LOCUS       NM_009503               3315 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus valosin containing protein (Vcp), mRNA.
ACCESSION   NM_009503
VERSION     NM_009503.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3315)
  AUTHORS   Shao,Z., Wang,L., Cao,L., Chen,T., Jia,X.M., Sun,W., Gao,C. and
            Xiao,H.
  TITLE     The protein segregase VCP/p97 promotes host antifungal defense via
            regulation of SYK activation
  JOURNAL   PLoS Pathog 20 (10), e1012674 (2024)
   PUBMED   39471181
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3315)
  AUTHORS   Jablonski,M., La Spina,F.A., Schiavi-Ehrenhaus,L.J.,
            Marin-Briggiler,C.I., Gomez-Elias,M.D., Krapf,D., Visconti,P.E.,
            Krapf,D., Luque,G.M. and Buffone,M.G.
  TITLE     Dual role of valosin-containing protein (VCP/p97) in mouse sperm
            during capacitation
  JOURNAL   Reproduction 168 (2), e240069 (2024)
   PUBMED   38912971
  REMARK    GeneRIF: Dual role of valosin-containing protein (VCP/p97) in mouse
            sperm during capacitation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3315)
  AUTHORS   Sun,X., Tang,X. and Qiu,H.
  TITLE     Cardiac-Specific Suppression of Valosin-Containing Protein Induces
            Progressive Heart Failure and Premature Mortality Correlating with
            Temporal Dysregulations in mTOR Complex 2 and Protein Phosphatase 1
  JOURNAL   Int J Mol Sci 25 (12), 6445 (2024)
   PUBMED   38928151
  REMARK    GeneRIF: Cardiac-Specific Suppression of Valosin-Containing Protein
            Induces Progressive Heart Failure and Premature Mortality
            Correlating with Temporal Dysregulations in mTOR Complex 2 and
            Protein Phosphatase 1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3315)
  AUTHORS   Shi,X., O'Connor,M. and Qiu,H.
  TITLE     Valosin-containing protein acts as a target and mediator of
            S-nitrosylation in the heart through distinct mechanisms
  JOURNAL   Redox Biol 72, 103166 (2024)
   PUBMED   38685170
  REMARK    GeneRIF: Valosin-containing protein acts as a target and mediator
            of S-nitrosylation in the heart through distinct mechanisms.
REFERENCE   5  (bases 1 to 3315)
  AUTHORS   Huang,T.N., Shih,Y.T., Yen,T.L. and Hsueh,Y.P.
  TITLE     Vcp overexpression and leucine supplementation extend lifespan and
            ameliorate neuromuscular junction phenotypes of a SOD1G93A-ALS
            mouse model
  JOURNAL   Hum Mol Genet 33 (11), 935-944 (2024)
   PUBMED   38382647
REFERENCE   6  (bases 1 to 3315)
  AUTHORS   Meyer,H.H., Shorter,J.G., Seemann,J., Pappin,D. and Warren,G.
  TITLE     A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to
            ubiquitin and nuclear transport pathways
  JOURNAL   EMBO J 19 (10), 2181-2192 (2000)
   PUBMED   10811609
REFERENCE   7  (bases 1 to 3315)
  AUTHORS   Muller,J.M., Meyer,H.H., Ruhrberg,C., Stamp,G.W., Warren,G. and
            Shima,D.T.
  TITLE     The mouse p97 (CDC48) gene. Genomic structure, definition of
            transcriptional regulatory sequences, gene expression, and
            characterization of a pseudogene
  JOURNAL   J Biol Chem 274 (15), 10154-10162 (1999)
   PUBMED   10187799
REFERENCE   8  (bases 1 to 3315)
  AUTHORS   Hoyle,J., Tan,K.H. and Fisher,E.M.
  TITLE     Mapping the valosin-containing protein (VCP) gene on human
            chromosome 9 and mouse chromosome 4, and a likely pseudogene on the
            mouse X chromosome
  JOURNAL   Mamm Genome 8 (10), 778-780 (1997)
   PUBMED   9321476
REFERENCE   9  (bases 1 to 3315)
  AUTHORS   Schulte,R.J., Campbell,M.A., Fischer,W.H. and Sefton,B.M.
