LOCUS       NM_009502               5267 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus vinculin (Vcl), mRNA.
ACCESSION   NM_009502
VERSION     NM_009502.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5267)
  AUTHORS   Borisova,E., Newman,A.G., Couce Iglesias,M., Dannenberg,R.,
            Schaub,T., Qin,B., Rusanova,A., Brockmann,M., Koch,J., Daniels,M.,
            Turko,P., Jahn,O., Kaplan,D.R., Rosario,M., Iwawaki,T.,
            Spahn,C.M.T., Rosenmund,C., Meierhofer,D., Kraushar,M.L.,
            Tarabykin,V. and Ambrozkiewicz,M.C.
  TITLE     Protein translation rate determines neocortical neuron fate
  JOURNAL   Nat Commun 15 (1), 4879 (2024)
   PUBMED   38849354
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5267)
  AUTHORS   Vukic,M., Chouaref,J., Della Chiara,V., Dogan,S., Ratner,F.,
            Hogenboom,J.Z.M., Epp,T.A., Chawengsaksophak,K., Vonk,K.K.D.,
            Breukel,C., Ariyurek,Y., San Leon Granado,D., Kloet,S.L. and
            Daxinger,L.
  TITLE     CDCA7-associated global aberrant DNA hypomethylation translates to
            localized, tissue-specific transcriptional responses
  JOURNAL   Sci Adv 10 (6), eadk3384 (2024)
   PUBMED   38335290
REFERENCE   3  (bases 1 to 5267)
  AUTHORS   Bai,Y., Bentley,L., Ma,C., Naveenan,N., Cleak,J., Wu,Y.,
            Simon,M.M., Westerberg,H., Canas,R.C., Horner,N., Pandey,R.,
            Paphiti,K., Schulze,U., Mianne,J., Hough,T., Teboul,L., de
            Baaij,J.H.F. and Cox,R.D.
  TITLE     Cleft palate and minor metabolic disturbances in a mouse global
            Arl15 gene knockout
  JOURNAL   FASEB J 37 (11), e23211 (2023)
   PUBMED   37773757
REFERENCE   4  (bases 1 to 5267)
  AUTHORS   Nag,P., Inubushi,T., Sasaki,J.I., Murotani,T., Kusano,S.,
            Nakanishi,Y., Shiraishi,Y., Kurosaka,H., Imazato,S., Yamaguchi,Y.
            and Yamashiro,T.
  TITLE     Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft Enamel in
            Mouse
  JOURNAL   J Dent Res 102 (10), 1162-1171 (2023)
   PUBMED   37449307
REFERENCE   5  (bases 1 to 5267)
  AUTHORS   Dos Santos,M., Shah,A.M., Zhang,Y., Bezprozvannaya,S., Chen,K.,
            Xu,L., Lin,W., McAnally,J.R., Bassel-Duby,R., Liu,N. and Olson,E.N.
  TITLE     Opposing gene regulatory programs governing myofiber development
            and maturation revealed at single nucleus resolution
  JOURNAL   Nat Commun 14 (1), 4333 (2023)
   PUBMED   37468485
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5267)
  AUTHORS   O'Brien,E.P., Zhen,L., Jiang,S.Y., Novak,E.K. and Swank,R.T.
  TITLE     High-resolution genetic mapping of the gunmetal gene which
            regulates platelet production
  JOURNAL   Mamm Genome 7 (3), 206-208 (1996)
   PUBMED   8833241
REFERENCE   7  (bases 1 to 5267)
  AUTHORS   Coll,J.L., Ben-Ze'ev,A., Ezzell,R.M., Rodriguez Fernandez,J.L.,
            Baribault,H., Oshima,R.G. and Adamson,E.D.
  TITLE     Targeted disruption of vinculin genes in F9 and embryonic stem
            cells changes cell morphology, adhesion, and locomotion
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9161-9165 (1995)
   PUBMED   7568093
REFERENCE   8  (bases 1 to 5267)
  AUTHORS   Schevzov,G., Lloyd,C. and Gunning,P.
  TITLE     Impact of altered actin gene expression on vinculin, talin, cell
            spreading, and motility
  JOURNAL   DNA Cell Biol 14 (8), 689-700 (1995)
   PUBMED   7646816
REFERENCE   9  (bases 1 to 5267)
  AUTHORS   Ben-Ze'ev,A., Reiss,R., Bendori,R. and Gorodecki,B.
