LOCUS       NM_033509               5714 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus VANGL planar cell polarity 2 (Vangl2), mRNA.
ACCESSION   NM_033509
VERSION     NM_033509.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5714)
  AUTHORS   Housset,M., Filion,D., Cortes,N., Vali,H., Mandato,C.A.,
            Casanova,C. and Cayouette,M.
  TITLE     Identification of a non-canonical planar cell polarity pathway
            triggered by light in the developing mouse retina
  JOURNAL   Dev Cell 60 (3), 447-458 (2025)
   PUBMED   39561777
REFERENCE   2  (bases 1 to 5714)
  AUTHORS   Ahmad,S., Christova,T., Pye,M., Narimatsu,M., Song,S., Wrana,J.L.
            and Attisano,L.
  TITLE     Small Extracellular Vesicles Promote Axon Outgrowth by Engaging the
            Wnt-Planar Cell Polarity Pathway
  JOURNAL   Cells 14 (1), 56 (2025)
   PUBMED   39791757
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5714)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5714)
  AUTHORS   Lu,J., Zhang,J., Jiang,H., Hu,Z., Zhang,Y., He,L., Yang,J., Xie,Y.,
            Wu,D., Li,H., Zeng,K., Tan,P., Xiao,Q., Song,Z., Pan,C., Bai,X. and
            Yu,X.
  TITLE     Vangl2 suppresses NF-kappaB signaling and ameliorates sepsis by
            targeting p65 for NDP52-mediated autophagic degradation
  JOURNAL   Elife 12, 87935 (2024)
   PUBMED   39269442
  REMARK    GeneRIF: Vangl2 suppresses NF-kappaB signaling and ameliorates
            sepsis by targeting p65 for NDP52-mediated autophagic degradation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5714)
  AUTHORS   Paramore,S.V., Goodwin,K., Fowler,E.W., Devenport,D. and
            Nelson,C.M.
  TITLE     Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and
            widening independently of the planar cell polarity complex
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39225402
  REMARK    GeneRIF: Mesenchymal Vangl1 and Vangl2 facilitate airway elongation
            and widening independently of the planar cell polarity complex.
REFERENCE   6  (bases 1 to 5714)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     Abnormal elevation of the neural folds in the loop-tail mutant
            mouse
  JOURNAL   Acta Anat (Basel) 143 (2), 89-95 (1992)
   PUBMED   1598821
REFERENCE   7  (bases 1 to 5714)
  AUTHORS   Wilcox,F.H., Hirschhorn,L., Taylor,B.A., Womack,J.E. and
            Roderick,T.H.
  TITLE     Genetic variation in alkaline phosphatase of the house mouse (Mus
            musculus) with emphasis on a manganese-requiring isozyme
  JOURNAL   Biochem Genet 17 (11-12), 1093-1107 (1979)
   PUBMED   540002
REFERENCE   8  (bases 1 to 5714)
  AUTHORS   Wilcox,F.H., Womack,J.E. and Roderick,T.H.
  TITLE     Linkage of the locus for conversion of albumin (Acf-1) in the house
            mouse, Mus musculus
  JOURNAL   Biochem Genet 17 (1-2), 159-162 (1979)
   PUBMED   454356
REFERENCE   9  (bases 1 to 5714)
  AUTHORS   Wilson,D.B. and Center,E.M.
  TITLE     Differences in cerebral morphology in 2 stocks of mutant mice
            heterozygous for the loop-tail (Lp)-gene
  JOURNAL   Experientia 33 (11), 1502-1503 (1977)
   PUBMED   923728
REFERENCE   10 (bases 1 to 5714)
  AUTHORS   Wilson,D.B. and Michael,S.D.
  TITLE     Surface defects in ventricular cells of brains of mouse embryos
            homozygous for the Loop-tail gene: scanning electron microscopic
            study
  JOURNAL   Teratology 11 (1), 87-98 (1975)
   PUBMED   1138408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY320814.1, AF365875.1, AK049613.1, AC158930.3, BC075636.1,
            AK082938.1 and AW046551.1.
