LOCUS       NM_019806               6958 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus vesicle-associated membrane protein, associated
            protein B and C (Vapb), mRNA.
ACCESSION   NM_019806
VERSION     NM_019806.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6958)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   2  (bases 1 to 6958)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6958)
  AUTHORS   Leca,I., Phillips,A.W., Hofer,I., Landler,L., Ushakova,L.,
            Cushion,T.D., Durnberger,G., Stejskal,K., Mechtler,K. and
            Keays,D.A.
  TITLE     A proteomic survey of microtubule-associated proteins in a R402H
            TUBA1A mutant mouse
  JOURNAL   PLoS Genet 16 (11), e1009104 (2020)
   PUBMED   33137126
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6958)
  AUTHORS   Nthiga,T.M., Kumar Shrestha,B., Sjottem,E., Bruun,J.A., Bowitz
            Larsen,K., Bhujabal,Z., Lamark,T. and Johansen,T.
  TITLE     CALCOCO1 acts with VAMP-associated proteins to mediate ER-phagy
  JOURNAL   EMBO J 39 (15), e103649 (2020)
   PUBMED   32525583
  REMARK    GeneRIF: CALCOCO1 acts with VAMP-associated proteins to mediate
            ER-phagy.
REFERENCE   5  (bases 1 to 6958)
  AUTHORS   Yamanaka,T., Nishiyama,R., Shimogori,T. and Nukina,N.
  TITLE     Proteomics-Based Approach Identifies Altered ER Domain Properties
            by ALS-Linked VAPB Mutation
  JOURNAL   Sci Rep 10 (1), 7610 (2020)
   PUBMED   32376919
  REMARK    GeneRIF: Proteomics-Based Approach Identifies Altered ER Domain
            Properties by ALS-Linked VAPB Mutation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6958)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   7  (bases 1 to 6958)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 6958)
  AUTHORS   Pazzaglia,S., Pariset,L., Rebessi,S., Saran,A., Coppola,M.,
            Covelli,V., Moody,J., Bouffler,S., Cox,R. and Silver,A.
  TITLE     Somatic cell hybrids for high-density mapping of chromosome 2
            breakpoints in radiation-induced myeloid leukemia cell lines from
            inbred mice
  JOURNAL   Mol Carcinog 27 (3), 219-228 (2000)
   PUBMED   10708484
REFERENCE   9  (bases 1 to 6958)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 6958)
  AUTHORS   Chambers,D.M. and Abbott,C.M.
  TITLE     Isolation and mapping of novel mouse brain cDNA clones containing
            trinucleotide repeats, and demonstration of novel alleles in
            recombinant inbred strains
  JOURNAL   Genome Res 6 (8), 715-723 (1996)
   PUBMED   8858346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845503.5 and AL844849.13.
            
            On Oct 25, 2022 this sequence version replaced NM_019806.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048231.1, AK081908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AL845503.5         142879-143044
            167-319             AL844849.13        20920-21072
            320-423             AL844849.13        30324-30427
            424-504             AL844849.13        33197-33277
            505-681             AL844849.13        34915-35091
            682-6958            AL844849.13        36866-43142
FEATURES             Location/Qualifiers
     source          1..6958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 97.37 cM"
     gene            1..6958
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
                     /note="vesicle-associated membrane protein, associated
