LOCUS       NM_001081249           12432 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus versican (Vcan), transcript variant 1, mRNA.
ACCESSION   NM_001081249 XM_488510
VERSION     NM_001081249.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12432)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   2  (bases 1 to 12432)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12432)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Zhao,L., Castillo,M., Xiao,Y., Guo,H.,
            Liu,Y., Gunaratne,P., Schwartz,R.J., Burns,A.R., Kumar,A.,
            DiPersio,C.M. and Wu,M.
  TITLE     beta1 integrins regulate cellular behaviour and cardiomyocyte
            organization during ventricular wall formation
  JOURNAL   Cardiovasc Res 120 (11), 1279-1294 (2024)
   PUBMED   38794925
REFERENCE   4  (bases 1 to 12432)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   5  (bases 1 to 12432)
  AUTHORS   Carabana,C., Sun,W., Veludo Ramos,C., Huyghe,M., Perkins,M.,
            Maillot,A., Journot,R., Hartani,F., Faraldo,M.M., Lloyd-Lewis,B.
            and Fre,S.
  TITLE     Spatially distinct epithelial and mesenchymal cell subsets along
            progressive lineage restriction in the branching embryonic mammary
            gland
  JOURNAL   EMBO J 43 (12), 2308-2336 (2024)
   PUBMED   38760574
REFERENCE   6  (bases 1 to 12432)
  AUTHORS   Naso,M.F., Morgan,J.L., Buchberg,A.M., Siracusa,L.D. and Iozzo,R.V.
  TITLE     Expression pattern and mapping of the murine versican gene (Cspg2)
            to chromosome 13
  JOURNAL   Genomics 29 (1), 297-300 (1995)
   PUBMED   8530092
REFERENCE   7  (bases 1 to 12432)
  AUTHORS   Shinomura,T., Zako,M., Ito,K., Ujita,M. and Kimata,K.
  TITLE     The gene structure and organization of mouse PG-M, a large
            chondroitin sulfate proteoglycan. Genomic background for the
            generation of multiple PG-M transcripts
  JOURNAL   J Biol Chem 270 (17), 10328-10333 (1995)
   PUBMED   7730339
REFERENCE   8  (bases 1 to 12432)
  AUTHORS   Zako,M., Shinomura,T., Ujita,M., Ito,K. and Kimata,K.
  TITLE     Expression of PG-M(V3), an alternatively spliced form of PG-M
            without a chondroitin sulfate attachment in region in mouse and
            human tissues
  JOURNAL   J Biol Chem 270 (8), 3914-3918 (1995)
   PUBMED   7876137
REFERENCE   9  (bases 1 to 12432)
  AUTHORS   Ito,K., Shinomura,T., Zako,M., Ujita,M. and Kimata,K.
  TITLE     Multiple forms of mouse PG-M, a large chondroitin sulfate
            proteoglycan generated by alternative splicing
  JOURNAL   J Biol Chem 270 (2), 958-965 (1995)
   PUBMED   7822336
REFERENCE   10 (bases 1 to 12432)
  AUTHORS   Iozzo,R.V., Naso,M.F., Cannizzaro,L.A., Wasmuth,J.J. and
            McPherson,J.D.
  TITLE     Mapping of the versican proteoglycan gene (CSPG2) to the long arm
            of human chromosome 5 (5q12-5q14)
  JOURNAL   Genomics 14 (4), 845-851 (1992)
   PUBMED   1478664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134397.6 and AC154460.2.
