LOCUS       NM_011691               4168 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Mus musculus vav 1 oncogene (Vav1), transcript variant 1, mRNA.
ACCESSION   NM_011691 XM_980038 XM_980079
VERSION     NM_011691.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4168)
  AUTHORS   Marrocco,R., Bernard,I., Joulia,E., Barascud,R., Dejean,A.S.,
            Lesourne,R. and Saoudi,A.
  TITLE     Positive regulation of Vav1 by Themis controls CD4 T cell
            pathogenicity in a mouse model of central nervous system
            inflammation
  JOURNAL   Cell Mol Life Sci 81 (1), 161 (2024)
   PUBMED   38565808
  REMARK    GeneRIF: Positive regulation of Vav1 by Themis controls CD4 T cell
            pathogenicity in a mouse model of central nervous system
            inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4168)
  AUTHORS   Machin,P.A., Johnsson,A.E., Massey,E.J., Pantarelli,C.,
            Chetwynd,S.A., Chu,J.Y., Okkenhaug,H., Segonds-Pichon,A.,
            Walker,S., Malliri,A., Fukui,Y. and Welch,H.C.E.
  TITLE     Dock2 generates characteristic spatiotemporal patterns of Rac
            activity to regulate neutrophil polarisation, migration and
            phagocytosis
  JOURNAL   Front Immunol 14, 1180886 (2023)
   PUBMED   37383235
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4168)
  AUTHORS   Robles-Valero,J., Fernandez-Nevado,L., Cuadrado,M.,
            Lorenzo-Martin,L.F., Fernandez-Pisonero,I., Abad,A., Redin,E.,
            Montuenga,L., Martin-Zanca,D., Bigas,A., Mallo,M., Dosil,M. and
            Bustelo,X.R.
  TITLE     Characterization of the spectrum of trivalent VAV1-mutation-driven
            tumours using a gene-edited mouse model
  JOURNAL   Mol Oncol 16 (19), 3533-3553 (2022)
   PUBMED   35895495
  REMARK    GeneRIF: Characterization of the spectrum of trivalent
            VAV1-mutation-driven tumours using a gene-edited mouse model.
REFERENCE   4  (bases 1 to 4168)
  AUTHORS   Shalom,B., Farago,M., Salaymeh,Y., Sebban,S., Risling,M.,
            Pikarsky,E. and Katzav,S.
  TITLE     Vav1 accelerates Ras-driven lung cancer and modulates its tumor
            microenvironment
  JOURNAL   Cell Signal 97, 110395 (2022)
   PUBMED   35752351
  REMARK    GeneRIF: Vav1 accelerates Ras-driven lung cancer and modulates its
            tumor microenvironment.
REFERENCE   5  (bases 1 to 4168)
  AUTHORS   Cortes,J.R., Filip,I., Albero,R., Patino-Galindo,J.A., Quinn,S.A.,
            Lin,W.W., Laurent,A.P., Shih,B.B., Brown,J.A., Cooke,A.J.,
            Mackey,A., Einson,J., Zairis,S., Rivas-Delgado,A., Laginestra,M.A.,
            Pileri,S., Campo,E., Bhagat,G., Ferrando,A.A., Rabadan,R. and
            Palomero,T.
  TITLE     Oncogenic Vav1-Myo1f induces therapeutically targetable
            macrophage-rich tumor microenvironment in peripheral T cell
            lymphoma
  JOURNAL   Cell Rep 39 (3), 110695 (2022)
   PUBMED   35443168
REFERENCE   6  (bases 1 to 4168)
  AUTHORS   Bustelo,X.R. and Barbacid,M.
  TITLE     Tyrosine phosphorylation of the vav proto-oncogene product in
            activated B cells
  JOURNAL   Science 256 (5060), 1196-1199 (1992)
   PUBMED   1375396
REFERENCE   7  (bases 1 to 4168)
  AUTHORS   Adams,J.M., Houston,H., Allen,J., Lints,T. and Harvey,R.
