LOCUS       NM_009500               5812 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus vav 2 oncogene (Vav2), transcript variant 1, mRNA.
ACCESSION   NM_009500
VERSION     NM_009500.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5812)
  AUTHORS   Lorenzo-Martin,L.F. and Bustelo,X.R.
  TITLE     The Rho GTPase exchange factor Vav2 promotes extensive
            age-dependent rewiring of the hair follicle stem cell transcriptome
  JOURNAL   Front Cell Dev Biol 11, 1252834 (2023)
   PUBMED   37822868
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5812)
  AUTHORS   Lorenzo-Martin,L.F., Menacho-Marquez,M., Fernandez-Parejo,N.,
            Rodriguez-Fdez,S., Pascual,G., Abad,A., Crespo,P., Dosil,M.,
            Benitah,S.A. and Bustelo,X.R.
  TITLE     The Rho guanosine nucleotide exchange factors Vav2 and Vav3
            modulate epidermal stem cell function
  JOURNAL   Oncogene 41 (24), 3341-3354 (2022)
   PUBMED   35534539
  REMARK    GeneRIF: The Rho guanosine nucleotide exchange factors Vav2 and
            Vav3 modulate epidermal stem cell function.
REFERENCE   3  (bases 1 to 5812)
  AUTHORS   Tsou,Y.S., Wang,C.Y., Chang,M.Y., Hsu,T.I., Wu,M.T., Wu,Y.H.,
            Tsai,W.L., Chuang,J.Y. and Kao,T.J.
  TITLE     Vav2 is required for Netrin-1 receptor-class-specific spinal motor
            axon guidance
  JOURNAL   Dev Dyn 251 (3), 444-458 (2022)
   PUBMED   34374463
REFERENCE   4  (bases 1 to 5812)
  AUTHORS   Sauzeau,V., Jerkic,M., Lopez-Novoa,J.M. and Bustelo,X.R.
  TITLE     Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular
            disease in mice
  JOURNAL   Mol Biol Cell 18 (3), 943-952 (2007)
   PUBMED   17202406
  REMARK    GeneRIF: These results indicate that Vav2 plays crucial roles in
            the maintenance of cardiovascular homeostasis in mice.
REFERENCE   5  (bases 1 to 5812)
  AUTHORS   Fujikawa,K., Miletic,A.V., Alt,F.W., Faccio,R., Brown,T., Hoog,J.,
            Fredericks,J., Nishi,S., Mildiner,S., Moores,S.L., Brugge,J.,
            Rosen,F.S. and Swat,W.
  TITLE     Vav1/2/3-null mice define an essential role for Vav family proteins
            in lymphocyte development and activation but a differential
            requirement in MAPK signaling in T and B cells
  JOURNAL   J Exp Med 198 (10), 1595-1608 (2003)
   PUBMED   14623913
REFERENCE   6  (bases 1 to 5812)
  AUTHORS   Tartare-Deckert,S., Monthouel,M.N., Charvet,C., Foucault,I., Van
            Obberghen,E., Bernard,A., Altman,A. and Deckert,M.
  TITLE     Vav2 activates c-fos serum response element and CD69 expression but
            negatively regulates nuclear factor of activated T cells and
            interleukin-2 gene activation in T lymphocyte
  JOURNAL   J Biol Chem 276 (24), 20849-20857 (2001)
   PUBMED   11262396
REFERENCE   7  (bases 1 to 5812)
  AUTHORS   Bustelo,X.R.
  TITLE     Regulatory and signaling properties of the Vav family
  JOURNAL   Mol Cell Biol 20 (5), 1461-1477 (2000)
   PUBMED   10669724
  REMARK    Review article
REFERENCE   8  (bases 1 to 5812)
  AUTHORS   Lee,C.G., Morse,H.C. 3rd, Kay,B.K. and Kozak,C.A.
  TITLE     Genetic mapping of eight SH3 domain genes on seven mouse
            chromosomes
  JOURNAL   Mamm Genome 10 (4), 402-404 (1999)
   PUBMED   10087302
REFERENCE   9  (bases 1 to 5812)
  AUTHORS   Schuebel,K.E., Bustelo,X.R., Nielsen,D.A., Song,B.J., Barbacid,M.,
            Goldman,D. and Lee,I.J.
  TITLE     Isolation and characterization of murine vav2, a member of the vav
            family of proto-oncogenes
  JOURNAL   Oncogene 13 (2), 363-371 (1996)
   PUBMED   8710375
REFERENCE   10 (bases 1 to 5812)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL772282.9, U37017.1,
            BC053060.1 and AI847175.1.
            
            On Dec 4, 2015 this sequence version replaced NM_009500.1.