  TITLE     Transient induction of vinculin gene expression in 3T3 fibroblasts
            stimulated by serum-growth factors
  JOURNAL   Cell Regul 1 (9), 621-636 (1990)
   PUBMED   2127699
REFERENCE   10 (bases 1 to 5267)
  AUTHORS   Weller,P.A., Ogryzko,E.P., Corben,E.B., Zhidkova,N.I., Patel,B.,
            Price,G.J., Spurr,N.K., Koteliansky,V.E. and Critchley,D.R.
  TITLE     Complete sequence of human vinculin and assignment of the gene to
            chromosome 10
  JOURNAL   Proc Natl Acad Sci U S A 87 (15), 5667-5671 (1990)
   PUBMED   2116004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154840.2, AC163681.3 and AEKQ02168448.1.
            
            On Apr 17, 2018 this sequence version replaced NM_009502.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077850.1, BC008520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               AC154840.2         12319-12609         c
            292-362             AC163681.3         124079-124149       c
            363-513             AC163681.3         108963-109113       c
            514-622             AC163681.3         108211-108319       c
            623-745             AC163681.3         105938-106060       c
            746-906             AC163681.3         104569-104729       c
            907-911             AC163681.3         96671-96675         c
            912-997             AEKQ02168448.1     9292-9377           c
            998-1145            AC163681.3         95695-95842         c
            1146-1299           AC163681.3         90403-90556         c
            1300-1475           AC163681.3         88417-88592         c
            1476-1666           AC163681.3         84383-84573         c
            1667-1866           AC163681.3         82627-82826         c
            1867-1995           AC163681.3         81521-81649         c
            1996-2145           AC163681.3         76627-76776         c
            2146-2254           AC163681.3         72299-72407         c
            2255-2557           AC163681.3         70906-71208         c
            2558-2682           AC163681.3         69560-69684         c
            2683-2868           AC163681.3         67396-67581         c
            2869-3072           AC163681.3         62308-62511         c
            3073-3177           AC163681.3         61801-61905         c
            3178-5267           AC163681.3         58011-60100         c
FEATURES             Location/Qualifiers
     source          1..5267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.53 cM"
     gene            1..5267
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /note="vinculin"
                     /db_xref="GeneID:22330"
                     /db_xref="MGI:MGI:98927"
     exon            1..291
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..3324
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /note="metavinculin"
                     /codon_start=1
                     /product="vinculin"
                     /protein_id="NP_033528.3"
                     /db_xref="CCDS:CCDS26860.1"
                     /db_xref="GeneID:22330"
                     /db_xref="MGI:MGI:98927"
                     /translation="MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPV
                     AAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSV
                     PARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTY
                     TKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNS
                     KNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSK
                     LNQAKGWLRDPNASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQ
                     VADLRARGQGASPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQ
                     NWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEIAALTSKLGDLRR
                     QGKGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPT
                     VDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGES
                     PQARALASQLQDSLKDLKAQMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREE
                     VFDERAANFENHSGRLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVISAARIL
                     LRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVA
