LOCUS       NM_144879               4045 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus vasohibin 2 (Vash2), transcript variant 1, mRNA.
ACCESSION   NM_144879
VERSION     NM_144879.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4045)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4045)
  AUTHORS   Miyake,H., Tanabe,K., Tanimura,S., Nakashima,Y., Morioka,T.,
            Masuda,K., Sugiyama,H., Sato,Y. and Wada,J.
  TITLE     Genetic Deletion of Vasohibin-2 Exacerbates
            Ischemia-Reperfusion-Induced Acute Kidney Injury
  JOURNAL   Int J Mol Sci 21 (12), 4545 (2020)
   PUBMED   32604722
  REMARK    GeneRIF: Genetic Deletion of Vasohibin-2 Exacerbates
            Ischemia-Reperfusion-Induced Acute Kidney Injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4045)
  AUTHORS   Zhou,C., Yan,L., Zhang,W.H. and Liu,Z.
  TITLE     Structural basis of tubulin detyrosination by VASH2/SVBP
            heterodimer
  JOURNAL   Nat Commun 10 (1), 3212 (2019)
   PUBMED   31324789
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4045)
  AUTHORS   Masuda,K., Tanabe,K., Ujike,H., Hinamoto,N., Miyake,H.,
            Tanimura,S., Sugiyama,H., Sato,Y., Maeshima,Y. and Wada,J.
  TITLE     Deletion of pro-angiogenic factor vasohibin-2 ameliorates
            glomerular alterations in a mouse diabetic nephropathy model
  JOURNAL   PLoS One 13 (4), e0195779 (2018)
   PUBMED   29641565
  REMARK    GeneRIF: High VASH2 expression is associated with diabetes-induced
            glomerular alterations, particularly impaired filtration barrier
            and mesangial expansion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4045)
  AUTHORS   Aillaud,C., Bosc,C., Peris,L., Bosson,A., Heemeryck,P., Van
            Dijk,J., Le Friec,J., Boulan,B., Vossier,F., Sanman,L.E., Syed,S.,
            Amara,N., Coute,Y., Lafanechere,L., Denarier,E., Delphin,C.,
            Pelletier,L., Humbert,S., Bogyo,M., Andrieux,A., Rogowski,K. and
            Moutin,M.J.
  TITLE     Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate
            neuron differentiation
  JOURNAL   Science 358 (6369), 1448-1453 (2017)
   PUBMED   29146868
REFERENCE   6  (bases 1 to 4045)
  AUTHORS   Kitahara,S., Suzuki,Y., Morishima,M., Yoshii,A., Kikuta,S.,
            Shimizu,K., Morikawa,S., Sato,Y. and Ezaki,T.
  TITLE     Vasohibin-2 modulates tumor onset in the gastrointestinal tract by
            normalizing tumor angiogenesis
  JOURNAL   Mol Cancer 13, 99 (2014)
   PUBMED   24885408
  REMARK    GeneRIF: VASH2 may modulate the onset of tumors in the
            gastrointestinal tract by regulating tumor angiogenesis.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4045)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   8  (bases 1 to 4045)
  AUTHORS   Takahashi,Y., Koyanagi,T., Suzuki,Y., Saga,Y., Kanomata,N.,
            Moriya,T., Suzuki,M. and Sato,Y.
  TITLE     Vasohibin-2 expressed in human serous ovarian adenocarcinoma
            accelerates tumor growth by promoting angiogenesis
  JOURNAL   Mol Cancer Res 10 (9), 1135-1146 (2012)
   PUBMED   22826464
REFERENCE   9  (bases 1 to 4045)
  AUTHORS   Kimura,H., Miyashita,H., Suzuki,Y., Kobayashi,M., Watanabe,K.,
            Sonoda,H., Ohta,H., Fujiwara,T., Shimosegawa,T. and Sato,Y.
  TITLE     Distinctive localization and opposed roles of vasohibin-1 and
            vasohibin-2 in the regulation of angiogenesis
  JOURNAL   Blood 113 (19), 4810-4818 (2009)
   PUBMED   19204325
  REMARK    GeneRIF: Loss of vasohibin-2 is associated with deficient
            angiogenesis in the termination sprouting front of endothelial
            cells.
REFERENCE   10 (bases 1 to 4045)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB840589.1, AK140989.1 and AW488800.1.
