LOCUS       NM_011693               3398 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus vascular cell adhesion molecule 1 (Vcam1), mRNA.
ACCESSION   NM_011693
VERSION     NM_011693.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3398)
  AUTHORS   Natarajan,N., Florentin,J., Johny,E., Xiao,H., O'Neil,S.P., Lei,L.,
            Shen,J., Ohayon,L., Johnson,A.R., Rao,K., Li,X., Zhao,Y., Zhang,Y.,
            Tavakoli,S., Shiva,S., Das,J. and Dutta,P.
  TITLE     Aberrant mitochondrial DNA synthesis in macrophages exacerbates
            inflammation and atherosclerosis
  JOURNAL   Nat Commun 15 (1), 7337 (2024)
   PUBMED   39187565
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3398)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (bases 1 to 3398)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   4  (bases 1 to 3398)
  AUTHORS   Pandey,N., Kaur,H., Chorawala,M.R., Anand,S.K., Chandaluri,L.,
            Butler,M.E., Aishwarya,R., Gaddam,S.J., Shen,X., Alfaidi,M.,
            Wang,J., Zhang,X., Beedupalli,K., Bhuiyan,M.S., Bhuiyan,M.A.N.,
            Buchhanolla,P., Rai,P., Shah,R., Chokhawala,H., Jordan,J.D.,
            Magdy,T., Orr,A.W., Stokes,K.Y., Rom,O. and Dhanesha,N.
  TITLE     Interactions between integrin alpha9beta1 and VCAM-1 promote
            neutrophil hyperactivation and mediate poststroke DVT
  JOURNAL   Blood Adv 8 (9), 2104-2117 (2024)
   PUBMED   38498701
  REMARK    GeneRIF: Interactions between integrin alpha9beta1 and VCAM-1
            promote neutrophil hyperactivation and mediate poststroke DVT.
REFERENCE   5  (bases 1 to 3398)
  AUTHORS   Candelaria,N.R. and Richards,J.S.
  TITLE     Targeted deletion of NR2F2 and VCAM1 in theca cells impacts ovarian
            follicular development: insights into polycystic ovary
            syndrome?dagger
  JOURNAL   Biol Reprod 110 (4), 782-797 (2024)
   PUBMED   38224314
  REMARK    GeneRIF: Targeted deletion of NR2F2 and VCAM1 in theca cells
            impacts ovarian follicular development: insights into polycystic
            ovary syndrome?
REFERENCE   6  (bases 1 to 3398)
  AUTHORS   Wuthrich,R.P.
  TITLE     Vascular cell adhesion molecule-1 (VCAM-1) expression in murine
            lupus nephritis
  JOURNAL   Kidney Int 42 (4), 903-914 (1992)
   PUBMED   1280699
REFERENCE   7  (bases 1 to 3398)
  AUTHORS   Gerber,L.D., Kodukula,K. and Udenfriend,S.
  TITLE     Phosphatidylinositol glycan (PI-G) anchored membrane proteins.
            Amino acid requirements adjacent to the site of cleavage and PI-G
            attachment in the COOH-terminal signal peptide
  JOURNAL   J Biol Chem 267 (17), 12168-12173 (1992)
   PUBMED   1601882
REFERENCE   8  (bases 1 to 3398)
  AUTHORS   Hession,C., Moy,P., Tizard,R., Chisholm,P., Williams,C., Wysk,M.,
            Burkly,L., Miyake,K., Kincade,P. and Lobb,R.
  TITLE     Cloning of murine and rat vascular cell adhesion molecule-1
  JOURNAL   Biochem Biophys Res Commun 183 (1), 163-169 (1992)
   PUBMED   1371918
REFERENCE   9  (bases 1 to 3398)
  AUTHORS   Miyake,K., Medina,K., Ishihara,K., Kimoto,M., Auerbach,R. and
            Kincade,P.W.
  TITLE     A VCAM-like adhesion molecule on murine bone marrow stromal cells
            mediates binding of lymphocyte precursors in culture
  JOURNAL   J Cell Biol 114 (3), 557-565 (1991)
   PUBMED   1713592
REFERENCE   10 (bases 1 to 3398)
  AUTHORS   Hession,C., Tizard,R., Vassallo,C., Schiffer,S.B., Goff,D., Moy,P.,
            Chi-Rosso,G., Luhowskyj,S., Lobb,R. and Osborn,L.
  TITLE     Cloning of an alternate form of vascular cell adhesion molecule-1
            (VCAM1)
  JOURNAL   J Biol Chem 266 (11), 6682-6685 (1991)
   PUBMED   1707873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108909.15.