            
            On Feb 6, 2007 this sequence version replaced XM_488510.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also referred to as
            V0).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D28599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               AC134397.6         19499-19938
            441-516             AC134397.6         30477-30552
            517-891             AC134397.6         36348-36722
            892-1066            AC134397.6         40065-40239
            1067-1194           AC134397.6         40317-40444
            1195-1488           AC134397.6         49513-49806
            1489-4368           AC134397.6         56214-59093
            4369-9585           AC134397.6         68510-73726
            9586-9699           AC134397.6         76819-76932
            9700-9813           AC134397.6         77498-77611
            9814-9972           AC134397.6         82053-82211
            9973-10055          AC134397.6         83854-83936
            10056-10200         AC154460.2         13225-13369
            10201-10383         AC154460.2         17601-17783
            10384-12432         AC154460.2         17928-19976
FEATURES             Location/Qualifiers
     source          1..12432
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 45.5 cM"
     gene            1..12432
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /note="versican"
                     /db_xref="GeneID:13003"
                     /db_xref="MGI:MGI:102889"
     exon            1..440
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            441..516
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     CDS             447..10511
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; PG-M core protein; versican core protein; large
                     fibroblast proteoglycan; chondroitin sulfate proteoglycan
                     core protein 2"
                     /codon_start=1
                     /product="versican core protein isoform 1 precursor"
                     /protein_id="NP_001074718.1"
                     /db_xref="CCDS:CCDS36740.1"
                     /db_xref="GeneID:13003"
                     /db_xref="MGI:MGI:102889"
                     /translation="MLINMKGILWMCSTLLLTHALHQAKMETSPPVKGSLSGKVVLPC
                     HFSTLPTLPPNYNTSEFLRIKWSKMEVDKNGKDIKETTVLVAQNGNIKIGQDYKGRVS
                     VPTHPDDVGDASLTMVKLRASDAGVYRCDVMYGIEDTQDTMSLAVDGVVFHYRAATSR
                     YTLNFAAAQQACLDIGAVIASPEQLFAAYEDGFEQCDAGWLSDQTVRYPIRAPREGCY
                     GDMMGKEGVRTYGFRSPQETYDVYCYVDHLDGDVFHITAPSKFTFEEAEAECTSRDAR
                     LATVGELQAAWRNGFDQCDYGWLSDASVRHPVTVARAQCGGGLLGVRTLYRFENQTCF
                     PLPDSRFDAYCFKPKQNISEATTIEMNILAETSSPSLSKEPHMVPDRATPVIPLATEL
                     PIFTTHFPPAGNIVNSEQKSVVYSQAITGRLAMESPTTTRNTINSWDLNDSLASGSGP
                     LGMPDISEIKEEELRSTTVISQHATGSQAVITEDTQTHESVSQIEQIEVGPLVTSMEI
                     TNHISLKELPEKNKTPYESTEVTLEHTTEMPTVSASPELATTSHYGFTLREDDREDRT
                     LTVRSDQSTRVFSQIPEVITVSKTSEDTTYSQLGDLESISTSTITMLGTDRSLIDKEK
                     EPKTNGKVTEDEFGQSQPTTTFPSQHLTEVELLPYSGDTTSVEGISTVIYPSLQTDVT
                     QGRERTETPRPELKKDPYTVDEIPEKVTKDPFIGKTEEVFSGMPLSTSSSESSVERTE
                     SVSPALTIEKLTVKPTEARDVEEMTTLTRLETDVTKSDKDVTRVHLTHSTLNVEVVTV
                     SKWPGDEDNSTSKPLPSTEHAGFTKLPPVPLSTIGINGKDKEIPSFTDGGGEYTLFPD
                     GTPKPLEKVSEEDLASGELTVTFHTSTSIGSAEKSASGEPTTGDRFLPTTSTEDQVIN
