LOCUS       NM_020505               5023 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus vav 3 oncogene (Vav3), transcript variant 1, mRNA.
ACCESSION   NM_020505
VERSION     NM_020505.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5023)
  AUTHORS   Schafer,I., Bauch,J., Wegrzyn,D., Roll,L., van Leeuwen,S.,
            Jarocki,A. and Faissner,A.
  TITLE     The guanine nucleotide exchange factor Vav3 intervenes in the
            migration pathway of oligodendrocyte precursor cells on tenascin-C
  JOURNAL   Front Cell Dev Biol 10, 1042403 (2022)
   PUBMED   36531963
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5023)
  AUTHORS   Lorenzo-Martin,L.F., Menacho-Marquez,M., Fernandez-Parejo,N.,
            Rodriguez-Fdez,S., Pascual,G., Abad,A., Crespo,P., Dosil,M.,
            Benitah,S.A. and Bustelo,X.R.
  TITLE     The Rho guanosine nucleotide exchange factors Vav2 and Vav3
            modulate epidermal stem cell function
  JOURNAL   Oncogene 41 (24), 3341-3354 (2022)
   PUBMED   35534539
  REMARK    GeneRIF: The Rho guanosine nucleotide exchange factors Vav2 and
            Vav3 modulate epidermal stem cell function.
REFERENCE   3  (bases 1 to 5023)
  AUTHORS   Hegde,S., Gasilina,A., Wunderlich,M., Lin,Y., Buchholzer,M.,
            Krumbach,O.H.F., Akbarzadeh,M., Ahmadian,M.R., Seibel,W., Zheng,Y.,
            Perentesis,J.P., Mizukawa,B.E., Vinnedge,L.P., Cancelas,J.A. and
            Nassar,N.N.
  TITLE     Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes
            RAC signaling and overcomes resistance to tyrosine kinase
            inhibition in acute lymphoblastic leukemia
  JOURNAL   Leukemia 36 (3), 637-647 (2022)
   PUBMED   34711926
REFERENCE   4  (bases 1 to 5023)
  AUTHORS   Tsou,Y.S., Wang,C.Y., Chang,M.Y., Hsu,T.I., Wu,M.T., Wu,Y.H.,
            Tsai,W.L., Chuang,J.Y. and Kao,T.J.
  TITLE     Vav2 is required for Netrin-1 receptor-class-specific spinal motor
            axon guidance
  JOURNAL   Dev Dyn 251 (3), 444-458 (2022)
   PUBMED   34374463
REFERENCE   5  (bases 1 to 5023)
  AUTHORS   Gao,Y., Pan,L., Zhao,L. and Dang,X.
  TITLE     HDAC1 promotes artery injury through activation of VAV3 by binding
            to miR-182-5p in atherosclerotic mice model
  JOURNAL   Cell Signal 78, 109840 (2021)
   PUBMED   33221374
  REMARK    GeneRIF: HDAC1 promotes artery injury through activation of VAV3 by
            binding to miR-182-5p in atherosclerotic mice model.
REFERENCE   6  (bases 1 to 5023)
  AUTHORS   Cella,M., Fujikawa,K., Tassi,I., Kim,S., Latinis,K., Nishi,S.,
            Yokoyama,W., Colonna,M. and Swat,W.
  TITLE     Differential requirements for Vav proteins in DAP10- and
            ITAM-mediated NK cell cytotoxicity
  JOURNAL   J Exp Med 200 (6), 817-823 (2004)
   PUBMED   15365099
  REMARK    GeneRIF: Three Vav proteins (vav1,vav2 and vav3) function
            specifically in distinct pathways that trigger NK cell
            cytotoxicity.
REFERENCE   7  (bases 1 to 5023)
  AUTHORS   Gakidis,M.A., Cullere,X., Olson,T., Wilsbacher,J.L., Zhang,B.,
            Moores,S.L., Ley,K., Swat,W., Mayadas,T. and Brugge,J.S.
  TITLE     Vav GEFs are required for beta2 integrin-dependent functions of
            neutrophils
  JOURNAL   J Cell Biol 166 (2), 273-282 (2004)
   PUBMED   15249579
  REMARK    GeneRIF: Vav1 and Vav3 proteins play an essential role coupling
            beta2 to Rho GTPases and regulating multiple integrin-induced
            events important in leukocyte adhesion and phagocytosis.