            
            On Mar 14, 2009 this sequence version replaced NM_144879.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is protein-coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140989.1, SRR7652917.716462.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BB840589.1         7-13
            8-3543              AK140989.1         2-3537
            3544-4045           AW488800.1         1-502               c
FEATURES             Location/Qualifiers
     source          1..4045
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 96.28 cM"
     gene            1..4045
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
                     /note="vasohibin 2"
                     /db_xref="GeneID:226841"
                     /db_xref="MGI:MGI:2444826"
     exon            1..293
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            294..700
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1492
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
                     /EC_number="3.4.17.17"
                     /note="vasohibin-like protein"
                     /codon_start=1
                     /product="tubulinyl-Tyr carboxypeptidase 2"
                     /protein_id="NP_659128.2"
                     /db_xref="CCDS:CCDS48482.1"
                     /db_xref="GeneID:226841"
                     /db_xref="MGI:MGI:2444826"
                     /translation="MTGSAADTHRCPHPKITKGTRSRSSHARPVSLATSGGSEEEDKD
                     GGVLFHVNKSGFPIDSHTWERMWLHVAKVHPRGGEMVGAIRNAAFLAKPSIPQVPNYR
                     LSMTIPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLE
                     AVILGIYLTNGQPSIERFPISFKTYFSGNYFHHVVLGIYCNGYYGSLGMSRRAELMDK
                     PLTFRTLSDLVFDFEDSYKKYLHTVKKVKIGLYVPHEPHSFQPIEWKQLVLNVSKMLR
                     ADIRKELEKYARDMRMKILKPASAHSPTQVRSRGKSLSPRRRQASPPRRLGRRDKSPA
                     LTEKKVADLGTLNEVGYQIRI"
     exon            701..789
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            790..846
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            847..921
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1303
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1419
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..4030
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3899..3904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3922
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
                     /note="major polyA site"
     polyA_site      4030
                     /gene="Vash2"
                     /gene_synonym="B130052G07Rik"
ORIGIN      
        1 ggggggcttc cgggaagacg ccaggcctcc ctaacaagca gaggctgctg cggctccctc
       61 gcgccaaccc cgggcgctca cgtgcccgct cgctgtggga ccgtggcagt ccaccacatc
      121 tggggaccca gggatgcgtg aagctggagg ggaccctcga gtcttcttgc tacacagctg
      181 tcttgctttt tcctaccccg tcccctcctc accccgcgct ccttgcatgc ctccccatcc
      241 ccgagtgcag ctgggtgtga ggcttcgtgg cgtctttcca gccgccttgc taggcccggt
      301 cggtgagcgg ggttcccttc gtgtgtccta cggccgcgag agttaaaggc caccccaacc
      361 tcccgcgggg ccctgatccc cggcgtgccg gcgtcctccg cccccttgcc gtgtgcccct
      421 catcatgacc ggctctgccg ccgacactca ccgctgcccc caccccaaaa tcaccaaagg
      481 cacccgatcc cggagcagcc acgcgcggcc cgtgagcctc gccaccagcg ggggctccga
      541 ggaggaggac aaagacggcg gggtgctgtt ccacgtgaac aagagcgggt tcccgatcga
      601 tagccacacc tgggagcgga tgtggctgca cgttgccaag gtccacccca gagggggaga
      661 gatggtaggc gccatcagaa acgctgcctt cctggctaag ccttcaattc cccaggtccc
      721 aaactacagg ttgtccatga cgatcccaga ctggctccag gccatccaga attacatgaa
      781 gactctacaa tacaaccaca cagggaccca gttctttgaa atcaggaaaa tgcgacctct
      841 gagcgggtta atggagacag cgaaggagat gacccgagaa tccttgccta tcaaatgcct
      901 ggaggcagtc atcctgggca tctatctcac caatgggcag ccttccattg agcggttccc
      961 tatcagcttt aaaacctact tctcaggaaa ctactttcac catgtcgtgc tggggattta
