LOCUS       NM_177545               4214 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus VANGL planar cell polarity 1 (Vangl1), mRNA.
ACCESSION   NM_177545 XM_910733 XM_921738 XM_921753 XM_921761
VERSION     NM_177545.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4214)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4214)
  AUTHORS   Dias,A.P., Rehmani,T., Applin,B.D., Salih,M. and Tuana,B.
  TITLE     SLMAP3 is crucial for organogenesis through mechanisms involving
            primary cilia formation
  JOURNAL   Open Biol 14 (10), rsob240206 (2024)
   PUBMED   39417621
REFERENCE   3  (bases 1 to 4214)
  AUTHORS   Paramore,S.V., Goodwin,K., Fowler,E.W., Devenport,D. and
            Nelson,C.M.
  TITLE     Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and
            widening independently of the planar cell polarity complex
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39225402
  REMARK    GeneRIF: Mesenchymal Vangl1 and Vangl2 facilitate airway elongation
            and widening independently of the planar cell polarity complex.
REFERENCE   4  (bases 1 to 4214)
  AUTHORS   Paramore,S.V., Trenado-Yuste,C., Sharan,R., Nelson,C.M. and
            Devenport,D.
  TITLE     Vangl-dependent mesenchymal thinning shapes the distal lung during
            murine sacculation
  JOURNAL   Dev Cell 59 (10), 1302-1316 (2024)
   PUBMED   38569553
  REMARK    GeneRIF: Vangl-dependent mesenchymal thinning shapes the distal
            lung during murine sacculation.
REFERENCE   5  (bases 1 to 4214)
  AUTHORS   Feng,X., Ye,Y., Zhang,J., Zhang,Y., Zhao,S., Mak,J.C.W., Otomo,N.,
            Zhao,Z., Niu,Y., Yonezawa,Y., Li,G., Lin,M., Li,X., Cheung,P.W.H.,
            Xu,K., Takeda,K., Wang,S., Xie,J., Kotani,T., Choi,V.N.T.,
            Song,Y.Q., Yang,Y., Luk,K.D.K., Lee,K.S., Li,Z., Li,P.S.,
            Leung,C.Y.H., Lin,X., Wang,X., Qiu,G., Watanabe,K., Wu,Z.,
            Posey,J.E., Ikegawa,S., Lupski,J.R., Cheung,J.P.Y., Zhang,T.J.,
            Gao,B. and Wu,N.
  CONSRTM   DISCO (Deciphering disorders Involving Scoliosis and COmorbidities)
            study group; Japanese Early Onset Scoliosis Research Group
  TITLE     Core planar cell polarity genes VANGL1 and VANGL2 in predisposition
            to congenital vertebral malformations
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2310283121 (2024)
   PUBMED   38669183
REFERENCE   6  (bases 1 to 4214)
  AUTHORS   Lee,J.H., Cho,E.S., Kim,M.Y., Seo,Y.W., Kho,D.H., Chung,I.J.,
            Kook,H., Kim,N.S., Ahn,K.Y. and Kim,K.K.
  TITLE     Suppression of progression and metastasis of established colon
            tumors in mice by intravenous delivery of short interfering RNA
            targeting KITENIN, a metastasis-enhancing protein
  JOURNAL   Cancer Res 65 (19), 8993-9003 (2005)
   PUBMED   16204073
REFERENCE   7  (bases 1 to 4214)
  AUTHORS   Torban,E., Wang,H.J., Groulx,N. and Gros,P.
  TITLE     Independent mutations in mouse Vangl2 that cause neural tube
            defects in looptail mice impair interaction with members of the
            Dishevelled family
  JOURNAL   J Biol Chem 279 (50), 52703-52713 (2004)
   PUBMED   15456783
REFERENCE   8  (bases 1 to 4214)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4214)
  AUTHORS   Park,M. and Moon,R.T.
  TITLE     The planar cell-polarity gene stbm regulates cell behaviour and
            cell fate in vertebrate embryos
  JOURNAL   Nat Cell Biol 4 (1), 20-25 (2002)
   PUBMED   11780127
  REMARK    Erratum:[Nat Cell Biol 2002 Jun;4(6):467]
REFERENCE   10 (bases 1 to 4214)
  AUTHORS   Kibar,Z., Vogan,K.J., Groulx,N., Justice,M.J., Underhill,D.A. and
            Gros,P.