REFERENCE   8  (bases 1 to 5023)
  AUTHORS   Fujikawa,K., Miletic,A.V., Alt,F.W., Faccio,R., Brown,T., Hoog,J.,
            Fredericks,J., Nishi,S., Mildiner,S., Moores,S.L., Brugge,J.,
            Rosen,F.S. and Swat,W.
  TITLE     Vav1/2/3-null mice define an essential role for Vav family proteins
            in lymphocyte development and activation but a differential
            requirement in MAPK signaling in T and B cells
  JOURNAL   J Exp Med 198 (10), 1595-1608 (2003)
   PUBMED   14623913
REFERENCE   9  (bases 1 to 5023)
  AUTHORS   Moores,S.L., Selfors,L.M., Fredericks,J., Breit,T., Fujikawa,K.,
            Alt,F.W., Brugge,J.S. and Swat,W.
  TITLE     Vav family proteins couple to diverse cell surface receptors
  JOURNAL   Mol Cell Biol 20 (17), 6364-6373 (2000)
   PUBMED   10938113
REFERENCE   10 (bases 1 to 5023)
  AUTHORS   Trenkle,T., McClelland,M., Adlkofer,K. and Welsh,J.
  TITLE     Major transcript variants of VAV3, a new member of the VAV family
            of guanine nucleotide exchange factors
  JOURNAL   Gene 245 (1), 139-149 (2000)
   PUBMED   10713454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033253.1, AF067816.1 and BC052739.1.
            
            On Jul 7, 2005 this sequence version replaced NM_020505.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052739.1, AF067816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1710              AK033253.1         2-1711
            1711-2705           AF067816.1         1381-2375
            2706-5023           BC052739.1         2453-4770
FEATURES             Location/Qualifiers
     source          1..5023
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 48.13 cM"
     gene            1..5023
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /note="vav 3 oncogene"
                     /db_xref="GeneID:57257"
                     /db_xref="MGI:MGI:1888518"
     exon            1..560
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..2900
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     guanine nucleotide exchange factor VAV3; VAV-3"
                     /codon_start=1
                     /product="guanine nucleotide exchange factor VAV3 isoform
                     1"
                     /protein_id="NP_065251.2"
                     /db_xref="CCDS:CCDS17773.1"
                     /db_xref="GeneID:57257"
                     /db_xref="MGI:MGI:1888518"
                     /translation="MEPWKQCAQWLIHSKVLPPNHRVTWDSAQVFDLAQTLRDGVLLC
                     QLLNNLRPHSINLKEINLRPQMSQFLCLKNIRTFLAACCDTFGMRKSELFEAFDLFDV
                     RDFGKVIETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETRVEDEEDLY
                     DCVYGEDEGGEVYEDLMKAEEAQQPKSQENDIRSCCLAEIRQTEEKYTETLESIEKYF
                     MAPLKRFLTAAEFDSVFINIPDLVKVHRSLMQEIHDSIVNKDDQNLYQVFINYKERLV
                     IYGQYCSGVESAISNLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKY
                     HLLLQELVKHTHDPMEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLN
                     QPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQY
                     KIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDY
                     ADSNFHDFKMHTFTRVTSCRVCQMLLRGTFYQGYLCFKCGAKAHKECLGRVDNCGRVN
                     SVEQGPFKPPEKRTNGLRRASRQVDPGLPKMQVIRNYTGTPAPGLHEGPPLHIQAGDT
                     VELLRGDAHSVFWQGRNLASGEVGFFPSDAVKPSPCVPKPVDYSCQPWYAGPMERLQA
                     ETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLM
                     ELVEYYKHHSLKEGFRTLDTTLQFPYKEPEQPAGQRGNRTGNSLLSPKVLGIAIARYD
                     FCARDMRELSLLKGDMVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE"
     exon            561..677
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..736
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..802
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..911
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1004
