigen,W.J.
  TITLE     Each mammalian mitochondrial outer membrane porin protein is
            dispensable: effects on cellular respiration
  JOURNAL   Biochim Biophys Acta 1452 (1), 68-78 (1999)
   PUBMED   10525161
REFERENCE   7  (bases 1 to 2611)
  AUTHORS   Sampson,M.J., Lovell,R.S. and Craigen,W.J.
  TITLE     The murine voltage-dependent anion channel gene family. Conserved
            structure and function
  JOURNAL   J Biol Chem 272 (30), 18966-18973 (1997)
   PUBMED   9228078
REFERENCE   8  (bases 1 to 2611)
  AUTHORS   Sampson,M.J., Lovell,R.S., Davison,D.B. and Craigen,W.J.
  TITLE     A novel mouse mitochondrial voltage-dependent anion channel gene
            localizes to chromosome 8
  JOURNAL   Genomics 36 (1), 192-196 (1996)
   PUBMED   8812436
REFERENCE   9  (bases 1 to 2611)
  AUTHORS   Huizing,M., Ruitenbeek,W., Thinnes,F.P., DePinto,V., Wendel,U.,
            Trijbels,F.J., Smit,L.M., ter Laak,H.J. and van den Heuvel,L.P.
  TITLE     Deficiency of the voltage-dependent anion channel: a novel cause of
            mitochondriopathy
  JOURNAL   Pediatr Res 39 (5), 760-765 (1996)
   PUBMED   8726225
REFERENCE   10 (bases 1 to 2611)
  AUTHORS   Sampson,M.J., Lovell,R.S. and Craigen,W.J.
  TITLE     Isolation, characterization, and mapping of two mouse mitochondrial
            voltage-dependent anion channel isoforms
  JOURNAL   Genomics 33 (2), 283-288 (1996)
   PUBMED   8660977
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713864.13 and AL645589.24.
            
            On Feb 1, 2022 this sequence version replaced NM_001362693.1.
            
            Summary: This gene encodes a voltage-dependent anion channel
            protein that is a major component of the outer mitochondrial
            membrane. The encoded protein facilitates the exchange of
            metabolites and ions across the outer mitochondrial membrane and
            may regulate mitochondrial functions. This protein also forms
            channels in the plasma membrane and may be involved in
            transmembrane electron transport. Multiple pseudogenes of this gene
            are found on chromosomes 1, 2, 3, 6, 8, 9, and X. [provided by
            RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363657.55797.1,
                                           SRR7345562.1608322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-882               AL713864.13        3782-4663
            883-952             AL645589.24        2806-2875
            953-1002            AL645589.24        3425-3474
            1003-1155           AL645589.24        4898-5050
            1156-1208           AL645589.24        5155-5207
            1209-1436           AL645589.24        12357-12584
            1437-1587           AL645589.24        14090-14240
            1588-1645           AL645589.24        15923-15980
            1646-2611           AL645589.24        16939-17904
FEATURES             Location/Qualifiers
     source          1..2611
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.86 cM"
     gene            1..2611
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /note="voltage-dependent anion channel 1"
                     /db_xref="GeneID:22333"
                     /db_xref="MGI:MGI:106919"
     exon            1..882
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /inference="alignment:Splign:2.1.0"
     CDS             640..1737
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     voltage-dependent anion-selective channel protein 1;
                     plasmalemmal porin; outer mitochondrial membrane protein
                     porin 1; voltage-dependent anion-selective channel protein
                     5; non-selective voltage-gated ion channel VDAC1"
                     /codon_start=1
                     /product="non-selective voltage-gated ion channel VDAC1
                     isoform 1"
                     /protein_id="NP_001349622.1"
                     /db_xref="GeneID:22333"
                     /db_xref="MGI:MGI:106919"
                     /translation="MPVSSRAERAALSGLRPQEQGPGPGLRARPHREPYAWPPWPRGR
                     SPCSVSPNATVHSGNCFQGLTSDWRPATLHGLSKVTLNMAVPPTYADLGKSARDVFTK
                     GYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVNGSLETKYRWTEYGLTFTEKWNTD
                     NTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDVDFDIAGP
