LOCUS       NM_139307               3189 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus vasorin (Vasn), mRNA.
ACCESSION   NM_139307
VERSION     NM_139307.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3189)
  AUTHORS   Andrique,C., Bonnet,A.L., Dang,J., Lesieur,J., Krautzberger,A.M.,
            Baroukh,B., Torrens,C., Sadoine,J., Schmitt,A., Rochefort,G.Y.,
            Bardet,C., Six,I., Houillier,P., Tharaux,P.L., Schrewe,H.,
            Gaucher,C. and Chaussain,C.
  TITLE     Vasorin as an actor of bone turnover?
  JOURNAL   J Cell Physiol 239 (6), e31257 (2024)
   PUBMED   38504496
  REMARK    GeneRIF: Vasorin as an actor of bone turnover?
            Erratum:[J Cell Physiol. 2024 Dec;239(12):e31425. doi:
            10.1002/jcp.31425.. PMID: 39192537]
REFERENCE   2  (bases 1 to 3189)
  AUTHORS   Guo,X., Sun,J., Liang,J., Zhu,S., Zhang,M., Yang,L., Huang,X.,
            Xue,K., Mo,Z., Wen,S., Hu,B., Liu,J., Ouyang,Y. and He,M.
  TITLE     Vasorin contributes to lung injury via FABP4-mediated inflammation
  JOURNAL   Mol Biol Rep 49 (10), 9335-9344 (2022)
   PUBMED   35945403
  REMARK    GeneRIF: Vasorin contributes to lung injury via FABP4-mediated
            inflammation.
REFERENCE   3  (bases 1 to 3189)
  AUTHORS   Louvet,L., Lenglet,G., Krautzberger,A.M., Mentaverri,R., Hague,F.,
            Kowalewski,C., Mahtal,N., Lesieur,J., Bonnet,A.L., Andrique,C.,
            Gaucher,C., Gomila,C., Schrewe,H., Tharaux,P.L., Kamel,S.,
            Chaussain,C. and Six,I.
  TITLE     Vasorin plays a critical role in vascular smooth muscle cells and
            arterial functions
  JOURNAL   J Cell Physiol 237 (10), 3845-3859 (2022)
   PUBMED   35892191
  REMARK    GeneRIF: Vasorin plays a critical role in vascular smooth muscle
            cells and arterial functions.
REFERENCE   4  (bases 1 to 3189)
  AUTHORS   Yang,L., Cheng,X., Shi,W., Li,H., Zhang,Q., Huang,S., Huang,X.,
            Wen,S., Gan,J., Liao,Z., Sun,J., Liang,J., Ouyang,Y. and He,M.
  TITLE     Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte Autophagy
            through Glycogen-Mediated mTOR Regulation
  JOURNAL   Nutrients 14 (17), 3600 (2022)
   PUBMED   36079859
  REMARK    GeneRIF: Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte
            Autophagy through Glycogen-Mediated mTOR Regulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3189)
  AUTHORS   Sun,J., Guo,X., Yu,P., Liang,J., Mo,Z., Zhang,M., Yang,L.,
            Huang,X., Hu,B., Liu,J., Ouyang,Y. and He,M.
  TITLE     Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7
            in young mice
  JOURNAL   J Cell Mol Med 26 (1), 88-98 (2022)
   PUBMED   34854218
  REMARK    GeneRIF: Vasorin deficiency leads to cardiac hypertrophy by
            targeting MYL7 in young mice.
REFERENCE   6  (bases 1 to 3189)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3189)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   8  (bases 1 to 3189)
  AUTHORS   Krautzberger,A.M., Kosiol,B., Scholze,M. and Schrewe,H.
  TITLE     Expression of vasorin (Vasn) during embryonic development of the
            mouse
  JOURNAL   Gene Expr Patterns 12 (5-6), 167-171 (2012)
   PUBMED   22426063
  REMARK    GeneRIF: Study characterized the expression pattern of Vasn during
            mouse embryonic development; with various distinct expression
            domains, results indicate important roles for Vasn e.g., in the
            developing skeletal system, the kidneys, and the lungs.
REFERENCE   9  (bases 1 to 3189)
  AUTHORS   Choksi,S., Lin,Y., Pobezinskaya,Y., Chen,L., Park,C., Morgan,M.,
            Li,T., Jitkaew,S., Cao,X., Kim,Y.S., Kim,H.S., Levitt,P., Shih,G.,
            Birre,M., Deng,C.X. and Liu,Z.G.
  TITLE     A HIF-1 target, ATIA, protects cells from apoptosis by modulating
            the mitochondrial thioredoxin, TRX2
  JOURNAL   Mol Cell 42 (5), 597-609 (2011)
   PUBMED   21658601
  REMARK    GeneRIF: ATIA is an HIF-1 target that regulates mitochondrial redox
            pathways.
REFERENCE   10 (bases 1 to 3189)
  AUTHORS   Ikeda,Y., Imai,Y., Kumagai,H., Nosaka,T., Morikawa,Y., Hisaoka,T.,
            Manabe,I., Maemura,K., Nakaoka,T., Imamura,T., Miyazono,K.,
            Komuro,I., Nagai,R. and Kitamura,T.