                     ATAEGSALGEDIEASKPLFTGPPFVHTSDVEELAFVNYSSTQEPTTYVDISHTSPLSI
                     IPKTEWSVLETSVSLEDEILGKSDQDILEQTHLEATMSPGALRTTGVSQGETQEEPQT
                     PGSPFPTFSSTAVMAKETTAFEEGEGSTYTPSEGRLMTGSERVPGLETTPVGTSYPPG
                     AITDQEVEMDTMVTLMSTIRPTVVSSTEPEVIYEAEGSSPTEFASTLRPFQTHVTQLM
                     EETTEEGKKASLDYTDLGSGLFEPRATELPKFPTTPSDISVFTAIDSLHRTPPLSPSS
                     SFTEEQRVFEEESSEKTTGDILPGESVTQHPVTTLIDIVAMKTESDIDHMTSKPPVTQ
                     PTRPSVVERKTTSKTQELSTSTPAAGTKFHPDINVYIIEVRENKTGRLSDMIVSGHPI
                     DSESKEEEPCSEETDPLHDLFAEILPELPDSFEIDIYHSEEDEDGEEDCVNATDVTTT
                     PSVQYINGKQLVTTVPKDPEAAEARRGQYESVAPSQNFPDSSATDTHQFILAETESST
                     TMQFKKSKEGTELLEITWKPETYPETPDHVSSGEPDVFPTLSSHDGKTTRWSESITES
                     SPNLENPVHKQPKPVPLFPEESSGEGAIEQASQETILSRATEVALGKETDQSPTLSTS
                     SILSSSVSVNVLEEEPLTLTGISQTDESMSTIESWVEITPSQTVKFSESSSAPIIEGS
                     GEVEENKNKIFNMVTDLPQRDPTDTLSPLDMSKIMITNHHIYIPATTAPLDSKLPSPD
                     ARPTQFGIQTATSEWVSDKSFEGRKREEDEEGAVNAAHQGEVRAATERSDHLLLTPEL
                     ESSNVDASSDLATWEGFILETTPTESEKEMANSTPVFRETIGVANVEAQPFEHSSSSH
                     PRVQEELTTLSGNPPSLFTDLGSGDASTGMELITASLFTLDLESETKVKKELPSTPSP
                     SVEISSSFEPTGLTPSTVLDIEIAGVMSQTSQKTLISEISGKPTSQSGVRDLYTGFPM
                     GEDFSGDFSEYPTVSYPTMKEETVGMGGSDDERVRDTQTSSSIPTTSDNIYPVPDSKG
                     PDSTVASTTAFPWEEVMSSAEGSGEQLASVRSSVGPVLPLAVDIFSGTESPYFDEEFE
                     EVAAVTEANERPTVLPTAASGNTVDLTENGYIEVNSTMSLDFPQTMEPSKLWSKPEVN
                     LDKQEIGRETVTKEKAQGQKTFESLHSSFAPEQTILETQSLIETEFQTSDYSMLTTLK
                     TYITNKEVEEEGMSIAHMSTPGPGIKDLESYTTHPEAPGKSHSFSATALVTESGAARS
                     VLMDSSTQEEESIKLFQKGVKLTNKESNADLSFSGLGSGEALPPLPTTSVNLTDMKQI
                     ISTLYAETSHMESLGTSILGDKMEDHERMEDVSNEVRMLISKTGSISQDSTEALDTTL
                     SHTGTEEPTTSTLPFVKLMDLERSPKQTLRWEEETQTHRPQTMSGLISNENSSASEAE
                     EAATSPTAFLPQTYSVEMTKHFAPSESQPSDLFNVNSGEGSGEVDTLDLVYTSGTTQA
                     SSQGDSMLASHGFLEKHPEVSKTEAGATDVSPTASAMFLHHSEYKSSLYPTSTLPSTE
                     PYKSPSEGIEDGLQDNIQFEGSTLKPSRRKTTESIIIDLDKEDSKDLGLTITESAIVE
                     ILPELTSDKNIIIDIDHTKPVYEYIPGIQTDLDPEIKLESHGSSEESLQVQEKYEGAV
                     TLSPTEESFEGSGDALLAGYTQAIYNESVTPNDGKQAEDISFSFATGIPVSSTETELH
                     TFFPTASTLHIPSKLTTASPEIDKPNIEAISLDDIFESSTLSDGQAIADQSEVISTLG
                     HLEKTQEEYEEKKYGGPSFQPEFFSGVGEVLTDPPAYVSIGSTYLIAQTLTELPNVVR
                     PSDSTHYTEATPEVSSLAELSPQIPSSPFPVYVDNGVSKFPEVPHTSAQPVSTVTSSQ
                     KSIESPFKEVHANIEETIKPLGGNVHRTEPPSMSRDPALDVSEDESKHKLLEELETSP
                     TKPETSQDFPNKAKDHIPGETVGMLAGIRTTESEPVITADDMELGGATQQPHSASAAF
                     RVETGMVPQPIQQEPERPTFPSLEINHETHTSLFGESILATSEKQVSQKILDNSNQAT
                     VSSTLDLHTAHALSPFSILDNSNETAFLIGISEESVEGTAVYLPGPDLCKTNPCLNGG
                     TCYPTETSYVCTCAPGYSGDQCELDFDECHSNPCRNGATCVDGFNTFRCLCLPSYVGA
                     LCEQDTETCDYGWHKFQGQCYKYFAHRRTWDAAERECRLQGAHLTSILSHEEQMFVNR
                     VGHDYQWIGLNDKMFEHDFRWTDGSALQYENWRPNQPDSFFSAGEDCVVIIWHENGQW
                     NDVPCNYHLTYTCKKGTVACGQPPVVENAKTFGKMKPRYEINSLIRYHCKDGFIQRHL
                     PTIRCLGNGRWAMPKITCMNPSAYQRTYSKKYLKNSSSAKDNSINTSKHEHRWSRRRQ
                     ETRR"
     exon            517..891
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1066