  TITLE     The hematopoietically expressed vav proto-oncogene shares homology
            with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene
            (CDC24) involved in cytoskeletal organization
  JOURNAL   Oncogene 7 (4), 611-618 (1992)
   PUBMED   1565462
REFERENCE   8  (bases 1 to 4168)
  AUTHORS   Katzav,S., Cleveland,J.L., Heslop,H.E. and Pulido,D.
  TITLE     Loss of the amino-terminal helix-loop-helix domain of the vav
            proto-oncogene activates its transforming potential
  JOURNAL   Mol Cell Biol 11 (4), 1912-1920 (1991)
   PUBMED   2005887
REFERENCE   9  (bases 1 to 4168)
  AUTHORS   Coppola,J., Bryant,S., Koda,T., Conway,D. and Barbacid,M.
  TITLE     Mechanism of activation of the vav protooncogene
  JOURNAL   Cell Growth Differ 2 (2), 95-105 (1991)
   PUBMED   2069873
REFERENCE   10 (bases 1 to 4168)
  AUTHORS   Katzav,S., Martin-Zanca,D. and Barbacid,M.
  TITLE     vav, a novel human oncogene derived from a locus ubiquitously
            expressed in hematopoietic cells
  JOURNAL   EMBO J 8 (8), 2283-2290 (1989)
   PUBMED   2477241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY139350.1, AK152555.1, CT010434.8 and BY496946.1.
            
            On Aug 5, 2009 this sequence version replaced NM_011691.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152073.1, AK150398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BY139350.1         2-16
            16-2882             AK152555.1         2-2868
            2883-4036           CT010434.8         35415-36568
            4037-4168           BY496946.1         263-394
FEATURES             Location/Qualifiers
     source          1..4168
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.76 cM"
     gene            1..4168
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /note="vav 1 oncogene"
                     /db_xref="GeneID:22324"
                     /db_xref="MGI:MGI:98923"
     exon            1..302
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2636
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proto-oncogene vav; p95vav; vav oncogene"
                     /codon_start=1
                     /product="proto-oncogene vav isoform 1"
                     /protein_id="NP_035821.3"
                     /db_xref="CCDS:CCDS28931.1"
                     /db_xref="GeneID:22324"
                     /db_xref="MGI:MGI:98923"
                     /translation="MELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLC
                     QLLNNLLPQAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDV
                     QDFGKVIYTLSALSWTPIAQNKGIMPFPTEDSALNDEDIYSGLSDQIDDTAEEDEDLY
                     DCVENEEAEGDEIYEDLMRLESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQ
                     HFMKPLQRFLKPQDMETIFVNIEELFSVHTHFLKELKDALAGPGATTLYQVFIKYKER
                     FLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVL
                     KYHLLLQELVKHTQDATEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIEN
                     LDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVNLH
                     SFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYP
                     ENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGR
                     HGQDFAGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGIPPPPGAFGPFLRLNPGDI
                     VELTKAEAEHNWWEGRNTATNEVGWFPCNRVHPYVHGPPQDLSVHLWYAGPMERAGAE
                     GILTNRSDGTYLVRQRVKDTAEFAISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLLE
                     LVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAISKPPAGSTKYFGTAKARYDFCARDR
                     SELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDYSEYC"
