LOCUS       NM_177354               6189 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus vasohibin 1 (Vash1), mRNA.
ACCESSION   NM_177354
VERSION     NM_177354.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6189)
  AUTHORS   Mifune,T., Tanabe,K., Nakashima,Y., Tanimura,S., Sugiyama,H.,
            Sato,Y. and Wada,J.
  TITLE     Vasohibin-1 has alpha-tubulin detyrosinating activity in glomerular
            podocytes
  JOURNAL   Biochem Biophys Res Commun 599, 93-99 (2022)
   PUBMED   35180473
  REMARK    GeneRIF: Vasohibin-1 has alpha-tubulin detyrosinating activity in
            glomerular podocytes.
REFERENCE   2  (bases 1 to 6189)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6189)
  AUTHORS   Song,K.M., Kim,W.J., Choi,M.J., Kwon,K.D., Limanjaya,A., Ghatak,K.,
            Ock,J., Yin,G.N., Sato,Y., Hong,S.S., Ryu,J.K. and Suh,J.K.
  TITLE     Vasohibin-1 rescues erectile function through up-regulation of
            angiogenic factors in the diabetic mice
  JOURNAL   Sci Rep 11 (1), 1114 (2021)
   PUBMED   33441910
  REMARK    GeneRIF: Vasohibin-1 rescues erectile function through
            up-regulation of angiogenic factors in the diabetic mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6189)
  AUTHORS   Hantelys,F., Godet,A.C., David,F., Tatin,F., Renaud-Gabardos,E.,
            Pujol,F., Diallo,L.H., Ader,I., Ligat,L., Henras,A.K., Sato,Y.,
            Parini,A., Lacazette,E., Garmy-Susini,B. and Prats,A.C.
  TITLE     Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that
            regulates translation in early hypoxia
  JOURNAL   Elife 8, e50094 (2019)
   PUBMED   31815666
  REMARK    GeneRIF: Vasohibin1, a new mouse cardiomyocyte IRES trans-acting
            factor that regulates translation in early hypoxia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6189)
  AUTHORS   Tanimura,S., Tanabe,K., Miyake,H., Masuda,K., Tsushida,K.,
            Morioka,T., Sugiyama,H., Sato,Y. and Wada,J.
  TITLE     Renal tubular injury exacerbated by vasohibin-1 deficiency in a
            murine cisplatin-induced acute kidney injury model
  JOURNAL   Am J Physiol Renal Physiol 317 (2), F264-F274 (2019)
   PUBMED   31091125
  REMARK    GeneRIF: VASH1 expression could have protective effects on
            cisplatin-induced AKI probably by maintaining the number and
            function of peritubular capillaries.
REFERENCE   6  (bases 1 to 6189)
  AUTHORS   Yamashita,H., Abe,M., Watanabe,K., Shimizu,K., Moriya,T., Sato,A.,
            Satomi,S., Ohta,H., Sonoda,H. and Sato,Y.
  TITLE     Vasohibin prevents arterial neointimal formation through
            angiogenesis inhibition
  JOURNAL   Biochem Biophys Res Commun 345 (3), 919-925 (2006)
   PUBMED   16707096
  REMARK    GeneRIF: vasohibin has an activity to prevent neointimal formation
            by inhibiting adventitial angiogenesis
REFERENCE   7  (bases 1 to 6189)
  AUTHORS   Shibuya,T., Watanabe,K., Yamashita,H., Shimizu,K., Miyashita,H.,
            Abe,M., Moriya,T., Ohta,H., Sonoda,H., Shimosegawa,T., Tabayashi,K.
            and Sato,Y.
  TITLE     Isolation and characterization of vasohibin-2 as a homologue of
            VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin
  JOURNAL   Arterioscler Thromb Vasc Biol 26 (5), 1051-1057 (2006)
   PUBMED   16528006
REFERENCE   8  (bases 1 to 6189)
  AUTHORS   Shen,J., Yang,X., Xiao,W.H., Hackett,S.F., Sato,Y. and
            Campochiaro,P.A.