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1194
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1488
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..4368
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            4369..9585
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            9586..9699
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            9700..9813
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            9814..9972
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            9973..10055
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            10056..10200
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            10201..10383
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     exon            10384..12432
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10886..10891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /note="hexamer: AATAAA"
     polyA_site      10903
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /note="major polyA site"
     regulatory      11498..11503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /note="hexamer: AATAAA"
     regulatory      11502..11507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /note="hexamer: AATGAA"
     polyA_site      11517
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
     polyA_site      11526
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
     regulatory      12403..12408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
                     /note="hexamer: AAGAAA"
     polyA_site      12430
                     /gene="Vcan"
                     /gene_synonym="5430420N07Rik; 9430051N09; Cspg2; DPEAAE;
                     hdf; NG2; PG-M; PG-M(V0); PG-M(V1)"
ORIGIN      
        1 gcctgtttcc aagcttgggc tctttggagt gactgagcta cggagctctt caggagcctg
       61 tgaatgaacc ctcctcctcc tctccctcct ccttctcgct gagtctcctc ctcggctctg
      121 acggtacagt gatataatga cggtgggtgt cacaacccgc atttgaactt gcaggcgagc
      181 tgccccgagc ctttctgggc gaagaactca aggagcgcgg gcgcagcagc tgtgagcatt
      241 aggtgctgtg gccaagcgct gggacaagga tctgccgcta ccagcgcatc ctctctcctc
      301 tccagctctg tcccgcactc gctgcaccct tccccaggcc accgcgcttc ctatgtgatc
      361 ttccggggca acgcggagcc ctttctcaca gctcagcagt gaatttccac cccgaaaact
      421 gcagtaagcc gcctttcaag gacaagatgt tgataaatat gaaaggcatc ttatggatgt
      481 gctcaacctt attactaacc catgcactac atcaagccaa aatggaaacc agcccacctg
      541 ttaaaggctc tctgtctgga aaagtggtcc taccttgtca tttttcaacc ttacctacct
      601 taccacccaa ttacaacacg agtgaatttc tcagaatcaa atggtctaag atggaagtgg
      661 acaaaaatgg aaaagatata aaggagacga ctgtcttggt ggcccagaac ggaaatatca
      721 agattggtca ggactacaag gggcgagtgt ccgtgcctac acatcccgat gatgtaggtg
      781 atgcttccct caccatggtc aaactccggg ctagtgatgc aggcgtctac cgatgtgatg
      841 tcatgtatgg gattgaagac actcaggaca ccatgtcact ggctgtggat ggtgttgtgt
      901 ttcactacag ggcagccacc agcaggtaca ctctgaactt tgccgctgct caacaggctt
      961 gtttggatat cggggcggtc atagcaagcc cagagcagct gtttgccgcc tatgaggatg
     1021 gatttgagca gtgtgatgca ggatggctgt ctgatcaaac tgtcagatat cccatacggg
     1081 ctccccgaga gggctgttac ggagacatga tggggaagga aggggttcgg acctatggat
     1141 tccgctctcc ccaggaaacc tatgatgtgt attgttatgt ggatcatctg gatggcgatg
     1201 tgttccacat cactgctccc agtaagttca ccttcgagga ggccgaagca gagtgtacaa
     1261 gcagggatgc gaggctggcg actgttggag aacttcaggc agcttggaga aatggctttg
     1321 accaatgcga ttacggctgg ctgtcggatg ccagcgtgcg gcaccctgtg actgtggcca
