LOCUS       NM_009499               2267 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus vasodilator-stimulated phosphoprotein (Vasp),
            transcript variant 1, mRNA.
ACCESSION   NM_009499
VERSION     NM_009499.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2267)
  AUTHORS   Waldman,M.M., Rahkola,J.T., Sigler,A.L., Chung,J.W.,
            Willett,B.A.S., Kedl,R.M., Friedman,R.S. and Jacobelli,J.
  TITLE     Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naive
            CD8+ T Cell Activation and Expansion by Promoting T Cell-APC
            Interactions In Vivo
  JOURNAL   Front Immunol 13, 856977 (2022)
   PUBMED   35757762
  REMARK    GeneRIF: Ena/VASP Protein-Mediated Actin Polymerization Contributes
            to Naive CD8(+) T Cell Activation and Expansion by Promoting T
            Cell-APC Interactions In Vivo.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2267)
  AUTHORS   Dennison,B.J.C., Larson,E.D., Fu,R., Mo,J. and Fantauzzo,K.A.
  TITLE     Srsf3 mediates alternative RNA splicing downstream of PDGFRalpha
            signaling in the facial mesenchyme
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34184034
REFERENCE   3  (bases 1 to 2267)
  AUTHORS   Ali,M., Zuzga,D.S. and Pitari,G.M.
  TITLE     Differential Ser phosphorylation of vasodilator-stimulated
            phosphoprotein regulates colon tumor formation and growth
  JOURNAL   Life Sci 264, 118671 (2021)
   PUBMED   33129878
  REMARK    GeneRIF: Differential Ser phosphorylation of vasodilator-stimulated
            phosphoprotein regulates colon tumor formation and growth.
REFERENCE   4  (bases 1 to 2267)
  AUTHORS   Cheng,K.W. and Mullins,R.D.
  TITLE     Initiation and disassembly of filopodia tip complexes containing
            VASP and lamellipodin
  JOURNAL   Mol Biol Cell 31 (18), 2021-2034 (2020)
   PUBMED   32579429
  REMARK    GeneRIF: Initiation and disassembly of filopodia tip complexes
            containing VASP and lamellipodin.
REFERENCE   5  (bases 1 to 2267)
  AUTHORS   Iwasaki,K., Obashi,K. and Okabe,S.
  TITLE     Vasodilator-stimulated phosphoprotein (VASP) is recruited into
            dendritic spines via G-actin-dependent mechanism and contributes to
            spine enlargement and stabilization
  JOURNAL   Eur J Neurosci 51 (3), 806-821 (2020)
   PUBMED   31793065
  REMARK    GeneRIF: Vasodilator-stimulated phosphoprotein (VASP) is recruited
            into dendritic spines via G-actin-dependent mechanism and
            contributes to spine enlargement and stabilization.
REFERENCE   6  (bases 1 to 2267)
  AUTHORS   Hauser,W., Knobeloch,K.P., Eigenthaler,M., Gambaryan,S., Krenn,V.,
            Geiger,J., Glazova,M., Rohde,E., Horak,I., Walter,U. and Zimmer,M.
  TITLE     Megakaryocyte hyperplasia and enhanced agonist-induced platelet
            activation in vasodilator-stimulated phosphoprotein knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 96 (14), 8120-8125 (1999)
   PUBMED   10393958
REFERENCE   7  (bases 1 to 2267)
  AUTHORS   Collins,S.P. and Uhler,M.D.
  TITLE     Cyclic AMP- and cyclic GMP-dependent protein kinases differ in
            their regulation of cyclic AMP response element-dependent gene
            transcription
  JOURNAL   J Biol Chem 274 (13), 8391-8404 (1999)
   PUBMED   10085070
REFERENCE   8  (bases 1 to 2267)
  AUTHORS   Lanier,L.M., Gates,M.A., Witke,W., Menzies,A.S., Wehman,A.M.,
            Macklis,J.D., Kwiatkowski,D., Soriano,P. and Gertler,F.B.
  TITLE     Mena is required for neurulation and commissure formation
  JOURNAL   Neuron 22 (2), 313-325 (1999)
   PUBMED   10069337
REFERENCE   9  (bases 1 to 2267)
  AUTHORS   Aszodi,A., Pfeifer,A., Ahmad,M., Glauner,M., Zhou,X.H., Ny,L.,
            Andersson,K.E., Kehrel,B., Offermanns,S. and Fassler,R.
  TITLE     The vasodilator-stimulated phosphoprotein (VASP) is involved in
            cGMP- and cAMP-mediated inhibition of agonist-induced platelet
            aggregation, but is dispensable for smooth muscle function
  JOURNAL   EMBO J 18 (1), 37-48 (1999)
   PUBMED   9878048
REFERENCE   10 (bases 1 to 2267)
  AUTHORS   Zimmer,M., Fink,T., Fischer,L., Hauser,W., Scherer,K., Lichter,P.
            and Walter,U.
  TITLE     Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes
            in human and mouse: structure, sequence, and chromosomal
            localization
  JOURNAL   Genomics 36 (2), 227-233 (1996)
   PUBMED   8812448
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB850928.1, AK140329.1 and CO040918.1.