  TITLE     Tyrosine phosphorylation of VCP, the mammalian homologue of the
            Saccharomyces cerevisiae CDC48 protein, is unusually sensitive to
            stimulation by sodium vanadate and hydrogen peroxide
  JOURNAL   J Immunol 153 (12), 5465-5472 (1994)
   PUBMED   7989749
REFERENCE   10 (bases 1 to 3315)
  AUTHORS   Egerton,M., Ashe,O.R., Chen,D., Druker,B.J., Burgess,W.H. and
            Samelson,L.E.
  TITLE     VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in
            response to T cell antigen receptor activation
  JOURNAL   EMBO J 11 (10), 3533-3540 (1992)
   PUBMED   1382975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY732145.1 and AK153249.1.
            
            On Mar 21, 2009 this sequence version replaced NM_009503.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153249.1, SRR1660821.13691.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY732145.1         1-29
            30-3315             AK153249.1         1-3286
FEATURES             Location/Qualifiers
     source          1..3315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 22.95 cM"
     gene            1..3315
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /note="valosin containing protein"
                     /db_xref="GeneID:269523"
                     /db_xref="MGI:MGI:99919"
     exon            1..346
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..2750
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /EC_number="3.6.4.6"
                     /note="AAA ATPase p97; TER ATPase; 15S Mg(2+)-ATPase p97
                     subunit; homolog of yeast cdc48; Inv protein"
                     /codon_start=1
                     /product="transitional endoplasmic reticulum ATPase"
                     /protein_id="NP_033529.3"
                     /db_xref="CCDS:CCDS18086.1"
                     /db_xref="GeneID:269523"
                     /db_xref="MGI:MGI:99919"
                     /translation="MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQP
                     KMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISI
                     QPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRA
                     VEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKE
                     MVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMS
                     KLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDG
                     LKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLAD
                     DVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMD
                     DFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGM
                     TPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKA
                     RQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATN
                     RPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGF
                     SGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAM
                     RFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGSGGGTGGSVYTE
                     DNDDDLYG"
     exon            347..458
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            459..631
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            632..774
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            775..905
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1037
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1140
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1274
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1410
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1523
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1688
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1811
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2024
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2333
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2489
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2644
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..3315
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2938..2943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /note="hexamer: AATAAA"
     polyA_site      2959
                     /gene="Vcp"
                     /gene_synonym="3110001E05; CDC48; p97; p97/VCP"