     1381 gggcccagtg tggaggaggt ctacttgggg tgagaaccct gtatcgtttt gagaaccaga
     1441 catgcttccc tctccctgat agcagatttg atgcctactg ctttaaacct aaacagaata
     1501 tatcagaggc aaccaccatc gaaatgaata tcctcgcaga aacttcatca cccagtttat
     1561 ccaaagaacc acacatggta cctgacagag ctacaccagt cattccatta gccaccgaat
     1621 tacctatttt taccacacac ttccctcctg caggaaatat agtcaattct gaacagaaat
     1681 ctgtagtcta ttctcaggct atcacaggca gattagccat ggaatcaccc acaactactc
     1741 ggaataccat caactcttgg gatctgaatg actccttggc ttctgggtca gggccacttg
     1801 gaatgccaga catatctgaa attaaggagg aggaactccg aagtacaact gtcatctccc
     1861 aacatgctac tggctcacag gctgtaatta cagaggatac gcaaacacat gaatcagttt
     1921 cacagattga acaaatagaa gtgggcccct tagtaacatc catggaaatc acaaatcata
     1981 tttctctcaa ggaattgcca gaaaaaaaca aaacaccata tgaatccaca gaagtgaccc
     2041 tggaacacac gactgaaatg ccaacggtaa gcgccagtcc tgaattggca accacaagtc
     2101 actatggatt caccttgaga gaagatgata gagaagacag aacactgaca gttagatctg
     2161 atcagagcac tcgggtcttt agccaaatcc ccgaagtcat cacagtatca aaaacatcag
     2221 aagacactac ctactcacag ctaggggact tagagtccat ttcaacatca acaataacca
     2281 tgcttggcac agatagatca ctgatagata aagagaaaga acccaaaact aatggtaagg
     2341 tgactgaaga tgagtttggt caatcacagc ctacaactac cttcccatca cagcatctta
     2401 cagaagtaga attacttcca tattctggtg acacaacatc agtagaggga atatccacag
     2461 ttatttatcc atcattacaa acagatgtga cacaaggaag agagaggaca gaaacaccaa
     2521 gaccagagtt aaaaaaagat ccgtacacag ttgatgaaat accagaaaag gtcactaaag
     2581 atccatttat aggtaaaaca gaagaagtct tctctggaat gcctctctct acatcttcct
     2641 cagagtcctc agtggaaagg acagaatctg tttcccctgc attgacaatt gagaagttaa
     2701 ctgtgaagcc aacagaagca agagatgtgg aagaaatgac aaccctgact agattagaaa
     2761 cagatgttac aaagtctgac aaagatgtta caagagttca tttgacccac agtactttaa
     2821 atgtggaagt ggtcacagta tcaaaatggc caggggatga agataattca acttcaaagc
     2881 ctttaccctc aacagaacat gcaggcttta caaaattgcc tcctgtccca cttagtacta
     2941 taggaataaa tggaaaagat aaagaaatcc caagtttcac agatggagga ggtgaataca
     3001 ctcttttccc agatggtact ccaaaaccat tagaaaaggt ttctgaagaa gatttagcat
     3061 ctggagaatt gacagtcacc tttcatacat ctacatcaat tggcagtgca gaaaagtcag
     3121 cttcaggaga gcctacaact ggagacaggt ttctgcccac cacaagcaca gaagaccagg
     3181 tcatcaatgc aactgcggaa gggagtgctt tgggtgaaga tatagaagcc tccaagccac
     3241 tatttactgg ccccccattt gtccacacct ccgatgtaga agaattggca tttgttaatt
     3301 atagtagcac gcaggagccc actacttatg tagacatatc ccatactagt cctctttcta
     3361 taattcccaa gacagaatgg agtgtgttgg aaacttctgt ttcactagaa gatgagattc
     3421 taggcaaatc tgatcaagat atccttgaac agactcatct agaagcaacc atgtctcctg
     3481 gagctttgag gacaacagga gtttcacagg gagaaaccca ggaagaacca caaactccag
     3541 ggagcccatt tcctactttc agttctactg cagttatggc caaggagaca acagcatttg
     3601 aagaggggga ggggtcaaca tatactccct ctgaaggcag attgatgaca ggttctgaaa
     3661 gagtcccagg tttagaaaca actccagttg gcacatctta tccacctggt gcaataacag
     3721 accaggaagt ggaaatggat acaatggtaa cactgatgtc aaccattagg ccaacagtgg
     3781 tttcaagtac agagccagaa gtaatttatg aagcagaagg tagtagtcca acagaatttg
     3841 catcaacttt gaggcctttc cagactcatg tcacacagct tatggaagaa actactgagg
     3901 aaggaaaaaa ggcatcctta gattatacag atttaggctc agggttattt gaacccagag
     3961 ccaccgagct cccaaaattt ccaacaactc caagtgatat cagtgtcttt actgccatcg
     4021 acagccttca cagaacgcca cccttgagtc cgtcttcatc attcactgag gaacaacgtg
     4081 tctttgagga agagtccagt gagaaaacaa caggtgacat acttcctgga gaatctgtaa