            
            On Sep 1, 2015 this sequence version replaced NM_033509.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049613.1, AY035370.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               BY320814.1         1-271
            272-2058            AF365875.1         9-1795
            2059-2716           AK049613.1         2047-2704
            2717-2858           AC158930.3         84634-84775         c
            2859-4083           BC075636.1         3542-4766
            4084-4264           AC158930.3         83228-83408         c
            4265-5697           AK082938.1         1-1433
            5698-5714           AW046551.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..5714
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.54 cM"
     gene            1..5714
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /note="VANGL planar cell polarity 2"
                     /db_xref="GeneID:93840"
                     /db_xref="MGI:MGI:2135272"
     exon            1..298
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..561
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..2056
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /note="loop tail associated protein; loop-tail protein 1;
                     van Gogh-like protein 2; vang-like 2 (van gogh,
                     Drosophila)"
                     /codon_start=1
                     /product="vang-like protein 2"
                     /protein_id="NP_277044.1"
                     /db_xref="CCDS:CCDS15505.1"
                     /db_xref="GeneID:93840"
                     /db_xref="MGI:MGI:2135272"
                     /translation="MDTESQYSGYSYKSGHSRSSRKHRDRRDRHRSKSRDGSRGDKSV
                     TIQAPGEPLLDNESTRGDERDDNWGETTTVVTGTSEHSISHDDLTRIAKDMEDSVPLD
                     CSRHLGVAAGAILALLSFLTPLAFLLLPPLLWREELEPCGTACEGLFISVAFKLLILL
                     LGSWALFFRRPKASLPRVFVLRALLMVLVFLLVISYWLFYGVRILDARERSYQGVVQF
                     AVSLVDALLFVHYLAVVLLELRQLQPQFTLKVVRSTDGASRFYNVGHLSIQRVAVWIL
                     EKYYHDFPVYNPALLNLPKSVLAKKVSGFKVYSLGEENSTNNSTGQSRAVIAAAARRR
                     DNSHNEYYYEEAEHERRVRKRRARLVVAVEEAFTHIKRLQEEEQKNPREVMDPREAAQ
                     AIFASMARAMQKYLRTTKQQPYHTMESILQHLEFCITHDMTPKAFLERYLAAGPTIQY
                     HKERWLAKQWTLVSEEPVTNGLKDGIVFLLKRQDFSLVVSTKKVPFFKLSEEFVDPKS
                     HKFVMRLQSETSV"
     exon            562..682
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            683..1290
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1427
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1563
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1795
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..5698
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2268..2273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /note="hexamer: GATAAA"
     polyA_site      2287
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /note="major polyA site"
     regulatory      5679..5684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /note="hexamer: AATAAA"
     polyA_site      5698
                     /gene="Vangl2"
                     /gene_synonym="C530001F03Rik; loop-tail; Lootl; Lp; Lpp1;
                     Ltap; ska17; ska<m17Jus>; stbm; strabismus; Vang1l2"
                     /note="major polyA site"
ORIGIN      
        1 gccggctcca gatctgattc ctgatccccg attgcttggt tctgggtccc gccatgggag
       61 cctgagtgcc ctgcagtccc ctccggcccc ctgcccccgg ggcctcgagg gggaaacagg