  TITLE     Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF
            receptor 2 and retinal neovascularization
  JOURNAL   FASEB J 20 (6), 723-725 (2006)
   PUBMED   16473886
  REMARK    GeneRIF: data support the hypothesis that vasohibin acts as a
            negative feedback regulator of neovascularization in the retina and
            suggest that suppression of VEGF receptor 2 may play some role in
            mediating its activity
REFERENCE   9  (bases 1 to 6189)
  AUTHORS   Watanabe,K., Hasegawa,Y., Yamashita,H., Shimizu,K., Ding,Y.,
            Abe,M., Ohta,H., Imagawa,K., Hojo,K., Maki,H., Sonoda,H. and
            Sato,Y.
  TITLE     Vasohibin as an endothelium-derived negative feedback regulator of
            angiogenesis
  JOURNAL   J Clin Invest 114 (7), 898-907 (2004)
   PUBMED   15467828
REFERENCE   10 (bases 1 to 6189)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102689.10.
            
            On Oct 29, 2008 this sequence version replaced NM_177354.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB284948.1, AK090166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1627              AC102689.10        109639-111265
            1628-1716           AC102689.10        116323-116411
            1717-1773           AC102689.10        117905-117961
            1774-1848           AC102689.10        119151-119225
            1849-2230           AC102689.10        119841-120222
            2231-2343           AC102689.10        121797-121909
            2344-6189           AC102689.10        122775-126620
FEATURES             Location/Qualifiers
     source          1..6189
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 40.84 cM"
     gene            1..6189
                     /gene="Vash1"
                     /gene_synonym="D930046M13Rik; G630009D10Rik; TTCP 1"
                     /note="vasohibin 1"
                     /db_xref="GeneID:238328"
                     /db_xref="MGI:MGI:2442543"
     exon            1..1627
                     /gene="Vash1"
                     /gene_synonym="D930046M13Rik; G630009D10Rik; TTCP 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1289..2416
                     /gene="Vash1"
                     /gene_synonym="D930046M13Rik; G630009D10Rik; TTCP 1"
                     /EC_number="3.4.17.17"
                     /note="tyrosine carboxypeptidase 1"
                     /codon_start=1
                     /product="tubulinyl-Tyr carboxypeptidase 1"
                     /protein_id="NP_796328.2"
                     /db_xref="CCDS:CCDS49118.1"
                     /db_xref="GeneID:238328"
                     /db_xref="MGI:MGI:2442543"
                     /translation="MPGGKKVVPSGSSSASPNAAATTTAAAAAAAAAPHSGTKRLETT
                     EGASAQRDEEPEEEGEEDLRDGGVPFFINRGGLPVDEATWERMWKHVAKIHPDGEKVA
                     LRIRGATDLPKIPIPSVPTFQPTTPVPERLEAVQRYIRELQYNHTGTQFFEIKKSRPL
                     TGLMDLAKEMTKEALPIKCLEAVILGIYLTNSMPTLERFPISFKTYFSGNYFRHIVLG