  TITLE     Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is
            altered in the mouse neural tube mutant Loop-tail
  JOURNAL   Nat Genet 28 (3), 251-255 (2001)
   PUBMED   11431695
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY729182.1, AF481860.1 and AC159255.3.
            
            On Nov 16, 2013 this sequence version replaced NM_177545.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF481860.1, ERR3835354.275551.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                BY729182.1         1-85
            86-640              AF481860.1         2-556
            641-641             AC159255.3         180369-180369       c
            642-1130            AF481860.1         558-1046
            1131-1131           AC159255.3         162900-162900       c
            1132-1453           AF481860.1         1048-1369
            1454-1454           AC159255.3         159406-159406       c
            1455-1918           AF481860.1         1371-1834
            1919-4214           AC159255.3         151845-154140       c
FEATURES             Location/Qualifiers
     source          1..4214
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 44.3 cM"
     gene            1..4214
                     /gene="Vangl1"
                     /gene_synonym="Kitenin; Lpp2; Stb2; Stbm"
                     /note="VANGL planar cell polarity 1"
                     /db_xref="GeneID:229658"
                     /db_xref="MGI:MGI:2159344"
     exon            1..182
                     /gene="Vangl1"
                     /gene_synonym="Kitenin; Lpp2; Stb2; Stbm"
                     /inference="alignment:Splign:2.1.0"
     exon            183..367
                     /gene="Vangl1"
                     /gene_synonym="Kitenin; Lpp2; Stb2; Stbm"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1877
                     /gene="Vangl1"
                     /gene_synonym="Kitenin; Lpp2; Stb2; Stbm"
                     /note="loop-tail protein 2; strabismus; van Gogh-like
                     protein 1; vang, van gogh-like 1; KAI1 COOH-terminal
                     interacting tetraspanin; vang-like 1 (van gogh,
                     Drosophila)"
                     /codon_start=1
                     /product="vang-like protein 1"
                     /protein_id="NP_808213.2"
                     /db_xref="CCDS:CCDS17686.1"
                     /db_xref="GeneID:229658"
                     /db_xref="MGI:MGI:2159344"
                     /translation="MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEK
                     SVTIQAPAGEPLLANDSARTGAEEVQDDNWGETTTAITGTSEHSISQEDIARISKDME
                     DSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPQILWREELKPCGAICEGLLISVSF
                     KLLILLIGTWALFFRKQRADVPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDQNY
                     KDIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQR
                     AALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMIAAA
                     ARRRDSSHNELYYEEAEHERRVKKRRARLVVAVEEAFIHIQRLQAEEQQKSPGEVMDP
                     REAAQAIFPSMARALQKYLRTTRQQHYHSMESILQHLAFCITNSMTPKAFLERYLSAG
                     PTLQYDKDRWLSTQWRLISEEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIVLSEEF
                     IDPKSHKFVLRLQSETSV"
     exon            368..506