                     MANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMV
                     MDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTD
                     ELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEARKWSS
                     KGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQC
                     TDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNL
                     MQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ"
     exon            292..362
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            363..513
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            514..622
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            623..745
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            746..906
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            907..997
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1145
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1299
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1475
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1666
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1866
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1995
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2145
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2254
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2557
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2682
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2868
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3072
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3177
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..5267
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5244..5249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /note="hexamer: AATAAA"
     polyA_site      5264
                     /gene="Vcl"
                     /gene_synonym="9430097D22"
                     /note="major polyA site"
ORIGIN      
        1 agttacgccg agggaagccc ggactctagt cgccgctccg agtcagtcac tcgccgccgg
       61 ctcccggccc tacggatccc agttttctgt tgcccgcggt acgccgcccc gctagccgcc
      121 gcgatgccgg tgtttcacac gcgtacgatc gagagcatcc tggagccggt ggcgcagcag
      181 atctcgcacc tggtgattat gcacgaggag ggcgaggtgg acggcaaagc cattcctgac
      241 ctcaccgcgc ccgtagccgc cgtgcaggcg gccgtcagca acctcgtccg ggttggaaaa
      301 gagactgttc agaccactga ggatcagatt ctgaagagag atatgccacc agcctttatt
      361 aaggttgaaa atgcttgcac caagcttgtt caggcagccc agatgcttca gtcagaccca
      421 tactcggttc ctgcgcggga ttacctcatt gacggctcta ggggaatcct ttctggcaca
      481 tctgacctac tgcttacctt cgatgaggct gaggttcgta aaattattag ggtttgcaaa
      541 ggaattttgg aatatcttac agtggcagag gtagtggaaa ctatggaaga cttggtcact
      601 tacacaaaga atcttgggcc aggaatgact aagatggcca aaatgattga tgagagacag
      661 caggagttga ctcaccagga acaccgtgtg atgttggtga actcaatgaa cactgtcaaa
      721 gagctgcttc ctgttctcat ttcagctatg aagatttttg ttacaaccaa aaactcaaaa
      781 aaccaaggaa tagaagaagc tttgaaaaat cgaaatttta ctgtagaaaa gatgagtgct
      841 gaaattaacg agatcattcg tgtgttacaa ctcacttcct gggatgaaga tgcctgggcc
      901 agcaaggaca ctgaagccat gaagagagcg ctggcgtcca tagactccaa attgaaccag
      961 gccaaaggtt ggctccgtga ccccaatgcc tccccagggg atgctggaga gcaggccatc
     1021 aggcagatct tagatgaagc tggaaaagtt ggtgaacttt gtgcaggcaa ggaacgcagg
     1081 gagatcctag gaacctgcaa aatgctaggg cagatgactg accaagtggc tgacctccga
     1141 gccagaggac aaggagcttc cccagtggcc atgcagaagg cccagcaagt gtctcagggg
     1201 ctcgacgtgc ttaccgccaa agtggagaat gcagctcgga agctggaagc catgacgaac
     1261 tcaaagcaga gcattgcaaa gaagattgat gctgcccaga attggctggc ggatccaaat
     1321 ggtggacctg agggagaaga acagattcga ggggctttgg ctgaagctcg gaagattgca
     1381 gaattatgtg atgatcctaa ggagagagat gacatcctcc gctcccttgg agagatagct
     1441 gctctgacct ctaaactagg agacttgcga agacagggga aaggagactc gccagaggct
     1501 cgagccttgg ctaaacaagt ggcgacggca ctacagaacc tgcagaccaa aaccaacagg
     1561 gccgtggcca acagcagacc tgccaaagca gctgtccacc tcgagggcaa gattgaacag
     1621 gcgcagcggt ggattgataa ccccacagta gatgaccgtg gagtcggtca ggctgccatc
     1681 cgtggacttg tggctgaggg gcatcggctg gccaatgtca tgatgggacc ttatcgccaa
     1741 gatcttcttg ccaaatgtga ccgtgtagac cagctaacag ctcagctggc tgacctggct
     1801 gcccgagggg agggggagag tcctcaggcg agagcacttg catcccagct tcaggactcc