                     protein B and C"
                     /db_xref="GeneID:56491"
                     /db_xref="MGI:MGI:1928744"
     exon            1..166
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
                     /inference="alignment:Splign:2.1.0"
     exon            167..319
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
                     /inference="alignment:Splign:2.1.0"
     exon            320..423
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
                     /inference="alignment:Splign:2.1.0"
     exon            424..504
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
                     /inference="alignment:Splign:2.1.0"
     exon            505..681
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
                     /inference="alignment:Splign:2.1.0"
     exon            682..6958
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1952..1957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
                     /note="hexamer: ATTAAA"
     regulatory      1957..1962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
                     /note="hexamer: AATAAA"
     polyA_site      1970
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
                     /note="major polyA site"
     polyA_site      1979
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
                     /note="major polyA site"
     regulatory      6929..6934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
                     /note="hexamer: AATAAA"
     polyA_site      6958
                     /gene="Vapb"
                     /gene_synonym="D2Abb2e; VAMP-B; Vamp33b; VAP-B; VAP33b"
ORIGIN      
        1 gtgcgtgccg tgagctcgcc cggcaccgcg gcctcgccct ccgcccctgc gccccgccac
       61 ccaggccgcc gccccccgcc cgcgccgtcg cccccgacgg ggaggaccat ggcgaaggtg
      121 gaacaggtcc tgagcctcga gccacaacac gagctcaagt tccgaggtcc cttcactgat
      181 gttgtcacca ccaacctaaa gcttggcaac ccaacagacc gaaatgtgtg ttttaaagtg
      241 aagaccacag cacctcgcag gtactgcgtg cggcccaaca gtggggtcat tgatgccggg
      301 gcctctctca atgtgtctgt gatgttacag cctttcgatt atgatcccaa tgagaaaagt
      361 aaacacaagt ttatggttca gtctatgttt gctccgcctg acacttctga tatggaggca
      421 gtatggaagg aggcaaaacc ggaagacctt atggattcaa aacttagatg tgtgtttgaa
      481 ttgccagcag aaaatgctaa accacatgat gtagaaataa ataaaatcat acctacgagt
      541 gcatccaaga cagaagcacc ggcagccgca aagtccctga catcgcccct cgatgacaca
      601 gaagtaaaga aggtgatgga agagtgcagg cggctgcagg gggaggtgca gaggcttcgg
      661 gaggagagca ggcagctcaa ggaagaagac ggacttcggg tgaggaaggc gatgccgagc
      721 aacagccccg tggcggctct ggcggccact gggaaggagg agggcctgag cgcccggctg
      781 ctggccctgg tggttctgtt ctttatcgtt ggtgtcatta tagggaagat tgccttgtag
      841 gggccgcatg cgaaggatgg caggttggat tgatggatct accacaccat gggattcaaa
      901 tttatcataa ccatgcgtaa aaagaaatta atgtatgacg gcatctcaca ggtcttgcct
      961 ttaaataccc ctccccatgc acacacaaat gcacacacaa atatagcata atataatgat
     1021 cttttagaaa gttaaaaatg tatagggaat ggatggggaa agaatggtct gttgccgtag
     1081 gacgggccgt gattaaccac agtggcatct tgtagctgtc acgctcaatt cgggtaggcc
     1141 tgggcacgtg ttgctagatc actctcttaa agcaagaagc tcctcctcgc atgttggggc
     1201 tggcccgtgg gagcgggagt cctgcaaggt ggggcgagct gtctttttct tacccacgtg
     1261 gcttccccag gcctgctgtt ctgtccaggc atcgtctcct caggcctaca gagctgcagg
     1321 tgccaaagtg cattgcacag aggccacatc tcgtgtacct gtgggtcgtg tgggagagac
     1381 atgagtggac cagcgggtcc aacacaggga aatccaagtc tgtgctctgt tctcttgaag
