LOCUS       NM_011912               1267 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus ventral anterior homeobox 2 (Vax2), mRNA.
ACCESSION   NM_011912
VERSION     NM_011912.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1267)
  AUTHORS   Nord,C., Jones,I., Garcia-Maestre,M., Hagglund,A.C. and Carlsson,L.
  TITLE     Reduced mTORC1-signaling in progenitor cells leads to retinal
            lamination deficits
  JOURNAL   Dev Dyn 253 (10), 922-939 (2024)
   PUBMED   38546215
REFERENCE   2  (bases 1 to 1267)
  AUTHORS   Min,K.W., Kim,N., Lee,J.H., Sung,Y., Kim,M., Lee,E.J., Kim,J.M.,
            Kim,J.H., Lee,J., Cho,W., Yang,J.M., Kim,N., Kim,J., Lee,C.J.,
            Park,Y.G., Lee,S.H., Lee,H.W. and Kim,J.W.
  TITLE     Visuomotor anomalies in achiasmatic mice expressing a
            transfer-defective Vax1 mutant
  JOURNAL   Exp Mol Med 55 (2), 385-400 (2023)
   PUBMED   36737666
REFERENCE   3  (bases 1 to 1267)
  AUTHORS   Boobalan,E., Thompson,A.H., Alur,R.P., McGaughey,D.M., Dong,L.,
            Shih,G., Vieta-Ferrer,E.R., Onojafe,I.F., Kalaskar,V.K., Arno,G.,
            Lotery,A.J., Guan,B., Bender,C., Memon,O., Brinster,L.,
            Soleilhavoup,C., Panman,L., Badea,T.C., Minella,A., Lopez,A.J.,
            Thomasy,S.M., Moshiri,A., Blain,D., Hufnagel,R.B., Cogliati,T.,
            Bharti,K. and Brooks,B.P.
  TITLE     Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure
            Closure
  JOURNAL   Invest Ophthalmol Vis Sci 63 (12), 5 (2022)
   PUBMED   36326727
REFERENCE   4  (bases 1 to 1267)
  AUTHORS   Bosze,B., Suarez-Navarro,J., Soofi,A., Lauderdale,J.D.,
            Dressler,G.R. and Brown,N.L.
  TITLE     Multiple roles for Pax2 in the embryonic mouse eye
  JOURNAL   Dev Biol 472, 18-29 (2021)
   PUBMED   33428890
REFERENCE   5  (bases 1 to 1267)
  AUTHORS   Yamada,R., Oguri,A., Fujiki,K., Shirahige,K., Takezoe,H.,
            Takahashi,N. and Kanai,Y.
  TITLE     Single-cell transcriptional analysis reveals developmental
            stage-dependent changes in retinal progenitors in the murine early
            optic vesicle
  JOURNAL   Biochem Biophys Res Commun 543, 80-86 (2021)
   PUBMED   33548738
REFERENCE   6  (bases 1 to 1267)
  AUTHORS   Lee,C.S., May,N.R. and Fan,C.M.
  TITLE     Transdifferentiation of the ventral retinal pigmented epithelium to
            neural retina in the growth arrest specific gene 1 mutant
  JOURNAL   Dev Biol 236 (1), 17-29 (2001)
   PUBMED   11456441
REFERENCE   7  (bases 1 to 1267)
  AUTHORS   Schulte,D., Furukawa,T., Peters,M.A., Kozak,C.A. and Cepko,C.L.
  TITLE     Misexpression of the Emx-related homeobox genes cVax and mVax2
            ventralizes the retina and perturbs the retinotectal map
  JOURNAL   Neuron 24 (3), 541-553 (1999)
   PUBMED   10595508
REFERENCE   8  (bases 1 to 1267)
  AUTHORS   Barbieri,A.M., Lupo,G., Bulfone,A., Andreazzoli,M., Mariani,M.,
            Fougerousse,F., Consalez,G.G., Borsani,G., Beckmann,J.S.,
            Barsacchi,G., Ballabio,A. and Banfi,S.
  TITLE     A homeobox gene, vax2, controls the patterning of the eye
            dorsoventral axis
  JOURNAL   Proc Natl Acad Sci U S A 96 (19), 10729-10734 (1999)
   PUBMED   10485894
REFERENCE   9  (bases 1 to 1267)
  AUTHORS   Ohsaki,K., Morimitsu,T., Ishida,Y., Kominami,R. and Takahashi,N.
  TITLE     Expression of the Vax family homeobox genes suggests multiple roles
            in eye development
  JOURNAL   Genes Cells 4 (5), 267-276 (1999)
   PUBMED   10421837
REFERENCE   10 (bases 1 to 1267)
  AUTHORS   Bulfone,A., Gattuso,C., Marchitiello,A., Pardini,C., Boncinelli,E.,
            Borsani,G., Banfi,S. and Ballabio,A.