     1861 ttaaaggatc ttaaagccca gatgcaggaa gctatgactc aagaggtatc cgatgttttc
     1921 agcgatacta caactcctat caagctgttg gcagtagccg ccactgctcc tcctgatgca
     1981 cccaataggg aagaggtatt tgatgaaagg gcagccaatt ttgaaaacca ttcaggaagg
     2041 cttggagcca cagcagagaa ggcggctgct gttggtactg ccaataaatc gacagtggaa
     2101 ggcattcagg catctgtgaa gacagcccga gaactcactc cccaggtcat ctccgctgct
     2161 cggatcttac tgaggaaccc tggtaaccag gctgcttatg aacattttga gaccatgaag
     2221 aaccagtgga ttgataatgt tgaaaaaatg acagggctgg tggacgaggc tattgatacc
     2281 aagtctctgt tggatgcttc tgaagaagca attaaaaaag acctggacaa gtgtaaggta
     2341 gccatggcca atattcagcc tcagatgctg gtcgctggag caaccagtat tgctcgtcgg
     2401 gccaaccgga ttctgctggt tgctaagagg gaggtagaga actctgagga cccgaagttc
     2461 cgagaggctg tgaaagctgc ctctgatgaa ctgagcaaaa caatctcccc catggtgatg
     2521 gatgccaagg ctgtggctgg aaacatctct gaccctggcc tgcaaaagag cttcctggac
     2581 tcaggatatc ggatcctggg agctgtggcc aaggtcagag aagccttcca acctcaggag
     2641 cctgacttcc cgcctcctcc accagacctt gaacagctac gactaactga tgagctggct
     2701 cctcctaagc cacctctgcc tgagggtgaa gtccctccac ccaggccccc accaccagaa
     2761 gagaaggatg aagagttccc tgagcagaaa gctggtgagg tgattaacca gccaatgatg
     2821 atggccgcca ggcagctcca cgatgaagct cggaaatggt ctagcaaggg caatgacatc
     2881 attgcagcag ccaagcgcat ggctctgctg atggcagaga tgtctcggct ggtaagaggg
     2941 ggcagtggta ccaagcgggc acttattcag tgtgccaagg atatcgccaa ggcctctgat
     3001 gaggtgacga ggttggccaa ggaggttgcc aagcagtgca cagataagcg gattagaacc
     3061 aatctcttac aggtatgcga gcgaatccca actataagca cccagctcaa aatcctatcc
     3121 acagtgaagg ccactatgct gggccggacc aacatcagtg atgaggagtc tgagcaggcc
     3181 acagagatgc tggttcataa tgcccagaac ctcatgcagt ctgtgaagga gactgtgcga
     3241 gaggctgaag ctgcttcaat caaaatccga acagatgctg gctttactct gcgctgggtc
     3301 agaaagactc cctggtacca gtaggcacct cgtcaaatct ggctggtaca tacacctctg
     3361 ctaaagagaa gagaaccatc ttgagttcca gaagccattc agagttgtca ggaatggaaa
     3421 catcaatccc tggcttcaca caccagaaag gaacatttat actcttgtca tgggcacttt
     3481 gaaatgtgtc tctctataaa ccctgtactt tcagttacta tgcgcactct ctcccatgga
     3541 ttttacagca gctcagaata agcgtgaaca ctagccggaa gccctgctct gccccggggg
     3601 tcatttctgt gtttacggtt caccaactcc ctttccccac tataggctct caagacctag
     3661 agctgaggca agtctaaata actgtgcttc caaagttatt ttgggtttcc ccccctgctg
     3721 ctgaccctgc ctaccttctc tgggctgtgc atcattgctg caggaaaaag tggtctctgg
     3781 agagttctag cttgtgcggc ctggattcat ttcctgcttt ctcccagtgt aaccctagtt
     3841 cctcacaatg ggaaaccaac tttcactgtt gtgaggaaat cattatttct gtttttacca
     3901 tgccactaac tagtatgtgt tatggaaact tcctgtctca catcctgcct tgtttggttg
     3961 ccaaggtaac catcctgtaa acacactggt gctctgtcac tagaggaaca gagtcactgg
     4021 ggtgttatcc tgcccatcct cccagtgggg ccactcccag attttctatg ctttgtcact
     4081 gccagtagat gtctgtgctg aggccttggc attcattctt cgcccttatt ttctttaatt
     4141 tctgagctga agtgctgcat ttacttttaa ccaaatcatc ctaggctttg gcagtcttct
     4201 tctgtatgct tctttaaaca agactttaaa gatacatagg tatgtgtttg tctgtaatcc
     4261 ctccatcccc cacttttttc ttttttttaa attttgagac tgggtctctt tatgttgtcc
     4321 aggctagtct tgaacttatg gattcaagtg atctacctgt gtcagcctgt tagctcctac
     4381 caccacactt gactttgctt gtaactttga aaggttcatt caaaattgag acttaagaat
     4441 tagggcttgc tccttaagag acttgaatgg aaaggcaatc ttgtctggga gactagcatt
     4501 tgcagattat acttctggtg cttctaggga aaaatcagta ggaactatta tagttcccag
     4561 ttgcttttaa tcaactacaa ccaagcattt ttcatccttc cataaatacg aagtattcaa
     4621 gaataatgag tatggtatct atttatcaga aaggcatgtt tcctattggg caaagttagt
     4681 gtaaaagtga ctttcctttt tttttgcatt tatcctggct gtataagcat ttcccagtat
     4741 acaaatgctt ctttcagaaa tcaggaacca gacgaataca ggagtgaggc cttcttcctg
     4801 gatgttcttc ccacatctag tatgtccaat cccaacactg aacttgtaaa tcttaagttg
     4861 accctgaata ctcaggctcc ccctatttct ttttgctgat aaaagattct tttcaaagct
     4921 ctcagcagat ctgtatagtt gcttacctga tataaatgca tatcaatgcc tttaaagtat
     4981 gaatctatgc caaagatcat tttttgtctt actaaagatt tcttagagga actaagaaga
     5041 atcatgttta ttctccaagt tccttcagtt ctggagacac atgtccacca gatgtgcttt
     5101 ctagtgtcag tgcttacagt acaaggaggc aaaaggaaac agtccctgaa tgacgtgtta
     5161 gagatgccac cactaaaaac tatgtttata agctaggact tatatgtaaa tgtttctgcc
     5221 tcttcttttg ttctgtttaa aacaataaag tacatttata tgaataa
//