     1441 ggaccaagct aaattaccgc tggttcaagt agtgaaccga gttgttctcg gagatggctg
     1501 atgcacatgt aacctatttc atctcgtgtg ttcctgctgc caccagagca caggcagtga
     1561 gtgctgcaga ccgccagtga ggagctgctg ctgtgggctc tggaggtctg agggaagggg
     1621 agggtctgag tcaggaagtg ttttgttgta ggtcagtaat agctgccctg aggaggaacg
     1681 ctctttttaa tgacagtcag ctctggatta cccagtcttc tagattgccc taccatccat
     1741 ccttctaaaa cataggccag ccttgacctg cccttctcag gatgagtgag tcaggctgca
     1801 gagggtgaag ggcatagagg gggtggggtg gggtggggga gccctcagca aatccatctg
     1861 ctggtgatga agagtcctga ctgtgaatta atttcatgcc ataaaagacc gatccagttc
     1921 tgctcaacta tgtagcatct taaaggaaga gattaaaata aagccccaaa ttaagagtcc
     1981 ttttgtcatt ttgtcacatt tgctgtgtgg ggttcttatt atcaatcatc gttagtgtgc
     2041 tatggaaggt tgattttaaa atgagctcta tcagtgggaa acacatgtgt aatgatttga
     2101 ctctgcacac atctgtgtac acacgcacac acatatatta ctattacttt tattattata
     2161 ttttggttgg cttcagctta acagcaggag ccatctcagg ctggctgtcc ttccccttct
     2221 gtgaccttgg cccttcagtg acaggcctga gtctgagagg acaagcccat ctaaaggaag
     2281 actggcctag acacccgaga tcacactgct gctgtgcctg agtgggcggg tgggagctgg
     2341 agacgggggg gggggggggg ggcactgggc ggtaagcagc cctgcccgct ctaatgcctc
     2401 ttaccgagtt tccagaccct ttccgtgtgc ctgaaggagg gagggtacga ctgagctgag
     2461 ggtgaggtct gagctgccac ctggcttccc ttgctacact gagaggttca gcagtctcag
     2521 gtgctgccag taatcctttt gcagcttttg agggcagagt aactcagtgc ctctgacagg
     2581 acctggggtg tcatctagct ctacgacaca ggagccgggg tttgcaagtg ttcttaaggg
     2641 atggatggct ctgtgtgcca gaaaagctct tgagaggcac agccagctgc cgagattaaa
     2701 gcgtgtctgg gagctgccgt ggcttgggcc atggaaggtg attgtgtgaa cgctgtcaga
     2761 atgctctaag agggccagag gttgtagaca cttctgcagt agcagcaaca acaaaaactc
     2821 cagatacaag ggtatccttc ctttgtctgg ccctcggaag tctgacctcg gagagatgcc
     2881 tggcagtgtg gtagttgttg gggcttcttg accaagggga tgatgggagc tctagggagg
     2941 ttagcaaggc agagtgggta aatctccgag tcaccgtcac tcatgagtgc tgtaagagag
     3001 gtgtcagtaa gaagcgtact tgcctgtggg ctctaaagag agctgtgcac atttggggtg
     3061 tcttttctga aaatctcaga gcagataaac ctgagtaaga cacagaagag gtgagtttca
     3121 ctctgtacta caactctgct gtctccaaag aagacagagt caggtgttct gggaggtgtg
     3181 aagctgagag ctaggagagc agccatgagg cagccagggc aggtcctcca tggttacagg
     3241 gcccgctgcc cctccttatt aagtgcctcg gctttggaag cgcagccacc gtgctcacag
     3301 atggacacag tagcagagtc ccaccaactg ctattgattg aatttccaag ttgataattt
     3361 aagcttggaa agagacagag cacctcttag acacagtgag cactattatc tgtccgtgtg
     3421 aggccctggc tttaattttc ttctcctcct actttgcatg ttttccctct ctggtctttt
     3481 aaactgctgg caccagcagt aataaatact gataaaatca aaattgattt ttaccagtgg
     3541 acagtttatg cctagagaga cggcttatac ctacataaca cagaaggggg aatgaggagc
     3601 ctccagtgag ccgtgaaaag ctgactgctt tcaaacaaat cctaggaaca gcattgctgt
     3661 gtgaagatag cagtacccag cctgcaggct gtgttgactc agacagaact gaatgcagcc
     3721 agagctaaat agcccctcag attaatttga aaacaagccc cgagtgtgca tgtgtgtgtt
     3781 tgtgtgtagc atatgtgcca tgtgtaagca gcctgacagt tcccaaatgg tgcctgtagt
     3841 tttttttttt gcacacagat cttggtgttt tcaaactcag agtccacgcc aaaatgcagt
     3901 atcgttttgt cattttcagg cttctcaaaa ttaactggct tgaatgcaaa tttctagtta
     3961 cagtttgcaa aaacctttat tttaagggag agactgggac acgggacagt tggtcctgtg
     4021 atctaggtca ttctgtattc ctgagtgacg ttctccttcc caggccttct ccagtataga
     4081 ggcccatgct cccctcgctg ctgtggtagc tgtgtcgtct cctgtggacc ctgtgctgtg
     4141 acagagggga agagtaaact ttgtaagtaa ccggaaggca ggcactagac tcgtcctagt