     exon            303..419
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            420..478
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            479..547
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            548..656
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            657..752
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            753..821
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            822..925
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1025
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1121
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1190
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1277
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1363
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1496
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1606
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1708
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1806
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1829
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1875
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2012
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2078
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2110
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2227
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2315
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2430
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2582
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..4168
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2866..2871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /note="hexamer: AATAAA"
     polyA_site      2887
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /note="major polyA site"
     regulatory      4142..4147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
                     /note="hexamer: AATAAA"
     polyA_site      4167
                     /gene="Vav1"
                     /gene_synonym="Vav; vav-T"
ORIGIN      
        1 gttgtagttg tccccactgg ggcaggcggc ggcggtggtg aaggaacgag ggtgcacggg
       61 gcctccccga ggggccaagt gagaggccgg cagccaccat ggagctctgg cgacagtgca
      121 cccactggct gatccagtgt cgggtgctgc ctcccagcca ccgtgtgacc tgggaggggg
      181 cccaggtgtg tgagctggca caggcactgc gggacggtgt cctcttgtgc caattgctta
      241 acaacctgct tccccaggcc attaatcttc gcgaggttaa cttgcggccc cagatgtccc
      301 agttcctttg tcttaagaac attcgaacct tcctgtctac ttgctgtgag aagttcggcc
      361 tcaagcgcag tgaactcttt gaggcttttg acctcttcga tgtgcaggac tttggaaagg
      421 tcatctacac cctgtctgct ctgtcatgga cacccattgc ccagaacaaa ggaatcatgc
      481 ccttcccaac agaggacagc gctctgaacg acgaagatat ttacagtggc ctttcagacc
      541 agattgatga caccgcagag gaagacgagg acctttatga ctgcgtggaa aatgaggagg
      601 cagaggggga cgagatctac gaggacctaa tgcgcttgga gtcggtgcct acgccaccca
      661 agatgacaga gtatgataag cgctgctgct gcctgcggga gatccagcag acggaggaga
      721 agtatacaga cacactgggc tccatccagc agcacttcat gaagcctctg cagcgattcc
      781 ttaagcctca agacatggag accatctttg tcaacattga ggagctgttc tctgtgcata
      841 cccacttctt aaaggaactg aaggatgccc tggctggccc gggagcaaca acactgtatc
      901 aggtcttcat caagtacaag gagaggttcc tggtttatgg ccgttattgc agtcaggtgg
      961 agtcagccag caagcacttg gatcaagtgg ccacagcacg ggaggatgtg cagatgaagc
     1021 tggaggaatg ttctcaaaga gctaacaatg gccgattcac cctacgggat ctgctgatgg
     1081 tacctatgca gcgggtgctg aagtaccacc tccttctcca ggagctagtg aaacacacac
     1141 aggatgctac agagaaggag aacctgcggt tggccctgga cgccatgagg gacctggcac
     1201 agtgcgtgaa cgaggtcaag agggacaatg aaaccctacg gcagatcaca aactttcagc