     4141 cacagcaccc tgtgacaact ctcattgata tcgtagccat gaaaacagaa tctgatattg
     4201 atcacatgac ctcaaaacct cctgtaacac agccaacaag accatcagtt gtggaaagaa
     4261 aaacaacctc caaaactcaa gagttgtcta cttcaacacc tgcagcaggg accaagttcc
     4321 accctgacat aaatgtttat attattgagg tcagagaaaa caagacaggt cgattgagtg
     4381 atatgattgt aagtggtcat ccaatagatt cagaatctaa agaagaggaa ccttgcagtg
     4441 aagaaacaga tccactgcat gatctgtttg ctgaaatttt acccgagtta ccagactcat
     4501 ttgaaataga catatatcac agtgaggaag atgaagacgg agaggaggac tgtgtaaatg
     4561 caacggatgt aacaactact ccgtcagtgc agtatatcaa tgggaagcag ctcgttacca
     4621 cagtgcctaa ggacccggaa gctgcagaag ctaggcgtgg ccagtacgaa agtgttgcac
     4681 cttctcagaa tttcccagat agttctgcaa ctgacaccca tcagtttata ctagcagaaa
     4741 cagaatcgtc aactaccatg caatttaaga aatctaaaga aggcacggaa ttgttagaaa
     4801 tcacatggaa acccgagacc taccctgaaa caccagacca tgtttcaagt ggtgagcctg
     4861 atgttttccc tactctctca tcccatgatg gtaaaaccac cagatggtca gagtccatca
     4921 cagagagcag tccaaacctt gaaaatccag tgcacaaaca acctaagcct gtccctctgt
     4981 ttcctgaaga gtcttcagga gagggtgcca ttgaacaagc atcccaggaa acaatcttat
     5041 ctagggctac agaagtagca cttggtaaag agacagacca aagtcctacc ttatctacct
     5101 ctagcatact ttcaagttct gtgtcagtaa atgtcttgga ggaagaacca cttactctaa
     5161 caggaatctc acagactgat gaatccatgt ctactataga aagctgggta gagataacac
     5221 ctagccaaac tgtaaagttc tcggagagtt cttcagctcc tatcattgaa gggtctgggg
     5281 aagtagaaga aaataaaaat aaaatcttta acatggtaac tgatttacca cagagagatc
     5341 ctacagatac actcagccct ttggatatga gcaagataat gatcacaaac catcacattt
     5401 atattcctgc aaccaccgct cctttggatt caaaactacc ttctccagat gcaaggccta
     5461 cacagtttgg aattcaaaca gccacctctg agtgggtttc cgataagtct tttgaaggaa
     5521 gaaaaagaga agaagatgaa gagggagctg tgaatgcagc ccaccaagga gaagttcgag
     5581 cagcaacaga gaggtcagat cacttacttt taacaccaga attagaaagt tcaaatgtag
     5641 atgcatctag tgatttggct acctgggaag gttttattct agagacaaca cccacagagt
     5701 ctgaaaagga aatggcaaat tcaactcctg tttttagaga aacaattggt gtagccaatg
     5761 tggaggcaca gccctttgag catagcagta gtagtcatcc cagggttcag gaagagctga
     5821 ccactctctc aggaaatccc ccctctcttt ttacggacct gggctcagga gatgctagta
     5881 ctggtatgga actcatcact gcttctttat ttacattaga tttagagtct gaaaccaaag
     5941 tcaaaaagga attacccagt actccgtctc ccagtgtgga gatatcatcc tcttttgagc
     6001 caacaggatt aaccccgagt actgtactag acatagaaat tgctggagtt atgagccaga
     6061 catcgcagaa gacactgatt tctgaaatat caggaaagcc aacttcccag tcaggagtaa
     6121 gggatttgta tacaggcttt ccaatgggag aagattttag tggtgacttc agtgaatatc
     6181 caacagtgtc ttatccaacg atgaaagagg aaacagttgg gatgggaggt tctgacgatg
     6241 aacgagttag ggatacacag acttcatcat ctataccgac tacctcagac aacatctacc
     6301 ccgtgcctga ctcaaaagga cctgacagta ctgtggccag caccacagcc ttcccctggg
     6361 aagaggtcat gtcctcagct gaggggtcag gtgagcaatt agcctcagtc aggagctctg
     6421 ttggtccagt gcttccacta gctgtggaca ttttttctgg aacagagtct ccatattttg
     6481 atgaagagtt tgaagaagtg gctgcagtga cagaagcaaa tgaaagaccc actgttttgc
     6541 caacagcagc aagtggaaat actgtagatc ttacagaaaa tgggtacata gaggtaaata
     6601 gcacgatgtc actggacttt ccccagacaa tggagccatc caaattgtgg tctaaaccag
     6661 aagtcaatct tgataaacaa gagattggaa gagaaacagt gacaaaggaa aaagctcagg
     6721 gacaaaagac ttttgaatcg ctccacagtt cttttgcacc agaacaaacc attttggaaa
     6781 cccaatcact tattgaaact gaattccaaa cttccgatta ctctatgtta acaacactga
     6841 aaacgtacat tactaataag gaagtggagg aggaaggtat gtccatagcg catatgtcta