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1073
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1177
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1277
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1373
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1442
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1529
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1615
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1748
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1858
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1960
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2061
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2087
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2133
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2270
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2336
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2371
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2488
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2576
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2706
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2858
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..4985
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4964..4969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /note="hexamer: AATAAA"
     polyA_site      4985
                     /gene="Vav3"
                     /gene_synonym="A530094I06Rik; Idd18.1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctccgg ggactcgcgg accgcacaga ccggccaggc gcgctgggca tgctcagtcg
       61 cggggcgcca ggctcgccag tcggaagcca gtgctcagcg gagccggccg gggcgcaccg
      121 agagcgcgcg gcactcgctg ctgcagcggc ggccgggccg cggcgcatcc gggcggggac
      181 ccgaggcgag tcccacgcgg cgtccccgag ccgccggcag cggcgcccgc tccagaaagg
      241 caaagcgaac caggggccat cagcgcgact ggcgtcggcg gggctctgac gctccgcggc
      301 ggccacctca gagtcgctgc ccgccccggc cgggccgggt ccgggagccg tcggacatgg
      361 agccgtggaa gcagtgcgct cagtggctca tccacagcaa ggtgctgccc cccaaccatc
      421 gggtgacctg ggactcggcg caggtgttcg acctggcgca gacccttcgc gatggagtcc
      481 tgctctgcca gctgctcaac aacctgcggc cacactccat caatctgaag gagatcaacc
      541 tgaggcccca gatgtcccag tttctctgtt tgaagaacat ccggacattc ctggccgcct
      601 gctgcgatac ctttggaatg aggaaaagtg aactttttga ggcatttgac ctatttgatg
      661 ttcgagactt tggaaaggtt atagaaacat tatctcggct atcccgaaca ccaatagcat
      721 tggccacagg aatcaggccg ttccccactg aagaaagtat aaatgatgaa gacatctaca
      781 aaggccttcc cgacttaata gatgaaaccc gcgtggaaga tgaagaagac ctctatgact
      841 gtgtgtacgg cgaggatgaa ggcggagaag tctatgaaga cttgatgaag gcggaggaag
      901 cccagcaacc taaatcacaa gaaaatgata tacggagttg ttgcctagca gaaattaggc
      961 agacagaaga aaaatacaca gaaacgttgg agtcaataga aaaatatttc atggcaccat
     1021 tgaaaagatt tctgacggcg gcggaatttg attcagtatt tattaacatt cctgaccttg
     1081 taaaagttca tcggagctta atgcaagaga ttcatgattc cattgtaaat aaagatgacc
     1141 agaacttgta tcaagttttt attaactaca aggaaagatt ggttatttat gggcagtact
     1201 gcagtggagt ggagtcagcc atctctaacc tagactacat ctctaagaca aaagaagatg
     1261 tcaaactgaa attagaggaa tgttcaaaaa gagccaataa cgggaagttt actctgcgcg
     1321 atttgctggt cgttccaatg cagcgcgtgc tgaagtatca cctcctcctt caggagctgg
     1381 taaaacacac ccatgaccct atggagaagg cgaacctgaa gctggctctg gatgcaatga
     1441 aggacttggc acaatatgtg aatgaagtaa aaagagataa tgagaccctt cgtgaaatta
     1501 agcagtttca gctatctata gagaatttga accagccagt tttgctcttt ggacgaccac
     1561 agggagacgg tgaaatccga ataaccactc tggacaagca tacaaaacaa gaaaggcata
     1621 tcttcttatt cgacttggca gtgattgtct gtaaaaggaa aggcgataac tacgagatga
     1681 aggaaataat agatctccag cagtacaaga tagccaacaa ccctaccact gacaaagaga
     1741 ataaaaagtg gtcttatggc ttctacctca tccataccca aggacaaaat gggttagaat
     1801 tttattgcaa aacaaaagat ttaaagaaaa aatggctgga acagtttgaa atggctctat
     1861 ccaacataag gccagactat gcagactcca atttccatga tttcaagatg cacaccttca