                     VNFGGRYGALGMSRREDLMYKPPAFRTLSELVLDYEAAYGRCWHVLKKVKLGQCVSHD
                     PHSVEQIEWKHSVLDVERLGREDFRKELERHARDMRLKIGKGTGPPSPTKDRKKDVSS
                     PQRAQSSPHRRNSRSERRPSGEKKPAEPKAMPDLSGYQIRV"
     exon            1628..1716
                     /gene="Vash1"
                     /gene_synonym="D930046M13Rik; G630009D10Rik; TTCP 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1773
                     /gene="Vash1"
                     /gene_synonym="D930046M13Rik; G630009D10Rik; TTCP 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1848
                     /gene="Vash1"
                     /gene_synonym="D930046M13Rik; G630009D10Rik; TTCP 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2230
                     /gene="Vash1"
                     /gene_synonym="D930046M13Rik; G630009D10Rik; TTCP 1"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2343
                     /gene="Vash1"
                     /gene_synonym="D930046M13Rik; G630009D10Rik; TTCP 1"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..6189
                     /gene="Vash1"
                     /gene_synonym="D930046M13Rik; G630009D10Rik; TTCP 1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcgcggc gcggaccggt gtcgagccgg gtgggcggcg ggagggctgg ggacccggca
       61 ggcggcagcg gtggcttctg cttcgccgag ccgggacgca gcgatcggcc gatgggctgc
      121 accttctcag gctgttgctc tccccaggga tccacgcacc gacgcccgcc ctcgctttgt
      181 cagtggattc cagccgccgc cacgggcgga gcctgaggac ctgcgctcgc gccccgcacg
      241 cccagcttcg ctcagcttgg ccgcgggaac cctagcgcag catccttttg cccgctcatg
      301 ctgcagctgc tggccagcgg cgaagctgcg gctggagcct gccgctcagt gacctcagcc
      361 cggtccccga gcgtcgcccg agccgctctc cacgatggct gagcttgggg ctccgcgccc
      421 ctctttagct cagctgggac cgtttagcgc caggtgcacc cggtgccccc gctgagccgc
      481 gccagtccag ggttcccagg gcctgggctc ccctagccct cgccttcccg ccgcgccctt
      541 cccctcccgc cctctccgct gctgctcccc ggggctaggg gctaggagac ccagacaaag
      601 ccccactttg tgagggaggc aggcttggaa tgtgcggagc ggcgcgcgcc ccctccccgc
      661 cccaccagct gcgagtcttg gttcccagga gggtcgtgac cgagaagtca ccccggacat
      721 cgccctctac ccttgcatcc ccggcccccg aggtccagac tcggagctca cgcgggtccc
      781 ctctgctcgc tccagtgtga gtgagcaagg atttcgtaga ggaatttgtt ctgtccaaaa
      841 ctgagagtgg gcaccggtga cttggcctgc ctttttggtg tagctgcagg tctgagctgt
      901 ctggcctcag tctccccacc ccgacccccc acttttctcc tctcagccat cgtagatcgc
      961 tgtgggtcat tgttctcgct gccaaatgga ggtgatttat acaggctgcc aagttggggt
     1021 gtgttctctt tatcctgttt tccaaacaaa acaaggcctc taaggtcgac cctgggcaac
     1081 ccacctggcc atcactcctg gttgatgctc tgagttacca aatggtattt tattgtacag
     1141 gagccacgcc ctggtttctt aaaggcgcca ggcactgttt gaccatgtgt tatctttata
     1201 gcgggtgtgt gggaggcctt ctgtgaggca cttattcccc ccccccccac ctcctgatca
     1261 tcgtcccacc cccgttgagg atttagggat gccaggggga aagaaggtgg tcccaagtgg
     1321 cagcagcagt gcctccccga acgcagccgc caccaccact gctgctgctg ctgctgccgc
     1381 tgctgccccc cactctggca ctaaacgttt ggagaccacc gaaggggcct cagcacagag