            
            Summary: This gene encodes a member of the Vav family of Rho
            guanine nucleotide exchange factors. Vav family proteins are
            involved in the development and activation of lymphocytes, and the
            encoded protein may also be involved in angiogenesis. Disruption of
            this gene in mice is associated with heart, artery, and kidney
            defects, as well as tachycardia and hypertension. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U37017.1, SRR17784644.1177134.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-783               AL772282.9         3492-4274           c
            784-4265            U37017.1           9-3490
            4266-5792           BC053060.1         3568-5094
            5793-5812           AI847175.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..5812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.36 cM"
     gene            1..5812
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /note="vav 2 oncogene"
                     /db_xref="GeneID:22325"
                     /db_xref="MGI:MGI:102718"
     exon            1..1333
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1130..3736
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /codon_start=1
                     /product="guanine nucleotide exchange factor VAV2"
                     /protein_id="NP_033526.1"
                     /db_xref="CCDS:CCDS15827.1"
                     /db_xref="GeneID:22325"
                     /db_xref="MGI:MGI:102718"
                     /translation="MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLC
                     QLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDV
                     RDFGKVISAVSRLSLHSIAQSKGIRPFPSEETAENDDDVYRSLEELADEHDLGEDIYD
                     CVPCEDEGDDIYEDIIKVEVQQPMKMGMTEDDKRSCCLLEIQETEAKYYRTLEDIEKN
                     YMGPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSMMAGGSTLAKVFLEFKERLL
                     IYGEYCSHMEHAQSTLNQLLASREDFRQKVEECTLRVQDGKFKLQDLLVVPMQRVLKY
                     HLLLKELLSHSADRPERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQCSIENLQ
                     VKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEVIELLFH
                     KMTDDPMHNKDIKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDK
                     ANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYLCTRCGVGAHKECLEVIPPCKMSS
                     PADVDAPGAGPGPKMVAVQNYHGNPAPPGKPVLTFQTGDVIELLRGDPDSPWWEGRLV
                     QTRKSGYFPSSSVKPCPVDGRPPTGRPPSREIDYTAYPWFAGNMERQQTDNLLKSHAS
                     GTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWIHITEAKKFESLLELVEYYQCH
                     SLKESFKQLDTTLKFPYKSRERTTSRASSRSPASCASYNFSFLSPQGLSFAPQAPSAP
                     FWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKGETNGRIGW
                     FPSTYVEEEGVQ"
     exon            1334..1450
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1509
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1578
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1681
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1780
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1849
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1950
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2050
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2146
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2215
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2302
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2388
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2521
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2631
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2733
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2822
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2839
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2861
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2989
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3064