                     /note="major polyA site"
ORIGIN      
        1 gagtcccaag gccggcgctg attggttggg gttagagcag ctttccttcc gatgattcgg
       61 cttttctcgg ttcagtctcc gtgaagcgtt tgcagccgtc gtttgattag tcgctgcccc
      121 cctcgcggat taggagctag cgtctcccgc ccgcccgcct gccgccccgg tgcccctggg
      181 aggaagcgag agggaggctg ccagagggtt tgtcactgct gttgctcctc cgcctcagcg
      241 agtccagccc cggcctagtc ggtcgcctgc ctttctcata gccgttaccc tcaggccgcc
      301 acagccgccg accgggagag gcgcgcgcca tggcctctgg agccgattca aaaggtgatg
      361 atttatcaac agccattctc aaacagaaga accgacccaa tcggttaatt gttgatgaag
      421 ccatcaatga agataacagc gtggtgtcct tgtcccagcc caagatggat gaactgcagt
      481 tgttccgagg tgacacggtg ttgctaaaag gaaagaaaag acgggaagct gtatgcattg
      541 ttctttctga tgacacgtgt tctgatgaga agattcgaat gaatagagtt gttcggaata
      601 acctccgagt tcgcctagga gatgtcatca gcatccagcc atgccctgat gtaaagtatg
      661 gcaaacgtat ccacgttcta cccatcgatg acacagtgga aggcatcact ggcaatctct
      721 ttgaggtata ccttaagccg tacttcctgg aagcttatcg gcccatccgt aaaggagata
      781 tttttcttgt ccggggtggg atgcgtgctg tggagttcaa agttgtagag acagatccca
      841 gcccttactg tattgttgct ccagacacag tgatccactg tgagggggag ccaatcaagc
      901 gagaggatga ggaggaatcc ttgaatgaag taggctatga tgacatcggt ggttgcagga
      961 agcagctagc tcagataaag gagatggtgg agctgccact gagacatcct gcgctcttta
     1021 aggcgattgg tgtaaagcct cctcggggaa tcttgttgta tgggcctcct gggacaggga
     1081 agaccctgat tgctcgagct gtggcaaatg aaactggagc cttcttcttt ctgatcaatg
     1141 gtcctgaaat catgagcaaa ttggctggtg agtctgagag caaccttcgt aaagcctttg
     1201 aggaagctga aaagaatgct cctgctatca tcttcatcga tgagcttgat gccattgcac
     1261 ccaaaagaga gaaaactcat ggggaagtgg agcgtcgcat cgtgtctcag ttgttgaccc
     1321 tcatggatgg cctaaagcag agagcacatg tgatagttat ggcagcaacc aatagaccca
     1381 acagcattga cccagcccta cggcgatttg gtcgctttga cagagaggta gatattggaa
     1441 tacctgatgc tacaggacgt ttggagattc ttcagatcca taccaagaac atgaaactgg
     1501 cagatgatgt ggacttggaa caggtagcca atgagactca tggtcatgtt ggtgctgatt
     1561 tggcagccct atgttcagag gctgctctgc aggccatccg gaaaaaaatg gacctcattg
     1621 acctagaaga tgagaccatt gatgctgagg tcatgaattc cctggcagtt actatggatg
     1681 acttccggtg ggctttgagt caaagcaacc catcagcact tcgggaaact gtggtagagg
     1741 tgccacaagt aacctgggaa gatattggag gcctggagga tgtcaaacgt gagcttcagg
     1801 agttggttca gtatcctgtg gaacatccag acaaattcct caaatttggc atgactccct
     1861 ccaaaggcgt tcttttctat ggacctcctg gctgtgggaa aaccttactg gctaaagcca
     1921 ttgctaatga atgccaggcc aacttcatct ccatcaaggg tcctgagctg cttaccatgt
     1981 ggtttgggga atctgaggcc aatgtccggg aaatttttga caaggcacgg caagctgccc
     2041 cctgtgtact cttctttgat gagttagatt caattgccaa ggctcgaggt ggtaatattg
     2101 gagatggtgg tggagctgct gaccgagtca tcaatcagat cctgacagaa atggatggca
     2161 tgtctacaaa aaagaatgtg tttatcattg gagctaccaa caggcctgac atcattgatc
     2221 ctgctatcct aagacctggc cgtctagatc agctcattta tatcccactt cctgatgaga
     2281 agtcccgtgt tgccatccta aaagccaatc tgcgaaagtc cccagttgcc aaggatgtgg
     2341 atttggagtt cctggctaag atgactaatg gcttttctgg agctgatttg acagaaattt
     2401 gccaacgggc ttgtaaactg gccattcgtg aatctattga gagtgagatt aggcgagaac
     2461 gagagaggca gacaaatcca tcggctatgg aggtagaaga ggacgatcca gtgcctgaga
     2521 tccgcagaga tcactttgag gaagccatgc gttttgcccg acgttctgtc agcgataatg
     2581 acattcggaa gtatgaaatg ttcgcccaga cactgcagca gagtcgaggt tttggcagct
     2641 tcagattccc ttcagggaac cagggtggag ctggtcccag ccagggcagt ggaggtggca
     2701 caggtggcag tgtgtacaca gaagacaatg acgatgacct gtatggctaa gtgatgtgcc
     2761 agcatgcagc gagctggcct ggctggacct tgttccctgg gggagggggc gcttgcccaa
     2821 gagggaccag gggtgtgccc atggcctgtt ccattcctca gtctgaacag ttcagcccca
     2881 gtcagactct ggacaggggt ttcctgttgc aaaaaaaaaa aattacaaaa gcgataaaat
     2941 aaaagtgatt ttcatttggg aggtgaagag tgaattacca gcaaggaatt gggtcttggg
     3001 cccacacggt ttctgtcgta gtttggggtg gtgcaggtaa cctgtgtggt gtgaaccaag
     3061 gcattgccac caccatcacc acagtaaagc atctatactc aatgctgtcc aagtcctccc
     3121 ttaccctagc caacctgggt aggtggatga ggggcctcag tttgctgggt gtttatatag
     3181 aaagtaggtt gatttttatt ttacatgctt ttgagttact gttggaagat taatcataag
     3241 cagtttctaa accaaaaaaa agaagaaaaa aaaaagacat gttgtaaaag gacaataaat
     3301 gttgggtcaa aatgg
//