                     /gene="Vangl1"
                     /gene_synonym="Kitenin; Lpp2; Stb2; Stbm"
                     /inference="alignment:Splign:2.1.0"
     exon            507..1114
                     /gene="Vangl1"
                     /gene_synonym="Kitenin; Lpp2; Stb2; Stbm"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1248
                     /gene="Vangl1"
                     /gene_synonym="Kitenin; Lpp2; Stb2; Stbm"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1381
                     /gene="Vangl1"
                     /gene_synonym="Kitenin; Lpp2; Stb2; Stbm"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1616
                     /gene="Vangl1"
                     /gene_synonym="Kitenin; Lpp2; Stb2; Stbm"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..4214
                     /gene="Vangl1"
                     /gene_synonym="Kitenin; Lpp2; Stb2; Stbm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3395..3400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vangl1"
                     /gene_synonym="Kitenin; Lpp2; Stb2; Stbm"
                     /note="hexamer: ATTAAA"
     polyA_site      3419
                     /gene="Vangl1"
                     /gene_synonym="Kitenin; Lpp2; Stb2; Stbm"
                     /note="major polyA site"
ORIGIN      
        1 ggccgcgccg ggctagcagg gctgggctgg ggctgcgggg cggcgccggg acaggaagcg
       61 gaaagcagca gagaccagcg gccgcggcgg ggctgtgcct ccactgcagc ccagcgcagg
      121 ccgcggagcc cgggcgctgc agccgagagc gcgggcgtgg agcgcgacgg gccggcgccg
      181 ggagtcctgt tgaagagtag tgtctctgag tcctccaagg cctttagagc tagtgggtga
      241 gacagcacgc ggaaggacag cccctgctcc ttcatcagac gaagcttgcc attgctatgg
      301 ataccgaatc cacgtattct ggatattcct actactcaag ccattccaaa aaatctcaca
      361 ggcaagggga aagaacaaga gaaagacaca aatcaccaag gaataaagat ggcagagggt
      421 cagaaaagtc tgtcaccatc caggctcctg ctggagagcc cctgctggca aatgactctg
      481 cccgcacagg cgcagaggaa gttcaggatg acaactgggg agagaccacc accgcaatca
      541 caggcacctc agagcacagt atatcccaag aggacattgc caggattagc aaggacatgg
      601 aggacagtgt ggggctggat tgcaagcgct atctgggcct caccgttgcc tcgttccttg
      661 gactacttgt cttcctcacc cccattgcct tcatcctgct accccaaatc ctgtggaggg
      721 aggagctgaa accctgtggc gccatttgtg agggacttct catttctgta tcattcaaac
      781 tgcttattct gctcatcgga acctgggcac ttttcttccg caagcaaaga gcggatgtgc
      841 cgcgggtgtt tgtgttccga gcgctgttac tggtccttat ctttcttttt gtggtttctt
      901 actggctttt ttatggggtc cgcattttgg actctcggga ccaaaattac aaggacatcg
      961 tgcaatacgc agtctctctt gtggacgcgc tgcttttcat ccactacctt gccatcgtcc
     1021 tgctggagct gaggcagctg caacccatgt tcaccctgca ggtggtccgc tccaccgacg
     1081 gagagtcccg cttctacagc ttgggacact tgagcatcca gcgagcagcc ttggtggttc
     1141 tggaaaatta ctacaaggac ttcaccatct ataacccgaa cctcctaaca gcatccaaat
     1201 tccgagcagc caagcacatg gctggcctga aagtctacaa tgtagatggg cctagtaata
     1261 acgccactgg tcagtcccga gccatgattg ctgcagcagc tcggcgcaga gactccagcc
     1321 acaacgagtt gtattatgaa gaggccgaac acgaacgcag ggtgaagaag cggagagcaa
     1381 gactggtagt ggctgtggag gaagccttca tccatatcca gcgtctccag gctgaggagc
     1441 agcagaagtc tcccggagag gtgatggacc ccagagaggc agcccaggcc atcttcccct
     1501 ccatggccag ggcactgcag aagtacctgc gcaccacacg gcagcagcac taccacagca