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3117
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3234
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3322
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3446
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3533
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..3688
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3689..5796
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5773..5778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /note="hexamer: AATAAA"
     polyA_site      5796
                     /gene="Vav2"
                     /gene_synonym="2810040F13Rik; Vav-2"
                     /note="major polyA site"
ORIGIN      
        1 tccagagcaa attaatttta atcacaaaaa tcagttattt atgcttttga agtccctccc
       61 actgtcacaa tgtcctcagg acacaacacg gtctatctct ccagcacctc ccactagaca
      121 atcaaggggg ctgaaagtga aggatttttt tccccctctc tccgttattg tggaggcgga
      181 gtgtcttgcg gaccctggca aggacagagg actggaagag gccatagggg cgtagggtgt
      241 gtaggccagc ctggttcgcg ttctggggtc tatctttgcc gaaagaccct gcaagggcac
      301 ccagcgttac cgcggtcatc ttctagtctc ttctgccgtg cggcggcctc atcgcaccgc
      361 aagaaagacc tccagcctcc acgtgcacct agggaaagtc gtgggcgggg agcctgctca
      421 ggagccccgc cttcctcaac tttcgctggc ggcccagggg caggaagtgg gaggacgggt
      481 tggaggcggt gcttgggtct ccggggaggt gccgggtgaa ggtgccagct ccgcccccgg
      541 ccccgcccgg ccgtggccgc gccccctgca cccccagcgc ctaggagccg cggagcctcg
      601 gagtcccagt gccccgcgag tggcgtagag cccgcgggcc cggcgaacaa agcgacggtg
      661 gagcgagcag ctcaggcgcc ggacgcaggg agcgagcgac ccgctgcgcc tttgtctcgg
      721 gtggggcagg agcggtggcc gaagcggggc gcccggagct cagaatgcgg cgcccagagg
      781 ggcggatcga gaagcgctgc gactgcagga ggcgtggagc cccggccgga gcacgagcgg
      841 acttgtgtgt gtgaaagagg gaccccgcac gctgccccgc gagcgccggt tggccgcacg
      901 tgggcgggag cggcggccgg ctagtagccc gaagaggagg aggaggaaga ggagggccgt
      961 gcggccgcgc agcggggacc cggggccgcc tgcgcgaagc cccgccccgg cggccgagcc
     1021 ccgcgcgggc gggcgggatg ccccgcggtc accgcacttt ggccggagcg ctaccctgag
     1081 ccagctggcc agcggccgca gcggcgagcg cacaggcgcc gcgggcgcca tggagcagtg
     1141 gcggcaatgc ggccgctggc tcatcgactg caaggtcctg ccgcccaacc accgcgtcgt
     1201 gtggccctcg gcggtggtct tcgacctggc gcaggcgctg cgcgacggcg tccttctgtg
     1261 ccagctgctg cacaacctct cccccggttc catcgacctt aaggacatca acttccggcc
     1321 gcagatgtcc cagttcttgt gtctgaagaa tattcgcacc ttcctcaaag tctgccatga
     1381 caaatttgga ctaagaaaca gtgagctgtt tgaccctttc gacctctttg atgtccgaga
     1441 cttcgggaag gtcatctctg cagtgtcccg tctgtccctg cacagcatcg cacagagcaa
     1501 agggatcagg ccatttccat cagaggagac agctgaaaat gatgacgacg tctaccggag
     1561 cctggaagag ctggctgacg agcatgacct gggtgaggac atctacgact gtgtcccgtg
     1621 tgaagatgaa ggagatgaca tttatgagga catcatcaag gtggaggtgc agcagcccat
     1681 gaaaatgggc atgactgagg acgacaagag aagctgctgc ttgttagaga ttcaggagac
     1741 cgaggccaag tactaccgca ccctggagga cattgagaag aactacatgg gtcccttgcg
     1801 gctggtgctg agcccggcgg atatggctgc tgtcttcatc aacctggagg acctcatcaa
     1861 ggtgcatcac agctttctgc gagccatcga tgtgtccatg atggctggtg gcagtaccct
     1921 ggctaaggtc tttctggagt ttaaggaaag gctcctgatc tatggagagt actgtagcca
     1981 catggaacac gctcagagta cactgaacca gctcctcgcc agccgagagg acttcaggca
     2041 gaaagtggag gagtgcacac tcagggttca ggatggcaag ttcaagctgc aagacctgct
     2101 ggtggtgccc atgcaacggg tgctgaagta ccacctgctg ctcaaggagc tcctgagcca
     2161 ttctgcagac cgaccagaaa gacaacagct caaagaagcc ctggaagcca tgcaggactt
     2221 ggccatgtac atcaatgaag tgaagcggga caaggagacc ttgaagaaga ttagcgagtt
     2281 ccagtgctcc atagaaaacc tgcaagtgaa gctggaggaa tttgggaggc caaagattga
     2341 cggggagctt aaagtccggt ccatagtcaa ccacaccaag caagacaggt acctgttcct
     2401 atttgacaag gtggtcatcg tgtgcaagag gaagggctac agctatgagc tgaaggaggt
     2461 cattgagctg ctcttccaca agatgaccga tgacccgatg cacaacaagg acatcaagaa
     2521 gtggtcctat ggcttctacc tgattcacct ccaaggaaag caaggctttc agttcttctg
     2581 caagacggaa gacatgaagc ggaagtggat ggagcagttc gagatggcca tgtcaaacat