  TITLE     The embryonic expression pattern of 40 murine cDNAs homologous to
            Drosophila mutant genes (Dres): a comparative and topographic
            approach to predict gene function
  JOURNAL   Hum Mol Genet 7 (13), 1997-2006 (1998)
   PUBMED   9817915
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090647.6.
            
            On May 30, 2018 this sequence version replaced NM_011912.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090635.1, AF028715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               AC090647.6         85331-85635         c
            306-493             AC090647.6         63588-63775         c
            494-1267            AC090647.6         58561-59334         c
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..1267
                     /gene="Vax2"
                     /gene_synonym="Dres93"
                     /note="ventral anterior homeobox 2"
                     /db_xref="GeneID:24113"
                     /db_xref="MGI:MGI:1346018"
     exon            1..305
                     /gene="Vax2"
                     /gene_synonym="Dres93"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..937
                     /gene="Vax2"
                     /gene_synonym="Dres93"
                     /note="ventral retina homeodomain protein; ventral
                     anterior homeobox containing gene 2"
                     /codon_start=1
                     /product="ventral anterior homeobox 2"
                     /protein_id="NP_036042.1"
                     /db_xref="CCDS:CCDS20282.1"
                     /db_xref="GeneID:24113"
                     /db_xref="MGI:MGI:1346018"
                     /translation="MGDGGAERDRGPKRREEPGGRSGRHGEHRGAEDLRADTGSASPR
                     EIAGTSASSPAGSRESGGDSDGQQALGETDHCRRILVRDAKGTIREIVLPKGLDLDRP
                     KRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKD
                     QSRDLEKRASSSASEAFATSNVLRLLEQGRLLSVPRAPSLLALTPGLPGLPASHRGTS
                     LVDPRNSSPRLNPMPSASASSPLPPPLPAICFSSAPLLDLPAGYKLGSSAFEPYSRLE
                     QQKVGSPGQSDKKADI"
     exon            306..493
                     /gene="Vax2"
                     /gene_synonym="Dres93"
                     /inference="alignment:Splign:2.1.0"
     exon            494..1267
                     /gene="Vax2"
                     /gene_synonym="Dres93"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1231..1236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vax2"
                     /gene_synonym="Dres93"
                     /note="hexamer: AATAAA"
     polyA_site      1263
                     /gene="Vax2"
                     /gene_synonym="Dres93"
                     /note="major polyA site"
ORIGIN      
        1 ctgctaccct gagctaggac tagcggctgc tgtggcccaa gcagcagtgg cggcgggcat
       61 gggcgatggg ggcgcggagc gggaccgcgg ccccaagcgc cgggaggagc ctggtggccg
      121 cagcgggcgt cacggagagc accgcggagc ggaagatttg cgtgctgaca caggtagcgc
      181 gagtccgagg gagattgctg ggacctccgc ctccagccct gcgggctcca gggagagcgg
      241 aggggacagc gacggacagc aggcgctcgg tgagacagac cactgccgcc gcatcctggt
      301 acgagatgct aaggggacca ttcgggaaat tgtcttgccc aagggcctgg acctcgaccg
      361 acccaagcgg acccgtactt ccttcacagc agagcagctg tatcgtctgg agatggagtt
      421 ccagcgctgc cagtatgtgg tgggccgaga gcgcactgag ttggcccgac agctgaacct
      481 ctctgagact caggtgaagg tctggttcca gaaccgccga accaagcaga agaaggacca
      541 gagcagagac ctggagaagc gggcatcctc ctctgcttcc gaggcctttg ccacctccaa
      601 cgtcctgcgg cttctggaac agggccggct gctctccgtg cccagggccc ccagcctcct
      661 agcactgacc cctggcctgc caggccttcc cgccagccac aggggcacct ccttggttga
      721 ccccagaaac tcctccccac gcctcaatcc aatgccctcg gcctcggcgt cgtcccctct
      781 gccaccccct ctgccagcca tctgcttttc ctcagctcca ctcctggact tgcctgctgg
      841 ctacaaactg gggtcctcgg cttttgagcc ctacagcaga ctagaacaac agaaagtagg
      901 cagccctggc caaagtgaca agaaagctga catttaagag tcccatccct gtgtgacact
      961 tgagtcccca gcagagcact accctagcct cctggccccc gtggactata ctgagcaggc
     1021 ctggaagagg aagggtgggc acagcatgcg catgtgcctc tccacctgcc ctcagctcag
     1081 agactgaacc aaatgacttt ggtcctaatg tactttctga tgtgtgagtg ctagctatgt
     1141 gcacctatgc gtgtgcgtgt gcgtgtgcgt gtgcgtgtgc gtgtgcgtgt gcgtgtgtgt
     1201 gtgtgtgtct gagtatgtat gtgtcactga aataaaaaag ggaactggtc ccagcatcac
     1261 caactca
//