            
            On Aug 14, 2013 this sequence version replaced NM_009499.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010223.1, AK140329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BB850928.1         1-37
            38-2249             AK140329.1         2-2213
            2250-2267           CO040918.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.51 cM"
     gene            1..2267
                     /gene="Vasp"
                     /note="vasodilator-stimulated phosphoprotein"
                     /db_xref="GeneID:22323"
                     /db_xref="MGI:MGI:109268"
     exon            1..341
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            342..513
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            514..679
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            680..764
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            765..802
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1044
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1145
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1197
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1231
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1277
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1368
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1426
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..2252
                     /gene="Vasp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2224..2229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vasp"
                     /note="hexamer: AATAAA"
     polyA_site      2252
                     /gene="Vasp"
                     /note="major polyA site"
ORIGIN      
        1 ggagtggaat tttggaacga aatgtagcaa agagagtaca gtagtaagag taaccgcgta
       61 ggtgcagccg gccgaggggg tgcgccggcg aggttcggac gctgcacccc gctttccatc
      121 gcaggggatc ccagcacatc agaacaccgg tgggaggagg cgcctgaaga cccgccccgg
      181 cccggtccac gttctcccca ggaagctgga ctctatgggg cgggaccccg agagagactg
      241 agcagaacct ggagccagcc ccgcacccct gcacttccaa tcaggggcgc cccgggagca
      301 ctccccgtgg gcgcgccgcc cgccctccgc gcagccatga gcgagacggt catctgttcc
      361 agccgggcta ctgtgatgct ttatgatgac agcaacaagc gatggctccc tgctggcact
      421 ggtccccagg ccttcagccg cgtccagatc taccacaacc ccactgctaa ctccttccga
      481 gttgttggcc gcaagatgca gccggatcag caggtggtta tcaactgtgc catcattcgg
      541 ggtgtcaagt acaatcaggc cactcccatc ttccatcagt ggcgagatgc ccgccaggtc
      601 tggggcctca acttcggcag caaggaggac gccatacagt ttgcaacagg catggccaac
      661 gccctagagg ccttggaagg aggtgggcct cccccagccc cagcaccccc tgcctggtct
      721 gcccagaatg gtccctcccc agaggagctg gaacaacaga aaaggcagcc ggagcatatg
      781 gagcgccggg tctccaatgc aggaggccca cctgctcccc cagctggggg ccctcctcca
      841 cctccaggac ctccccctcc tccaggtccc cccccacccc caggtctgcc ctcctcaggg
      901 gtatctgggg caggtcatgg agcaggggca gccccacccc ctgcaccccc actccctaca
      961 gcacagggcc ccaatagtgg gggttccggg gccccaggcc tggctgctgc cattgctgga
     1021 gccaaactca ggaaagtgag caagcaggag gaggcctctg gggggcccct ggcccccaaa
     1081 gctgagaaca gtcgaagcac tggtgggggg cttatggaag agatgaacgc catgctggcc
     1141 cggagaagaa aagccacaca ggttggggag aagcccccca aagacgagtc agccagtgag
     1201 gagtcagagg cccgactccc tgcccagagt gaacctgtga gaagaccctg ggagaagaac
     1261 agcacaacct tgccaaggat gaagtcgtcc tcttctgtga ctacctccga ggcccacccc
     1321 tcgacgccct gctccagtga tgactccgac ttggagaggg tgaagcagga gcttctggaa
     1381 gaggtgcgga aggagctaca gaaaatgaaa gaggaaatca tcgaagtctt tgtccaggag
     1441 ctgaggaagc ggggttctcc ttgactacag ggacccagaa gacccatttc ttctttctgt
     1501 acttcctgcc tggcacctgc tttccctgcc tctacttgac caagagttac acaagaatgc
     1561 gttctccccc gccagctccc acttggaaga ttccacgtgg ggtgtggctt cctggtgcca
     1621 tggtcacacc cacgctggct gctgattgga taaggaggtc ccaccccttt gttttctttg
     1681 gtcctttccc ttcaccatcc ccttggggct ggttcctctg ctggggatgg accgagtaac
     1741 cccgcagtga gggaaggaag gaggggtctc accttctctt gttctggatt cactttaacg
     1801 ctttaatgcc ttggaatttt tttttaagaa aaagtatata tatatatttg ggtttggggg
     1861 cggggaaggg aaattttttt ctctttggtt ttgataaaaa tggggtgtgg gagtttttaa
     1921 atgctagacc ccaggcttgt cccatcggag gcagctatat ataagagggg aggtatccca
     1981 ctaggtgggg ggtatttccc ccacccctgg gacacccttt tgccttggct cctccctctt
     2041 ttctatgagg aattaagatt ctttaacttt tttggaacct cagttttgtg gtttttttat
     2101 ttgggttagg atttcagggt ccagaccatt tttgccctcc gggaagatga agtgaggggg
     2161 agaagaggaa aaataggtcc tccgacttct acaccatagc ttcttggaca cgggccctcg
     2221 ctgaataaat ctgcagtttt tataaatgca aaaaaaaaaa aaaaaaa
//