                     SIRGALVLGYEGWLAGYQMNFETSKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSI
                     YQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQVDPDACFSAKVNNSSLIGLGYTQTLK
                     PGIKLTLSALLDGKNVNAGGHKLGLGLEFQA"
     exon            883..952
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1002
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1155
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1208
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1436
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1587
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1645
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..2611
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2581..2586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /note="hexamer: AATAAA"
     polyA_site      2611
                     /gene="Vdac1"
                     /gene_synonym="mVDAC1; mVDAC5; Vdac5"
                     /note="major polyA site"
ORIGIN      
        1 gttcgctgcg ctcccagcct cctcgccgca acccccgccg tagctgccgc tgctcccgcc
       61 gtcaccgcct ccgaggtagg cgcagcggag agggcctggg ctatgcctga gtccccaggg
      121 cctcgggtcg cgctcctggg aagtctccag ggaggcgatc gagggaggtt cgggcgaggg
      181 cgctgggcct aagcgcttgg ccccgggaag ggtgaaccag ggacgatcat tgcgggcctg
      241 gaggggcagc gggcttgtag aggaggcctg gagggcgggc gcagagcgga tctcccagat
      301 tctagctcga gcgttcagag cacctgcatt tggaagccag gggcggttcg aacatgcgag
      361 gagcggaagg gcaagggcgg ccgcgtggag gcccggcggg ccgcgggtct aggtgacctt
      421 cccggcggcg ccctctggct ctagatcccg tcggtgtgga tctggtagag accctcccac
      481 ggcccaagcc cttccccacc agctccaagg gcctgtgcag acccagcttc ctccgccgag
      541 aggacgaact ccaggcacgg ccatgccctg gatcccccag cccctacacg ccctagccgg
      601 cccacgcccg gagtaggtgg cgccgggtcc ctcccgcgca tgccagtgtc ttcccgggcg
      661 gaacgggctg ccctgagtgg acttaggccg caggaacagg gacctgggcc tggactgaga
      721 gcgagacccc atagggagcc atacgcttgg cctccttggc ctcggggacg gagtccgtgt
      781 tctgtgtcgc caaatgcaac tgtgcattct ggaaactgtt ttcagggcct gacatcagat
      841 tggaggcccg caactctaca cggtttgtcc aaggtcacac tgaacatggc cgtgcctccc
      901 acatacgccg atcttggcaa gtccgccagg gatgtcttca ccaagggcta cggctttggc
      961 ttaataaaac ttgatttgaa aacgaagtca gagaatggat tggaatttac cagctcaggc
     1021 tctgccaaca cggaaaccac caaagtgaac ggcagcctgg aaaccaagta cagatggact
     1081 gagtatgggc tgacgtttac agagaagtgg aacacagaca acaccctggg cactgagatc
     1141 actgtggaag accagcttgc tcgtggactg aagctcacct ttgattcgtc attctcgccg
     1201 aacactggga aaaaaaatgc taaaatcaag acagggtaca agagggagca catcaacctc
     1261 ggctgtgacg tggactttga catcgctggg ccctcgatcc ggggcgctct ggtgcttggc
     1321 tatgagggtt ggctggctgg ctaccagatg aattttgaga cctcgaagtc ccgagtgacc
     1381 cagagcaact tcgcagttgg ctataagacg gatgaattcc agcttcatac taatgtgaat
     1441 gacgggacag agtttggtgg ctccatttac cagaaggtga acaagaagtt ggagactgct
     1501 gtcaatctcg cctggactgc aggaaacagt aacactcgct tcggaatagc agccaagtat
     1561 caggtcgacc ctgatgcctg cttttcggcc aaagtgaaca actctagcct gattggctta
     1621 gggtacactc agaccctaaa accaggtatc aaactgacgt tgtcagccct gctcgatggc
     1681 aagaacgtca atgcgggtgg ccacaagctt ggcctaggac tggaatttca agcataaatg
     1741 aatattgtac aatcgtttaa ttttaaacta ttttgcagca tagctacctt cagaatttag
     1801 tgtacctttt aatgttgtat gttggggatg cgagagttga taaataccac gttagacctc
     1861 caggctaagg atgactcggc tttaaggtgt ttaccatttc agaggtacag cagaaacccc
     1921 attccagaaa gggtcctttt tagctgtagg cgtgggttgg ggaggagccc ctgtagagat
     1981 gccaggctac aagtggaaag ctgggaacat gtgggtcctt tgtaaatctg tatccagtcc
     2041 ccagatgaaa ttgtgacttc ccgagcatcg aaccctggtg tccagatcct atctgctcgg
     2101 aagcatgtac acacctgcgt gaaagggatg tttttagact gatcctcaca ccctgttccc
     2161 atcgtgccct gttcccatcc tagcccatca cttaacctgt tttacaccaa aagtagtctt
     2221 tagggtgtgg ttagctattt cttttgtgcc attttagggt ggagagggtg ggcgtgatgg
     2281 agccagtcat tcaggactta attcttcctt gtgttgtggt gtggttttct ttcttcttct
     2341 tctttttttt ttttaattcc ttctttcgcc attgcaccag agtatgaaat agcttccggg
     2401 ttctccggct ctgagctggg cggtgattgt ggtcacaccc tgacaacact agggatctca
     2461 actgactcct cttgtagcct caccactatt ttttagcagt ttaatgggta cattatagag
     2521 tcttccattt tgtgtggaat tagctcctcc ccttcaaatg ctgtaattaa catcacttaa
     2581 aataaaactt gaataaaata ctgaaacctc a
//