  TITLE     Vasorin, a transforming growth factor beta-binding protein
            expressed in vascular smooth muscle cells, modulates the arterial
            response to injury in vivo
  JOURNAL   Proc Natl Acad Sci U S A 101 (29), 10732-10737 (2004)
   PUBMED   15247411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132325.1, AI448688.1 and BF657819.1.
            
            On Jun 18, 2008 this sequence version replaced NM_139307.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132325.1, AK083684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2807              AK132325.1         6-2812
            2808-2933           AI448688.1         131-256
            2934-3189           BF657819.1         262-517             c
FEATURES             Location/Qualifiers
     source          1..3189
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.46 cM"
     gene            1..3189
                     /gene="Vasn"
                     /gene_synonym="2610528G05Rik; Atia; Slitl2"
                     /note="vasorin"
                     /db_xref="GeneID:246154"
                     /db_xref="MGI:MGI:2177651"
     exon            1..204
                     /gene="Vasn"
                     /gene_synonym="2610528G05Rik; Atia; Slitl2"
                     /inference="alignment:Splign:2.1.0"
     exon            205..3189
                     /gene="Vasn"
                     /gene_synonym="2610528G05Rik; Atia; Slitl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..2235
                     /gene="Vasn"
                     /gene_synonym="2610528G05Rik; Atia; Slitl2"
                     /note="protein slit-like 2; Slit-like 2"
                     /codon_start=1
                     /product="vasorin precursor"
                     /protein_id="NP_647468.2"
                     /db_xref="CCDS:CCDS27921.1"
                     /db_xref="GeneID:246154"
                     /db_xref="MGI:MGI:2177651"
                     /translation="MHSRSCLPPLLLLLLVLLGSGVQGCPSGCQCNQPQTVFCTARQG
                     TTVPRDVPPDTVGLYIFENGITTLDVGCFAGLPGLQLLDLSQNQITSLPGGIFQPLVN
                     LSNLDLTANKLHEISNETFRGLRRLERLYLGKNRIRHIQPGAFDALDRLLELKLPDNE
                     LRVLPPLHLPRLLLLDLSHNSIPALEAGILDTANVEALRLAGLGLRQLDEGLFGRLLN
                     LHDLDVSDNQLEHMPSVIQGLRGLTRLRLAGNTRIAQIRPEDLAGLTALQELDVSNLS
                     LQALPSDLSSLFPRLRLLAAARNPFNCLCPLSWFGPWVRENHVVLASPEETRCHFPPK
                     NAGRLLLDLDYADFGCPVTTTTATVPTIRSTIREPTLSTSSQAPTWPSLTEPTTQAST
                     VLSTAPPTMRPAPQPQDCPASICLNGGSCRLGARHHWECLCPEGFIGLYCESPVEQGM
                     KPSSIPDTPRPPPLLPLSIEPVSPTSLRVKLQRYLQGNTVQLRSLRLTYRNLSGPDKR
                     LVTLRLPASLAEYTVTQLRPNATYSICVTPLGAGRTPEGEEACGEANTSQAVRSNHAP
                     VTQAREGNLPLLIAPALAAVLLAVLAAAGAAYCVRRARATSTAQDKGQVGPGTGPLEL
                     EGVKAPLEPGSKATEGGGEALSGGPECEVPLMGYPGPSLQGVLPAKHYI"
     regulatory      2788..2793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vasn"
                     /gene_synonym="2610528G05Rik; Atia; Slitl2"
                     /note="hexamer: AAGAAA"
     regulatory      2793..2798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vasn"
                     /gene_synonym="2610528G05Rik; Atia; Slitl2"
                     /note="hexamer: AATAAA"
     polyA_site      2805
                     /gene="Vasn"
                     /gene_synonym="2610528G05Rik; Atia; Slitl2"
     polyA_site      2819
                     /gene="Vasn"
                     /gene_synonym="2610528G05Rik; Atia; Slitl2"
                     /note="major polyA site"
ORIGIN      
        1 agagaccagc ctcttacgag tcaacttcga gtctggagcc ggagccagag accggggctg
       61 ggaaacccca gcccgggacg ggacgcagca gcctctggat cccgggaccc cggacctctc
      121 aggaccggcc agaggtgaag gactgaggcc ccactgaggc cttggaccgc accgcctggc