     1441 agatgaggaa cccgaagagg aaggggaaga ggacctacga gatggaggtg tccctttttt
     1501 catcaaccga ggtggactgc cagtggatga ggccacctgg gaaaggatgt ggaagcatgt
     1561 ggccaagatc cacccagatg gagagaaggt ggccctgcgc atccgtgggg ccaccgacct
     1621 gcccaagatt cccataccaa gtgtgcctac tttccagccg acgacgcccg tccctgagcg
     1681 cctggaagcc gtgcagcgct acatcaggga gctgcagtac aatcacacag ggacacaatt
     1741 ctttgaaatt aagaagagca gacctctgac ggggctgatg gacctggcca aggaaatgac
     1801 caaagaggct ctgccaatca aatgcctgga agctgtgatc ctgggaattt acctcaccaa
     1861 cagtatgccc accctggaac gctttcccat cagcttcaag acctatttct cagggaacta
     1921 cttccgccac attgtgctgg gggtgaactt cgggggccgc tatggcgccc tgggtatgag
     1981 ccgaagggag gacctgatgt acaaaccgcc cgccttccgc acgctcagtg agctcgtgct
     2041 ggactacgaa gcggcctacg gccgctgctg gcacgtgctg aagaaggtga agctgggtca
     2101 gtgtgtgtcc cacgacccgc acagtgtgga acagattgaa tggaagcact cggtgctgga
     2161 tgtggagagg ctggggcggg aagacttccg caaggagctg gagcgtcatg cccgagacat
     2221 gcggctcaag attggcaagg ggacaggccc tccttctccc accaaggacc ggaagaagga
     2281 tgtttcctcc ccacagaggg cccagtccag cccccatcgc aggaacagcc gcagtgagag
     2341 acggccttca ggggagaaga agcccgcaga gcccaaagcc atgccagacc tcagtgggta
     2401 ccagatccgg gtgtgaggca gatgccagca tccccagatc tcctctgcgt ctggaggccc
     2461 aggaaagaaa ctacttcatc caggcagggg ctagtgatgg ggtggacttg gggtgggagg
     2521 ccagaaggag gccttgccat tcagccccaa gtgacttgcc ctcccatgaa gccaagcccc
     2581 taactttggg ccaagaagca gttagtgttt tatttggagt tttagctcta caactgaagt
     2641 ataaggtatt tgaacagaaa gacaaatgga tatgttggta gctgtcaggg tctgttctct
     2701 ctctctgagc actgcgtggc ttggggagga gggctgcctc gttctgtggt gctccttctc
     2761 tcaacagtga tcaggtttat gagcctcccc agcctgtggg gtgagggtgg ggcagtgtag
     2821 gaatggaggt gttttctcca actgggcctg tcctggcaga atcatgaccc agggaaagga
     2881 aagcagggtg ggaggttctc ctgagaaagg tctatttgtt tttcaaatca ggaacttggc
     2941 agaagccaca tctgcctaag gtccaggaga gccctttaga tagtactgtg cacccccccc
     3001 acctccccct acatcttcac catggccagt ttaggactag gctataggag gaccaggaga
     3061 ggactatagt gggaagagtt ctggctctta gcacatctgc tggctccgtc tagttctgac
     3121 tattgctgca gcccaggggc tccctgaaga agggctgggc tttgtagaga gcccagcctt
     3181 gtactgggga caccatgacc ttatgaaact tggctgggca cggggtagtt gagaagaact
     3241 acctactcta gctgtgtggg agtgggctct tctctcccca tctaataatc tcagcacttg
     3301 gtggggaaac aagaccagag caggctgcct aacctccagg gtgccttccc aggcctagct
     3361 gcctgtttag gcttggagta gtggccagtt ttagcagctc tttgggacac tggcaggagg
     3421 gggtgggagt tgtctgcccc ctggccctgg agcacaagat cccaggtaga aaagtgaggt
     3481 gtggagaggg gctgtctggg ctggggagga gaaccagccc ttgagttggg aatgtaagtg
     3541 agaagggctg agagaggcag ttcaggatgg ggatgcggtg gggactgtgt ggggaccgag
     3601 ttccctgcag cacaggtggc actcttcaag ttgctggaga cttcaagtga cagagggcag
     3661 ctggatgagg tggtgaccgt taagggactt tactgagagg tggagtcagc ttgggcagct
     3721 gccaataaga ctgcagaggg ctgagggctg gctgggataa gagctagaga cctagggact
     3781 caaatgccta cagggccagc aagaggcaaa gaagagggct ggatggggac tgtgtcccac