     1261 tgtccattga gaacctggac cagtctctgg ctaactatgg ccggcccaag attgacggtg
     1321 agctcaagat tacctcagtg gagcgtcgct caaagacaga caggtatgcc ttcctgctgg
     1381 acaaagcact gctcatctgt aaacgccgcg gggactctta cgacctcaaa gcctcggtga
     1441 acttgcacag cttccaagtt cgagatgact cctccgggga gcgagacaac aagaagtgga
     1501 gccatatgtt ccttctgatt gaggatcaag gcgcccaggg ctatgagctg ttcttcaaga
     1561 ctcgggagct gaagaagaag tggatggaac agttcgaaat ggccatctcc aacatttacc
     1621 cagagaatgc tacagccaat gggcatgatt ttcagatgtt ctcctttgag gagaccactt
     1681 cctgcaaggc ctgccagatg ttactcagag gcacattcta ccagggatat cgctgttaca
     1741 ggtgccgggc acctgcacac aaggagtgtc tggggagagt gcctccctgt ggtcgccatg
     1801 ggcaagattt cgcaggaacc atgaagaagg acaagctcca tcgaagggcc caggacaaga
     1861 aaaggaatga attgggtctg cctaagatgg aagtgtttca ggaatactat gggatccctc
     1921 ctccacctgg agcctttggg ccatttttac ggctcaaccc tggggacatt gtggagctca
     1981 ctaaggcaga ggctgagcac aactggtggg agggaaggaa tactgctaca aatgaagtcg
     2041 gctggtttcc ctgtaacaga gtgcatccct atgtccacgg ccctcctcag gacctgtctg
     2101 tgcatctctg gtatgcgggc cctatggaac gagcaggcgc tgagggcatc ctcaccaacc
     2161 gttctgatgg gacctatctg gtgcggcaga gggtgaaaga tacagcggag ttcgccatca
     2221 gcattaagta taacgtggag gtcaagcata ttaaaatcat gacgtcagag gggttgtacc
     2281 ggatcacaga gaagaaggct ttccggggcc ttctggaact ggtagagttt tatcagcaga
     2341 attccctcaa agattgcttc aagtcgttgg acaccacctt gcagtttcct tataaggaac
     2401 ctgagaggag agccatcagc aagccaccag ctggaagcac caagtatttt ggcactgcca
     2461 aagcccgcta cgacttctgt gcccgggaca ggtcggaact gtcccttaag gagggtgata
     2521 tcatcaagat cctcaataag aagggacagc aaggctggtg gcgtggggag atctacggcc
     2581 ggatcggctg gttcccttct aactatgtgg aggaagacta ttccgaatat tgctgagcct
     2641 ggtgccctgt aggacacaga gagaggcaga tgaaggctga gcccaggatg ctagcagggt
     2701 tgaggggcca tgaactgtcc tcaccagcgg aggatctgga tggcgtgcag atggctagtg
     2761 gccagctggc agggttccca ggataaagcc cagagatgcg taatttataa cacactgatt
     2821 ttctccagtc ctccacgaaa ggtggggctt gaggcaactg attctaataa agtgaggaga
     2881 gcaggaactg gcgtgttcca gactgactgt aaggggagcc acagggtggg cacgcactga
     2941 ccaaagttca ctcaagcaat gccctccttg tgtcaaggcc tcccttctct gacttttaca
     3001 gtacaggttg aaggagacct gggatttcta cgcagcagaa gagagtgctg tctttacagg
     3061 gtctggattg cagaaatcaa gtctatacct ccccttccct tctttttgtc ctcaacgcca
     3121 aggaaagacc tcttgacctc agcatgatag gaagacacac tacagctgag cgcctcactg
     3181 ggagattcta ggcaggggat ccaccacaac cattccctaa ctcctcactg gggggattct
     3241 gggtggggct ccaccccctg accacgcccc agcccttatt gtgggcttct ggtagtgggg
     3301 ttgggggagg ggaggggact ctactgctgt gccacactcc cagtccttta aaatcttcga
     3361 gacaaggtct tgctaaatag gccagactga ccttgaacat attgcagctg gacttcaact
     3421 tgtcatcctc ctgcctcagc ttccttataa tagaagttaa tgttttgagt tctctccttc
     3481 cgctgagtaa gggaaaaaaa cctcaatata ttctctcttc cccccccccc tttattatat
     3541 atatgagtac gccctcgctg tcttcacaca caccagaaga gggcatcaga tcccattaca
     3601 gatgattgtg agacaccatg tggttgctgg gattcgaact caggacctct ggaagagcag
     3661 tcagtgctct taacccctga gccatctctc caacctctca aaataagctc ttcaaaaatc
     3721 tagggtaaat cctataaacc ttggctctgg tgtactgagg agatagccag ctctcctttg
     3781 ctgccttgct tcctgtggag acgacattgc tcacatcaga acccttcttg gcccgccagg
     3841 tagaacaacc gcacgcactc tggtttaccc aggctcattt tgcctgttgc cctggtgtag
     3901 ttatctgtga cctgtgtcct actttgattt ttgttgctgt ggcaaacgac ttgacctaat
     3961 gctccccgcg gaggaaaaga tgtatgtttt ggctacactt ccagtgtcca cagtttgtca
     4021 ctgatggaag tcagggcagg agctgaatca ggagctgaag caggggccag ggggcggggg
     4081 atgctcttac tggctcatta ttggctttat gcccagctac catcctttct tctttttcag
     4141 taataaagtt tttacttact ttatagcc
//
