LOCUS       NM_016872               1648 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus vesicle-associated membrane protein 5 (Vamp5),
            transcript variant 1, mRNA.
ACCESSION   NM_016872
VERSION     NM_016872.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1648)
  AUTHORS   Sakurai,C., Yamashita,N., Azuma,K. and Hatsuzawa,K.
  TITLE     VAMP5 promotes Fcgamma receptor-mediated phagocytosis and regulates
            phagosome maturation in macrophages
  JOURNAL   Mol Biol Cell 35 (3), ar44 (2024)
   PUBMED   38265888
  REMARK    GeneRIF: VAMP5 promotes Fcgamma receptor-mediated phagocytosis and
            regulates phagosome maturation in macrophages.
REFERENCE   2  (bases 1 to 1648)
  AUTHORS   Ikezawa,M., Tajika,Y., Ueno,H., Murakami,T., Inoue,N. and
            Yorifuji,H.
  TITLE     Loss of VAMP5 in mice results in duplication of the ureter and
            insufficient expansion of the lung
  JOURNAL   Dev Dyn 247 (5), 754-762 (2018)
   PUBMED   29330887
  REMARK    GeneRIF: Loss of VAMP5 in mice results in duplication of the ureter
            and insufficient expansion of the lung
REFERENCE   3  (bases 1 to 1648)
  AUTHORS   Takahashi,M., Tajika,Y., Khairani,A.F., Ueno,H., Murakami,T. and
            Yorifuji,H.
  TITLE     The localization of VAMP5 in skeletal and cardiac muscle
  JOURNAL   Histochem Cell Biol 139 (4), 573-582 (2013)
   PUBMED   23180306
  REMARK    GeneRIF: study found that VAMP5 was expressed in the type IIa
            fibers of skeletal muscle and that in cardiomyocytes, VAMP5
            expression was localized to the vicinity of intercalated discs
REFERENCE   4  (bases 1 to 1648)
  AUTHORS   Schwenk,R.W., Dirkx,E., Coumans,W.A., Bonen,A., Klip,A., Glatz,J.F.
            and Luiken,J.J.
  TITLE     Requirement for distinct vesicle-associated membrane proteins in
            insulin- and AMP-activated protein kinase (AMPK)-induced
            translocation of GLUT4 and CD36 in cultured cardiomyocytes
  JOURNAL   Diabetologia 53 (10), 2209-2219 (2010)
   PUBMED   20582536
REFERENCE   5  (bases 1 to 1648)
  AUTHORS   Zeng,Q., Tran,T.T., Tan,H.X. and Hong,W.
  TITLE     The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their
            correct subcellular targeting: the N-terminal extenSion of VAMP4
            contains a dominant autonomous targeting signal for the trans-Golgi
            network
  JOURNAL   J Biol Chem 278 (25), 23046-23054 (2003)
   PUBMED   12682051
  REMARK    GeneRIF: The cytoplasmic domain of this protein is responsible for
            its correct subcellular targeting.
REFERENCE   6  (bases 1 to 1648)
  AUTHORS   Zeng,Q., Subramaniam,V.N., Wong,S.H., Tang,B.L., Parton,R.G.,
            Rea,S., James,D.E. and Hong,W.
  TITLE     A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased
            during in vitro myogenesis and present in the plasma membrane
  JOURNAL   Mol Biol Cell 9 (9), 2423-2437 (1998)
   PUBMED   9725904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116115.11 and BC086925.1.