      181 tccttcagcc gcagtcgtct cctgggacag aagatgcact ccaggagctg cctgccacct
      241 ctcctgttgt tgcttctggt gctcctgggg tctggagtac agggttgccc atcaggctgc
      301 cagtgcaacc agccacagac agtcttctgc actgcccgtc agggaaccac agtgccccga
      361 gacgtgccac ctgacacagt gggcctgtac atctttgaga acggcatcac gacacttgat
      421 gtgggctgtt ttgctggcct tccgggcctg cagcttctgg acttgtcaca gaaccagatc
      481 actagcctgc ccgggggcat ctttcagcca cttgttaacc tcagtaacct ggacctgact
      541 gccaacaaac tgcacgagat ctccaacgag accttccgtg gcctgcggcg cctggagcgc
      601 ctctacctgg gcaagaaccg aattcgccac atccaaccgg gtgccttcga cgcgcttgat
      661 cgcctcctgg agctcaagct gccagacaat gagcttcggg tgttgccccc attgcacttg
      721 ccccgcctgc tgctgcttga cctcagccac aacagcatcc cagccctgga agccggaata
      781 ctggataccg ccaatgtaga ggcattgagg ttggctggcc tagggctgcg gcagctggat
      841 gaggggcttt ttggccgcct tctcaacctc catgacttgg atgtttctga caaccagttg
      901 gagcatatgc catctgtgat tcaaggcctg cgtggcctga cacgcctgcg gctggctggc
      961 aacacccgta ttgcccagat acggcccgag gacctcgctg gtctgactgc cctacaggaa
     1021 ttggatgtga gcaacctaag cctgcaggcc ctgcccagtg acctctcgag tctctttccc
     1081 cgcctgcgcc tcttagcagc tgccaggaac cccttcaact gcttgtgccc cttgagctgg
     1141 tttggtcctt gggtgcgtga gaaccatgtt gtgttggcca gccctgagga gacgcgttgt
     1201 cactttccac ccaagaatgc tggccgactg ctcctggatc tggattatgc agattttggc
     1261 tgcccagtca ccactaccac ggccacagta cctactataa ggtctactat cagggaaccc
     1321 acactttcaa cttctagcca agctcccacc tggcccagcc tcacagagcc aactacccag
     1381 gcctccaccg tactatcgac tgccccacca accatgaggc cagctcctca gccccaggac
     1441 tgtccagcat ccatctgcct gaatggtggt agctgccgtt tgggagcaag acaccactgg
     1501 gagtgcctat gccctgaggg cttcattggc ctgtactgtg agagtccagt ggagcaaggg
     1561 atgaagccca gctccatacc agacactcca aggccccctc cactgctgcc tctcagcatt
     1621 gagccggtga gccccacctc cttgcgtgtg aagctgcagc gctacttgca gggtaacact
     1681 gtgcagctac ggagcctccg gctcacctat cgcaacctgt ctggccctga caaacgactg
     1741 gtgacattac ggctgcctgc ttcacttgca gagtatacag tcacccagct gcgacccaat
     1801 gccacctatt ctatctgtgt cacacccttg ggagctggac ggacacctga aggtgaggag
     1861 gcctgtgggg aggccaacac ttcccaggca gtccgctcta accatgcccc agttacccag
     1921 gcccgtgagg gcaacctgcc actcctcatt gcgcctgccc tggctgctgt acttctggct
     1981 gtgttagccg ctgcaggggc agcctactgt gtgcggcggg cacgggcaac ttctacagct
     2041 caggacaaag ggcaggtggg gccagggact ggacccctgg aactagaggg ggtgaaagcc
     2101 cctttggagc caggctccaa ggcaacagag ggaggtgggg aggctttgtc aggtggtcct
     2161 gaatgtgagg tgcctcttat gggctaccca gggcccagcc ttcagggggt cctccctgct
     2221 aagcactaca tttagactgg tgagaaagag cagccagggg gtcaggcttt cagtcaccac
     2281 cctcctgctg ccacagaagg aagttctcag tatacaccac agtgcacgtg catgatggag
     2341 ctgtgggacc ctctctgggc tgggtctcat ctgtaagctg ctacagccca gatgaactct
     2401 gccagccgcc agtgcatcca gtacagcgcc tgccatcttg tgcaatgtgc aaccctggga
     2461 tgtgagccct gccatgtgct ggtaacatgg ctaggcatgt tgggcttccc aaaccatgga
     2521 gtctggtaac cagtgaagga agcccccaga aataatgagt ggggaaggta ctagggcact
     2581 ggccttggcc tcaaaagtgc aggcacactt gaaactggaa aggaaggtgc tctgggcaca
     2641 tgtggatttg cttctattgt tttgttttgt tttttctaat gtatttataa aagatctttt
     2701 cccatttatg ctgggaaagt gtttttcaaa ctcagtgaca aggactttgg tttttgtaag
     2761 actgttgatg atatgaaggc cttttgtaag aaaataaaaa ataaagtaaa ttgcctgtct
     2821 ctctggttgg gcttgagatt taaggtctgt ggacatgcac aggattggag ggctgctgcc
     2881 ctgccattag aatgctctag ccatgggtcc tgacccatgg taaggcttgc acttgggtgg
     2941 ggccggaaaa tggacttgtt aggtagctta ccctaggcta ggcctcctct tctgccagca
     3001 ggaaccacag tgcttaatgt ataaggcaga aaggggctca tagaaaacac agaacacaaa
     3061 gggaggtcac atccctcctt gggtgttctg aaagtgcagt ccactatctt caactagaga
     3121 agacagcctg gagcttcctc attctagagc ctaacagctg atcctgggac caggtggctt
     3181 ccagactgg
//