      121 cgagtggtct gggacggagc cggggtgagc gacctcagga gcccccctcg tcaaccccca
      181 tcgcccgcgc tgccggttct ggagcgcgga gttcggaaag accgggtgcg ctgcggatac
      241 aaaggcgcgg agcggagtgg ggcgtgcgcc cagtccaccg ggctgttcgc agtggcgggg
      301 agctgccgct tgaatttctc tgagataagc ccacttgtcc agcaaaatag agtccctcag
      361 ggtgacggtt gacttcctaa aggtgcctct tggcctgaag aagcctgtgc tgaaggaggt
      421 ggctgtggga ccccccaaga ggtcccagcc cgcggccctg gagcgctaca aggcacggcg
      481 ttcggacgcc atggacaccg agtcccagta ctcgggctat tcctacaagt cgggccactc
      541 ccgcagctcc cggaagcaca gggaccgccg ggaccgacac cgctctaaga gccgggatgg
      601 gagtcgtgga gataaatcag tgacgatcca ggctccggga gaacccctgc tggacaatga
      661 gtccacgagg ggggatgagc gggatgacaa ctggggagaa acaacaacgg tggtcacggg
      721 cacttctgag cacagtatct cccatgatga cctcacgcgc atcgccaagg acatggagga
      781 cagtgtcccg ttggattgtt cccgccacct gggcgtggcg gcaggggcca ttctggcgct
      841 gctctcgttc ctcaccccgc tggctttcct gctgctgcct ccactgctgt ggcgggagga
      901 gctggagccg tgtgggacgg cctgtgaggg cctcttcatc tccgtggcct tcaagctgct
      961 catcctgctg ttgggcagct gggctctgtt cttccgccgg cccaaggcct cactgccccg
     1021 agtcttcgtg ttacgagctc tgctcatggt gcttgtcttc ctgctggtta tttcctattg
     1081 gctcttctac ggtgtgcgca tcttggacgc ccgggagcgg agctaccagg gcgtggttca
     1141 gtttgccgtt tctctagtgg atgctttact cttcgtgcac tatctggccg tagttctgct
     1201 ggagctccgt cagctccagc cccagttcac actcaaggtc gtgcgatcca cagatggggc
     1261 cagccgcttc tacaatgtcg gccatctcag catccagcga gtggcagtgt ggatcctgga
     1321 gaagtattac catgacttcc ctgtctacaa ccccgccctc ctcaacctgc ccaagtccgt
     1381 cctggccaag aaagtgtctg gcttcaaggt gtattctctc ggagaggaaa atagcaccaa
     1441 taactccacg ggccaatcaa gggctgtgat cgcggctgcg gcacggaggc gcgacaacag
     1501 ccacaatgag tactactacg aggaagccga gcatgagcgc agagtgcgca agcgcagggc
     1561 caggctcgtg gtggctgtgg aggaggcctt cacgcacatt aagcggctgc aggaagagga
     1621 gcagaagaac cccagggagg tgatggaccc ccgggaagca gcccaagcga tctttgcatc
     1681 catggctcgt gccatgcaga agtaccttcg caccaccaaa cagcagcctt accataccat
     1741 ggagagcatc cttcagcacc tggagttctg cattacccac gacatgacgc ccaaggcctt
     1801 cctggagcga tatttggctg ctggacccac catccagtac cacaaggaac gttggctggc
     1861 caaacagtgg accttggtga gcgaggagcc ggtgaccaat gggcttaagg atggcatcgt
     1921 gttcctcttg aagcgccagg acttcagctt ggtagtgagc accaagaagg tgcccttctt
     1981 caaactctct gaggaatttg tggatcccaa gtcacataag ttcgtcatgc ggctgcagtc
     2041 ggagacctct gtgtgacttt tgcagcagcc gcggaggagg gatgtggggg gttcctgcgg
     2101 agtgggaggg gcttggttct ctggccctga cacatttctg ccagtcctac ttcctcttgc
     2161 tcttgtttgt ttttgttttt tgttttttgt tttttttttt acttgaatta acttatcctg
     2221 tacccagtct cccctcttcc tcagtttttc ccatctggaa atctggagat aaatcttgtt
     2281 aacaatacct gggaaccacc ctgccctcca attttgtatc actccaggcc ctgcaggaaa
     2341 cagtgcctca caactctccc atccccccac cccattcttc ccccgcaaac cttccctgga
     2401 tggaagcatt cagggccttc cggattctac ccttgcctcc tgagctccaa cttagaaatg
     2461 tacattctta gagccgcgct ctctagtggc ccctgataga gtttctcttg ggggcacagc
     2521 tctgacccta gaggaccatg gtgccaaact cctgtgggac aacagctaat cctatcctcg
     2581 gtccctacgc ttagccctga gtccctgggc aaggatgcac ctgtgacata atcccagaat
     2641 taggattctc tctgcagtct tgctcgccag tgttacagct gtgcttcctg gtacacacac
     2701 acacacacac acacacacac ggacacacac ggacacggac acacacacac agcacctcac
     2761 agatacacac actcacacac acacacacac acacacacac ggacacacac acggacacgg
     2821 acacggacac ggacacacac acacacacac ggacacggac acacacacgg acacacagca
     2881 cctcacagat acacacacac acatacacac acacacacac acacacacac agaaacatag