     6901 ctccaggtcc agggatcaaa gacttggaat catatactac ccatcccgaa gctcctggaa
     6961 agtcacactc tttctcagct actgctttag tgactgaatc tggagcagct agaagtgtac
     7021 tcatggattc ctcaactcaa gaggaagaaa gcataaaact cttccaaaag ggtgtgaaac
     7081 taacaaataa agagtcaaat gctgatctct cattctctgg actgggatca ggagaggctt
     7141 tgcctcctct acctacaaca tcagtgaatt tgactgacat gaagcagatc attagcacat
     7201 tgtatgctga gacatctcac atggaaagct taggaacaag catcttaggt gataaaatgg
     7261 aagaccatga aagaatggaa gatgtgtcca atgaagttag aatgctcatt tccaaaacag
     7321 gcagcatctc tcaagacagc acagaggcac tcgacacaac tttgagtcat accggaacag
     7381 aagaacctac aacttcaact cttcctttcg tgaagctcat ggacttggaa cgttctccaa
     7441 agcagaccct caggtgggaa gaggaaaccc agacccatag accacaaact atgagtggac
     7501 tgatctctaa tgaaaattct tcagcatcag aagctgaaga agcagcaact tcccccactg
     7561 cttttctgcc tcaaacttac agtgttgaaa tgaccaaaca ctttgctcca tcagagtcac
     7621 aaccatccga cttgtttaat gtaaactctg gagagggatc tggagaagtg gatactcttg
     7681 acttagtgta cacttctgga actactcagg caagcagtca aggagacagc atgcttgctt
     7741 ctcatggatt tctggaaaaa catccagagg tgtcaaagac tgaggctgga gctactgatg
     7801 tatctccaac agcctcagca atgttcctgc atcactcaga gtacaagagt tctctgtatc
     7861 caaccagcac actgccaagc acagagccat ataaaagtcc ctcagaaggt attgaagatg
     7921 gtttgcaaga caatatccaa tttgaaggtt ctaccttgaa acctagcaga agaaaaacca
     7981 ctgaaagcat tattatagat ctagacaaag aggatagtaa ggacctagga ttgacaatta
     8041 ctgagagtgc tattgttgaa attctccctg agctgacatc agataaaaat attattatag
     8101 acattgatca cactaaacct gtatatgagt acatccctgg aatacaaaca gacctagatc
     8161 cagagataaa attggaatca catggcagta gtgaagaaag ccttcaagtt caagagaagt
     8221 atgagggagc tgttaccctt tctccaactg aggaatcatt tgaaggctct ggtgatgcgc
     8281 ttcttgctgg ctatactcaa gcaatataca atgagtctgt gactcccaac gatggaaagc
     8341 aggcagagga cataagcttt agttttgcca ctgggatccc agtttctagc acagagacag
     8401 aattacacac tttcttcccc acagcgtcaa ccctgcacat tcctagtaaa ctaaccacag
     8461 ctagtccgga gattgataaa cccaacattg aagcaatatc tctggatgat atatttgaat
     8521 caagcacctt gtctgatggc caagctattg cagaccagag tgaagtaata tcaacattag
     8581 ggcatttgga aaaaacacag gaagaatatg aagaaaagaa atatggaggt ccttcatttc
     8641 agccagaatt cttttcagga gtgggggaag tattgacaga tccccctgct tatgtaagta
     8701 ttggtagtac ataccttata gctcagactt taacagaatt acccaatgtg gtaagaccat
     8761 ctgactccac acattacact gaagcaacac ctgaagtttc ctctctggca gagctctctc
     8821 cacagatacc atcttctccc ttccctgtct acgtagacaa tggagtctct aaattcccag
     8881 aggttcccca tacaagtgct cagccagttt ctactgtcac ctcatcacaa aagtctatag
     8941 agagtccttt taaggaagtc catgctaata ttgaagaaac catcaagcca ttgggtggaa
     9001 atgtccacag aacagagcct ccatccatgt ctcgtgaccc tgctttagat gtttcagaag
     9061 atgaaagtaa gcataagtta ctagaagaac tggaaacgtc tcccaccaaa cctgagactt
     9121 cccaagactt cccaaacaaa gcaaaggatc acattccagg agaaacagtt gggatgcttg
     9181 ctggtatcag aacaacagag agcgaacctg tcattactgc agacgacatg gagctaggag
     9241 gtgccacaca gcagccacat tctgcttctg cagctttcag agttgagaca ggtatggtac
     9301 ctcagcccat ccaacaggag cctgagaggc caacctttcc ttccttggaa attaaccatg
     9361 aaacacacac atcattattt ggagaatcta tactggcaac atctgaaaaa caagtgtctc
     9421 aaaaaattct tgataatagt aaccaggcaa cagtcagtag tactctggat ctacatactg
     9481 cacatgcatt atcaccattt tccattctgg acaattctaa tgaaactgct ttcctgattg
     9541 gcattagtga agagtccgtg gaaggcacag cagtttacct accaggacct gatctctgca
     9601 aaacaaaccc atgcctcaac ggaggcacct gttatcctac cgagacttcc tatgtgtgca