     1021 ctgcaacggt tactacggtt cactgggcat gagccgaagg gctgagctga tggacaagcc
     1081 gctgaccttt cggactctga gtgaccttgt ctttgacttc gaagattcct ataagaaata
     1141 cctgcacacg gttaagaagg tcaagatcgg gctgtacgtc ccccacgagc cgcacagctt
     1201 ccagcccatc gagtggaagc aacttgtcct caacgtctcc aagatgctga gggctgacat
     1261 caggaaggag ctggagaagt acgccaggga catgcggatg aagatcttga aacctgcaag
     1321 tgcccactct ccaacccaag tgagaagccg gggcaagtcc ctgtctccac gaaggagaca
     1381 agcaagccct ccaaggaggc tcggcaggcg agacaaatcg cctgctctga ccgagaagaa
     1441 ggtggctgac ctcggcactc tgaacgaagt gggctatcag atccggatct agccgagcca
     1501 ggccggccag gcttctatgg tgctcttctc tgcactttac ccagcagctt caggaggaac
     1561 tgcaacttgt ggagttttga ttttgaagga tttacctgga gatggaatct gagtgggttt
     1621 tgaaaactca ccgggcagca ggcatgactg ggctgaagtg atgggcaaag ccctgggttg
     1681 actgactccc tcactcagga tcctaagaac aatgctgact gcagttttct acttttctcc
     1741 atttgccgac tcttctgctt gctttggaca ttatgcctca gctctagaaa ccgtttatgg
     1801 agttcctccc actttttggt acagcaggca actcagccag tattactgtc tcctcagcaa
     1861 taacaagcaa agatgggtgg gtttttttta agcagttgat attacctcaa cattttggca
     1921 tcagatatgc aatcttaatg agttttttat attctatttg tattgtttcc tatagggatc
     1981 tcgatggttt ggtgggggtt tttttgtttt tttttctggt tcacatgtga gatgagattt
     2041 aagttgttat atgcaaatgc tttagaagca ctcaaattct ggcaataagg gaatataatc
     2101 cgctttggga tgttggcgtc acttttctta aagcatctgc cgacaggttt ccttctaaca
     2161 agcacgctga ggagctcggg tccatgcagt tgctgacatt taagcctttt ctgaggcaag
     2221 caaaaggcac aagagatcat ctgctcccaa aaaaacgcag cagtgctgag acgtcccaga
     2281 cagcctcggt tcctagtggc tccttgttgt taatgtgttc tgctgtctca catgaaggca
     2341 aacatgatgg tggactgttt cccaggggct tgtctttagg tactacgtca cggcatcagg
     2401 aggtgctggg ggaaaccagg acctcgtgga tcgagcctgt cgtgaaggga aagcgttcca
     2461 gcacagtgtc gtgccgccgt gtcagtgtca cccgtgccgc cgtgtcaccc aggccctgaa
     2521 gcacagcccg cctgcctgtg gcgactgcag cgcagcttct gcttgcagac catggagaag
     2581 gaaacacagt ttcaagtcat tgatcttagt gcagtcacca tgccaactca ggacagagga
     2641 ccggcttcag ctggattgct agccccgaga gctcagcatg ccaccctctg gctgtgactg
     2701 cggcagagct ccaagtcaac cgtctgctta tggagtcttt gccaggaaac ctagggccat
     2761 atggagggca aaacctcact ccacccttaa accagtatta ttaatgaaaa gtcgttttct
     2821 tggaaaagct tagtgtcctt tagcggtcag gacccggaaa ctaaaaccga gtgtaaactt
     2881 caaattctga actcaatggc tttcttcaag aatcctatga ctggagttca aagtgagtta
     2941 tggggcctcc acatgtcctc acgagctgct acctgttgtc agcctcaggg cagtgtgcat
     3001 ttaaatgttc caaggagcaa tctgttaaac taaagccacc gggcaaagtg cctgcaactg
     3061 cctgtgttca aggacagctc ccaggaacag agcgccaaac agcgggacaa ccttgttgtg
     3121 tggcaaggga aagaagagca gctggctgtg acactgccct tgtaatctct cccacaacta
     3181 ctttctgatt tttaggttca tttttcaagg cagagttagt cacagaaaca tctaaaaatg
     3241 tttgtctttg tcactcaatt ttactgcctg tagttaaact aactcccaaa aaaccagaag
     3301 gaagccccga aacacctaca ttctaatgca atagtttatt gggataaaaa ggcggcaaaa
     3361 atgaatgcag cacgtctgac ctctcagact gacctttcag cctggctgtg atgaagatga
     3421 aaactgactt gacaggaaca attatcctat gcaccatgac aagatgccct gagctgacaa
     3481 gtttcaagct gactgctatt ggttgtgaga ggtggcctgg gtgttttctg cacacgtggg
     3541 agccgtgagc acaccccttt ccttgagtca gctgtttcat ggatgtcctc agcagacatg
     3601 ggtaagcaaa gggaagcctt tgcagccctc cagctcacta tacaaggctt tcctaggcta
     3661 gacttttatg tacaaccttg tacagttttt ttgacataca cttcagattc ttgtttattc
     3721 tcttagactt tgatctggcc aatacatttt taaaaaatct ttctgaagaa ccataattgt
     3781 tttggtgggt atttttctaa gtatgtgaag acttgatggt attctacaga acaccacaag
     3841 tgcatgcttc aggctcgacg actctctctc atcatgtgtc cacacagcat ggaactgtaa
     3901 taaaaccgtt ctggaaactg aaggacttca cgatgtttgt tttgtttctg tttgtcccac
     3961 tcaacatatt gaccactatg tttcctcttc cagactttgt taaatattac tctattttcg
     4021 tgtacatcaa aaaaaaaaaa aaaaa
//