     2941 aagaagggga agtgcagtct tctactcagg agtctttact gctgtttctg acttgtatgg
     3001 tcatgtgatc ataggcaaac agaggtggaa cctctctgac cactttacca gggctgtggg
     3061 gaaggtgtaa tgtgtctttc ttagacaact cccgagagga agggcaggat agacccctga
     3121 ggttggagag acccttgtca ctgacctcac ttgtccctct gaacccactg acctgttctt
     3181 ccccaccctt ccccatgaag gatacatgtt gacttcttaa ggactccatg acatgcagac
     3241 cctgaccaac cttggggtcg aagacatttt gtgttttgcg ccagctacca cagtcctgct
     3301 gaattcgggc tccgagacct gtggcctcgt ctcttatggg gaggggccag gaactccttc
     3361 tcatcccctg ccttaaatcc agttctttgc ctcaggggtc tctttaccat ggccttccag
     3421 ggtcccatcc tcttttctcc cgcctcgctt tctgggctct ttatcagggt gagggaccag
     3481 gattactgcc ttttgtgggt attagctcct cgccccattc taactaacac agcctttgca
     3541 gcaaatctga acgaatctca gtagtcactt tgagcaggat tccctaaccc tctaatggat
     3601 atttttcaga gtaaacttga gcctttaaat tagacacctt taaattattt tttaccacaa
     3661 ggactagaaa tagggaacac ccacatcttt ctttctggga tccatgcgga tgactgtcct
     3721 ggtggcttcg atggagaaat gtccctgtgt cacttcttta aataaccctc aaagcccctg
     3781 cacgggccct tcacgtccct gggtattctg ctggtatttg ctgtgcaaag cacgccctaa
     3841 gatggggtac ctttgatctc accgtgcggc tgcaggattc aaagtggaag cctacctacc
     3901 agttactaaa gggcttgtcc attagggctt actttgttct catgggaatg gtctttggag
     3961 ctgacttacg cagggcctcg aggttagctt agggctgtga tagaggtgcc tgaataaatt
     4021 ccagtgaaat tacgatgtcc ttgggtaatg ggaaggtatc ttttctttaa aaaaaaaaaa
     4081 aaagaaagaa agaaagaaga agaaggagaa gaagaagaaa gaaaattcag gtttcagagg
     4141 agaacctttt gagtcacgta aatacctcac tatcctggaa agcagggccc ggatggtgat
     4201 tggggtcatt gcctttgtgg gcaagagcgg gttttgctgt tgctttgagg agtgggtggg
     4261 tggggtgggc cgaaggaaaa gatttgggat cttagttgat gccctaggtt aggggcacag
     4321 gagtgtttat tttaagaacc tgccatgttt tttaatcact gtgatatttc cattcctttt
     4381 atcctaaaac aaagagaaga agtttccctg actccctgtc taagcactaa gggctgtgac
     4441 ttaagaatgg tagcgttttg gtccttcgtg tcagaactgt ggtatcttcg tctgctttgg
     4501 ttgttattat tttttaagat gtcaggatga attgtcaaat gtatggctct gtgtgtgcga
     4561 ggtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtctt ttgcttctcc
     4621 agaatgggaa gttgtcttca tgctgtgaac tgctatgggt gggcagctga cccagtctct
     4681 ctgagcagtt tcctcaacca gcgctgtccc accggtggct ccgtggtttc tcatgcttgc
     4741 actgcgggca tgagactagc ctgctcagct ctctcaccat aggggatgct gggctgggct
     4801 actccagtgc actctgtgtg tgtgctccgg ctgggtggca tcctggctca tccccactac
     4861 acaacttggc ctttgttttc atgacctcag tgcgggctta ccgctcttcc ctctacacca
     4921 ggacgccgtg cctccacacc aggacaccgt gcctccgtcc atcacctacc tcgccactgt
     4981 caccctcccc attggtccct ttccagtttc tccttaaatg tatgtctttg ttctctctgt
     5041 tgatctccca cttcctctga tccctgccat tacgctctgt gctttcgctc ctagctggct
     5101 ggccacagca ttcccgttgt gaatcctgat ttaataaaga caaggaggca ggattctctt
     5161 agtccctgtt tgtctgggtc cctgctctcc ctgttggttg ggcctagctc tgccttgtcc
     5221 cttcctggtg tctgtctgtc ggtctttttt ctttcctctc ttctccccgt ggggcagcat
     5281 ctgctgatgg attctgttct gattgtgtga ttgttgtaat ttgtccttct gtgcgcaaaa
     5341 ggaagggctt cttgaatctc ttccaagtga gattgtaaat gtagaacttt ccattgttgg
     5401 atctagattt tttaaaatcc tttttcttct ctctctttct tttcttcttt tttattttca
     5461 aaatttttaa aacaaatttt tggggctatt ttttttttgt ttgttccaga gctgagacct
     5521 tgtgcatgca tgtagaaaat tgtaaaatgt aaattttttt taatatataa aaagcttgtt
     5581 tttacatttg cagtggatta aacattatgg caattttagg gacttttttt tcttaaacat
     5641 aggaactaaa actgtacaaa aatttttttt atatataaaa taaagacatt tgactttaaa
     5701 aaaaaaaaaa aaaa
//
