LOCUS       NM_016794                786 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus vesicle-associated membrane protein 8 (Vamp8), mRNA.
ACCESSION   NM_016794
VERSION     NM_016794.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 786)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 786)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   3  (bases 1 to 786)
  AUTHORS   Kunii,M., Noguchi,Y., Yoshimura,S.I., Kanda,S., Iwano,T.,
            Avriyanti,E., Atik,N., Sato,T., Sato,K., Ogawa,M. and Harada,A.
  TITLE     SNAP23 deficiency causes severe brain dysplasia through the loss of
            radial glial cell polarity
  JOURNAL   J Cell Biol 220 (1) (2021)
   PUBMED   33332551
REFERENCE   4  (bases 1 to 786)
  AUTHORS   Pilliod,J., Desjardins,A., Pernegre,C., Jamann,H., Larochelle,C.,
            Fon,E.A. and Leclerc,N.
  TITLE     Clearance of intracellular tau protein from neuronal cells via
            VAMP8-induced secretion
  JOURNAL   J Biol Chem 295 (51), 17827-17841 (2020)
   PUBMED   33454017
  REMARK    GeneRIF: Clearance of intracellular tau protein from neuronal cells
            via VAMP8-induced secretion.
REFERENCE   5  (bases 1 to 786)
  AUTHORS   Cornick,S., Kumar,M., Moreau,F., Gaisano,H. and Chadee,K.
  TITLE     VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells
            maintains innate intestinal homeostasis
  JOURNAL   Nat Commun 10 (1), 4306 (2019)
   PUBMED   31541089
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 786)
  AUTHORS   Gerst,J.E.
  TITLE     SNAREs and SNARE regulators in membrane fusion and exocytosis
  JOURNAL   Cell Mol Life Sci 55 (5), 707-734 (1999)
   PUBMED   10379359
  REMARK    Review article
REFERENCE   7  (bases 1 to 786)
  AUTHORS   Bui,T.D., Wong,S.H., Lu,L. and Hong,W.
  TITLE     Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse
  JOURNAL   Genomics 54 (3), 579-580 (1998)
   PUBMED   9878266
REFERENCE   8  (bases 1 to 786)
  AUTHORS   Wong,S.H., Zhang,T., Xu,Y., Subramaniam,V.N., Griffiths,G. and
            Hong,W.
  TITLE     Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially
            associated with the early endosome
  JOURNAL   Mol Biol Cell 9 (6), 1549-1563 (1998)
   PUBMED   9614193
REFERENCE   9  (bases 1 to 786)
  AUTHORS   Advani,R.J., Bae,H.R., Bock,J.B., Chao,D.S., Doung,Y.C.,
            Prekeris,R., Yoo,J.S. and Scheller,R.H.
  TITLE     Seven novel mammalian SNARE proteins localize to distinct membrane
            compartments
  JOURNAL   J Biol Chem 273 (17), 10317-10324 (1998)
   PUBMED   9553086
REFERENCE   10 (bases 1 to 786)
  AUTHORS   Zambrowicz,B.P., Friedrich,G.A., Buxton,E.C., Lilleberg,S.L.,
            Person,C. and Sands,A.T.
  TITLE     Disruption and sequence identification of 2,000 genes in mouse
            embryonic stem cells
  JOURNAL   Nature 392 (6676), 608-611 (1998)
   PUBMED   9560157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116115.11 and AK013279.1.
            
            On Aug 12, 2009 this sequence version replaced NM_016794.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG968756.1, CB194009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC116115.11        154660-154755       c
            97-776              AK013279.1         5-684
            777-786             AC116115.11        149309-149318       c
FEATURES             Location/Qualifiers
     source          1..786
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.27 cM"
     gene            1..786
                     /gene="Vamp8"
                     /gene_synonym="Edb; endobrevin"
                     /note="vesicle-associated membrane protein 8"
                     /db_xref="GeneID:22320"
                     /db_xref="MGI:MGI:1336882"
     exon            1..194
                     /gene="Vamp8"
                     /gene_synonym="Edb; endobrevin"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..497
                     /gene="Vamp8"
                     /gene_synonym="Edb; endobrevin"
                     /note="VAMP-8"
                     /codon_start=1
                     /product="vesicle-associated membrane protein 8"
                     /protein_id="NP_058074.2"
                     /db_xref="CCDS:CCDS39514.1"
                     /db_xref="GeneID:22320"
                     /db_xref="MGI:MGI:1336882"
                     /translation="MEEASGSAGNDRVRNLQSEVEGVKNIMTQNVERILARGENLDHL
                     RNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVIICVIVLIIVILIILFATGTIPT"
     exon            195..353
                     /gene="Vamp8"
                     /gene_synonym="Edb; endobrevin"
                     /inference="alignment:Splign:2.1.0"
     exon            354..786
                     /gene="Vamp8"
                     /gene_synonym="Edb; endobrevin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      755..760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vamp8"
                     /gene_synonym="Edb; endobrevin"
                     /note="hexamer: AATAAA"
     polyA_site      779
                     /gene="Vamp8"
                     /gene_synonym="Edb; endobrevin"
                     /note="major polyA site"
ORIGIN      
        1 gcagcagagg gcagccgcct acctggagaa acctgcagtt acgtgtgtgg caggagccgg
       61 agtggctgga gtcgcgggat ggtcaggagg cgggctgaaa gttggagtaa gcaggaagtg
      121 aagctgtggc tgccttgggt ggaaacagac taggcgaagt tctgctttga gaggcccaag
      181 tgctccgaga catggaggag gccagtggga gtgccggaaa tgaccgagtt aggaacctgc
      241 agagtgaggt ggagggagtc aagaatatta tgacccagaa tgtggagcgg atcttggcca
      301 gaggggagaa cctggaccac ctccgaaaca agacagagga cttggaagcc acgtctgaac
      361 acttcaagac aacgtcccag aaggtggccc ggaagttctg gtggaagaat gtgaagatga
      421 ttgtcatcat ctgtgtgatt gtccttatca tcgtcatcct cattatactt tttgccactg
      481 gtaccatccc cacttaagag tcccttccat cccaccctac tcctcagggg tgacctccct
      541 aatatgtgcc aagaggagcc ctctcctgtc ctcctccacc caagtgctgc tcagtccctg
      601 tgagggcctt ctgctgcatc agatgcccca gacgcacctt gatcccctgg gaggagacag
      661 ctggactgta gctgcatctc atggtcctga gagtgggtta cagagaccca gaggaccctg
      721 tctgtggctg ggaaactgtt ggtggctggt gggcaataaa gacctcttgg tatccctaag
      781 tgtacg
//