     9661 cctgtgcacc tggatacagc ggagaccagt gtgaacttga ttttgatgaa tgtcactcta
     9721 acccttgtcg gaatggtgcc acctgtgtgg atggttttaa tacatttaga tgtctctgtc
     9781 tcccaagtta tgttggtgca ctctgtgaac aagacactga gacatgtgac tatggctggc
     9841 acaaattcca aggacagtgc tacaagtact ttgctcatcg acgcacatgg gatgctgctg
     9901 aaagggagtg tcgcctgcag ggtgcccacc tcacaagcat cctttctcat gaggaacaaa
     9961 tgtttgtgaa tcgtgtgggc catgattacc agtggatcgg cctcaatgac aagatgtttg
    10021 aacatgactt ccgctggact gacggcagtg cactgcaata tgagaactgg agacccaacc
    10081 agccagacag tttcttttct gcaggagaag actgcgttgt gatcatttgg catgaaaatg
    10141 gtcagtggaa tgacgtcccc tgcaattacc acctcaccta cacttgcaag aagggaacag
    10201 ttgcttgcgg ccaaccccct gttgtagaaa atgccaagac ctttggaaag atgaaaccac
    10261 gctatgaaat caactccttg attagatatc actgcaaaga tggtttcatt cagcgacacc
    10321 ttccaactat ccggtgccta ggaaacggga gatgggcaat gcctaaaata acctgcatga
    10381 acccatctgc ataccaaagg acttattcta agaaatactt aaaaaattcc tcatccgcaa
    10441 aggacaattc tataaataca tcaaaacatg agcatcgctg gagccggagg cggcaggaaa
    10501 ccaggcgctg atccttaaaa tggcgaacat gtgcttcact catcatttca gccaaagtcc
    10561 tgcctttccg tgcctttcct atcacctcaa gaagaattag aagttggttt ggattatggg
    10621 actgccgtct ggtcatttgg ggtggctgta ctcttaaaat attttcaatg aaacatggaa
    10681 ttttgaaaaa gcgaataaaa tgaaagaaaa tgaacgaaga agataaccat tttcagccta
    10741 tctaatttct ttagttctct caatgcctcc agtgcagact gtttcctgta caccagccta
    10801 ctgtactatt ttaaaaaaac gcaatttcag caccgatggc catgtaaata agatgattta
    10861 atgttgattt taatcctgta tataaaataa aacatcacac tcagttcagg catatttaat
    10921 gatgattatg cagctttcaa ggtctttaat cgttggtttg gctgctttgc tatagcttgc
    10981 ttaggctgga aatggttttg tctacccttt gactgtcagc aagtttgagg acggcttttc
    11041 tggacagcca gcaaacagca tcttgcaggt ctctgcacgt gtgtcagccg cgggagccac
    11101 actgatgcct ggctgattcc tggctgatga aactctcgct cggagctcca gggtgtaact
    11161 ccgctttgtc atgttccctt ttcttcactt acacgaagcg cctgaatgga ggacttttct
    11221 atgacctgga acattttttt aggggtcaaa ttgctaacta ttaactcaac caggtttcat
    11281 ttacaatggc tttcttaaca ctaaccctgg taaggtaaca gatcaagata tttggaatgg
    11341 atatagatca agggttgagg agggtggggg agggggtttt cttaaaacaa caacactcgt
    11401 gcaaaaaaaa aaaacatttt gtacatataa ccattttaat tctttataaa aaatttgaat
    11461 gttcatgtat gaatgctgca actgcggagc acacgtaaat aaatgaagta agccatacgg
    11521 atttaattta ttggatgtta ttttccccaa gacctgaaat caatgtagta tgctagtaat
    11581 ttctcagtgt taccttttat attttcttca cagtttaaaa ccttataata taggtacttc
    11641 cttctaagtg tttattacgg agaatggaaa tgtgtttagc tatccataag tggtatttgc
    11701 ccatcccaag caagtgtgaa aatgtagaat agtgtggcca ttgcttactg ttagatggag
    11761 tgtatgtgct gacgttttca cttcaccctt caccccttgc atttgaatag tggttgctga
    11821 agatgacatg ggaatcatta tctagataat ttaaggctca aagttaaaac tgctctcaga
    11881 aagaaggcat ttaaggctca tccattccct tcatttacaa ctaacagaaa aggcaaataa
    11941 aacctgaaca gaaaccagct ttgaaatgac acaatgaaag caagcattga agcatcgtgc
    12001 ggtgtcccat aagtatggtc agactttatg ttttatacat caggtcaaaa tatatattca
    12061 gcaaagaaga gtagaggaag agcagactgg agttggtcct atgttgactg tttcccatga
    12121 atgctacttt agcttagagg gaatgactgt gctcacaagc atacatagtg tcttagacat
    12181 ggtcctgggt ctcagcagta aatgtaattc atcctaatgt gtactagagc acagaaaatc
    12241 actgtgttga cttactaggg ctttttttct ttttcattac aatgcacata atacttccct
    12301 gtatttatat tataacatgt atagtgtaaa atgtgaatgg ctttttttgt gaatgaaaat
    12361 ctaaaatctt tgtaactttt tatatctgct tttgtttcac caaagaaacc taaaaattct
    12421 tcttttacta ca
//