     1921 ctcgggtgac atcctgcagg gtctgccaga tgctcctgag gggaacattt tatcaaggct
     1981 acttatgttt taagtgtgga gcaaaagcac ataaagaatg tttgggaaga gtagacaatt
     2041 gtggcagagt taattccgtt gaacaagggc cattcaaacc accagagaaa cggaccaatg
     2101 gacttcggag agcttccaga caggtggacc caggtttgcc gaagatgcag gtcattagga
     2161 actacactgg caccccggcc ccagggcttc atgaaggacc accattgcat atccaggcag
     2221 gcgacactgt tgaacttctg agaggagatg cacacagtgt gttctggcag ggacgaaact
     2281 tagcttcagg agaggttgga tttttcccaa gtgatgctgt caaaccctct ccatgtgtac
     2341 ctaaaccagt agattattct tgccaaccct ggtatgctgg cccaatggaa agattgcagg
     2401 cagaaactga acttattaac agggtgaata gtacttacct tgtaaggcac aggaccaaag
     2461 aatctggaga atatgcaatt agcattaagt acaataatga agcaaaacac atcaagattt
     2521 taacaagaga tggctttttt cacattgcag aaaatagaaa atttaaaagc ttaatggaac
     2581 ttgtggagta ctacaagcac cattctctca aagaagggtt caggacctta gatacaacgc
     2641 tacagtttcc atacaaggag ccagaacagc cagctggaca gaggggtaat agaacaggca
     2701 acagcttgtt gagtcccaaa gtactgggta ttgccatcgc tcggtacgac ttctgtgcaa
     2761 gagatatgcg ggagctctcc ctattgaaag gagacatggt gaagatttac acgaagatga
     2821 gtgcaaatgg ctggtggaga ggtgaagtaa atggcagggt gggctggttt ccatccacat
     2881 atgtggaaga agatgaataa agtcctatcc agtgttgacc ctgcactaaa atctcaaaga
     2941 caacataagc agaagcctgc acggcattga gttaactgaa gtgtttaaaa agcagcgttc
     3001 ttggctgttc aacaccctct ttttttctct tcctaagtct taatgctggg atttctaaag
     3061 atgctggtac tgacagatta atggctcgcc tagagcagtg caagaaacag cctgccagtc
     3121 tgtcattgtc aggaaccagg gcaaaaccaa tggcttttct acccccaaag agtccagcaa
     3181 acccatcagt ttagctttct cttacttcat tgggccagac accatggatc cagccattag
     3241 gaaacgcttt ttgcatattt actttgttct cacagttttt gatgatacaa agaaacagaa
     3301 gtttaatttt gcttttcccc agcatgaaga gaaagtagag cctgccatct gggaaagatc
     3361 cagcttgctg gaaagatcca gcatttctcg tcttaaattg ttcaacaggt gactcactgc
     3421 ctggcaaacc cttttatccc cagatgttac tcatgataac aaaaaagagg ctcatgctca
     3481 ggtttgcatc ataagtgata aattacagag agggttttaa ttattcattt gatgtcctga
     3541 ttatatttcc acacttcttt atgaagaaga aaaagagaag cacatgaaag gaggtgtctt
     3601 tgtgttaaag cttcacagct ttcgtgattt cgtggagtgt tttggaaatg tcgtgcttga
     3661 caaagggaat catggccggc cagatcatgc ttagttgcca ggaatcccag aaaggtagag
     3721 gtgtttacag agacagatca agcactgtaa tcaatccaca ggacatcact gtatagctgc
     3781 aatagctatt aacacaagcc ttttccttct ctctagaagg acccagggca gatttgctga
     3841 tttacaatct tttttttttt ttaatagtag cacaaaagag ctttattgag gatttgggaa
     3901 gaaaggcagc ccgagtcctt catttctttc tgagacggat ggaagggcac ctgatgtccg
     3961 tgtcctcctg cctgctctgt tggtccttct gatgcctttc tagctatgtc ttaatcagta
     4021 ggaagatcca ccttgcagca tgtttctttc tctaagcttt cactgtgttc catgaggagt
     4081 cttcagtatc ttcctcctga gatgcatggg gtccctagcc caggctgaca actcggctct
     4141 tccatggtgg agtgtttctt tggtagcagt agctgtgttc tgacaagctt ctgaaaatgt
     4201 ttcttcttgg ggaaaaaaaa gatgtatttt tatcttacaa gtgatctaga agcttctctt
     4261 gtaccagact ttcttggtca cctcttacat gtaagggctg agacaacctg ttctctccca
     4321 tctcacagga gtgccagaac ctggaagaga ccccatgggg gctaggactt ctcatttaaa
     4381 tagactcaag acctttacct cagaattatg taaactgtga ttgtgtttta gaacaattga
     4441 gcttttgtat gtgtgtaaat ggtcaggaaa atgtatttta taaaatgtct atagagtcaa
     4501 cttgtgctgg caaggtctac tcttggaatg gattcctacc tataaggtct tacttgtgtc
     4561 ttggggatgt tttgtctgtt catgccagca agtgttgcta tggagagtac agcttcccac
     4621 agattgtaac actcctgtgt acagtattgt agcatgtatt gtttatttca gtcaatagac
     4681 tccctgcctc acaaatggta tgtggtcttc ctgttgcatt tcattggcct cagagtttca
     4741 tagcagagga tacagagcct cttttcatga cattaccaat gacaactttg tctacattta
     4801 atactttata ttggaggttt taaatgccac gatctgtgta gatttctaat accaaagaca
     4861 gacataaatg ttttccatag actttgtctt gcctgtctgt agcccttgtg tcatatggtg
     4921 agttagaatg acattttact ttgtaatatt ttgtaaatat gtcaataaaa tagttactac
     4981 ttgcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