     1561 tggagagtat cctgcagcac ctggccttct gcatcaccaa cagcatgacc cccaaggctt
     1621 tccttgaacg atacctcagt gcgggcccca ccttgcagta tgacaaggat cgatggctct
     1681 cgacacagtg gagacttatt agtgaggagg ctgtgacaaa cgggttacgg gatggaattg
     1741 ttttcgtcct taaatgcttg gacttcagcc tcgtggtcaa tgtgaagaaa atcccattca
     1801 ttgtactctc agaagagttc atagacccta aatctcacaa gtttgttctt cgcttacagt
     1861 ctgagacatc agtctaaaat ttctatactt gtggctttat gaaaaacaaa agaatatata
     1921 aatatatata tatatatatg tccaggagga agttctttta taaagatttt ttaaaattct
     1981 tcaatgctga ctcaaactgg cagaggatag accagtatcc ttcgaccatc tgcactttat
     2041 ttggaaggaa gcaggagatg cccaccccaa caagtgactg ttggcatctg actttaatag
     2101 atgggacttc tgaagaagct gttccctgga gtttctgtga cagctgtaaa ccaaagtgta
     2161 gctgctgtgt gtccttggga gcctcgcctt acaactggtc cctgcctgtg gcccagtacc
     2221 acacccgcct ggacttctgg tctaccacct catagatcct aggggcctca ctttattctg
     2281 cttcaggaag ccaaacacta cacacccact tgcgtgtttg tgcatgtagt tatccacatc
     2341 accacaccac cctggggagt ggtgggcagt acaggaaatg tccaaccgcc tgagttttta
     2401 atcatttgtt gccttacatt gcgaagagaa agaaactgat aggaaatgtg cactgccgtt
     2461 ttgcagctgt taagtgattg gctttccatt ttcccctgag agagagccta cctgccctgt
     2521 ttttggccct gctcctctgt tggcccttcc ctagccctgg gattgcctac ctgggcttca
     2581 ctctaacgcc cactctcctt agcatctgga ccacagctgt acatggtggg cagcctggcc
     2641 aggctagctt ggtcctccag agatgtcagg gatttggctt tccaagtata cccacagctc
     2701 tttgcacagc ctctcccagt ctttctcccg agaagtaggg tatgactctg gggatctatt
     2761 cagccgcagc acctccctta ggctgcagca ggagcccatc cacccagtcc tcctcagccc
     2821 tgcttcacac aaaccaggag agaccaacac tgtgactccc agttggcagg tgccccatgt
     2881 agccatctaa tttcccaggg agacaagtat tcaacaaagc tcatgtgcca agcttccctg
     2941 ccacgggaaa ccaaacagtg cccaccaccc tggcaactac tgctgtccca tccctgaggt
     3001 ttgtgaccac caccactgtg caacttatca caaggaaaag ggtcgctggg aaagggagag
     3061 ttgagtcagc cgtgcagtcc cgaaggctcc ttctgtcagc atgttgtagc tggtttcaga
     3121 ggacaatgcc cttgatgtcc catttgtaga catagctgct tcctggcaga gtcctgtgca
     3181 ggggagtgcc caaggagtca tttcctgaca ccttgtagtg ggctgtccca gtctctgctt
     3241 gcctacatcc gaagcaatgc tccaccaagt actctttcct ttatcagttt cagggatctc
     3301 atttcaggaa aggagaaggc cgccatcatc tccgtgccca tatatgtgta cccttctgtc
     3361 tgtgcattcc acgaaccaag cgattttgtc tgtcattaaa aaaaaaaaaa aaatccaaat
     3421 tggcatggaa tatttgtgat acacctgtgc ttagaaaagc caatgttatt tttttgttca
     3481 ataacttttg ctcagaaaga tgtgctagag aaggaagaga aacctgtgac acacacacac
     3541 acacacacac atatagtgta accaggtgct ttggtcttac tttgaaacct ttaggtccct
     3601 tctactggaa gttcctcagg atgtcttact caggaaatat tttaggagaa cgaggtaagg
     3661 ggtgggcagt ctgtgagaga ccagctgtgt gtggagggta atgtcacagc agagctgctc
     3721 cgccaccaac accattcagt tgttaagtgc cataaatgta agtactgcag cgttaaaggt
     3781 aacatcttac agtactatgc ttcctgctcc tggttaaacc atgggtctta aaggggttaa
     3841 attggagccc tgtgttggta tgtgcattcc cagaagggca aagaacggtt taaattaagg
     3901 aattaattta ttttccctcc tggcccctct ccatctcctt tgcatagaac ttcagacttc
     3961 ctgaaattat tgttttggtt gtaaattgaa tatcgatttt ttttttcttc aaaatgctta
     4021 agtttgcatc gattcctgaa agaaaagcca aaatcacaag caggatcctt taaagtcttt
     4081 gtgctcccag cgttttacca ggccgagttg acgtggaagc gaacggtgta gaggagagtt
     4141 tgcaaaagaa atgtgaagtt gcagaaagct gcatcacaca actgaagaca ataaagtttt
     4201 atttcatttc ttgg
//