            
            On Dec 5, 2009 this sequence version replaced NM_016872.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086925.1, AF035643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC116115.11        144511-144556       c
            47-304              BC086925.1         1-258
            305-1648            AC116115.11        132137-133480       c
FEATURES             Location/Qualifiers
     source          1..1648
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.27 cM"
     gene            1..1648
                     /gene="Vamp5"
                     /gene_synonym="Camp"
                     /note="vesicle-associated membrane protein 5"
                     /db_xref="GeneID:53620"
                     /db_xref="MGI:MGI:1858622"
     exon            1..88
                     /gene="Vamp5"
                     /gene_synonym="Camp"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..394
                     /gene="Vamp5"
                     /gene_synonym="Camp"
                     /note="VAMP-5; myobrevin"
                     /codon_start=1
                     /product="vesicle-associated membrane protein 5"
                     /protein_id="NP_058568.1"
                     /db_xref="CCDS:CCDS39513.1"
                     /db_xref="GeneID:53620"
                     /db_xref="MGI:MGI:1858622"
                     /translation="MAGKELKQCQQQADEVTEIMLNNFDKVLERHGKLAELEQRSDQL
                     LDMSSAFSKTTKTLAQQKRWENIRCRVYLGLAVAVGLLIILIVLLVVFLPSGGDSSKP
                     "
     exon            89..226
                     /gene="Vamp5"
                     /gene_synonym="Camp"
                     /inference="alignment:Splign:2.1.0"
     exon            227..1648
                     /gene="Vamp5"
                     /gene_synonym="Camp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      644..649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vamp5"
                     /gene_synonym="Camp"
                     /note="hexamer: AGTAAA"
     polyA_site      669
                     /gene="Vamp5"
                     /gene_synonym="Camp"
                     /note="major polyA site"
ORIGIN      
        1 ttcctcccgg gccgcgggca ctgaggccgc tcggggcaga ggaatcggag ccggcgagca
       61 ggcagcggcg gcggctgcgg aggcaatggc agggaaagaa ctgaagcaat gccagcagca
      121 ggcggacgaa gtgacggaaa tcatgctcaa caatttcgac aaggtcctgg agcgtcacgg
      181 caagctggcg gagttggagc agcgttcaga ccagctcctg gacatgagtt cggccttcag
      241 caagacaacc aagactttag cccagcagaa gcgctgggaa aatatccggt gccgggtcta
      301 cttggggcta gcagtggctg ttggcctgct catcatcctg attgtgttgc tggtcgtctt
      361 tcttccgagt ggtggggaca gtagtaaacc ataggcctag gatgcaggtg atgccttagg
      421 gactggggac tgacccagcc cggcctgaag ggaaggctga atgactgcac tggcctgttt
      481 tggtctccag agaatcctgg tgtttgcttc catctaggac acccaaatga ctgctgaagg
      541 gcatccagga ttatgtgcac ctctgcatct cccatcatgc catggactgg cccttgagag
      601 tggactgctg cactggccct attaggccac accactggag ctcagtaaaa gctgctcttt
      661 ggttaaaaat gctctctctc tctctctctc tctctctctc tctctctctc actcacacac
      721 acaccacaga cacaaaagta tatcatatac atacacacac cctacagaca ccagacatag
      781 gcattacaca tatacacccc ccccacacac acacagatac acatacacac atatacacta
      841 cagacacaga ccctgtagca caaacatact atatgacccc cccccaaatt aatgtaatct
      901 cttaaaaaaa aaagaaagaa aagaaaagaa aacctatcac ctcatccaaa ggactatatt
      961 tcaggagaca gccccttcct ctccttttcc aacttgatcc tgtcctacac agatggacct
     1021 ttaaggaatg tgggccaagg gcacagtagt ccacaaacca gacctttgca cccattccca
     1081 tgaaaatgaa atccatcatc tttgatatct tgaacattct cagaggacca atggaactcc
     1141 agatagaagg ataaaaagga aagggcttgc tgggagtata actcagttga cagaaatgcc
     1201 tgccctgtat gaacaaagtc ctggggttga tggtggtgca tacatctata gtttcagcac
     1261 tcaggaagta gagacaggag gaatacaaat tcaagatcat ccttggctac agttagttag
     1321 gagctattct gggctatatg agagaccctg tcttaaaagg aaaaaaaatg gttggagagc
     1381 tggtccagag attaagagca ctggctattc ttctagagga tccaggttca gttcccagca
     1441 cccacatggc agctcacagc tgtctttaac tctagttcca aaggatctga caccctcaca
     1501 cagacacaca tgcagataaa acatcaacaa tcataaaata aaaataaatt caacaaacaa
     1561 acaaaaaaaa aaacaaacat gaagttaaaa aaaaaaaaaa aaaggtgtac tgctctacag
     1621 aggatccaag tctgcaagtt cagtttcc
//