            
            On Mar 19, 2008 this sequence version replaced NM_011693.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029823.1, AK143401.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               AC108909.15        623-1007
            386-661             AC108909.15        1503-1778
            662-982             AC108909.15        4036-4356
            983-1249            AC108909.15        5662-5928
            1250-1525           AC108909.15        9238-9513
            1526-1846           AC108909.15        12768-13088
            1847-2113           AC108909.15        14160-14426
            2114-2380           AC108909.15        15692-15958
            2381-3398           AC108909.15        19274-20291
FEATURES             Location/Qualifiers
     source          1..3398
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 50.17 cM"
     gene            1..3398
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /note="vascular cell adhesion molecule 1"
                     /db_xref="GeneID:22329"
                     /db_xref="MGI:MGI:98926"
     exon            1..385
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..2541
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /note="vascular cell adhesion protein 1; V-CAM 1"
                     /codon_start=1
                     /product="vascular cell adhesion protein 1 precursor"
                     /protein_id="NP_035823.3"
                     /db_xref="CCDS:CCDS17785.1"
                     /db_xref="GeneID:22329"
                     /db_xref="MGI:MGI:98926"
                     /translation="MPVKMVAVLGASTVLWILFAVSQAFKIEISPEYKTIAQIGDSMA
                     LTCSTTGCESPLFSWRTQIDSPLNAKVRTEGSKSVLTMEPVSFENEHSYLCTATCGSG
                     KLERSIHVDIYSFPKDPEIQFSGPLEVGKPVTVKCLAPDIYPVYRLEIDLFKGDQLMN
                     RQEFSSEEMTKSLETKSLEVTFTPVIEDIGKALVCRAKLHIDQIDSTLKERETVKELQ
                     VYISPRNTTISVHPSTRLQEGGAVTMTCSSEGLPAPEIFWGRKLDNEVLQLLSGNATL
                     TLIAMRMEDSGVYVCEGVNLIGRDKAEVELVVQEKPFIVDISPGSQVAAQVGDSVVLT
                     CAAIGCDSPSFSWRTQTDSPLNGVVRNEGAKSTLVLSSVGFEDEHSYLCAVTCLQRTL
                     EKRTQVEVYSFPEDPVIKMSGPLVHGRPVTVNCTVPNVYPFDHLEIELLKGETTLMKK
                     YFLEEMGIKSLETKILETTFIPTIEDTGKSLVCLARLHSGEMESEPKQRQSVQPLYVN
                     VAPKETTIWVSPSPILEEGSPVNLTCSSDGIPAPKILWSRQLNNGELQPLSENTTLTF
                     MSTKRDDSGIYVCEGINEAGISRKSVELIIQVSPKDIQLTVFPSKSVKEGDTVIISCT
                     CGNVPETWIILKKKAKTGDMVLKSVDGSYTIRQAQLQDAGIYECESKTEVGSQLRSLT
                     LDVKGKEHNKNYFSPELLALYCASSLVIPAIGMIVYFARKANMKGSYSLVEAQKSKV"
     exon            386..661
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..982
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1249
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1525
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1846
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2113
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2380
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..3398
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3260..3265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /note="hexamer: AGTAAA"
     polyA_site      3280
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /note="major polyA site"
     regulatory      3354..3359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
                     /note="hexamer: AGTAAA"
     polyA_site      3380
                     /gene="Vcam1"
                     /gene_synonym="CD106; Vcam-1"
ORIGIN      
        1 gccctttcgg agctgaaggt caggaaaagc cagagattta tatacttgga agtgtcgtgt
       61 ttcccaggac tcagaatgac ttcagcccag aaagcagctg aaggggttaa cgtggggact
      121 tggctggctg tcagttaaac tttttccctg gctctgggtt tccccttgaa gggatttccc
      181 tccgcctctc tagcaagacc ctttataaag agcagacttt ctatttcact cacaccagcc
      241 cggctggctt tggaggctga acacttttcc cagacacttt tcacgtgggg cacaaagaag