     4201 tacatttggc cttgtctgct gttactgaga atgaatgctt ctcagagccc agcagaaatg
     4261 caattgtgtt taacactccc ctgcagagca tagatggaca gatgcagcat aggtgaggct
     4321 gggcgatcat tctctgggat catggcccga tggctccctc agggttccct ggcctgattg
     4381 gacttggagg aggtctttcc tctccccaga cagagctaca actgtgggaa cctttgtcaa
     4441 cactaccctg gctgcagagc acctcacaaa accgcaagtt aggctctgcc ctgtaaaaaa
     4501 gacccagtgc gtggaggtgg gcagcatttt agtttggaac taaatgagcc ccagtttgtg
     4561 tgtgcatgct aaagcactgc ttgttggaga tctgcacatc aatgaaggga acaaggcgga
     4621 gggaggtatc tgctccaggc acctcagctc accagccgcc gcgtctgcca ccctgatgca
     4681 gctgctgttt ccaggctgag caggaggaag agccagggct ctagtgtgac ctgaacacat
     4741 cccacaagat aaatgcatat ggttgtttcc atttcgctca ctgcccatgt gcctggggaa
     4801 ttgtggaagc tttagaaaga aaattaccac tgtgtctcag tgaggtgagg ctgctgtgtc
     4861 tggaggctcc tcataacttg taaattaaat gtgaatgaga gaagttcatt aaaattggca
     4921 ttatagaagt ggcctattga gatttgaaag cagctgagct catggtgtct gggctccctc
     4981 taaacctgtg gagaaatgca tgaacaagtg acaggcgaca gtcacaggag catagggcgc
     5041 aggcagcttg ggcgctgtga gtggatcgct gcctggctcc ctgccctctg actgttactg
     5101 catgttcaac acatgaggct ctgccactaa gaatatttgc tgtttggagt gcacaaggga
     5161 ggggactagt gccatttcca cagcagtgcg gacattgttt tcatttattc ccagcacata
     5221 ggtatgtgta aacattttaa aggcacagca cacacaaaca tctgtgtatt atggttcaga
     5281 gagataccgg gaaggtggaa gagaggtgga tacagcgaat ataataatta ctttaatttt
     5341 tctccttaat ggaattaatg aattagaaga tgtgtgcttc tgctctacag aaaaggaagg
     5401 aaagctaaca gtaaaaaaac acagctatta tccacctcgc cacaaatgtt tgcagttatg
     5461 ctaccttgga attttgccac agtgtgggtt ccactgatga aaagatgtga ctgggaagaa
     5521 gagtgactgc gcgtcgctga gcactgcagc ctgtaaatgc tgctgtttct tttgaaccag
     5581 gaagcactgg tcctgtaaca atgccctatt acagttgctg tattgcagcg aggggctgat
     5641 gcgggtttaa tcatctctct aatggatgtg ggtgcaggat agatgctctg tcctgcttcc
     5701 ctgcctgcat cctgatgagc ctctgtagcc atcagggctg ctgtgtactg gagcagcagc
     5761 tgcagttccg tgtctgtccg aaataaaaca gatcacctgt tcctctctgc ctctctcaga
     5821 agacaccaac tatgggagac aaatcagatc ttttaacaca atctcattaa ggctccatgc
     5881 taacaggagt acagagctta catgacgtac ggacgtgata aattatcatg cacgctctac
     5941 acgtcaactc atcagctctc cctgtaacac agaaagaaag gcctccatct tttttatggt
     6001 cgggctgcct gcattcccat ctctttgctt tttaggaagt aaactaaatt cagctgctag
     6061 ccctctagtg cagcatttat ttaaaagaaa aaaaaaatgc cttttcccat tgagtctctt
     6121 acatggcctc aaaggcaaga atttattgtc tgtgatagtg aaacccgtgt gtacaaaact
     6181 gcctcctgtt catgatccat gtggcagatg ttcctaaatc gctgcctcta ttttccatac
     6241 aacgaggtcc tcagaaaata accagcagga ttcatttagt gattgtgtgg ttcactggta
     6301 agcagtctta agtgcaaaat gcatcaggct tcctcctcct ccttctcctc ctcctcctcc
     6361 tcctcctcct cctcctcttc tgttttggtt tttaaataaa atatatgaac tgctggcatt
     6421 tggaacttcc tataataaac acaatataat gttcccgtca ctggcccctc ctcgtggagg
     6481 agagacacag tctcagtaat tccccatccg gttttacatc ttttctcatc tctaaaaatc
     6541 tctgcagcct gtgactgtgc atgtcacttc tgacctcagg atatgtcaac attttaggga
     6601 ctgagcattt taaggggtgt tttagaatgc tgttcttccc tgatctctcc tttatgcttt
     6661 taagctgtat ttcctgttct ggtgtgggac tcgttcacag aatcagagca cggagggact
     6721 ctgtcgtggt gcacgttggt tgtctgatgt gtgataaatc catggtttta tggctaactt
     6781 tacattttcc agaggaaagg aaacggattt ctagtgtcca gaccaaaaga gccattcacc
     6841 cagagttctc acctgttgta tactggtctg atgaaacctg ccctgactcg gcctaaactt
     6901 ccgtatgagc tgtctccata taatgttcaa taaattgtgt gctctgaatg tatgtaaa
//