     2641 caagccagat aaggccaatg ccaaccatca tagcttccag atgtacacat tcgacaagac
     2701 taccaactgc aaagcctgca agatgtttct caggggtacc ttctaccagg gatacctgtg
     2761 taccagatgt ggcgtcgggg cacacaagga atgcctggag gtgatccccc cctgcaagat
     2821 gagttcacct gcagatgtgg atgctcctgg agcaggacca ggtcccaaga tggttgctgt
     2881 gcagaattac catggtaacc cagcccctcc tgggaagcct gtgttgacct tccagacagg
     2941 agacgtgata gaactgctcc ggggtgaccc cgattctcct tggtgggaag ggcggctggt
     3001 tcaaaccagg aagtcagggt attttcccag ctcatctgtg aagccctgcc cagtggatgg
     3061 aaggccgcct actggccgcc caccatcccg ggagatcgat tacactgcct acccgtggtt
     3121 tgctggcaac atggaacggc agcagacgga caatctgctc aagtctcatg ccagtgggac
     3181 ctacctcatc agagagcgtc cagcagaggc agaacgcttc gccatcagca tcaagttcaa
     3241 tgatgaggtg aaacatatca aggtggtgga gaaagatagc tggatccaca tcacggaagc
     3301 taagaagttt gagagcctcc tggagctggt ggagtactac cagtgtcact cactcaagga
     3361 aagcttcaag cagttggaca ctacactcaa gttcccctac aagtctcggg agcgaaccac
     3421 cagcagggcc tcaagccggt ctccagcttc ctgcgcttcc tacaactttt cttttctcag
     3481 tcctcagggc ctcagctttg ccccccaggc cccttctgct cccttctggt cagtgttcac
     3541 accgcgggtc atcggcacag ccgtggccag gtacaacttt gctgctcgag acatgcggga
     3601 gctgtcactg cgagaaggtg atgtggtgaa gatctacagc cgaattggtg gggaccaggg
     3661 ctggtggaaa ggagagacaa atgggcggat cggttggttt ccttcgacgt acgtggaaga
     3721 ggaaggcgtc cagtgaggac gagacctgga caggacccgt ggatgttctt gggagtctcc
     3781 ccagctctga agtccacctc tggcttctcc atagttctgg gaactgcctg ctaagcctgc
     3841 agctgttatg gcccataggg atggggaggg tgttccacca tcacctgccc taggtggcct
     3901 gtccctgggt acagtccttg tacatagagg aaatctgtgc tggccacatt cagagcacca
     3961 aggagaagga cctcaggcag tgtggctaag catgtgtggt tgacagcaaa ggtcagaagc
     4021 cactgcctgc atctctggtt tagatgattg ttcagaaacc tagaactcaa ctcatggtgg
     4081 ctagggaggg ctagggacag cagggggttc cttcccaggc ccatctgctg ccccacactg
     4141 atctgcctgt cttttctgct gctctctaga gtatgtgtca ggtcttggga ggcaggcagg
     4201 accagagccg agctgtgctg tagcacacac taggctcagc cgggagccag agcttgcaca
     4261 accgccactg aatcacgcta gctctggagc tctccctggc cgcctccctt cctaacacat
     4321 cagggtcctg ctgagcgctg accgggcagg cccctccctc agacgggcct gtggaacgat
     4381 gacattgctg acccaccccc agcccaccca gtcagtggta ctgctctttg cttgttgaag
     4441 cccctttcct gagccaagaa acaggtcttc tctgccctgc tgccagggga cacatctgtg
     4501 aaccccaaag ggcagggtag aaaaccaggt tcccctccct gctgccgctt ttctttccag
     4561 aaaggcactc ttgggtcttc tgcattccaa accacggtca ccaggagtct gctggccttt
     4621 gcactagatg ctggttctag cccttgacag gttgctccgc gaggatccct gtagctcaca
     4681 cactgggcct atggccagct caaaataagt gctcttgggt gtctctgctc ttccacttcc
     4741 ttctcctggt gcttcctggc ctttggcctc tggcttggtt ggccagcccc tggtttcctc
     4801 ccaaggagtt ctgagtgaaa gcttacttga agacacacac acccttgctg ccctttctcc
     4861 cttcatctag ctgccccttc ctggataagt agggagccaa ggctaggaac actgtcccca
     4921 ctggagtggg acaatgcact accttgctcc tggggacact gtccggggtt ggcctcgtgt
     4981 cctccagccc agtgtccaca tgcagcatgc tggatgttag gggaagcagg gagggatcat
     5041 gagacgggga gcagccggaa gcgacacctt agaaagcccc agctatgaga aactgggagc
     5101 gaagggtttg ccctggagag agttggggca caggccactt tgcacagctc ctcagcctag
     5161 cctgcctagt gtaagtgcag actgtgggga gggctctgcc cgcccttccg tgtgaaccac
     5221 atgaacaccc tcccaacacc ctgtgctttc cgttttggtc tgtttgtttt tctgttgttg
     5281 tagctttttt tgtcctgtta tgttttatct gtttgtattt tagaaggggg aggggaagtt
     5341 gtaattattt catctaagtc tcccattata tatctgtgaa taagagattc tataatagca
     5401 aaagtatgta tattttagct tgtcatgaaa tgtcaacgaa ggacactgag aaagagaata
     5461 ctcagagccc cgttcttgtg aatgttgtgt gtttgttttg acatgtgtgt ttggtttggt
     5521 tttttgtttg tttgtttgtt tgtttgtttt tgagctgcac tgagcagggt gctgggcagg
     5581 ccggtgtgtg ggcacctctg caggagactg gacaccgtct aaggactggg ggcctgagat
     5641 cagctgtgaa catttgcagc acaatgcatg caagtcaggg atgtgggggt cccacagcca
     5701 gcagcacccc ctgatggaac aactgtacat ttgccaatgg gttttcccca caagactacg
     5761 gtttttacta caaataaacc tacgttctat tctgcaaaaa aaaaaaaaaa aa
//