      301 gctttgaagc agagacttga aatgcctgtg aagatggtcg cggtcttggg agcctcaacg
      361 gtactttgga tactgtttgc agtctctcaa gcttttaaaa tcgagatctc ccctgaatac
      421 aaaacgattg ctcaaatcgg tgactccatg gccctcactt gcagcactac gggctgcgag
      481 tcaccattgt tctcatggag aacccagata gacagcccac taaacgcgaa ggtgaggacg
      541 gaggggtcca agtccgttct gaccatggag cctgtcagtt ttgagaatga acactcttac
      601 ctgtgcacag caacatgtgg ctctgggaag ctggaacgaa gtatccacgt ggacatctac
      661 tctttcccca aggatccaga gattcaattc agtggccccc tggaggttgg gaagccggtc
      721 acggtcaagt gtttggctcc agacatttac ccagtttaca ggctggagat tgatctgttc
      781 aagggtgacc agctcatgaa cagacaggag ttttcttcag aagagatgac aaagtctcta
      841 gaaaccaaga gtttggaagt aacctttact cccgtcattg aggatattgg aaaagctctt
      901 gtttgccgag ctaaattaca cattgaccaa attgattcta cactcaaaga aagggagact
      961 gtcaaagaac tacaagtcta catctctccc aggaatacaa cgatctctgt acatccctcc
     1021 acaaggcttc aagagggtgg tgctgtgaca atgacctgtt ccagcgaggg tctaccagct
     1081 cctgagattt tctggggcag gaagttagat aatgaagttc tccagcttct ctcaggaaat
     1141 gccaccctca ccttaattgc tatgaggatg gaagactctg gagtctatgt gtgtgaagga
     1201 gttaatctga ttgggagaga caaagcagaa gtggaattag ttgttcaaga gaaaccattt
     1261 attgttgaca tctcccccgg atctcaggtg gctgcacaag ttggggattc ggttgttctg
     1321 acgtgtgctg ctattggctg tgactcccct tctttttctt ggagaaccca gacagacagt
     1381 cccctcaatg gggtggtaag gaatgagggg gccaaatcca cgcttgtgtt gagctctgtg
     1441 ggttttgagg atgaacactc ttacctgtgc gctgtgacct gtctgcaaag gacactggaa
     1501 aagagaaccc aggtggaggt ctactcattc cctgaagatc cagtaattaa aatgagtggg
     1561 ccacttgtgc atgggagacc tgtcactgtc aactgcacag tccctaatgt gtatcccttt
     1621 gaccatctgg agattgaatt actgaagggg gagactacac tgatgaagaa atattttttg
     1681 gaggaaatgg gcataaagtc cctagagacc aaaattttgg aaacgacctt catccccacc
     1741 attgaagata ccgggaaatc tcttgtttgc ctcgctaggt tacacagtgg tgaaatggaa
     1801 tctgaaccca aacagaggca gagtgtacag cctctttatg tcaacgttgc ccccaaggaa
     1861 accaccatct gggtcagccc ctctcctata ctagaggagg gcagtcctgt gaacctgacc
     1921 tgctcaagtg atgggatacc agctcccaaa atcctgtgga gcagacagct aaataatggg
     1981 gaactgcagc ctctttctga aaatactaca ctcaccttca tgtctacaaa aagggacgat
     2041 tccggcattt atgtgtgtga agggattaac gaggctggaa ttagcagaaa atcagttgaa
     2101 ctgattatcc aagtctctcc aaaagatata cagcttacag tctttccatc taagagtgtc
     2161 aaagagggag acaccgtcat tatctcctgc acttgtggaa atgtgcccga aacatggata
     2221 atcctgaaga agaaagcaaa gacaggagac atggtattaa agtctgtgga tggctcgtac
     2281 accatccgcc aggcacagct gcaggatgcc ggcatatacg agtgtgaatc taagactgaa
     2341 gttggctcac aattaagaag tttaacactt gatgtaaaag gaaaagaaca taacaagaac
     2401 tatttttcgc ccgaactcct tgcactctac tgcgcatctt ccttggtaat acctgccatc
     2461 gggatgatcg tttattttgc aagaaaagct aacatgaaag gatcgtacag tctggtggag
     2521 gcacagaaat ccaaagtgta gctaacatct gaaatgtttg agaagagaca ttatttataa
     2581 aacccagatc cttaatactg tttattacag ccccgccccc tccacaaacc aagccatgca
     2641 ttcagacttc ccagaaccct tctcagtaaa gaaggcaaag tggctgcttg atcccttgct
     2701 gaatgcaagg agctaaccag aaaagttctg cttgacaagt ccccatcgtt gaagtgactg
     2761 gaatggtccc atgatgtgta tgtaaataac ataaactgta tatatgtaaa ataaaattat
     2821 gccgtcgcga ggttgtttag agtagcagca ctccatatgc aggtcagaac gtaatcagag
     2881 agtgttgctt ggactgactg ttgtaactta atgcttctta gaaaagttta atattaatgt
     2941 taatgttgac taggcagcta accagtgtca cctttttatg ttttattttc ttcaacataa
     3001 ttttattcct atgaatttta ttaacaatga tttcatgttt tttaaaagaa gtcagggttc
     3061 tatattttta taggcaaacg gtaaagaggt cactgggttg actttcaggt actactttct
     3121 aattcatggt agaatggcta agtaattttc tctacatggt actgtacggt acggggacct
     3181 gtttcttcat tggggtcttg tgtaatgact aacctgattt aaatgcgact tcatttgact
     3241 tgtcttttat aaatactata gtaaagtgga agtttctgaa catggaagag ttgtgtttca
     3301 tttgttgtaa attgtctccc ttaattgttt tgttcttctg gaattgttat aagagtaaaa
     3361 acttcaaact gctaacctaa tacagatact cgaaacat
//