     3841 caaagagaac atatcccatt aaagtaggat gctgccattg tactgtccca cagtgcaagc
     3901 cctaaggggt gtaagccctt tttttttttt tttttttttt ttttaggcca aggctctgaa
     3961 ctaatatatg aattgtaatt ttttaaaagt taccagttca agaagtgatc accatagctg
     4021 agggagtatc agtccacaat gtctggggta gagagcatgg gctggttgtg gggagactgt
     4081 gggtggaaaa tgtgacagtt taaagtttcc caaaggcagc aggagccact tcctgtatct
     4141 ctctccttag ccccatcctg caggcagagg ctgagtttgt gcttgctggg tagagtagga
     4201 tagaagggtg gaattcttcc tgcctggaaa tggatggtgg ctggaatgag gaggaggagg
     4261 aggaggagga ggaggaggag gaggaggagg aggaggagga ggaggaggag gaggaggaag
     4321 aagaggagga ggaggaggag gaggaagagg gatgcccctg ctggtgacac accaacagct
     4381 cctgggccca gcacaggcac catggggggg ggctgagtgt ttagtccctt gtcttgcctg
     4441 gttcctcctg gggtcagggg ggcccttgga aagtgcatag cctaggctac accctctagc
     4501 cagacccatg aaaagacatg acactatttg atccatctca gagttcaggg agtagggatg
     4561 gcagtagctc ccatgccttc tttgagaggt ataagactgg acaagatctt ttttggatct
     4621 cagtgtggct gcttatccct gggacagcag ccctatgtgt ctctggaaac ttcaagatat
     4681 gacaaaatat gggagaagga ggtgtgggga gagctagagt caggtgtatt tggagaacag
     4741 caccaggtcc cagagcctta ggacaggagc gctgagctcc agttcctctg aggcccagga
     4801 aagaaggaag cagggggagc cccgacttgt tcaggatttg agggagcagc tgatggctag
     4861 gggtacacac acccctgctg ttcacctctc ccaggctaag ggcgtccggc ctgtggagac
     4921 tgtcataggc tgtcatgggc cacagtggtg ctttttttat tattatttta ttttttactc
     4981 tttctcatat gtagcaagcc acgcttccct ctgtggccat ttacacaggc tgtgctcttg
     5041 ggggctggcc tggctgtctg gtttctgggg aggcagaggc aaggactttg aggccttagt
     5101 caccatccat gacatcacct catctcactt cctataagag ccagggatct ggcagatgtc
     5161 tgcagacctc ctgactcagg cctgcccttt cagctcttct accccaccct tggggactgc
     5221 tggctgaaga gggtcaaggt gaggtcagag gaggctggtt ggtggaggtg gcatgggcag
     5281 agaggttcct tgtgtttggt gttgggtcaa aacactggga agctagctcc agagaacctt
     5341 ccttctccat ccagctacct gccagtcctt tccccctcca taacctcata tttccttgtt
     5401 cccccgaact gtcatgctag ccacccatcc ttagtgggca tggccaagcg ggtagaacag
     5461 cagcccgctg gccccagact tgatgatgaa gcctagagac tgggtactga ggaacagatt
     5521 caggagactg accatggctg atgtctggtc cagtcagatc atgccctgac ccctttccag
     5581 ctgggaagac atcctggctc aggggaggag taggtctaat gatagctgtg caggctttgt
     5641 gctctgaggt ctgtgcccgt gtaccacccc agctttccta cctgggatga gtttgggctt
     5701 aacacatcag cgcccaccct gacatgctgt cagtggtgtt aaagtgcaag gatgcacagg
     5761 tggggaccaa taagccagag gtgtgaaggg caagggtatt ctctgaagga gtggaggtgg
     5821 gagctaggga ttctccctac gggtaccaca gcctctccca gcagcatctc cagccaggtg
     5881 gggctgtcac tgtactagct gtgagtcctg tgctaggacc ccctcactcc agttcgatgc
     5941 actggggtcc caagcttcct tgttaagtct ggaaagaaat ctgggtacac ttgacccctg
     6001 ggccagtgat gacggaccgc ccatcccctg tgctttgtta ggctcttgtg ttgtccctga
     6061 tgccattatt gtgcccttgt atcagtatta cccctgcctt tcagtgcaca ctttgtctca
     6121 ttcctttctc accttcccct gaaatgaata aagtctccca gctcccatcg tatgggctgg
     6181 cagaaatca
//
